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Entry version 121 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Microtubule-associated protein

Gene

Map2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map2Imported
Synonyms:Mtap2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

Rat genome database

More...
RGDi
3044, Map2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation, MicrotubuleUniRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q64715, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini374 – 1507MAP2_projctnInterPro annotationAdd BLAST1134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 86DisorderedSequence analysisAdd BLAST86
Regioni109 – 226DisorderedSequence analysisAdd BLAST118
Regioni301 – 465DisorderedSequence analysisAdd BLAST165
Regioni571 – 659DisorderedSequence analysisAdd BLAST89
Regioni762 – 793DisorderedSequence analysisAdd BLAST32
Regioni822 – 862DisorderedSequence analysisAdd BLAST41
Regioni880 – 899DisorderedSequence analysisAdd BLAST20
Regioni925 – 983DisorderedSequence analysisAdd BLAST59
Regioni1002 – 1023DisorderedSequence analysisAdd BLAST22
Regioni1083 – 1166DisorderedSequence analysisAdd BLAST84
Regioni1203 – 1243DisorderedSequence analysisAdd BLAST41
Regioni1339 – 1380DisorderedSequence analysisAdd BLAST42
Regioni1402 – 1633DisorderedSequence analysisAdd BLAST232
Regioni1775 – 1799DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 80Polar residuesSequence analysisAdd BLAST18
Compositional biasi168 – 186Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi359 – 378Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi421 – 435Polar residuesSequence analysisAdd BLAST15
Compositional biasi436 – 465Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi575 – 606Polar residuesSequence analysisAdd BLAST32
Compositional biasi627 – 648Polar residuesSequence analysisAdd BLAST22
Compositional biasi773 – 788Polar residuesSequence analysisAdd BLAST16
Compositional biasi880 – 894Polar residuesSequence analysisAdd BLAST15
Compositional biasi945 – 983Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi1103 – 1161Basic and acidic residuesSequence analysisAdd BLAST59
Compositional biasi1351 – 1380Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1402 – 1481Basic and acidic residuesSequence analysisAdd BLAST80
Compositional biasi1502 – 1519Polar residuesSequence analysisAdd BLAST18
Compositional biasi1561 – 1577Polar residuesSequence analysisAdd BLAST17
Compositional biasi1584 – 1619Polar residuesSequence analysisAdd BLAST36
Compositional biasi1777 – 1799Polar residuesSequence analysisAdd BLAST23

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIEMPME

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030797, MAP2
IPR013588, MAP2_projctn
IPR001084, MAP_tubulin-bd_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR11501:SF15, PTHR11501:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08377, MAP2_projctn, 1 hit
PF00418, Tubulin-binding, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00229, TAU_MAP_1, 1 hit
PS51491, TAU_MAP_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q64715-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGSGEG LSRSANGFPY
60 70 80 90 100
REEEEGAFGE HGSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA
110 120 130 140 150
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET VNLPPSPPPS PASEQTAALE
160 170 180 190 200
EASKMEFPEQ QKLPSSFAEP LDKEETEFKM QSKPGEDFEH AALVPQPDTS
210 220 230 240 250
KTPQDKKDPQ DMEGEKSPAS PFAQTFGTNL EDIKQITEPS ITVPSIGLSA
260 270 280 290 300
EPLAPKDQKD WFIEMPVESK KDEWGLAAPI SPGPLTPMRE KDVLEDIPRW
310 320 330 340 350
EGKQFDSPMP SPFHSGSFTL PLDTVKDERV TEGSQPFAPV FFQSDDKMSL
360 370 380 390 400
QDTSGSATSK ESSKDEEPQK DKADKVADVP VSEATTVLGD VHSPAVEGFV
410 420 430 440 450
GENISGEEKG TTDQEKKETS TPSVQEPTLT ETEPQTKLEE TSKVSIEETV
460 470 480 490 500
AKEEESLKLK DDKAGVIQTS TEHSFSKEDQ KGEEQTIEAL KQDSFPISLE
510 520 530 540 550
QAVTDAAMAT KTLEKVTSEP EAVSEKREIQ GLFEEDIADK SKLEGAGSAT
560 570 580 590 600
VAEVEMPFYE DKSGMSKYFE TSALKEDVTR STGLGSDYYE LSDSRGNAQE
610 620 630 640 650
SLDTVSPKNQ QDEKELLAKA SQPSPPAHEA GYSTLAQSYT SDHPSELPEE
660 670 680 690 700
PSSPQERMFT IDPKVYGEKR DLHSKNKDDL TLSRSLGLGG RSAIEQRSMS
710 720 730 740 750
INLPMSCLDS IALGFNFGRG HDLSPLASDI LTNTSGTMDE GDDYLPPTTP
760 770 780 790 800
AVEKIPCFPI ESKEEEDKTE QAKVTGGQTT QVETSSESPF PAKEYYKNGT
810 820 830 840 850
VMAPDLPEML DLAGTRSRLA SVSADAEVAR RKSVPSEAVV AESSTGLPPV
860 870 880 890 900
ADDSQPVKPD SQLEDMGYCV FNKYTVPLPS PVQDSENLSG ESGSFYEGTD
910 920 930 940 950
DKVRRDLATD LSLIEVKLAA AGRVKDEFTA EKEASPPSSA DKSGLSREFD
960 970 980 990 1000
QDRKANDKLD TVLEKSEEHV DSKEHAKESE EVGDKVELFG LGVTYEQTSA
1010 1020 1030 1040 1050
KELITTKETA PERAEKGLSS VPEVAEVETT TKADQGLDVA AKKDDQSPLD
1060 1070 1080 1090 1100
IKVSDFGQMA SGMSVDAGKT IELKFEVDQQ LTLSSEAPQE TDSFMGIESS
1110 1120 1130 1140 1150
HVKDGAKVSE TEVKEKVAKP DLVHQEAVDK EESYESSGEH ESLTMESLKP
1160 1170 1180 1190 1200
DEGKKETSPE TSLIQDEVAL KLSVEIPCPP PVSEADSSID EKAEVQMEFI
1210 1220 1230 1240 1250
QLPKEESTET PDIPAIPSDV TQPQPEAVVS EPAEVRGEEE EIEAEGEYDK
1260 1270 1280 1290 1300
LLFRSDTLQI TDLLVPGSRE EFVETCPGEH KGVVESVVTI EDDFITVVQT
1310 1320 1330 1340 1350
TTDEGELGSH SVRFAAPVQP EEERRPYPHD EELEVLMAAE AQAEPKDGSP
1360 1370 1380 1390 1400
DAPATPEKEE VPFSEYKTET YDDYKDETTI DDSIMDADSL WVDTQDDDRS
1410 1420 1430 1440 1450
ILTEQLETIP KEERAEKEAR RPSLEKHRKE KPFKTGRGRI STPERKVAKK
1460 1470 1480 1490 1500
EPSTVSRDEV RRKKAVYKKA ELAKKSEVQA HSPSRKLILK PAIKYTRPTH
1510 1520 1530 1540 1550
LSCVKRKTTA TSGESAQAPS AFKQAKDKVT DGITKSPEKR SSLPRPSSIL
1560 1570 1580 1590 1600
PPRRGVSGDR EENSFSLNSS ISSARRTTRS EPIRRAGKSG TSTPTTPGST
1610 1620 1630 1640 1650
AITPGTPPSY SSRTPGTPGT PSYPRTPGTP KFGILVPSEK KVAIIRTPPK
1660 1670 1680 1690 1700
SPATPKQLRL INQPLPDLKN VKSKIGSTDN IKYQPKGGQV QIVTKKIDLS
1710 1720 1730 1740 1750
HVTSKCGSLK NIRHRPGGGR VKIESVKLDF KEKAQAKVGS LDNAHHVPGG
1760 1770 1780 1790 1800
GNVKIDSQKL NFREHAKARV DHGAEIITQS PSRSSVASPR RLSNVSSSGS
1810 1820
INLLESPQLA TLAEDVTAAL AKQGL
Length:1,825
Mass (Da):198,566
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A920FD9B22213BC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54100 mRNA Translation: CAA38034.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S13507

NCBI Reference Sequences

More...
RefSeqi
NP_037198.1, NM_013066.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25595

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25595

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54100 mRNA Translation: CAA38034.1
PIRiS13507
RefSeqiNP_037198.1, NM_013066.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi25595
KEGGirno:25595

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4133
RGDi3044, Map2

Phylogenomic databases

OMAiFIEMPME

Gene expression databases

GenevisibleiQ64715, RN

Family and domain databases

InterProiView protein in InterPro
IPR030797, MAP2
IPR013588, MAP2_projctn
IPR001084, MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF15, PTHR11501:SF15, 1 hit
PfamiView protein in Pfam
PF08377, MAP2_projctn, 1 hit
PF00418, Tubulin-binding, 3 hits
PROSITEiView protein in PROSITE
PS00229, TAU_MAP_1, 1 hit
PS51491, TAU_MAP_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ64715_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q64715
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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