UniProtKB - Q64640 (ADK_RAT)
Protein
Adenosine kinase
Gene
Adk
Organism
Rattus norvegicus (Rat)
Status
Functioni
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Catalytic activityi
- EC:2.7.1.20
Cofactori
Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity
: AMP biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes AMP from adenosine.Proteins known to be involved in this subpathway in this organism are:
- Adenosine kinase (Adk)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenosine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 48 | Magnesium 1By similarity | 1 | |
Metal bindingi | 147 | Magnesium 2By similarity | 1 | |
Active sitei | 316 | By similarity | 1 |
GO - Molecular functioni
- adenosine kinase activity Source: RGD
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- adenosine metabolic process Source: RGD
- AMP salvage Source: UniProtKB-UniPathway
- circadian regulation of gene expression Source: RGD
- positive regulation of cardiac muscle hypertrophy Source: RGD
- positive regulation of T cell proliferation Source: RGD
- purine ribonucleoside salvage Source: RGD
- type B pancreatic cell proliferation Source: RGD
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Purine salvage |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-74217 Purine salvage |
UniPathwayi | UPA00588;UER00659 |
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine kinase (EC:2.7.1.20)Short name: AK Alternative name(s): Adenosine 5'-phosphotransferase |
Gene namesi | Name:Adk |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2046 Adk |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080055 | 1 – 361 | Adenosine kinaseAdd BLAST | 361 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 76 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q64640 |
PaxDbi | Q64640 |
PRIDEi | Q64640 |
PTM databases
iPTMneti | Q64640 |
PhosphoSitePlusi | Q64640 |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016709 |
Chemistry databases
BindingDBi | Q64640 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 7 – 15 | Nuclear localization signalBy similarity | 9 |
Sequence similaritiesi
Belongs to the carbohydrate kinase PfkB family.Curated
Phylogenomic databases
eggNOGi | KOG2854 Eukaryota COG0524 LUCA |
HOGENOMi | HOG000172419 |
InParanoidi | Q64640 |
KOi | K00856 |
OrthoDBi | 1226324at2759 |
PhylomeDBi | Q64640 |
TreeFami | TF300745 |
Family and domain databases
Gene3Di | 3.40.1190.20, 1 hit |
InterProi | View protein in InterPro IPR001805 Adenokinase IPR002173 Carboh/pur_kinase_PfkB_CS IPR011611 PfkB_dom IPR029056 Ribokinase-like |
Pfami | View protein in Pfam PF00294 PfkB, 1 hit |
PRINTSi | PR00989 ADENOKINASE |
SUPFAMi | SSF53613 SSF53613, 1 hit |
PROSITEi | View protein in PROSITE PS00584 PFKB_KINASES_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q64640-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAADEPKPK KLKVEAPEAL SENVLFGMGN PLLDISAVVD KDFLDKYSLK
60 70 80 90 100
PNDQILAEDK HKELFDELVK KFKVEYHAGG STQNSMKVAQ WMIQEPHRAA
110 120 130 140 150
TFFGCIGIDK FGEILKSKAA DAHVDAHYYE QNEQPTGTCA ACITGGNRSL
160 170 180 190 200
VANLAAANCY KKEKHLDLEN NWMLVEKARV YYIAGFFLTV SPESVLKVAR
210 220 230 240 250
YAAENNRTFT LNLSAPFISQ FFKEALMEVM PYVDILFGNE TEAATFAREQ
260 270 280 290 300
GFETKDIKEI ARKTQALPKV NSKRQRTVIF TQGRDDTIVA TGNDVTAFPV
310 320 330 340 350
LDQNQEEIVD TNGAGDAFVG GFLSQLVSNK PLTECIRAGH YAASVIIRRT
360
GCTFPEKPDF H
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K6X9 | A0A0G2K6X9_RAT | Adenosine kinase | Adk | 403 | Annotation score: | ||
A0A0G2JSL8 | A0A0G2JSL8_RAT | Adenosine kinase | Adk rCG_41881 | 361 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 121 | D → N in AAB03110 (PubMed:8917457).Curated | 1 | |
Sequence conflicti | 144 | T → S in AAB03110 (PubMed:8917457).Curated | 1 | |
Sequence conflicti | 155 | A → R in AAB03110 (PubMed:8917457).Curated | 1 | |
Sequence conflicti | 198 | V → M in AAB03110 (PubMed:8917457).Curated | 1 | |
Sequence conflicti | 217 – 218 | FI → LL in AAB03110 (PubMed:8917457).Curated | 2 | |
Sequence conflicti | 228 | E → A in AAB03110 (PubMed:8917457).Curated | 1 | |
Sequence conflicti | 359 | D → N in AAH81712 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90340 mRNA Translation: AAB50236.1 BC081712 mRNA Translation: AAH81712.1 U57042 mRNA Translation: AAB03110.1 |
PIRi | JC5362 |
RefSeqi | NP_037027.2, NM_012895.3 |
Genome annotation databases
GeneIDi | 25368 |
KEGGi | rno:25368 |
UCSCi | RGD:2046 rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90340 mRNA Translation: AAB50236.1 BC081712 mRNA Translation: AAH81712.1 U57042 mRNA Translation: AAB03110.1 |
PIRi | JC5362 |
RefSeqi | NP_037027.2, NM_012895.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LNJ | model | - | A | 1-361 | [»] | |
SMRi | Q64640 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016709 |
Chemistry databases
BindingDBi | Q64640 |
ChEMBLi | CHEMBL2384 |
PTM databases
iPTMneti | Q64640 |
PhosphoSitePlusi | Q64640 |
Proteomic databases
jPOSTi | Q64640 |
PaxDbi | Q64640 |
PRIDEi | Q64640 |
Genome annotation databases
GeneIDi | 25368 |
KEGGi | rno:25368 |
UCSCi | RGD:2046 rat |
Organism-specific databases
CTDi | 132 |
RGDi | 2046 Adk |
Phylogenomic databases
eggNOGi | KOG2854 Eukaryota COG0524 LUCA |
HOGENOMi | HOG000172419 |
InParanoidi | Q64640 |
KOi | K00856 |
OrthoDBi | 1226324at2759 |
PhylomeDBi | Q64640 |
TreeFami | TF300745 |
Enzyme and pathway databases
UniPathwayi | UPA00588;UER00659 |
Reactomei | R-RNO-74217 Purine salvage |
Miscellaneous databases
PROi | PR:Q64640 |
Family and domain databases
Gene3Di | 3.40.1190.20, 1 hit |
InterProi | View protein in InterPro IPR001805 Adenokinase IPR002173 Carboh/pur_kinase_PfkB_CS IPR011611 PfkB_dom IPR029056 Ribokinase-like |
Pfami | View protein in Pfam PF00294 PfkB, 1 hit |
PRINTSi | PR00989 ADENOKINASE |
SUPFAMi | SSF53613 SSF53613, 1 hit |
PROSITEi | View protein in PROSITE PS00584 PFKB_KINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADK_RAT | |
Accessioni | Q64640Primary (citable) accession number: Q64640 Secondary accession number(s): O09162, Q642G1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 9, 2007 | |
Last modified: | May 8, 2019 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references