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Protein

Taste receptor type 2 member 13

Gene

TAS2R13

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 13
Short name:
T2R13
Gene namesi
Name:TAS2R13
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:13477 TAS2R13

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 28Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini29 – 55CytoplasmicSequence analysisAdd BLAST27
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 85ExtracellularSequence analysis9
Transmembranei86 – 106Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 128CytoplasmicSequence analysisAdd BLAST22
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 184ExtracellularSequence analysisAdd BLAST35
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 232CytoplasmicSequence analysisAdd BLAST27
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 261ExtracellularSequence analysis8
Transmembranei262 – 282Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini283 – 303CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822491 – 303Taste receptor type 2 member 13Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ646B6
PRIDEiQ646B6

Expressioni

Gene expression databases

BgeeiENSPTRG00000032539 Expressed in 1 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000054728

Structurei

3D structure databases

ProteinModelPortaliQ646B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9F7 Eukaryota
ENOG4111BEG LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ646B6
KOiK08474
OMAiIVLINCI
OrthoDBiEOG091G0GT1
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

Q646B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESALPSIFT LVIIAEFIIG NLSNGFIVLI NCIDWVSKRE LSSVDKLLII
60 70 80 90 100
LAISRIGLIW EILVSWFLAL HSLAIFVSGT GLRIMIFSWI VSNHFNLWLA
110 120 130 140 150
TILSIFYLLK IASFSSPAFL YLKRRVNKVI LMILLGTLVF LFLNLIQINM
160 170 180 190 200
LIKDWLDRYE RNTTWNFSMS DFETFSVSVR FTMTMFSLTP FTVAFISFLL
210 220 230 240 250
LVFSLQKHLQ KMQLNYKGHR DPRTKVHTNA LKIVISFLLL YASFFLSILI
260 270 280 290 300
SWISELYQNT VIYMLCETIG AFYPSSHSFL LILGNAKLRQ AFLLVAAKVW

AKR
Length:303
Mass (Da):34,980
Last modified:October 25, 2004 - v1
Checksum:i91FC3D2423122E0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724881 Genomic DNA Translation: AAU21103.1
RefSeqiNP_001009141.1, NM_001009141.1
UniGeneiPtr.6384

Genome annotation databases

EnsembliENSPTRT00000062175; ENSPTRP00000054728; ENSPTRG00000032539
GeneIDi493891
KEGGiptr:493891

Similar proteinsi

Entry informationi

Entry nameiT2R13_PANTR
AccessioniPrimary (citable) accession number: Q646B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: September 12, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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