Sp9

Functionⁱ

Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	332 – 356	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	362 – 386	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	392 – 414	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from sequence or structural similarityⁱ
- 15820306
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

embryonic limb morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15358670
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor Sp9
Gene namesⁱ	Name:Sp9
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:3574660 Sp9

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000395451	1 – 484	Transcription factor Sp9Add BLAST		484

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	440	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q64HY3
PRIDEⁱ	Q64HY3

PTM databases

iPTMnetⁱ	Q64HY3
PhosphoSitePlusⁱ	Q64HY3

Expressionⁱ

Developmental stageⁱ

Detected in the apical ectodermal ridge (AER) during limb development as well as in the distal region of the ectoderm.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000068859 Expressed in 20 organ(s), highest expression level in embryo

Bgeeⁱ

ENSMUSG00000068859 Expressed in 20 organ(s), highest expression level in embryo

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000088322

STRINGⁱ

10090.ENSMUSP00000088322

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q64HY3
SMRⁱ	Q64HY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	53 – 56	Poly-Ser	4
Compositional biasⁱ	113 – 120	Poly-Ala	8
Compositional biasⁱ	241 – 244	Poly-Ala	4
Compositional biasⁱ	272 – 299	Ala-richAdd BLAST	28
Compositional biasⁱ	452 – 478	Ala-richAdd BLAST	27

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	332 – 356	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	362 – 386	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	392 – 414	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000231067
HOVERGENⁱ	HBG036899
InParanoidⁱ	Q64HY3
KEGG Orthology (KO) More...KOⁱ	K09199
OMAⁱ	SGQSAFI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HX6
PhylomeDBⁱ	Q64HY3
TreeFamⁱ	TF350150

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q64HY3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSILGEEP RFGTTPLAML AATCNKIGNT SPLTTLPESS AFAKGGFHPW 
        60         70         80         90        100
KRSSSSCNLG SSLSGFAVAT GGRGSGSLAG GSGAANSAFC LASTSPTSSA 
       110        120        130        140        150
FSSDYGGLFS NSAAAAAAAA GVSPQEAGGQ SAFISKVHTT AADGLYPRVG 
       160        170        180        190        200
MAHPYESWYK SGFHSTLAAG EVTNGAASSW WDVHSSPGSW LEVQNPAGGL 
       210        220        230        240        250
QSSLHSGAPQ ASLHSQLGTY NPDFSSLTHS AFSSTGLGSS AAAASHLLST 
       260        270        280        290        300
SQHLLAQDGF KPVLPSYSDS SAAVAAAAAS AMISGAAAAA AGGSSARSAR 
       310        320        330        340        350
RYSGRATCDC PNCQEAERLG PAGASLRRKG LHSCHIPGCG KVYGKTSHLK 
       360        370        380        390        400
AHLRWHTGER PFVCNWLFCG KRFTRSDELQ RHLRTHTGEK RFACPVCNKR 
       410        420        430        440        450
FMRSDHLSKH IKTHNGGGGG KKGSDSDTDA SNLETPRSES PDLILHDSGV 
       460        470        480 
SAARAAAAAA AAAAAAAAAA SAGGKEAATG PNDS

Length:484

Mass (Da):48,959

Last modified:October 25, 2004 - v1

Checksum:ⁱ57ADE8A82E9B12E7

GO

Isoform 2 (identifier: Q64HY3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-18: Missing.

« Hide

        10         20         30         40         50
MLAATCNKIG NTSPLTTLPE SSAFAKGGFH PWKRSSSSCN LGSSLSGFAV 
        60         70         80         90        100
ATGGRGSGSL AGGSGAANSA FCLASTSPTS SAFSSDYGGL FSNSAAAAAA 
       110        120        130        140        150
AAGVSPQEAG GQSAFISKVH TTAADGLYPR VGMAHPYESW YKSGFHSTLA 
       160        170        180        190        200
AGEVTNGAAS SWWDVHSSPG SWLEVQNPAG GLQSSLHSGA PQASLHSQLG 
       210        220        230        240        250
TYNPDFSSLT HSAFSSTGLG SSAAAASHLL STSQHLLAQD GFKPVLPSYS 
       260        270        280        290        300
DSSAAVAAAA ASAMISGAAA AAAGGSSARS ARRYSGRATC DCPNCQEAER 
       310        320        330        340        350
LGPAGASLRR KGLHSCHIPG CGKVYGKTSH LKAHLRWHTG ERPFVCNWLF 
       360        370        380        390        400
CGKRFTRSDE LQRHLRTHTG EKRFACPVCN KRFMRSDHLS KHIKTHNGGG 
       410        420        430        440        450
GGKKGSDSDT DASNLETPRS ESPDLILHDS GVSAARAAAA AAAAAAAAAA 
       460 
AASAGGKEAA TGPNDS

Show »

Length:466

Mass (Da):47,086

Checksum:ⁱC7080FA22DC56B0F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	273	A → S in CAH59970 (Ref. 2) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039467	1 – 18	Missing in isoform 2. 1 PublicationAdd BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY591908 mRNA Translation: AAU04517.1 AJ844915 mRNA Translation: CAH59970.1 AL954713 Genomic DNA No translation available. BC139398 mRNA Translation: AAI39399.1 BC139407 mRNA Translation: AAI39408.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16126.1 [Q64HY3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001005343.1, NM_001005343.2 [Q64HY3-1]
UniGeneⁱ	Mm.330293

Genome annotation databases

Ensemblⁱ	ENSMUST00000090813; ENSMUSP00000088322; ENSMUSG00000068859 [Q64HY3-1]
GeneIDⁱ	381373
KEGGⁱ	mmu:381373
UCSC genome browser More...UCSCⁱ	uc008kcj.2 mouse [Q64HY3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q64HY3	Transcription factor Sp9		HUMAN		484	UniRef90_Q64HY3
Isoform 2 of Transcription factor Sp9		MOUSE		466
Sp9 transcription factor		CALJA		519
Uncharacterized protein		PROCO		487
transcription factor Sp9		Enhydra lutris kenyoni		486
+83

Protein	Similar proteins		Species	Score	Length	Source
Q64HY3	Transcription factor Sp9		DANRE		439	UniRef50_Q6NW96
Transcription factor Sp9		HUMAN		484
Transcription factor Sp9		XENTR		422
Sp9 transcription factor		NOTFU		484
Sp9 (Fragment)		AMBME		110
+220

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY591908 mRNA Translation: AAU04517.1 AJ844915 mRNA Translation: CAH59970.1 AL954713 Genomic DNA No translation available. BC139398 mRNA Translation: AAI39399.1 BC139407 mRNA Translation: AAI39408.1
CCDSⁱ	CCDS16126.1 [Q64HY3-1]
RefSeqⁱ	NP_001005343.1, NM_001005343.2 [Q64HY3-1]
UniGeneⁱ	Mm.330293

3D structure databases

ProteinModelPortalⁱ	Q64HY3
SMRⁱ	Q64HY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000088322

STRINGⁱ

10090.ENSMUSP00000088322

PTM databases

iPTMnetⁱ	Q64HY3
PhosphoSitePlusⁱ	Q64HY3

Proteomic databases

PaxDbⁱ	Q64HY3
PRIDEⁱ	Q64HY3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000090813; ENSMUSP00000088322; ENSMUSG00000068859 [Q64HY3-1]
GeneIDⁱ	381373
KEGGⁱ	mmu:381373
UCSCⁱ	uc008kcj.2 mouse [Q64HY3-1]

Organism-specific databases

CTDⁱ	100131390
MGIⁱ	MGI:3574660 Sp9

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000231067
HOVERGENⁱ	HBG036899
InParanoidⁱ	Q64HY3
KOⁱ	K09199
OMAⁱ	SGQSAFI
OrthoDBⁱ	EOG091G0HX6
PhylomeDBⁱ	Q64HY3
TreeFamⁱ	TF350150

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q64HY3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000068859 Expressed in 20 organ(s), highest expression level in embryo

Bgeeⁱ

ENSMUSG00000068859 Expressed in 20 organ(s), highest expression level in embryo

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SP9_MOUSE
Accessionⁱ	Q64HY3Primary (citable) accession number: Q64HY3 Secondary accession number(s): Q5QR89
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 13, 2010
	Last sequence update:	October 25, 2004
	Last modified:	November 7, 2018
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q64HY3 (SP9_MOUSE)

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Transcription factor Sp9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ