Tgfbr1

Functionⁱ

Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity).By similarity

Catalytic activityⁱ

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactorⁱ

Mg²⁺By similarity, Mn²⁺By similarity

Activity regulationⁱ

Kept in an inactive conformation by FKBP1A preventing receptor activation in absence of ligand. CD109 is another inhibitor of the receptor (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	232	ATPPROSITE-ProRule annotation		1
Active siteⁱ	333	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	211 – 219	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

activin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ATP binding Source: MGI
growth factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
I-SMAD binding Source: MGI
metal ion binding Source: UniProtKB-KW
protein-containing complex binding Source: MGI
protein heterodimerization activity Source: MGI
protein kinase activity Source: MGI
protein serine/threonine kinase activity Source: MGI
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 25065622
SMAD binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 12773577
transforming growth factor beta-activated receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 25065622
transforming growth factor beta binding
Source: MGI
Inferred from physical interactionⁱ
- 17878231
transforming growth factor beta receptor activity, type I Source: AgBase
type II transforming growth factor beta receptor binding Source: MGI
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPKK activity Source: MGI
activin receptor signaling pathway Source: AgBase
angiogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 11285230
angiogenesis involved in coronary vascular morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18718461
anterior/posterior pattern specification
Source: MGI
Inferred from genetic interactionⁱ
- 16845371
apoptotic process Source: UniProtKB-KW
artery morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 17078885
blastocyst development
Source: MGI
Inferred from direct assayⁱ
- 9921650
cardiac epithelial to mesenchymal transition Source: AgBase
cell motility Source: MGI
cellular response to transforming growth factor beta stimulus
Source: BHF-UCL
Inferred from direct assayⁱ
- 19494318
collagen fibril organization
Source: MGI
Inferred from mutant phenotypeⁱ
- 15993878
coronary artery morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18718461
embryonic cranial skeleton morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 16806156
endothelial cell activation Source: AgBase
endothelial cell migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 11285230
epicardium morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18718461
epithelial to mesenchymal transition Source: MGI
germ cell migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 15993878
heart development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17078885
intracellular signal transduction Source: AgBase
in utero embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
kidney development
Source: MGI
Inferred from genetic interactionⁱ
- 16845371
lens development in camera-type eye
Source: MGI
Inferred from mutant phenotypeⁱ
- 11641223
male gonad development
Source: MGI
Inferred from mutant phenotypeⁱ
- 23342175
mesenchymal cell differentiation Source: AgBase
negative regulation of apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 16806156
- 17078885
negative regulation of chondrocyte differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19494318
negative regulation of endothelial cell differentiation Source: MGI
negative regulation of endothelial cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 21832243
negative regulation of extrinsic apoptotic signaling pathway Source: MGI
negative regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
neuron fate commitment
Source: MGI
Inferred from mutant phenotypeⁱ
- 15744664
parathyroid gland development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17078885
pathway-restricted SMAD protein phosphorylation Source: MGI
pattern specification process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptidyl-serine phosphorylation Source: MGI
peptidyl-threonine phosphorylation Source: MGI
pharyngeal system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17078885
positive regulation of apoptotic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 24835278
positive regulation of apoptotic signaling pathway Source: MGI
positive regulation of cell growth Source: MGI
positive regulation of cell migration Source: MGI
positive regulation of cell proliferation Source: MGI
positive regulation of cellular component movement Source: MGI
positive regulation of endothelial cell proliferation Source: AgBase
positive regulation of epithelial to mesenchymal transition
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 18718461
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18718461
positive regulation of filopodium assembly
Source: MGI
Inferred from mutant phenotypeⁱ
- 16806156
positive regulation of gene expression Source: AgBase
positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
positive regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
positive regulation of protein kinase B signaling Source: MGI
positive regulation of SMAD protein signal transduction Source: MGI
positive regulation of stress fiber assembly
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 18718461
positive regulation of tight junction disassembly
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 18718461
positive regulation of transcription, DNA-templated Source: AgBase
post-embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16806156
protein autophosphorylation Source: MGI
protein phosphorylation Source: MGI
regulation of cardiac muscle cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18718461
regulation of epithelial to mesenchymal transition Source: AgBase
regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 16806156
regulation of protein binding
Source: MGI
Inferred from mutant phenotypeⁱ
- 16601693
regulation of protein ubiquitination Source: MGI
regulation of transcription, DNA-templated Source: MGI
response to cholesterol
Source: BHF-UCL
Inferred from direct assayⁱ
- 17878231
response to estrogen Source: MGI
roof of mouth development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16806156
signal transduction Source: MGI
skeletal system development
Source: MGI
Inferred from genetic interactionⁱ
- 16845371
skeletal system morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 16845371
thymus development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17078885
transforming growth factor beta receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 14580334
- 15820682
ventricular compact myocardium morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18718461
ventricular septum morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18718461
ventricular trabecula myocardium morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18718461

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological process	Apoptosis, Differentiation, Growth regulation
Ligand	ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 3474
Reactomeⁱ	R-MMU-2173788 Downregulation of TGF-beta receptor signaling R-MMU-2173789 TGF-beta receptor signaling activates SMADs R-MMU-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-MMU-5689880 Ub-specific processing proteases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TGF-beta receptor type-1 (EC:2.7.11.30) Short name: TGFR-1 Alternative name(s): ESK2 Transforming growth factor-beta receptor type I Short name: TGF-beta receptor type I Short name: TbetaR-I
Gene namesⁱ	Name:Tgfbr1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:98728 Tgfbr1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	30 – 126	ExtracellularSequence analysisAdd BLAST	97
Transmembraneⁱ	127 – 147	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	148 – 503	CytoplasmicSequence analysisAdd BLAST	356

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2021750

ChEMBLⁱ

CHEMBL2021750

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 29	By similarityAdd BLAST		29
ChainⁱPRO_0000024424	30 – 503	TGF-beta receptor type-1Add BLAST		474

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	32 ↔ 50	By similarity
Disulfide bondⁱ	34 ↔ 37	By similarity
Glycosylationⁱ	41	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	44 ↔ 67	By similarity
Disulfide bondⁱ	82 ↔ 96	By similarity
Disulfide bondⁱ	97 ↔ 102	By similarity
Modified residueⁱ	165	PhosphoserineBy similarity	1
Modified residueⁱ	185	Phosphothreonine; by TGFBR2By similarity	1
Modified residueⁱ	186	Phosphothreonine; by TGFBR2By similarity	1
Modified residueⁱ	187	Phosphoserine; by TGFBR2By similarity	1
Modified residueⁱ	189	Phosphoserine; by TGFBR2By similarity	1
Modified residueⁱ	191	Phosphoserine; by TGFBR2By similarity	1
Cross-linkⁱ	391	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationⁱ

Phosphorylated at basal levels in the absence of ligand. Activated upon phosphorylation by TGFBR2, mainly in the GS domain. Phosphorylation in the GS domain abrogates FKBP1A-binding (By similarity).By similarity

N-Glycosylated.By similarity

Ubiquitinated; undergoes ubiquitination catalyzed by several E3 ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the proteasomal and/or lysosomal degradation of the receptor thereby negatively regulating its activity. Deubiquitinated by USP15, leading to stabilization of the protein and enhanced TGF-beta signal. Its ubiquitination and proteasome-mediated degradation is negatively regulated by SDCBP (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q64729
PRIDEⁱ	Q64729

PTM databases

iPTMnetⁱ	Q64729
PhosphoSitePlusⁱ	Q64729

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000007613 Expressed in 312 organ(s), highest expression level in metanephric cortical collecting duct
CleanExⁱ	MM_TGFBR1
ExpressionAtlasⁱ	Q64729 baseline and differential
Genevisibleⁱ	Q64729 MM

Interactionⁱ

Subunit structureⁱ

Homodimer; in the endoplasmic reticulum but also at the cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits TGF-beta receptor activation in keratinocytes. Interacts with RBPMS. Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with TRAF6 and MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PARD6A; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to the TGF-beta receptor (By similarity). Interacts with USP15 and VPS39. Interacts with SDCBP (via C-terminus). Interacts with CAV1 and this interaction is impaired in the presence of SDCBP (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AP2B1	P63010	3	EBI-2899393,EBI-432924	From Homo sapiens.
Ap2b1	Q9DBG3	2	EBI-2899393,EBI-775229
Cav1	P49817	4	EBI-2899393,EBI-1161338
Cd44	P15379	4	EBI-2899393,EBI-7565891
Cdh5	P55284	2	EBI-2899393,EBI-7087433
DLG5	Q8TDM6	3	EBI-2899393,EBI-715138	From Homo sapiens.
Ly6a	P05533	2	EBI-2899393,EBI-11600492
Shc1	P98083-2	7	EBI-2899393,EBI-1019301
SMAD3	P84022	6	EBI-2899393,EBI-347161	From Homo sapiens.
Tgfbr2	Q62312	3	EBI-2899393,EBI-2899332

GO - Molecular functionⁱ

growth factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
I-SMAD binding Source: MGI
protein heterodimerization activity Source: MGI
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 25065622
SMAD binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 12773577
transforming growth factor beta binding
Source: MGI
Inferred from physical interactionⁱ
- 17878231
type II transforming growth factor beta receptor binding Source: MGI
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204163, 25 interactors
ComplexPortalⁱ	CPX-823 TGF-beta-1-TGFR complex CPX-826 TGF-beta-3-TGFR complex CPX-836 TGF-beta-2-TGFR complex
CORUMⁱ	Q64729
Database of interacting proteins More...DIPⁱ	DIP-42262N
IntActⁱ	Q64729, 31 interactors
Molecular INTeraction database More...MINTⁱ	Q64729
STRINGⁱ	10090.ENSMUSP00000007757

Chemistry databases

BindingDBⁱ

Q64729

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q64729
SMRⁱ	Q64729
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	175 – 204	GSPROSITE-ProRule annotationAdd BLAST		30
Domainⁱ	205 – 495	Protein kinasePROSITE-ProRule annotationAdd BLAST		291

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	193 – 194	FKBP1A-binding		2

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2052 Eukaryota ENOG410XQT0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000230587
HOVERGENⁱ	HBG054502
InParanoidⁱ	Q64729
KEGG Orthology (KO) More...KOⁱ	K04674
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BIU
PhylomeDBⁱ	Q64729
TreeFamⁱ	TF314724

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR003605 GS_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF00069 Pkinase, 1 hit PF08515 TGF_beta_GS, 1 hit
SMARTⁱ	View protein in SMART SM00467 GS, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51256 GS, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q64729-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAAAAAPRR PQLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC 
        60         70         80         90        100
FVSVTETTDK VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTTTYCCNQD 
       110        120        130        140        150
HCNKIELPTT GPFSEKQSAG LGPVELAAVI AGPVCFVCIA LMLMVYICHN 
       160        170        180        190        200
RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT 
       210        220        230        240        250
IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ 
       260        270        280        290        300
TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 
       310        320        330        340        350
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA 
       360        370        380        390        400
DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD 
       410        420        430        440        450
IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL 
       460        470        480        490        500
RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG 

IKM

Length:503

Mass (Da):56,179

Last modified:November 1, 1996 - v1

Checksum:ⁱBB8BB6D2261793AF

GO

Isoform 2 (identifier: Q64729-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
111-114: Missing.

« Hide

        10         20         30         40         50
MEAAAAAPRR PQLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC 
        60         70         80         90        100
FVSVTETTDK VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTTTYCCNQD 
       110        120        130        140        150
HCNKIELPTT EKQSAGLGPV ELAAVIAGPV CFVCIALMLM VYICHNRTVI 
       160        170        180        190        200
HHRVPNEEDP SLDRPFISEG TTLKDLIYDM TTSGSGSGLP LLVQRTIART 
       210        220        230        240        250
IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML 
       260        270        280        290        300
RHENILGFIA ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK 
       310        320        330        340        350
LALSTASGLA HLHMEIVGTQ GKPAIAHRDL KSKNILVKKN GTCCIADLGL 
       360        370        380        390        400
AVRHDSATDT IDIAPNHRVG TKRYMAPEVL DDSINMKHFE SFKRADIYAM 
       410        420        430        440        450
GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV VCEQKLRPNI 
       460        470        480        490 
PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTLSQ LSQQEGIKM

Note: May be due to a competing donor splice site.

Show »

Length:499

Mass (Da):55,790

Checksum:ⁱ914DE6236B689C1C

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q9D5H8	Q9D5H8_MOUSE	Receptor protein serine/threonine k... Receptor protein serine/threonine kinase, EC 2.7.11.30	Tgfbr1	420	Annotation score:
E9Q418	E9Q418_MOUSE	Receptor protein serine/threonine k... Receptor protein serine/threonine kinase, EC 2.7.11.30	Tgfbr1	434	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_021593	111 – 114	Missing in isoform 2. 1 Publication		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D28526 mRNA Translation: BAA05878.1 D25540 mRNA Translation: BAA05023.1 AL772232, AL772150 Genomic DNA Translation: CAM13897.1 AL772150, AL772232 Genomic DNA Translation: CAM24923.1 BC063260 mRNA Translation: AAH63260.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18160.1 [Q64729-1] CCDS84728.1 [Q64729-2]
PIRⁱ	JC2061 JC2062
NCBI Reference Sequences More...RefSeqⁱ	NP_001299797.1, NM_001312868.1 [Q64729-2] NP_001299798.1, NM_001312869.1 NP_033396.1, NM_009370.3 [Q64729-1]
UniGeneⁱ	Mm.197552

Genome annotation databases

Ensemblⁱ	ENSMUST00000007757; ENSMUSP00000007757; ENSMUSG00000007613 [Q64729-1] ENSMUST00000044234; ENSMUSP00000048501; ENSMUSG00000007613 [Q64729-2]
GeneIDⁱ	21812
KEGGⁱ	mmu:21812
UCSC genome browser More...UCSCⁱ	uc008sun.1 mouse [Q64729-1] uc008suo.1 mouse [Q64729-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q64729	Receptor protein serine/threonine kinase		MOUSE		503	UniRef100_Q64729
Receptor protein serine/threonine kinase (Fragment)		MOUSE		426
UPI0007EE1DA7		MOUSE		438
Q64729-2	Receptor protein serine/threonine kinase		MOUSE		434	UniRef100_E9Q418

Protein	Similar proteins		Species	Score	Length	Source
Q64729	TGF-beta receptor type-1	)	HUMAN		503	UniRef90_P36897
TGF-beta receptor type-1		PIG		503
TGF-beta receptor type-1		RAT		501
TGF-beta receptor type-1		BOVIN		499
Receptor protein serine/threonine kinase (Fragment)		MACMU		475
+173

Protein	Similar proteins		Species	Score	Length	Source
Q64729	TGF-beta receptor type-1	)	HUMAN		503	UniRef50_P36897
TGF-beta receptor type-1		PIG		503
TGF-beta receptor type-1		RAT		501
TGF-beta receptor type-1		BOVIN		499
Receptor protein serine/threonine kinase (Fragment)		MACMU		475
+298

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D28526 mRNA Translation: BAA05878.1 D25540 mRNA Translation: BAA05023.1 AL772232, AL772150 Genomic DNA Translation: CAM13897.1 AL772150, AL772232 Genomic DNA Translation: CAM24923.1 BC063260 mRNA Translation: AAH63260.1
CCDSⁱ	CCDS18160.1 [Q64729-1] CCDS84728.1 [Q64729-2]
PIRⁱ	JC2061 JC2062
RefSeqⁱ	NP_001299797.1, NM_001312868.1 [Q64729-2] NP_001299798.1, NM_001312869.1 NP_033396.1, NM_009370.3 [Q64729-1]
UniGeneⁱ	Mm.197552

3D structure databases

ProteinModelPortalⁱ	Q64729
SMRⁱ	Q64729
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204163, 25 interactors
ComplexPortalⁱ	CPX-823 TGF-beta-1-TGFR complex CPX-826 TGF-beta-3-TGFR complex CPX-836 TGF-beta-2-TGFR complex
CORUMⁱ	Q64729
DIPⁱ	DIP-42262N
IntActⁱ	Q64729, 31 interactors
MINTⁱ	Q64729
STRINGⁱ	10090.ENSMUSP00000007757

Chemistry databases

BindingDBⁱ	Q64729
ChEMBLⁱ	CHEMBL2021750

PTM databases

iPTMnetⁱ	Q64729
PhosphoSitePlusⁱ	Q64729

Proteomic databases

PaxDbⁱ	Q64729
PRIDEⁱ	Q64729

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000007757; ENSMUSP00000007757; ENSMUSG00000007613 [Q64729-1] ENSMUST00000044234; ENSMUSP00000048501; ENSMUSG00000007613 [Q64729-2]
GeneIDⁱ	21812
KEGGⁱ	mmu:21812
UCSCⁱ	uc008sun.1 mouse [Q64729-1] uc008suo.1 mouse [Q64729-2]

Organism-specific databases

CTDⁱ	7046
MGIⁱ	MGI:98728 Tgfbr1

Phylogenomic databases

eggNOGⁱ	KOG2052 Eukaryota ENOG410XQT0 LUCA
GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000230587
HOVERGENⁱ	HBG054502
InParanoidⁱ	Q64729
KOⁱ	K04674
OrthoDBⁱ	EOG091G0BIU
PhylomeDBⁱ	Q64729
TreeFamⁱ	TF314724

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 3474
Reactomeⁱ	R-MMU-2173788 Downregulation of TGF-beta receptor signaling R-MMU-2173789 TGF-beta receptor signaling activates SMADs R-MMU-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-MMU-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRSⁱ	Tgfbr1 mouse
Protein Ontology More...PROⁱ	PR:Q64729
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000007613 Expressed in 312 organ(s), highest expression level in metanephric cortical collecting duct
CleanExⁱ	MM_TGFBR1
ExpressionAtlasⁱ	Q64729 baseline and differential
Genevisibleⁱ	Q64729 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR003605 GS_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF00069 Pkinase, 1 hit PF08515 TGF_beta_GS, 1 hit
SMARTⁱ	View protein in SMART SM00467 GS, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51256 GS, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TGFR1_MOUSE
Accessionⁱ	Q64729Primary (citable) accession number: Q64729 Secondary accession number(s): A2AJN0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q64729 (TGFR1_MOUSE)

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TGF-beta receptor type-1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ