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Protein

Collagen alpha-2(XI) chain

Gene

Col11a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1589CalciumBy similarity1
Metal bindingi1591CalciumBy similarity1
Metal bindingi1592Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1594Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1597CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-2(XI) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col11a2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88447 Col11a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000584228 – 1736Collagen alpha-2(XI) chainAdd BLAST1709
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000058431501 – 1736C-terminal propeptideAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1571 ↔ 1603PROSITE-ProRule annotation
Disulfide bondi1577InterchainPROSITE-ProRule annotation
Disulfide bondi1594InterchainPROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1604N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1612 ↔ 1733PROSITE-ProRule annotation
Disulfide bondi1655 ↔ 1689PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q64739

PRoteomics IDEntifications database

More...
PRIDEi
Q64739

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q64739

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q64739

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024330 Expressed in 101 organ(s), highest expression level in humerus cartilage element

CleanEx database of gene expression profiles

More...
CleanExi
MM_COL11A2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q64739 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q64739 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is a post-translational modification of alpha 1(II). Alpha 1(V) can also be found instead of alpha 3(XI)=1(II) (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198806, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2975 Collagen type XI trimer variant 1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q64739

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q64739

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 228Laminin G-likeAdd BLAST172
Domaini399 – 447Collagen-like 1Add BLAST49
Domaini487 – 545Collagen-like 2Add BLAST59
Domaini546 – 583Collagen-like 3Add BLAST38
Domaini682 – 737Collagen-like 4Add BLAST56
Domaini868 – 924Collagen-like 5Add BLAST57
Domaini967 – 1025Collagen-like 6Add BLAST59
Domaini1026 – 1055Collagen-like 7Add BLAST30
Domaini1056 – 1086Collagen-like 8Add BLAST31
Domaini1114 – 1172Collagen-like 9Add BLAST59
Domaini1393 – 1447Collagen-like 10Add BLAST55
Domaini1448 – 1499Collagen-like 11Add BLAST52
Domaini1541 – 1735Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni215 – 486Nonhelical regionAdd BLAST272
Regioni487 – 1500Triple-helical regionAdd BLAST1014

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159762

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085654

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q64739

KEGG Orthology (KO)

More...
KOi
K19721

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPVCFQG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01AE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q64739

TreeFam database of animal gene trees

More...
TreeFami
TF323987

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 2 hits
PF01391 Collagen, 7 hits
PF02210 Laminin_G_2, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q64739-2) [UniParc]FASTAAdd to basket
Also known as: E56789

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERCSRCHRL LLFLPLVLGL SAAPGWAGAP SVDVLRALRF PSLPDGVRRS
60 70 80 90 100
KGVCPGDVAY RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL
110 120 130 140 150
LTLYSAQGVQ QLGLELGRPV RFLYEDQRGR PQASAQPIFR GLSLADGKWH
160 170 180 190 200
HVAVAVKGQS VTLIVDCKKR VTRPLPRSVH PVLDTHGVVI FGAHILDDEV
210 220 230 240 250
FEGDVQELLV VPGVQAAYQS CGQKDLECER EQRDGPQTQK PHRAQRSPKK
260 270 280 290 300
EPARLHKPQS QEPQKQPTES LYYDYEPPYY DVMTTGTAPD YQYPTPGEEE
310 320 330 340 350
GVLESSPLPF LEEEQTDLQV SPTADSFQAE EYGEGGTDSP AGFYDYTYGY
360 370 380 390 400
GDDYREETEL GPALSAETAH SGAVAHGPRG LKGEKGEPAV LEPGMFVEGP
410 420 430 440 450
PGPEGPAGLA GPPGIQGNPG PVGDPGERGP PGRAGLPGSD GPPGPPGTSL
460 470 480 490 500
MLPFRFGSSG GDKGPVVAAQ EAQAQAILQQ ARLALRGPPG PMGYTGRPGP
510 520 530 540 550
LGQPGSPGLK GESGDLGPQG PRGPQGLTGP PGKAGRRGRA GADGARGMPG
560 570 580 590 600
EPGMKGDRGF DGLPGLPGEK GQRGDTGAQG LPGPPGEDGE RGDDGEIGPR
610 620 630 640 650
GLPGESGPRG LLGPKGPPGI PGPPGVRGMD GPHGPKGSLG PQGEPGPPGQ
660 670 680 690 700
QGTPGAQGLP GPQGAIGPHG EKGARGKPGL PGMPGSDGLP GHPGKEGPPG
710 720 730 740 750
TKGNQGPSGP QGPLGYPGPR GVKGVDGIRG LKGHKGEKGE DGFPGFKGDI
760 770 780 790 800
GVKGDRGEVG VPGSRGEDGP EGPKGRTGPT GDPGPTGLMG EKGKLGVPGL
810 820 830 840 850
PGYPGRQGPK GSLGFPGFPG ASGEKGARGL SGKSGPRGER GPTGPRGQRG
860 870 880 890 900
PRGATGKSGA KGTSGGDGPH GPPGERGLPG PQGPNGFPGP KGPPGPAGKD
910 920 930 940 950
GLPGHPGQRG EVGFQGKTGP PGPPGVVGPQ GTAGESGPMG ERGHSGPPGP
960 970 980 990 1000
PGEQGLPGTS GKEGTKGDPG PPGAPGKDGP AGLRGFPGER GLPGTAGGPG
1010 1020 1030 1040 1050
LKGNEGPAGP PGPAGSPGER GAAGSGGPIG PPGRPGPQGP PGAAGEKGVP
1060 1070 1080 1090 1100
GEKGPIGPTG RDGVQGPVGL PGPAGPPGVA GEDGDKGEVG DPGQKGTKGN
1110 1120 1130 1140 1150
KGEHGPPGPP GPIGPVGQPG AAGADGEPGA RGPQGHFGAK GDEGTRGFNG
1160 1170 1180 1190 1200
PPGPIGLQGL PGPSGEKGET GDGGPMGPPG PPGPRGPAGP NGADGPQGSP
1210 1220 1230 1240 1250
GGVGNLGPPG EKGEPGESGS PGVQGEPGVK GPRGERGEKG ESGQAGEAGP
1260 1270 1280 1290 1300
PGPKGPTGDN GPKGNPGPVG FPGDPGPPGE AGPRGQDGAK GDRGEDGEPG
1310 1320 1330 1340 1350
QPGSPGPTGE NGPPGPLGKR GPAGTPGPEG RQGEKGAKGD PGAVGAPGKT
1360 1370 1380 1390 1400
GPVGPAGLAG KPGPDGLRGL PGSVGQQGRP GATGQAGPPG PVGPPGLPGL
1410 1420 1430 1440 1450
RGDAGAKGEK GHPGLIGLIG PTGEQGEKGD RGLPGPQGSP GQKGETGIPG
1460 1470 1480 1490 1500
ASGPIGPGGP PGLPGPSGPK GAKGATGPAG PKGEKGVQGP PGHPGPPGEV
1510 1520 1530 1540 1550
IQPLPIQMPK KTRRSVDGSK LIQDEEAVPT GGAPGSPAGL EEIFGSLDSL
1560 1570 1580 1590 1600
REEIEQMRRP AGTQDSPART CQDLKLCHPE LPDGEYWVDP NQGCARDAFR
1610 1620 1630 1640 1650
VFCNFTAGGE TCVTPRDDVT QFSYVDSEGS PVGVVQLTFL RLLSVSAHQD
1660 1670 1680 1690 1700
VSYPCSGVSQ DGPLKLRGAN EDELSPETSP YVKEFRDGCQ TQQGRTVLEV
1710 1720 1730
RTPVLEQLPV LDASFADLGA PTRRGGVLLG PVCFMG
Length:1,736
Mass (Da):171,535
Last modified:April 30, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18D792D4A3387C61
GO
Isoform 2 (identifier: Q64739-3) [UniParc]FASTAAdd to basket
Also known as: E5689

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: Missing.

Show »
Length:1,715
Mass (Da):169,234
Checksum:iCC2B4D1773123877
GO
Isoform 3 (identifier: Q64739-4) [UniParc]FASTAAdd to basket
Also known as: E5789

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.

Show »
Length:1,710
Mass (Da):168,473
Checksum:i8BAB1973804954C2
GO
Isoform 4 (identifier: Q64739-5) [UniParc]FASTAAdd to basket
Also known as: E569

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: Missing.
     314-373: Missing.

Show »
Length:1,655
Mass (Da):162,833
Checksum:i28ECA47A24C6174B
GO
Isoform 5 (identifier: Q64739-6) [UniParc]FASTAAdd to basket
Also known as: E589

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.
     293-313: Missing.

Show »
Length:1,689
Mass (Da):166,172
Checksum:iFBBF356DBACE1482
GO
Isoform 6 (identifier: Q64739-7) [UniParc]FASTAAdd to basket
Also known as: E59

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.
     293-313: Missing.
     314-373: Missing.

Show »
Length:1,629
Mass (Da):159,771
Checksum:i618E1167953435BF
GO
Isoform 7 (identifier: Q64739-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.
     314-373: Missing.

Show »
Length:1,650
Mass (Da):162,072
Checksum:i8ECDB8702E71E2DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7HPY2I7HPY2_MOUSE
Collagen alpha-2(XI) chain
Col11a2 RP23-222K15.2-002
624Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3UUU1Q3UUU1_MOUSE
Collagen alpha-2(XI) chain
Col11a2 RP23-222K15.2-003
771Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti536R → L in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti621P → S in BAA18910 (PubMed:7836472).Curated1
Sequence conflicti704 – 705NQ → KP in AAA67751 (PubMed:8981332).Curated2
Sequence conflicti797V → A in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti843 – 845TGP → HGS in AAA67751 (PubMed:8981332).Curated3
Sequence conflicti854A → S in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti876R → G in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti889G → V in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti922G → D in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti1005E → V in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti1253P → S in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti1386A → T in AAA67751 (PubMed:8981332).Curated1
Sequence conflicti1522I → M in AAA67751 (PubMed:8981332).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007345267 – 292Missing in isoform 3, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_007346293 – 313Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_007347314 – 373Missing in isoform 4, isoform 6 and isoform 7. 2 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF100956 Genomic DNA Translation: AAC69905.1
U16789 mRNA Translation: AAA67751.1
U16790 Genomic DNA Translation: AAA67752.1
D38412 mRNA Translation: BAA18910.1
D84066 Genomic DNA Translation: BAA12208.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS28640.1 [Q64739-1]

Protein sequence database of the Protein Information Resource

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PIRi
A55576

NCBI Reference Sequences

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RefSeqi
NP_001304651.1, NM_001317722.1 [Q64739-3]
NP_034056.1, NM_009926.2 [Q64739-1]
XP_006523627.1, XM_006523564.3 [Q64739-2]
XP_006523629.1, XM_006523566.3 [Q64739-4]
XP_006523630.1, XM_006523567.3 [Q64739-6]
XP_006523632.1, XM_006523569.3 [Q64739-5]
XP_006523633.1, XM_006523570.3 [Q64739-7]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.20230

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000087497; ENSMUSP00000084772; ENSMUSG00000024330 [Q64739-1]
ENSMUST00000114252; ENSMUSP00000109890; ENSMUSG00000024330 [Q64739-5]
ENSMUST00000114255; ENSMUSP00000109893; ENSMUSG00000024330 [Q64739-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
12815

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:12815

UCSC genome browser

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UCSCi
uc056zel.1 mouse [Q64739-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100956 Genomic DNA Translation: AAC69905.1
U16789 mRNA Translation: AAA67751.1
U16790 Genomic DNA Translation: AAA67752.1
D38412 mRNA Translation: BAA18910.1
D84066 Genomic DNA Translation: BAA12208.1
CCDSiCCDS28640.1 [Q64739-1]
PIRiA55576
RefSeqiNP_001304651.1, NM_001317722.1 [Q64739-3]
NP_034056.1, NM_009926.2 [Q64739-1]
XP_006523627.1, XM_006523564.3 [Q64739-2]
XP_006523629.1, XM_006523566.3 [Q64739-4]
XP_006523630.1, XM_006523567.3 [Q64739-6]
XP_006523632.1, XM_006523569.3 [Q64739-5]
XP_006523633.1, XM_006523570.3 [Q64739-7]
UniGeneiMm.20230

3D structure databases

ProteinModelPortaliQ64739
SMRiQ64739
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198806, 1 interactor
ComplexPortaliCPX-2975 Collagen type XI trimer variant 1

PTM databases

iPTMnetiQ64739
PhosphoSitePlusiQ64739

Proteomic databases

MaxQBiQ64739
PRIDEiQ64739

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
12815
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087497; ENSMUSP00000084772; ENSMUSG00000024330 [Q64739-1]
ENSMUST00000114252; ENSMUSP00000109890; ENSMUSG00000024330 [Q64739-5]
ENSMUST00000114255; ENSMUSP00000109893; ENSMUSG00000024330 [Q64739-6]
GeneIDi12815
KEGGimmu:12815
UCSCiuc056zel.1 mouse [Q64739-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1302
MGIiMGI:88447 Col11a2

Phylogenomic databases

GeneTreeiENSGT00940000159762
HOGENOMiHOG000085654
HOVERGENiHBG004933
InParanoidiQ64739
KOiK19721
OMAiGPVCFQG
OrthoDBiEOG091G01AE
PhylomeDBiQ64739
TreeFamiTF323987

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

Protein Ontology

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PROi
PR:Q64739

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024330 Expressed in 101 organ(s), highest expression level in humerus cartilage element
CleanExiMM_COL11A2
ExpressionAtlasiQ64739 baseline and differential
GenevisibleiQ64739 MM

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 2 hits
PF01391 Collagen, 7 hits
PF02210 Laminin_G_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOBA2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q64739
Secondary accession number(s): Q61432, Q9Z1W0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 30, 2003
Last modified: December 5, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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