Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor Sp9

Gene

Sp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 356C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri362 – 386C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri392 – 414C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • embryonic limb morphogenesis Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp9
Gene namesi
Name:Sp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3574660 Sp9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003954511 – 484Transcription factor Sp9Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei440PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ64HY3
PRIDEiQ64HY3

PTM databases

iPTMnetiQ64HY3
PhosphoSitePlusiQ64HY3

Expressioni

Developmental stagei

Detected in the apical ectodermal ridge (AER) during limb development as well as in the distal region of the ectoderm.1 Publication

Gene expression databases

BgeeiENSMUSG00000068859 Expressed in 20 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088322

Structurei

3D structure databases

ProteinModelPortaliQ64HY3
SMRiQ64HY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 56Poly-Ser4
Compositional biasi113 – 120Poly-Ala8
Compositional biasi241 – 244Poly-Ala4
Compositional biasi272 – 299Ala-richAdd BLAST28
Compositional biasi452 – 478Ala-richAdd BLAST27

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 356C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri362 – 386C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri392 – 414C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG036899
InParanoidiQ64HY3
KOiK09199
OMAiSGQSAFI
OrthoDBiEOG091G0HX6
PhylomeDBiQ64HY3
TreeFamiTF350150

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q64HY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATSILGEEP RFGTTPLAML AATCNKIGNT SPLTTLPESS AFAKGGFHPW
60 70 80 90 100
KRSSSSCNLG SSLSGFAVAT GGRGSGSLAG GSGAANSAFC LASTSPTSSA
110 120 130 140 150
FSSDYGGLFS NSAAAAAAAA GVSPQEAGGQ SAFISKVHTT AADGLYPRVG
160 170 180 190 200
MAHPYESWYK SGFHSTLAAG EVTNGAASSW WDVHSSPGSW LEVQNPAGGL
210 220 230 240 250
QSSLHSGAPQ ASLHSQLGTY NPDFSSLTHS AFSSTGLGSS AAAASHLLST
260 270 280 290 300
SQHLLAQDGF KPVLPSYSDS SAAVAAAAAS AMISGAAAAA AGGSSARSAR
310 320 330 340 350
RYSGRATCDC PNCQEAERLG PAGASLRRKG LHSCHIPGCG KVYGKTSHLK
360 370 380 390 400
AHLRWHTGER PFVCNWLFCG KRFTRSDELQ RHLRTHTGEK RFACPVCNKR
410 420 430 440 450
FMRSDHLSKH IKTHNGGGGG KKGSDSDTDA SNLETPRSES PDLILHDSGV
460 470 480
SAARAAAAAA AAAAAAAAAA SAGGKEAATG PNDS
Length:484
Mass (Da):48,959
Last modified:October 25, 2004 - v1
Checksum:i57ADE8A82E9B12E7
GO
Isoform 2 (identifier: Q64HY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:466
Mass (Da):47,086
Checksum:iC7080FA22DC56B0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273A → S in CAH59970 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0394671 – 18Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY591908 mRNA Translation: AAU04517.1
AJ844915 mRNA Translation: CAH59970.1
AL954713 Genomic DNA No translation available.
BC139398 mRNA Translation: AAI39399.1
BC139407 mRNA Translation: AAI39408.1
CCDSiCCDS16126.1 [Q64HY3-1]
RefSeqiNP_001005343.1, NM_001005343.2 [Q64HY3-1]
UniGeneiMm.330293

Genome annotation databases

EnsembliENSMUST00000090813; ENSMUSP00000088322; ENSMUSG00000068859 [Q64HY3-1]
GeneIDi381373
KEGGimmu:381373
UCSCiuc008kcj.2 mouse [Q64HY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY591908 mRNA Translation: AAU04517.1
AJ844915 mRNA Translation: CAH59970.1
AL954713 Genomic DNA No translation available.
BC139398 mRNA Translation: AAI39399.1
BC139407 mRNA Translation: AAI39408.1
CCDSiCCDS16126.1 [Q64HY3-1]
RefSeqiNP_001005343.1, NM_001005343.2 [Q64HY3-1]
UniGeneiMm.330293

3D structure databases

ProteinModelPortaliQ64HY3
SMRiQ64HY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088322

PTM databases

iPTMnetiQ64HY3
PhosphoSitePlusiQ64HY3

Proteomic databases

PaxDbiQ64HY3
PRIDEiQ64HY3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090813; ENSMUSP00000088322; ENSMUSG00000068859 [Q64HY3-1]
GeneIDi381373
KEGGimmu:381373
UCSCiuc008kcj.2 mouse [Q64HY3-1]

Organism-specific databases

CTDi100131390
MGIiMGI:3574660 Sp9

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG036899
InParanoidiQ64HY3
KOiK09199
OMAiSGQSAFI
OrthoDBiEOG091G0HX6
PhylomeDBiQ64HY3
TreeFamiTF350150

Miscellaneous databases

PROiPR:Q64HY3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068859 Expressed in 20 organ(s), highest expression level in embryo

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSP9_MOUSE
AccessioniPrimary (citable) accession number: Q64HY3
Secondary accession number(s): Q5QR89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 25, 2004
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again