We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q64HY3 (SP9_MOUSE)
Protein
Transcription factor Sp9
Gene
Sp9
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 332 – 356 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 362 – 386 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 392 – 414 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- embryonic limb morphogenesis Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Sp9 |
Gene namesi | Name:Sp9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3574660, Sp9 |
VEuPathDBi | HostDB:ENSMUSG00000068859 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395451 | 1 – 484 | Transcription factor Sp9Add BLAST | 484 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 440 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q64HY3 |
PaxDbi | Q64HY3 |
PRIDEi | Q64HY3 |
ProteomicsDBi | 263300 [Q64HY3-1] 263301 [Q64HY3-2] |
PTM databases
iPTMneti | Q64HY3 |
PhosphoSitePlusi | Q64HY3 |
Expressioni
Developmental stagei
Detected in the apical ectodermal ridge (AER) during limb development as well as in the distal region of the ectoderm.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000068859, Expressed in embryo and 55 other tissues |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000088322 |
Miscellaneous databases
RNActi | Q64HY3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 409 – 446 | DisorderedSequence analysisAdd BLAST | 38 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 178 – 186 | 9aaTAD; inactiveBy similarity | 9 |
Domaini
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP9, the motif is inactive.By similarity
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 332 – 356 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 362 – 386 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 392 – 414 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162304 |
HOGENOMi | CLU_019484_4_1_1 |
InParanoidi | Q64HY3 |
OMAi | HHHATSV |
OrthoDBi | 664813at2759 |
PhylomeDBi | Q64HY3 |
TreeFami | TF350150 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q64HY3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATSILGEEP RFGTTPLAML AATCNKIGNT SPLTTLPESS AFAKGGFHPW
60 70 80 90 100
KRSSSSCNLG SSLSGFAVAT GGRGSGSLAG GSGAANSAFC LASTSPTSSA
110 120 130 140 150
FSSDYGGLFS NSAAAAAAAA GVSPQEAGGQ SAFISKVHTT AADGLYPRVG
160 170 180 190 200
MAHPYESWYK SGFHSTLAAG EVTNGAASSW WDVHSSPGSW LEVQNPAGGL
210 220 230 240 250
QSSLHSGAPQ ASLHSQLGTY NPDFSSLTHS AFSSTGLGSS AAAASHLLST
260 270 280 290 300
SQHLLAQDGF KPVLPSYSDS SAAVAAAAAS AMISGAAAAA AGGSSARSAR
310 320 330 340 350
RYSGRATCDC PNCQEAERLG PAGASLRRKG LHSCHIPGCG KVYGKTSHLK
360 370 380 390 400
AHLRWHTGER PFVCNWLFCG KRFTRSDELQ RHLRTHTGEK RFACPVCNKR
410 420 430 440 450
FMRSDHLSKH IKTHNGGGGG KKGSDSDTDA SNLETPRSES PDLILHDSGV
460 470 480
SAARAAAAAA AAAAAAAAAA SAGGKEAATG PNDS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 273 | A → S in CAH59970 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039467 | 1 – 18 | Missing in isoform 2. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY591908 mRNA Translation: AAU04517.1 AJ844915 mRNA Translation: CAH59970.1 AL954713 Genomic DNA No translation available. BC139398 mRNA Translation: AAI39399.1 BC139407 mRNA Translation: AAI39408.1 |
CCDSi | CCDS16126.1 [Q64HY3-1] |
RefSeqi | NP_001005343.1, NM_001005343.2 [Q64HY3-1] |
Genome annotation databases
Ensembli | ENSMUST00000090813; ENSMUSP00000088322; ENSMUSG00000068859 [Q64HY3-1] |
GeneIDi | 381373 |
KEGGi | mmu:381373 |
UCSCi | uc008kcj.2, mouse [Q64HY3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY591908 mRNA Translation: AAU04517.1 AJ844915 mRNA Translation: CAH59970.1 AL954713 Genomic DNA No translation available. BC139398 mRNA Translation: AAI39399.1 BC139407 mRNA Translation: AAI39408.1 |
CCDSi | CCDS16126.1 [Q64HY3-1] |
RefSeqi | NP_001005343.1, NM_001005343.2 [Q64HY3-1] |
3D structure databases
SMRi | Q64HY3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000088322 |
PTM databases
iPTMneti | Q64HY3 |
PhosphoSitePlusi | Q64HY3 |
Proteomic databases
MaxQBi | Q64HY3 |
PaxDbi | Q64HY3 |
PRIDEi | Q64HY3 |
ProteomicsDBi | 263300 [Q64HY3-1] 263301 [Q64HY3-2] |
Protocols and materials databases
Antibodypediai | 57975, 19 antibodies from 7 providers |
DNASUi | 381373 |
Genome annotation databases
Ensembli | ENSMUST00000090813; ENSMUSP00000088322; ENSMUSG00000068859 [Q64HY3-1] |
GeneIDi | 381373 |
KEGGi | mmu:381373 |
UCSCi | uc008kcj.2, mouse [Q64HY3-1] |
Organism-specific databases
CTDi | 100131390 |
MGIi | MGI:3574660, Sp9 |
VEuPathDBi | HostDB:ENSMUSG00000068859 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162304 |
HOGENOMi | CLU_019484_4_1_1 |
InParanoidi | Q64HY3 |
OMAi | HHHATSV |
OrthoDBi | 664813at2759 |
PhylomeDBi | Q64HY3 |
TreeFami | TF350150 |
Miscellaneous databases
BioGRID-ORCSi | 381373, 1 hit in 64 CRISPR screens |
PROi | PR:Q64HY3 |
RNActi | Q64HY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068859, Expressed in embryo and 55 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SP9_MOUSE | |
Accessioni | Q64HY3Primary (citable) accession number: Q64HY3 Secondary accession number(s): Q5QR89 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 13, 2010 |
Last sequence update: | October 25, 2004 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families