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Protein

Zinc-alpha-2-glycoprotein

Gene

Azgp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers.By similarity

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • detection of chemical stimulus involved in sensory perception of bitter taste Source: MGI
  • immune response Source: GO_Central
  • regulation of multicellular organism growth Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-alpha-2-glycoprotein
Short name:
Zn-alpha-2-GP
Short name:
Zn-alpha-2-glycoprotein
Gene namesi
Name:Azgp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:103163 Azgp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
ChainiPRO_000001901318 – 307Zinc-alpha-2-glycoproteinAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi118 ↔ 181PROSITE-ProRule annotation
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi220 ↔ 275PROSITE-ProRule annotation
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiQ64726
PaxDbiQ64726
PeptideAtlasiQ64726
PRIDEiQ64726

PTM databases

iPTMnetiQ64726
PhosphoSitePlusiQ64726

Expressioni

Gene expression databases

BgeeiENSMUSG00000037053 Expressed in 129 organ(s), highest expression level in left lobe of liver
CleanExiMM_AZGP1
ExpressionAtlasiQ64726 baseline and differential
GenevisibleiQ64726 MM

Interactioni

Subunit structurei

Interacts with PIP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038559

Structurei

3D structure databases

ProteinModelPortaliQ64726
SMRiQ64726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 287Ig-like C1-typeAdd BLAST86

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9FR Eukaryota
ENOG4111CJX LUCA
GeneTreeiENSGT00740000114936
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiQ64726
OMAiYQSWVVV
OrthoDBiEOG091G0K1X
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q64726-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPVLLSLPL LLGPAVFQET GSYYLTFLYT GLSRPSKGFP RFQATAFLND
60 70 80 90 100
QAFFHYNSNS GKAEPVGPWS QVEGMEDWEK ESQLQRAREE IFLVTLKDIM
110 120 130 140 150
DYYKDTTGSH TFQGMFGCEI TNNRSSGAVW RYAYDGEDFI EFNKEIPAWI
160 170 180 190 200
PLDPAAANTK LKWEAEKVYV QRAKAYLEEE CPEMLKRYLN YSRSHLDRID
210 220 230 240 250
PPTVTITSRV IPGGNRIFKC LAYGFYPQRI SLHWNKANKK LAFEPERGVF
260 270 280 290 300
PNGNGTYLSW AEVEVSPQDI DPFFCLIDHR GFSQSLSVQW DRTRKVKDEN

NVVAQPQ
Length:307
Mass (Da):35,332
Last modified:July 27, 2011 - v2
Checksum:iA116304EFE10F814
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDI8A0A0G2JDI8_MOUSE
Zinc-alpha-2-glycoprotein
Azgp1
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24Y → S in BAB23777 (PubMed:7852290).Curated1
Sequence conflicti24Y → S in AAH61646 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21059 mRNA Translation: BAA04638.1
AF281658 Genomic DNA Translation: AAQ14325.1
AY248694 mRNA Translation: AAO93093.1
AK005051 mRNA Translation: BAB23777.1
BC061646 mRNA Translation: AAH61646.1
D44593 Genomic DNA Translation: BAA07996.1
CCDSiCCDS19783.1
PIRiJX0352
RefSeqiNP_038506.2, NM_013478.2
UniGeneiMm.30061

Genome annotation databases

EnsembliENSMUST00000035390; ENSMUSP00000038559; ENSMUSG00000037053
GeneIDi12007
KEGGimmu:12007
UCSCiuc009aeh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21059 mRNA Translation: BAA04638.1
AF281658 Genomic DNA Translation: AAQ14325.1
AY248694 mRNA Translation: AAO93093.1
AK005051 mRNA Translation: BAB23777.1
BC061646 mRNA Translation: AAH61646.1
D44593 Genomic DNA Translation: BAA07996.1
CCDSiCCDS19783.1
PIRiJX0352
RefSeqiNP_038506.2, NM_013478.2
UniGeneiMm.30061

3D structure databases

ProteinModelPortaliQ64726
SMRiQ64726
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038559

PTM databases

iPTMnetiQ64726
PhosphoSitePlusiQ64726

Proteomic databases

MaxQBiQ64726
PaxDbiQ64726
PeptideAtlasiQ64726
PRIDEiQ64726

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035390; ENSMUSP00000038559; ENSMUSG00000037053
GeneIDi12007
KEGGimmu:12007
UCSCiuc009aeh.2 mouse

Organism-specific databases

CTDi563
MGIiMGI:103163 Azgp1

Phylogenomic databases

eggNOGiENOG410J9FR Eukaryota
ENOG4111CJX LUCA
GeneTreeiENSGT00740000114936
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiQ64726
OMAiYQSWVVV
OrthoDBiEOG091G0K1X
TreeFamiTF336617

Enzyme and pathway databases

ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

Miscellaneous databases

ChiTaRSiAzgp1 mouse
PROiPR:Q64726
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037053 Expressed in 129 organ(s), highest expression level in left lobe of liver
CleanExiMM_AZGP1
ExpressionAtlasiQ64726 baseline and differential
GenevisibleiQ64726 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZA2G_MOUSE
AccessioniPrimary (citable) accession number: Q64726
Secondary accession number(s): Q9DBB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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