UniProtKB - Q64737 (PUR2_MOUSE)
Protein
Trifunctional purine biosynthetic protein adenosine-3
Gene
Gart
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- 5-phospho-β-D-ribosylamine + ATP + glycine = ADP + H+ + N1-(5-phospho-β-D-ribosyl)glycinamide + phosphateEC:6.3.4.13
- 2-formamido-N1-(5-O-phospho-β-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + ADP + H+ + phosphateEC:6.3.3.1
- (6S)-10-formyltetrahydrofolate + N1-(5-phospho-β-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H+ + N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamideEC:2.1.2.2
: IMP biosynthesis via de novo pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Phosphoribosylformylglycinamidine synthase (Pfas)
- Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (Gart)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.
Pathwayi: IMP biosynthesis via de novo pathway
This protein is involved in step 2 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Amidophosphoribosyltransferase (Ppat), Amidophosphoribosyltransferase (Ppat), Amidophosphoribosyltransferase (Ppat), Amidophosphoribosyltransferase (Ppat), Amidophosphoribosyltransferase (Ppat)
- Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (Gart), Glycinamide ribonucleotide synthetase (Gart)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.
Pathwayi: IMP biosynthesis via de novo pathway
This protein is involved in step 1 of the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route).Proteins known to be involved in this subpathway in this organism are:
- Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (Gart)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 288 | ManganeseBy similarity | 1 | |
Metal bindingi | 290 | ManganeseBy similarity | 1 | |
Binding sitei | 871 | 10-formyltetrahydrofolateBy similarity | 1 | |
Binding sitei | 913 | 10-formyltetrahydrofolateBy similarity | 1 | |
Active sitei | 915 | Proton donorBy similarity | 1 | |
Sitei | 951 | Raises pKa of active site HisBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 137 – 199 | ATPBy similarityAdd BLAST | 63 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- phosphoribosylamine-glycine ligase activity Source: MGI
- phosphoribosylformylglycinamidine cyclo-ligase activity Source: MGI
- phosphoribosylglycinamide formyltransferase activity Source: MGI
GO - Biological processi
- 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
- adenine biosynthetic process Source: GO_Central
- brainstem development Source: Ensembl
- cerebellum development Source: Ensembl
- cerebral cortex development Source: Ensembl
- glycine metabolic process Source: MGI
- purine nucleotide biosynthetic process Source: GO_Central
- response to inorganic substance Source: MGI
- response to organic substance Source: MGI
- ribonucleoside monophosphate biosynthetic process Source: MGI
- tetrahydrofolate biosynthetic process Source: MGI
Keywordsi
Molecular function | Ligase, Multifunctional enzyme, Transferase |
Biological process | Purine biosynthesis |
Ligand | ATP-binding, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-73817, Purine ribonucleoside monophosphate biosynthesis |
SABIO-RKi | Q64737 |
UniPathwayi | UPA00074;UER00125 UPA00074;UER00126 UPA00074;UER00129 |
Names & Taxonomyi
Protein namesi | Recommended name: Trifunctional purine biosynthetic protein adenosine-3Including the following 3 domains: Phosphoribosylamine--glycine ligase (EC:6.3.4.13) Alternative name(s): Glycinamide ribonucleotide synthetase Short name: GARS Phosphoribosylglycinamide synthetase Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1) Alternative name(s): AIR synthase Short name: AIRS Phosphoribosyl-aminoimidazole synthetase Phosphoribosylglycinamide formyltransferase (EC:2.1.2.2) Alternative name(s): 5'-phosphoribosylglycinamide transformylase GAR transformylase Short name: GART |
Gene namesi | Name:Gart |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95654, Gart |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Pathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL3690 |
DrugCentrali | Q64737 |
GuidetoPHARMACOLOGYi | 2612 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000074938 | 2 – 1010 | Trifunctional purine biosynthetic protein adenosine-3Add BLAST | 1009 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 10 | PhosphoserineBy similarity | 1 | |
Modified residuei | 350 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 440 | PhosphoserineCombined sources | 1 | |
Modified residuei | 467 | PhosphoserineCombined sources | 1 | |
Modified residuei | 682 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q64737 |
jPOSTi | Q64737 |
PaxDbi | Q64737 |
PeptideAtlasi | Q64737 |
PRIDEi | Q64737 |
PTM databases
iPTMneti | Q64737 |
PhosphoSitePlusi | Q64737 |
SwissPalmi | Q64737 |
Expressioni
Tissue specificityi
Detected in liver, kidney and brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000022962, Expressed in epiblast (generic) and 337 other tissues |
ExpressionAtlasi | Q64737, baseline and differential |
Genevisiblei | Q64737, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 199831, 4 interactors |
IntActi | Q64737, 1 interactor |
MINTi | Q64737 |
STRINGi | 10090.ENSMUSP00000023684 |
Chemistry databases
BindingDBi | Q64737 |
Miscellaneous databases
RNActi | Q64737, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 111 – 318 | ATP-graspAdd BLAST | 208 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 434 – 807 | AIRSAdd BLAST | 374 | |
Regioni | 808 – 1010 | GARTAdd BLAST | 203 | |
Regioni | 818 – 820 | 5'-phosphoribosylglycinamide bindingBy similarity | 3 | |
Regioni | 896 – 899 | 10-formyltetrahydrofolate bindingBy similarity | 4 | |
Regioni | 947 – 951 | 10-formyltetrahydrofolate bindingBy similarity | 5 | |
Regioni | 977 – 980 | 5'-phosphoribosylglycinamide bindingBy similarity | 4 |
Sequence similaritiesi
In the N-terminal section; belongs to the GARS family.Curated
In the central section; belongs to the AIR synthase family.Curated
In the C-terminal section; belongs to the GART family.Curated
Phylogenomic databases
eggNOGi | KOG0237, Eukaryota KOG3076, Eukaryota |
GeneTreei | ENSGT00390000000292 |
HOGENOMi | CLU_005361_0_2_1 |
InParanoidi | Q64737 |
OMAi | KATVCKY |
OrthoDBi | 105366at2759 |
TreeFami | TF106368 |
Family and domain databases
CDDi | cd08645, FMT_core_GART, 1 hit cd02196, PurM, 1 hit |
Gene3Di | 3.30.1330.10, 1 hit 3.30.1490.20, 1 hit 3.90.600.10, 1 hit 3.90.650.10, 1 hit |
HAMAPi | MF_00741, AIRS, 1 hit MF_00138, GARS, 1 hit MF_01930, PurN, 1 hit |
InterProi | View protein in InterPro IPR011761, ATP-grasp IPR013815, ATP_grasp_subdomain_1 IPR002376, Formyl_transf_N IPR036477, Formyl_transf_N_sf IPR004607, GART IPR001555, GART_AS IPR016185, PreATP-grasp_dom_sf IPR020561, PRibGlycinamid_synth_ATP-grasp IPR000115, PRibGlycinamide_synth IPR020560, PRibGlycinamide_synth_C-dom IPR037123, PRibGlycinamide_synth_C_sf IPR020559, PRibGlycinamide_synth_CS IPR020562, PRibGlycinamide_synth_N IPR010918, PurM-like_C_dom IPR036676, PurM-like_C_sf IPR016188, PurM-like_N IPR036921, PurM-like_N_sf IPR004733, PurM_cligase IPR011054, Rudment_hybrid_motif |
PANTHERi | PTHR10520, PTHR10520, 1 hit |
Pfami | View protein in Pfam PF00586, AIRS, 1 hit PF02769, AIRS_C, 1 hit PF00551, Formyl_trans_N, 1 hit PF01071, GARS_A, 1 hit PF02843, GARS_C, 1 hit PF02844, GARS_N, 1 hit |
SMARTi | View protein in SMART SM01210, GARS_C, 1 hit |
SUPFAMi | SSF51246, SSF51246, 1 hit SSF52440, SSF52440, 1 hit SSF53328, SSF53328, 1 hit SSF55326, SSF55326, 1 hit SSF56042, SSF56042, 1 hit |
TIGRFAMsi | TIGR00877, purD, 1 hit TIGR00878, purM, 1 hit TIGR00639, PurN, 1 hit |
PROSITEi | View protein in PROSITE PS50975, ATP_GRASP, 1 hit PS00184, GARS, 1 hit PS00373, GART, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform Long (identifier: Q64737-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAARVLVIGS GGREHTLAWK LAQSPQVKQV LVAPGNAGTA CAGKISNAAV
60 70 80 90 100
SVNDHSALAQ FCKDEKIELV VVGPEAPLAA GIVGDLTSAG VRCFGPTAQA
110 120 130 140 150
AQLESSKKFA KEFMDRHEIP TAQWRAFTNP EDACSFITSA NFPALVVKAS
160 170 180 190 200
GLAAGKGVIV AKSQAEACRA VQEIMQEKSF GAAGETVVVE EFLEGEEVSC
210 220 230 240 250
LCFTDGKTVA EMPPAQDHKR LLDGDEGPNT GGMGAYCPAP QVSKDLLVKI
260 270 280 290 300
KNTILQRAVD GMQQEGAPYT GILYAGIMLT KDGPKVLEFN CRFGDPECQV
310 320 330 340 350
ILPLLKSDLY EVMQSTLDGL LSASLPVWLE NHSAVTVVMA SKGYPGAYTK
360 370 380 390 400
GVEITGFPEA QALGLQVFHA GTALKDGKVV TSGGRVLTVT AVQENLMSAL
410 420 430 440 450
AEARKGLAAL KFEGAIYRKD IGFRAVAFLQ RPRGLTYKDS GVDIAAGNML
460 470 480 490 500
VKKIQPLAKA TSRPGCSVDL GGFAGLFDLK AAGFKDPLLA SGTDGVGTKL
510 520 530 540 550
KIAQLCNKHD SIGQDLVAMC VNDILAQGAE PLFFLDYFSC GKLDLSTTEA
560 570 580 590 600
VIAGIAAACQ QAGCALLGGE TAEMPNMYPP GEYDLAGFAV GAMERHQKLP
610 620 630 640 650
QLERITEGDA VIGVASSGLH SNGFSLVRKI VERSSLQYSS PAPGGCGDQT
660 670 680 690 700
LGDLLLTPTR IYSHSLLPII RSGRVKAFAH ITGGGLLENI PRVLPQKFGV
710 720 730 740 750
DLDASTWRVP KVFSWLQQEG ELSEEEMART FNCGIGAALV VSKDQAEQVL
760 770 780 790 800
HDVRRRQEEA WVIGSVVACP EDSPRVRVKN LIETIQTNGS LVANGFLKSN
810 820 830 840 850
FPVQQKKARV AVLISGTGSN LQALIDSTRD PKSSSHIVLV ISNKAAVAGL
860 870 880 890 900
DRAERAGIPT RVINHKLYKN RVEFDNAVDH VLEEFSVDIV CLAGFMRILS
910 920 930 940 950
GPFVRKWDGK MLNIHPSLLP SFKGSNAHEQ VLEAGVTITG CTVHFVAEDV
960 970 980 990 1000
DAGQIILQEA VPVRRGDTVA TLSERVKVAE HKIFPAALQL VASGAVQLRE
1010
DGKIHWAKEQ
Isoform Short (identifier: Q64737-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
434-1010: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RCG1 | D6RCG1_MOUSE | Trifunctional purine biosynthetic p... | Gart | 306 | Annotation score: | ||
A0A338P6X4 | A0A338P6X4_MOUSE | Trifunctional purine biosynthetic p... | Gart | 199 | Annotation score: | ||
A0A338P676 | A0A338P676_MOUSE | Trifunctional purine biosynthetic p... | Gart | 64 | Annotation score: | ||
A0A338P6T2 | A0A338P6T2_MOUSE | Trifunctional purine biosynthetic p... | Gart | 99 | Annotation score: | ||
A0A338P6W0 | A0A338P6W0_MOUSE | Trifunctional purine biosynthetic p... | Gart | 82 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | C → G in AAA19012 (PubMed:8299947).Curated | 1 | |
Sequence conflicti | 41 | C → G in AAA19013 (PubMed:8299947).Curated | 1 | |
Sequence conflicti | 41 | C → G in AAC53250 (PubMed:7829519).Curated | 1 | |
Sequence conflicti | 41 | C → G in AAC53251 (PubMed:7829519).Curated | 1 | |
Sequence conflicti | 318 | D → G in AAC53250 (PubMed:7829519).Curated | 1 | |
Sequence conflicti | 318 | D → G in AAC53251 (PubMed:7829519).Curated | 1 | |
Sequence conflicti | 563 | G → A in AAA19013 (PubMed:8299947).Curated | 1 | |
Sequence conflicti | 690 | I → T in AAA19013 (PubMed:8299947).Curated | 1 | |
Sequence conflicti | 868 | Y → S in AAA19013 (PubMed:8299947).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005518 | 434 – 1010 | Missing in isoform Short. 1 PublicationAdd BLAST | 577 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U01023 mRNA Translation: AAA19012.1 U01024 mRNA Translation: AAA19013.1 U20886 , U20875, U20876, U20877, U20879, U20880, U20881, U20882, U20883 Genomic DNA Translation: AAC53250.1 U20892 , U20875, U20876, U20877, U20879, U20880, U20881, U20882, U20883, U20886, U20884, U20887, U20885, U20889, U20890, U20891 Genomic DNA Translation: AAC53251.1 AK168501 mRNA Translation: BAE40386.1 AK168724 mRNA Translation: BAE40565.1 AK168796 mRNA Translation: BAE40629.1 AK168864 mRNA Translation: BAE40683.1 AK168876 mRNA Translation: BAE40694.1 CH466602 Genomic DNA Translation: EDL03819.1 BC070465 mRNA Translation: AAH70465.1 |
CCDSi | CCDS28329.1 [Q64737-1] |
PIRi | I67805 |
RefSeqi | NP_034386.2, NM_010256.2 [Q64737-1] XP_006522973.1, XM_006522910.3 XP_006522974.1, XM_006522911.2 [Q64737-1] XP_006522975.1, XM_006522912.1 [Q64737-1] |
Genome annotation databases
Ensembli | ENSMUST00000023684; ENSMUSP00000023684; ENSMUSG00000022962 [Q64737-1] ENSMUST00000120450; ENSMUSP00000114034; ENSMUSG00000022962 [Q64737-2] ENSMUST00000231380; ENSMUSP00000156232; ENSMUSG00000022962 [Q64737-2] ENSMUST00000232289; ENSMUSP00000156002; ENSMUSG00000022962 [Q64737-1] |
GeneIDi | 14450 |
KEGGi | mmu:14450 |
UCSCi | uc007zxu.1, mouse [Q64737-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U01023 mRNA Translation: AAA19012.1 U01024 mRNA Translation: AAA19013.1 U20886 , U20875, U20876, U20877, U20879, U20880, U20881, U20882, U20883 Genomic DNA Translation: AAC53250.1 U20892 , U20875, U20876, U20877, U20879, U20880, U20881, U20882, U20883, U20886, U20884, U20887, U20885, U20889, U20890, U20891 Genomic DNA Translation: AAC53251.1 AK168501 mRNA Translation: BAE40386.1 AK168724 mRNA Translation: BAE40565.1 AK168796 mRNA Translation: BAE40629.1 AK168864 mRNA Translation: BAE40683.1 AK168876 mRNA Translation: BAE40694.1 CH466602 Genomic DNA Translation: EDL03819.1 BC070465 mRNA Translation: AAH70465.1 |
CCDSi | CCDS28329.1 [Q64737-1] |
PIRi | I67805 |
RefSeqi | NP_034386.2, NM_010256.2 [Q64737-1] XP_006522973.1, XM_006522910.3 XP_006522974.1, XM_006522911.2 [Q64737-1] XP_006522975.1, XM_006522912.1 [Q64737-1] |
3D structure databases
SMRi | Q64737 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199831, 4 interactors |
IntActi | Q64737, 1 interactor |
MINTi | Q64737 |
STRINGi | 10090.ENSMUSP00000023684 |
Chemistry databases
BindingDBi | Q64737 |
ChEMBLi | CHEMBL3690 |
DrugCentrali | Q64737 |
GuidetoPHARMACOLOGYi | 2612 |
PTM databases
iPTMneti | Q64737 |
PhosphoSitePlusi | Q64737 |
SwissPalmi | Q64737 |
Proteomic databases
EPDi | Q64737 |
jPOSTi | Q64737 |
PaxDbi | Q64737 |
PeptideAtlasi | Q64737 |
PRIDEi | Q64737 |
Protocols and materials databases
Antibodypediai | 1063, 198 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000023684; ENSMUSP00000023684; ENSMUSG00000022962 [Q64737-1] ENSMUST00000120450; ENSMUSP00000114034; ENSMUSG00000022962 [Q64737-2] ENSMUST00000231380; ENSMUSP00000156232; ENSMUSG00000022962 [Q64737-2] ENSMUST00000232289; ENSMUSP00000156002; ENSMUSG00000022962 [Q64737-1] |
GeneIDi | 14450 |
KEGGi | mmu:14450 |
UCSCi | uc007zxu.1, mouse [Q64737-1] |
Organism-specific databases
CTDi | 2618 |
MGIi | MGI:95654, Gart |
Phylogenomic databases
eggNOGi | KOG0237, Eukaryota KOG3076, Eukaryota |
GeneTreei | ENSGT00390000000292 |
HOGENOMi | CLU_005361_0_2_1 |
InParanoidi | Q64737 |
OMAi | KATVCKY |
OrthoDBi | 105366at2759 |
TreeFami | TF106368 |
Enzyme and pathway databases
UniPathwayi | UPA00074;UER00125 UPA00074;UER00126 UPA00074;UER00129 |
Reactomei | R-MMU-73817, Purine ribonucleoside monophosphate biosynthesis |
SABIO-RKi | Q64737 |
Miscellaneous databases
BioGRID-ORCSi | 14450, 6 hits in 19 CRISPR screens |
ChiTaRSi | Gart, mouse |
PROi | PR:Q64737 |
RNActi | Q64737, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022962, Expressed in epiblast (generic) and 337 other tissues |
ExpressionAtlasi | Q64737, baseline and differential |
Genevisiblei | Q64737, MM |
Family and domain databases
CDDi | cd08645, FMT_core_GART, 1 hit cd02196, PurM, 1 hit |
Gene3Di | 3.30.1330.10, 1 hit 3.30.1490.20, 1 hit 3.90.600.10, 1 hit 3.90.650.10, 1 hit |
HAMAPi | MF_00741, AIRS, 1 hit MF_00138, GARS, 1 hit MF_01930, PurN, 1 hit |
InterProi | View protein in InterPro IPR011761, ATP-grasp IPR013815, ATP_grasp_subdomain_1 IPR002376, Formyl_transf_N IPR036477, Formyl_transf_N_sf IPR004607, GART IPR001555, GART_AS IPR016185, PreATP-grasp_dom_sf IPR020561, PRibGlycinamid_synth_ATP-grasp IPR000115, PRibGlycinamide_synth IPR020560, PRibGlycinamide_synth_C-dom IPR037123, PRibGlycinamide_synth_C_sf IPR020559, PRibGlycinamide_synth_CS IPR020562, PRibGlycinamide_synth_N IPR010918, PurM-like_C_dom IPR036676, PurM-like_C_sf IPR016188, PurM-like_N IPR036921, PurM-like_N_sf IPR004733, PurM_cligase IPR011054, Rudment_hybrid_motif |
PANTHERi | PTHR10520, PTHR10520, 1 hit |
Pfami | View protein in Pfam PF00586, AIRS, 1 hit PF02769, AIRS_C, 1 hit PF00551, Formyl_trans_N, 1 hit PF01071, GARS_A, 1 hit PF02843, GARS_C, 1 hit PF02844, GARS_N, 1 hit |
SMARTi | View protein in SMART SM01210, GARS_C, 1 hit |
SUPFAMi | SSF51246, SSF51246, 1 hit SSF52440, SSF52440, 1 hit SSF53328, SSF53328, 1 hit SSF55326, SSF55326, 1 hit SSF56042, SSF56042, 1 hit |
TIGRFAMsi | TIGR00877, purD, 1 hit TIGR00878, purM, 1 hit TIGR00639, PurN, 1 hit |
PROSITEi | View protein in PROSITE PS50975, ATP_GRASP, 1 hit PS00184, GARS, 1 hit PS00373, GART, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PUR2_MOUSE | |
Accessioni | Q64737Primary (citable) accession number: Q64737 Secondary accession number(s): Q3TGI3, Q6NS48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 176 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families