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UniProtKB - Q64632 (ITB4_RAT)

Entry version 169 (17 Jun 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Integrin beta-4

Gene

Itgb4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-3000157 Laminin interactions
R-RNO-3000170 Syndecan interactions
R-RNO-446107 Type I hemidesmosome assembly

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin beta-4
Alternative name(s):
GP150
CD_antigen: CD104
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itgb4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		2928 Itgb4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 713ExtracellularSequence analysisAdd BLAST686
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei714 – 734HelicalSequence analysisAdd BLAST21
Topological domaini735 – 1807CytoplasmicSequence analysisAdd BLAST1073

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27By similarityAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001634728 – 1807Integrin beta-4Add BLAST1780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 456By similarity
Disulfide bondi38 ↔ 48By similarity
Disulfide bondi41 ↔ 72By similarity
Disulfide bondi51 ↔ 61By similarity
Disulfide bondi245 ↔ 288By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi424 ↔ 673By similarity
Disulfide bondi453 ↔ 458By similarity
Disulfide bondi469 ↔ 480By similarity
Disulfide bondi477 ↔ 513By similarity
Disulfide bondi482 ↔ 491By similarity
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi493 ↔ 504By similarity
Disulfide bondi519 ↔ 524By similarity
Disulfide bondi521 ↔ 552By similarity
Disulfide bondi526 ↔ 537By similarity
Disulfide bondi558 ↔ 563By similarity
Disulfide bondi565 ↔ 574By similarity
Disulfide bondi576 ↔ 583By similarity
Glycosylationi580N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi597 ↔ 602By similarity
Disulfide bondi599 ↔ 650By similarity
Disulfide bondi604 ↔ 616By similarity
Glycosylationi619N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi628 ↔ 637By similarity
Disulfide bondi634 ↔ 708By similarity
Disulfide bondi653 ↔ 682By similarity
Glycosylationi697N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei773PhosphoserineCombined sources1
Modified residuei1071PhosphoserineCombined sources1
Modified residuei1121PhosphoserineCombined sources1
Modified residuei1386PhosphoserineCombined sources1
Modified residuei1389PhosphoserineCombined sources1
Modified residuei1405PhosphoserineBy similarity1
Modified residuei1418PhosphothreonineBy similarity1
Modified residuei1425PhosphoserineCombined sources1
Modified residuei1514PhosphothreonineBy similarity1
Modified residuei1776PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q64632

PRoteomics IDEntifications database

More...PRIDEi		Q64632

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q64632

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q64632

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6.

Interacts (via cytoplasmic region) with COL17A1 (via cytoplasmic region).

Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus).

Interacts (via cytoplasmic domain) with DST (via N-terminus).

Interacts with RAC1. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3. ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R. ITGA6:ITGB4 interacts with IGF2.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000059783

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11807
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q64632

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 73PSIAdd BLAST45
Domaini131 – 340VWFAAdd BLAST210
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati457 – 503IAdd BLAST47
Repeati504 – 543IIAdd BLAST40
Repeati544 – 582IIIAdd BLAST39
Repeati583 – 621IVAdd BLAST39
Domaini981 – 1086Calx-betaAdd BLAST106
Domaini1131 – 1220Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST90
Domaini1224 – 1323Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini1514 – 1609Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini1627 – 1723Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni194 – 199Involved in NRG1- and IGF1-bindingBy similarity6
Regioni457 – 621Cysteine-rich tandem repeatsAdd BLAST165
Regioni734 – 751Palmitoylated on several cysteinesBy similarityAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1226 Eukaryota
ENOG410XP60 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q64632

KEGG Orthology (KO)

More...KOi		K06525

Database of Orthologous Groups

More...OrthoDBi		473040at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q64632

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 4 hits
2.60.40.2030, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR013032 EGF-like_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR040622 I-EGF_1
IPR013783 Ig-like_fold
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR012013 Integrin_bsu-4
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR10082 PTHR10082, 4 hits
PTHR10082:SF42 PTHR10082:SF42, 4 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03160 Calx-beta, 1 hit
PF00041 fn3, 4 hits
PF18372 I-EGF_1, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002513 Integrin_B4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01186 INTEGRINB

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00237 Calx_beta, 1 hit
SM00060 FN3, 4 hits
SM00187 INB, 1 hit
SM01242 Integrin_B_tail, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF141072 SSF141072, 1 hit
SSF49265 SSF49265, 2 hits
SSF53300 SSF53300, 1 hit
SSF69687 SSF69687, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50853 FN3, 4 hits
PS00243 INTEGRIN_BETA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q64632-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLCSSPWV KLLLAVVLSA GLPGNMANRC KKAQVKSCTE CIRVDKSCAY 
        60         70         80         90        100
CTDELFKERR CNTQADVLAA GCRGESVLVM ESSLEITENI QIDTSLHRSQ 
       110        120        130        140        150
VSPQGLQVRL RPGEERNFVF KVFEPLESPV DLYILMDFSN SMSDDLDNLK 
       160        170        180        190        200
QMGQNLAKIL RQLTSDYTIG FGKFVDKVSV PQTDMRPEKL KEPWPNSDPP 
       210        220        230        240        250
FSFKNVISLT ENVEEFWDKL QGERISGNLD APEGGFDAIL QTAVCTRDIG 
       260        270        280        290        300
WRADSTHLLV FSTESAFHYE ADGANVLAGI MNRNDEKCHL DATGAYTQYK 
       310        320        330        340        350
TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHKYF PVSSLGVLQE 
       360        370        380        390        400
DSSNIVELLE EAFYRIRSNL DIRALDSPRG LRTEVTSDTL QKTETGSFHI 
       410        420        430        440        450
KRGEVGTYNV HLRAVEDIDG THVCQLAKED QRGNIHLKPS FSDGLRMDAS 
       460        470        480        490        500
VICDMCACEL QKEVQSARCH YRGDFMCGHC VCNEGWSGKT CNCSTGSLSD 
       510        520        530        540        550
TQPCLREGED KPCSGHGECQ CGRCVCYGEG RYEGHFCEYD NFQCPRTSGF 
       560        570        580        590        600
LCNDRGRCSM GECVCEPGWT GRSCDCPLSN ATCIDSNGGI CNGLGFCECG 
       610        620        630        640        650
RCHCNQRSSL YTDTTCEINY SAIRLGLCED LRSCVQCQAW GTGEKKGRTC 
       660        670        680        690        700
EECNFKVKMV DELKKAEEVV EYCSFRDEDD DCTYSYTVEG DGSPGPNSTV 
       710        720        730        740        750
LVHKKKDCLP APSWWLIPLL IFLLLLLVLL LLLCWKYCAC CKACLGLLPC 
       760        770        780        790        800
CNQGHMVGFK EDHYMLRENL MASDHLDTPM LRSGNLKGRD TVRWKITNNV 
       810        820        830        840        850
QRPGFATHAA SISPTELVPY GLSLRLGRLC TENLMKPGTR ECDQLRQEVE 
       860        870        880        890        900
ENLNEVYRQV NGVHKLQQTK FRQQPNAGKK QDHTIVDTVL LAPRSAKQSL 
       910        920        930        940        950
LKLTEKQVEQ GSFHELKVAP GYYTLTAEQD ARGMVEFQEG VELVDVRVPL 
       960        970        980        990       1000
FIRPEDDDEK QLLVEAIDVP VGTATLGRRL VNITIIKEQA SGIVSFEQPE 
      1010       1020       1030       1040       1050
YSVSRGDQVA RIPVIRHILD NGKSQVSYST QDNTAHGHRD YVPVEGELLF 
      1060       1070       1080       1090       1100
YPGETWKELQ VKLLELQEVD SLLRGRQVRR FQVQLSNPKF GARLGQPNTA 
      1110       1120       1130       1140       1150
TVIIGEQDET DRSLINEISA SPPLPRGDLG APQNPNAKAA GSRKIHFNWL 
      1160       1170       1180       1190       1200
PPPGKPMGYR VKYWVQGDSE SEAHLLDSKV PSVELTNLYP YCDYEMKVCA 
      1210       1220       1230       1240       1250
YGAHGEGPYS SLVSCRTHQE VPSEPGRLAF NVVSSTVTQL SWAEPAETNG 
      1260       1270       1280       1290       1300
EITAYEVCYG LVNEDNRPIG PMKKVLVDNP KNRMLLIENL RESQPYRYTV 
      1310       1320       1330       1340       1350
KARNGAGWGP EREAIINLAT QPKRPMSIPI IPDIPIVDAQ GGEDYENFLM 
      1360       1370       1380       1390       1400
YSDDVLRSPA SSQRPSVSDD TEHLVNGRMD FAYPGSANSL HRMTAANVAY 
      1410       1420       1430       1440       1450
GTHLSPHQTH RMLSTSSTLT RDYHSLTRTD HSQSGTLPRD YSTLTSLSSQ 
      1460       1470       1480       1490       1500
GLPPIWEDGR SRLPLSWTLG SWSRAQMKGV PASRGSPDSI ILAGQSAAPS 
      1510       1520       1530       1540       1550
WGTDSRGAMG VPDTPTRLVF SALGPTSLKV SWQEPQCDRA LLGYSVEYQL 
      1560       1570       1580       1590       1600
LNGGEMHRLN IPNPGQTSVV VEDLLPNHSY VFRVRAQSQE GWGREREGVI 
      1610       1620       1630       1640       1650
TIESQVHPQS PLCPLPGSAF TLSTPSAPGP LVFTALSPDS LQLSWERPRR 
      1660       1670       1680       1690       1700
PNGDILGYLV TCEMAQGGGP ARTFRVDGDN PESRLTVPGL SENVPYKFKV 
      1710       1720       1730       1740       1750
QARTTEGFGP EREGIITIES QDGGPFPQLG SHSGLFQNPL QSEYSTVTST 
      1760       1770       1780       1790       1800
HSTTTTEPFL IDGLTLGTQR LEAGGSLTRH VTQEFVSRTL TTSGSLSTHM 

DQQFFQT
Length:1,807
Mass (Da):200,589
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EF9BD4E345829A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K4V5A0A0G2K4V5_RAT
Integrin beta
Itgb4 rCG_33384
1,807Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LSD3F1LSD3_RAT
Integrin beta
Itgb4
1,806Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U60096 mRNA Translation: AAC53094.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC6319

NCBI Reference Sequences

More...RefSeqi		NP_037312.1, NM_013180.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25724

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:25724

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60096 mRNA Translation: AAC53094.1
PIRiJC6319
RefSeqiNP_037312.1, NM_013180.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6HYFX-ray1.60A/B/C/D1512-1602[»]
SMRiQ64632
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059783

PTM databases

iPTMnetiQ64632
PhosphoSitePlusiQ64632

Proteomic databases

PaxDbiQ64632
PRIDEiQ64632

Genome annotation databases

GeneIDi25724
KEGGirno:25724

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3691
RGDi2928 Itgb4

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
InParanoidiQ64632
KOiK06525
OrthoDBi473040at2759
PhylomeDBiQ64632

Enzyme and pathway databases

ReactomeiR-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-3000157 Laminin interactions
R-RNO-3000170 Syndecan interactions
R-RNO-446107 Type I hemidesmosome assembly

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q64632

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 4 hits
2.60.40.2030, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR013032 EGF-like_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR040622 I-EGF_1
IPR013783 Ig-like_fold
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR012013 Integrin_bsu-4
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 4 hits
PTHR10082:SF42 PTHR10082:SF42, 4 hits
PfamiView protein in Pfam
PF03160 Calx-beta, 1 hit
PF00041 fn3, 4 hits
PF18372 I-EGF_1, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002513 Integrin_B4, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00237 Calx_beta, 1 hit
SM00060 FN3, 4 hits
SM00187 INB, 1 hit
SM01242 Integrin_B_tail, 1 hit
SUPFAMiSSF141072 SSF141072, 1 hit
SSF49265 SSF49265, 2 hits
SSF53300 SSF53300, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50853 FN3, 4 hits
PS00243 INTEGRIN_BETA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITB4_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q64632
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 17, 2020
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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