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Protein

Taste receptor type 2 member 7

Gene

TAS2R7

Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).By similarity

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 7
Short name:
T2R7
Gene namesi
Name:TAS2R7
OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)
Taxonomic identifieri9597 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000240080 Componenti: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 55CytoplasmicSequence analysisAdd BLAST25
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 94ExtracellularSequence analysisAdd BLAST18
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 128CytoplasmicSequence analysisAdd BLAST13
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 187ExtracellularSequence analysisAdd BLAST38
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 235CytoplasmicSequence analysisAdd BLAST27
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 266ExtracellularSequence analysis10
Transmembranei267 – 287Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini288 – 319CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822221 – 325Taste receptor type 2 member 7Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ646D6

Structurei

3D structure databases

ProteinModelPortaliQ646D6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119096
HOVERGENiHBG060698
KOiK08474

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
IPR007960 T2R
IPR030053 TAS2R7
PANTHERiPTHR11394:SF58 PTHR11394:SF58, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q646D6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKVQTTLL FLAVGEFSVG ILGNAFIGLV NCMDWVKKRK IASIDLILTS
60 70 80 90 100
LAISRICLLC VILLDCFILV LYPDVYATGK EMRIIDFFWT LTNHLSIWFA
110 120 130 140 150
TCLSIYYFFR IANFFHPLFL WMKWRIDRVI SWILLGCVVL SVFISLPATE
160 170 180 190 200
NLNADFRFCV KAKRKTNLTW SCRVNKTQHA STKLFLNLAT LLPFCVCLMS
210 220 230 240 250
FFLLILSLRR HIRRMQLSAT GCRDPSTEAH VRALKAVISF LLLFIAYYLS
260 270 280 290 300
FLVATSSYFM PETELAVIFG ESIALIYPSS HSFILILGNN KLRHASLKVI
310 320
WKVMSILKGR KFQQHKQIGR ETMLF
Length:325
Mass (Da):37,413
Last modified:March 29, 2005 - v2
Checksum:i9B0A9C03FDFAF605
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY677136 Genomic DNA Translation: AAV28565.1
AY724855 Genomic DNA Translation: AAU21083.1
RefSeqiXP_014202577.1, XM_014347091.1

Genome annotation databases

EnsembliENSPPAT00000017708; ENSPPAP00000003840; ENSPPAG00000016164
GeneIDi106635341
KEGGipps:106635341

Similar proteinsi

Entry informationi

Entry nameiTA2R7_PANPA
AccessioniPrimary (citable) accession number: Q646D6
Secondary accession number(s): Q5Y510
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 29, 2005
Last modified: September 12, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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