UniProtKB - Q64731 (FOXL1_MOUSE)
Protein
Forkhead box protein L1
Gene
Foxl1
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 48 – 139 | Fork-headPROSITE-ProRule annotationAdd BLAST | 92 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: MGI
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- heart development Source: MGI
- Peyer's patch morphogenesis Source: MGI
- proteoglycan biosynthetic process Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of Wnt signaling pathway Source: MGI
- visceral mesoderm-endoderm interaction involved in midgut development Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein L1Alternative name(s): Forkhead-related protein FKHL11 Transcription factor FKH-6 |
Gene namesi | Name:Foxl1 Synonyms:Fkh6, Fkhl11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1347469, Foxl1 |
Pathology & Biotechi
Disruption phenotypei
Deficient mice show postnatal growth retardation secondary to severe structural abnormalities of the stomach, duodenum, jejunum and decreased intestinal uptake of D-glucose and levels of the intestinal D-glucose transporter Slc5a1.2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091860 | 1 – 336 | Forkhead box protein L1Add BLAST | 336 |
Proteomic databases
MaxQBi | Q64731 |
PaxDbi | Q64731 |
PRIDEi | Q64731 |
PTM databases
iPTMneti | Q64731 |
PhosphoSitePlusi | Q64731 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000097084, Expressed in cardiac ventricle and 82 other tissues |
Genevisiblei | Q64731, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 199698, 1 interactor |
IntActi | Q64731, 1 interactor |
STRINGi | 10090.ENSMUSP00000137732 |
Miscellaneous databases
RNActi | Q64731, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162251 |
HOGENOMi | CLU_052451_0_0_1 |
InParanoidi | Q64731 |
OMAi | PLHWPGT |
OrthoDBi | 1270467at2759 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q64731-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHLFSPPLA ALAASPLLYV YSPERPGLPL AFAPAAALAG PGRVEPPQKP
60 70 80 90 100
PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN
110 120 130 140 150
LSLNECFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPAAG
160 170 180 190 200
SPEAKRTRVE PPESEVGCDV GSPDLATALP TRAPDRSQSP AVGTARPALL
210 220 230 240 250
PWPGPEPRDP DADLTVQGAG AVASGQLQRP AHHLGSPLCP APSGSPKGSK
260 270 280 290 300
SKSFSIDSIL AVRPTPASGA EAPGIPKPVP GALGSSLLAA SSGLAPPFNA
310 320 330
SLVFDAHVQG GFSQLGIPFL SYFPLQVPEA TVLRFH
Sequence cautioni
The sequence CAA63243 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 175 | L → LV in CAA50746 (Ref. 2) Curated | 1 | |
Sequence conflicti | 175 | L → LV in CAA63243 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92498 Genomic DNA Translation: CAA63243.1 Frameshift. CH466525 Genomic DNA Translation: EDL11654.1 BC137805 mRNA Translation: AAI37806.1 BC137806 mRNA Translation: AAI37807.1 X71944 Genomic DNA Translation: CAA50746.1 |
CCDSi | CCDS59744.1 |
PIRi | F47746 |
RefSeqi | NP_032050.2, NM_008024.2 |
Genome annotation databases
Ensembli | ENSMUST00000181609; ENSMUSP00000137732; ENSMUSG00000097084 |
GeneIDi | 14241 |
KEGGi | mmu:14241 |
UCSCi | uc009nrs.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92498 Genomic DNA Translation: CAA63243.1 Frameshift. CH466525 Genomic DNA Translation: EDL11654.1 BC137805 mRNA Translation: AAI37806.1 BC137806 mRNA Translation: AAI37807.1 X71944 Genomic DNA Translation: CAA50746.1 |
CCDSi | CCDS59744.1 |
PIRi | F47746 |
RefSeqi | NP_032050.2, NM_008024.2 |
3D structure databases
SMRi | Q64731 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199698, 1 interactor |
IntActi | Q64731, 1 interactor |
STRINGi | 10090.ENSMUSP00000137732 |
PTM databases
iPTMneti | Q64731 |
PhosphoSitePlusi | Q64731 |
Proteomic databases
MaxQBi | Q64731 |
PaxDbi | Q64731 |
PRIDEi | Q64731 |
Protocols and materials databases
Antibodypediai | 17198, 455 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000181609; ENSMUSP00000137732; ENSMUSG00000097084 |
GeneIDi | 14241 |
KEGGi | mmu:14241 |
UCSCi | uc009nrs.1, mouse |
Organism-specific databases
CTDi | 2300 |
MGIi | MGI:1347469, Foxl1 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162251 |
HOGENOMi | CLU_052451_0_0_1 |
InParanoidi | Q64731 |
OMAi | PLHWPGT |
OrthoDBi | 1270467at2759 |
Miscellaneous databases
BioGRID-ORCSi | 14241, 1 hit in 15 CRISPR screens |
PROi | PR:Q64731 |
RNActi | Q64731, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000097084, Expressed in cardiac ventricle and 82 other tissues |
Genevisiblei | Q64731, MM |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXL1_MOUSE | |
Accessioni | Q64731Primary (citable) accession number: Q64731 Secondary accession number(s): B2RQ86 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot