UniProtKB - Q64709 (HLF_RAT)
Hepatic leukemia factor
Hlf
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- rhythmic process Source: UniProtKB-KW
- skeletal muscle cell differentiation Source: RGD
Keywordsi
Molecular function | DNA-binding |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatic leukemia factor |
Gene namesi | Name:Hlf |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1582828, Hlf |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
- RNA polymerase II transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000003514 | 1 – 295 | Hepatic leukemia factorAdd BLAST | 295 |
Proteomic databases
PaxDbi | Q64709 |
PTM databases
iPTMneti | Q64709 |
PhosphoSitePlusi | Q64709 |
Expressioni
Tissue specificityi
Inductioni
Interactioni
Subunit structurei
Binds DNA specifically as homodimer or heterodimer with other PAR factors.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000052527 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 225 – 288 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 69 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 93 – 160 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 227 – 247 | Basic motifPROSITE-ProRule annotationAdd BLAST | 21 | |
Regioni | 248 – 255 | Leucine-zipperPROSITE-ProRule annotation | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 36 – 52 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 112 – 126 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
InParanoidi | Q64709 |
PhylomeDBi | Q64709 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR029829, HLF IPR040223, PAR_bZIP |
PANTHERi | PTHR11988, PTHR11988, 1 hit PTHR11988:SF28, PTHR11988:SF28, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEKMSRQLPL NPTFIPPPYG VLRSLLENPL KLPLHPEDAF SKDRDKGKKL
60 70 80 90 100
DDGSNSPTVP QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS
110 120 130 140 150
PSQHDHSPHP PGLQPASSTA PSVMDLSSRA TAPLHPGIPS PNCMQNPIRP
160 170 180 190 200
GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA DLALSSIPGP EMFDPRKRKF
210 220 230 240 250
SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK RSRDARRLKE
260 270 280 290
NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL
The sequence of this isoform differs from the canonical sequence as follows:
1-49: Missing.
50-50: L → M
171-295: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
170-295: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-49: Missing.
50-50: L → M
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A8I6APH7 | A0A8I6APH7_RAT | Hepatic leukemia factor | Hlf | 296 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018687 | 1 – 49 | Missing in isoform HLF17 and isoform HLF36. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_018688 | 50 | L → M in isoform HLF17 and isoform HLF36. 1 Publication | 1 | |
Alternative sequenceiVSP_000584 | 170 – 295 | Missing in isoform HLF24. 1 PublicationAdd BLAST | 126 | |
Alternative sequenceiVSP_000585 | 171 – 295 | Missing in isoform HLF17. 1 PublicationAdd BLAST | 125 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S79820 mRNA Translation: AAB35322.1 |
PIRi | S58525 |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S79820 mRNA Translation: AAB35322.1 |
PIRi | S58525 |
3D structure databases
AlphaFoldDBi | Q64709 |
SMRi | Q64709 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000052527 |
PTM databases
iPTMneti | Q64709 |
PhosphoSitePlusi | Q64709 |
Proteomic databases
PaxDbi | Q64709 |
Organism-specific databases
RGDi | 1582828, Hlf |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
InParanoidi | Q64709 |
PhylomeDBi | Q64709 |
Miscellaneous databases
PROi | PR:Q64709 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR029829, HLF IPR040223, PAR_bZIP |
PANTHERi | PTHR11988, PTHR11988, 1 hit PTHR11988:SF28, PTHR11988:SF28, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HLF_RAT | |
Accessioni | Q64709Primary (citable) accession number: Q64709 Secondary accession number(s): Q64708 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families