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Protein

Taste receptor type 2 member 4

Gene

TAS2R4

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).By similarity

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 4
Short name:
T2R4
Gene namesi
Name:TAS2R4
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 46CytoplasmicSequence analysisAdd BLAST16
Transmembranei47 – 67Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini68 – 81ExtracellularSequence analysisAdd BLAST14
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 131CytoplasmicSequence analysisAdd BLAST29
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 172ExtracellularSequence analysisAdd BLAST20
Transmembranei173 – 193Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini194 – 230CytoplasmicSequence analysisAdd BLAST37
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 262ExtracellularSequence analysisAdd BLAST11
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 299CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822071 – 299Taste receptor type 2 member 4Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ646B0
PRIDEiQ646B0

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000054263

Structurei

3D structure databases

ProteinModelPortaliQ646B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKCN Eukaryota
ENOG4111DWC LUCA
HOVERGENiHBG098740
InParanoidiQ646B0
KOiK08474

Family and domain databases

CDDicd15013 7tm_TAS2R4, 1 hit
InterProiView protein in InterPro
IPR007960 T2R
IPR030055 TAS2R4
PANTHERiPTHR11394:SF55 PTHR11394:SF55, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q646B0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRLFYFSAI IASVILNFVG IIMNLFITVV NCKTWVKSHR ISSSDRILFS
60 70 80 90 100
LGITRFLMLG LFLVNTIYFV SSNXERSVYL SAFFVLCFMF LDSSSLWFVT
110 120 130 140 150
LLNILYCVKI TNFQHSVFLL LKRNISPKIP RLLLACVLIS AFTTCLYITL
160 170 180 190 200
SQASPFPELV TTRNNTSFNI NEGILSLVVS LVLSSSLQFI INVTSASLLI
210 220 230 240 250
HSLRRHIQKM QKNATGFWNP QTEAHVGAMK LMVYFLILYI PYSVATLVQY
260 270 280 290
LPFYAGMDMG TKSICLIFAT LYSPGHSVLI IITHPKLKTT AKKILCFKK
Length:299
Mass (Da):33,892
Last modified:October 25, 2004 - v1
Checksum:iF5CB0CA9F1270088
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2RAP5H2RAP5_PANTR
Taste receptor type 2
TAS2R4 LOC107971681, CK820_G0014001
299Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724893 Genomic DNA Translation: AAU21109.1
RefSeqiNP_001009161.1, NM_001009161.1
UniGeneiPtr.6377

Genome annotation databases

GeneIDi494114
KEGGiptr:494114

Similar proteinsi

Entry informationi

Entry nameiTA2R4_PANTR
AccessioniPrimary (citable) accession number: Q646B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: September 12, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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