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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei212SubstrateUniRule annotation1
Binding sitei242SubstrateUniRule annotation1
Binding sitei246SubstrateUniRule annotation1
Binding sitei247NADUniRule annotation1
Binding sitei299NADUniRule annotation1
Binding sitei334NADUniRule annotation1
Binding sitei403NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 215NADUniRule annotation3
Nucleotide bindingi276 – 281NADUniRule annotation6
Nucleotide bindingi355 – 357NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:BF4468
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002197 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169421 – 487AdenosylhomocysteinaseAdd BLAST487

Proteomic databases

PRIDEiQ64MT2

Structurei

3D structure databases

ProteinModelPortaliQ64MT2
SMRiQ64MT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227986
KOiK01251
OMAiTGNRDII
OrthoDBiPOG091H00W2

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q64MT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYLCTTLYF KQFTFMSTEL FSTLPYKVAD ITLADFGRKE IDLAEKEMPG
60 70 80 90 100
LMALREKYGE SKPLKGARIM GSLHMTIQTA VLIETLVALG AEVRWCSCNI
110 120 130 140 150
YSTQDHAAAA IAASGVAVFA WKGETLADYW WCTLQALNFE GGKGPTVIVD
160 170 180 190 200
DGGDATMMIH VGYEAENNAA VLDKEVHAED EIELNAILKK VLAEDKERWH
210 220 230 240 250
RVAAEVRGVS EETTTGVHRL YQMQEEGKLL FPAFNVNDSV TKSKFDNLYG
260 270 280 290 300
CRESLADGIK RATDVMIAGK VVVVCGYGDV GKGCSHSMRS YGARVLVTEV
310 320 330 340 350
DPICALQAAM EGFEVVTMED ACKEGNIFVT TTGNIDIIRI DHMEQMKDQA
360 370 380 390 400
IVCNIGHFDN EIQVDALKHY PGIKRVNIKP QVDRYYFPDG HSIILLADGR
410 420 430 440 450
LVNLGCATGH PSFVMSNSFT NQTLAQIELF NKKYDINVYR LPKHLDEEVA
460 470 480
RLHLEKIGVK LTKLTPEQAA YIGVSVDGPY KADHYRY
Length:487
Mass (Da):54,186
Last modified:October 25, 2004 - v1
Checksum:i64AA176C52CF0B00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006841 Genomic DNA Translation: BAD51205.1
RefSeqiWP_008770078.1, NC_006347.1
YP_101739.1, NC_006347.1

Genome annotation databases

EnsemblBacteriaiBAD51205; BAD51205; BF4468
GeneIDi3085544
KEGGibfr:BF4468
PATRICifig|295405.11.peg.4306

Similar proteinsi

Entry informationi

Entry nameiSAHH_BACFR
AccessioniPrimary (citable) accession number: Q64MT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 25, 2004
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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