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Protein

Syntaxin-3

Gene

Stx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

  • arachidonic acid binding Source: MGI
  • SNAP receptor activity Source: MGI
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:Stx3
Synonyms:Stx3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:103077 Stx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 263CytoplasmicSequence analysisAdd BLAST263
Transmembranei264 – 283Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST20
Topological domaini284 – 289ExtracellularSequence analysis6

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102001 – 289Syntaxin-3Add BLAST289

Proteomic databases

PaxDbiQ64704
PeptideAtlasiQ64704
PRIDEiQ64704

PTM databases

iPTMnetiQ64704
PhosphoSitePlusiQ64704

Expressioni

Gene expression databases

BgeeiENSMUSG00000041488 Expressed in 286 organ(s), highest expression level in retina
CleanExiMM_STX3
ExpressionAtlasiQ64704 baseline and differential
GenevisibleiQ64704 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203562, 4 interactors
STRINGi10090.ENSMUSP00000069529

Structurei

3D structure databases

ProteinModelPortaliQ64704
SMRiQ64704
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 111Sequence analysisAdd BLAST80

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiQ64704
KOiK08486
OMAiKMANSVR
OrthoDBiEOG091G0EUK
PhylomeDBiQ64704
TreeFamiTF313763

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR031186 Stx3
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF34 PTHR19957:SF34, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3A1 Publication (identifier: Q64704-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KRAMKYQGQA RKKLIIIIVV VVVLLGILAL IIGLSVGLK
Length:289
Mass (Da):33,243
Last modified:November 1, 1996 - v1
Checksum:i4A8EAFC2049EEE6F
GO
Isoform 3B1 Publication (identifier: Q64704-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LASTIGGIFA

Show »
Length:287
Mass (Da):32,953
Checksum:iA0417FB810FC7157
GO
Isoform 3C1 Publication (identifier: Q64704-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-72: IEETRLNIDKISEHVEEAKKLYSIILSAPIPEPK → NFHGILSYLLRLSSHE
     227-289: EMLDNIELNV...LIIGLSVGLK → AMIDRIENNM...LASTIGGIFA

Show »
Length:269
Mass (Da):30,934
Checksum:i02EA1FCAE471CB33
GO
Isoform 3D1 Publication (identifier: Q64704-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-86: TKDDLEQLTTEIKK → LPWNPLLSPEIELT
     87-289: Missing.

Show »
Length:86
Mass (Da):9,971
Checksum:i948B6A5C88498A9A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRC2A0A1B0GRC2_MOUSE
Syntaxin-3
Stx3
289Annotation score:
A0A1C7CYU4A0A1C7CYU4_MOUSE
Syntaxin-3
Stx3
86Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3D1 Publication (identifier: Q64704-4)
Sequence conflicti75W → R in BAA07454 (PubMed:7598732).1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00634139 – 72IEETR…IPEPK → NFHGILSYLLRLSSHE in isoform 3C. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_00634273 – 86TKDDL…TEIKK → LPWNPLLSPEIELT in isoform 3D. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_00634487 – 289Missing in isoform 3D. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_006346227 – 289EMLDN…SVGLK → AMIDRIENNMDQSVGFVERA VADTKKAVKYQSEARRKKIM IMICCIILAIILASTIGGIF A in isoform 3B and isoform 3C. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29797 mRNA Translation: BAA06180.1
D29798 mRNA Translation: BAA06181.1
D29799 mRNA Translation: BAA06182.1
D29800 mRNA Translation: BAA06183.1
D38375 mRNA Translation: BAA07454.1
AK171135 mRNA Translation: BAE42269.1
AC126036 Genomic DNA No translation available.
AC126266 Genomic DNA No translation available.
CH466534 Genomic DNA Translation: EDL41444.1
BC024844 mRNA Translation: AAH24844.1
CCDSiCCDS29611.1 [Q64704-2]
CCDS29612.1 [Q64704-3]
CCDS29613.1 [Q64704-1]
PIRiI60170
I83197
I83198
RefSeqiNP_001020478.1, NM_001025307.1 [Q64704-2]
NP_001273472.1, NM_001286543.1
NP_035632.1, NM_011502.3 [Q64704-3]
NP_689344.1, NM_152220.2 [Q64704-1]
UniGeneiMm.272264

Genome annotation databases

EnsembliENSMUST00000069285; ENSMUSP00000069529; ENSMUSG00000041488 [Q64704-1]
ENSMUST00000075304; ENSMUSP00000074776; ENSMUSG00000041488 [Q64704-2]
ENSMUST00000211641; ENSMUSP00000147398; ENSMUSG00000041488 [Q64704-3]
GeneIDi20908
KEGGimmu:20908
UCSCiuc008gsy.1 mouse
uc008gsz.1 mouse [Q64704-3]
uc008gtb.2 mouse [Q64704-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29797 mRNA Translation: BAA06180.1
D29798 mRNA Translation: BAA06181.1
D29799 mRNA Translation: BAA06182.1
D29800 mRNA Translation: BAA06183.1
D38375 mRNA Translation: BAA07454.1
AK171135 mRNA Translation: BAE42269.1
AC126036 Genomic DNA No translation available.
AC126266 Genomic DNA No translation available.
CH466534 Genomic DNA Translation: EDL41444.1
BC024844 mRNA Translation: AAH24844.1
CCDSiCCDS29611.1 [Q64704-2]
CCDS29612.1 [Q64704-3]
CCDS29613.1 [Q64704-1]
PIRiI60170
I83197
I83198
RefSeqiNP_001020478.1, NM_001025307.1 [Q64704-2]
NP_001273472.1, NM_001286543.1
NP_035632.1, NM_011502.3 [Q64704-3]
NP_689344.1, NM_152220.2 [Q64704-1]
UniGeneiMm.272264

3D structure databases

ProteinModelPortaliQ64704
SMRiQ64704
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203562, 4 interactors
STRINGi10090.ENSMUSP00000069529

PTM databases

iPTMnetiQ64704
PhosphoSitePlusiQ64704

Proteomic databases

PaxDbiQ64704
PeptideAtlasiQ64704
PRIDEiQ64704

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069285; ENSMUSP00000069529; ENSMUSG00000041488 [Q64704-1]
ENSMUST00000075304; ENSMUSP00000074776; ENSMUSG00000041488 [Q64704-2]
ENSMUST00000211641; ENSMUSP00000147398; ENSMUSG00000041488 [Q64704-3]
GeneIDi20908
KEGGimmu:20908
UCSCiuc008gsy.1 mouse
uc008gsz.1 mouse [Q64704-3]
uc008gtb.2 mouse [Q64704-1]

Organism-specific databases

CTDi6809
MGIiMGI:103077 Stx3

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiQ64704
KOiK08486
OMAiKMANSVR
OrthoDBiEOG091G0EUK
PhylomeDBiQ64704
TreeFamiTF313763

Enzyme and pathway databases

ReactomeiR-MMU-449836 Other interleukin signaling

Miscellaneous databases

ChiTaRSiStx3 mouse
PROiPR:Q64704
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041488 Expressed in 286 organ(s), highest expression level in retina
CleanExiMM_STX3
ExpressionAtlasiQ64704 baseline and differential
GenevisibleiQ64704 MM

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR031186 Stx3
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF34 PTHR19957:SF34, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX3_MOUSE
AccessioniPrimary (citable) accession number: Q64704
Secondary accession number(s): Q3TBP0, Q8R1B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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