UniProtKB - Q64625 (GPX6_RAT)
Protein
Glutathione peroxidase 6
Gene
Gpx6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- EC:1.11.1.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | By similarity | 1 |
GO - Molecular functioni
- glutathione peroxidase activity Source: GO_Central
- peroxidase activity Source: GO_Central
GO - Biological processi
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Enzyme and pathway databases
Reactomei | R-RNO-3299685, Detoxification of Reactive Oxygen Species |
Protein family/group databases
PeroxiBasei | 3736, RnoGPx06 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione peroxidase 6 (EC:1.11.1.9)Short name: GPx-6 Short name: GSHPx-6 Alternative name(s): Odorant-metabolizing protein RY2D1 |
Gene namesi | Name:Gpx6 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 628789, Gpx6 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000013083 | 20 – 221 | Glutathione peroxidase 6Add BLAST | 202 |
Proteomic databases
PaxDbi | Q64625 |
PRIDEi | Q64625 |
Expressioni
Tissue specificityi
Expressed in the Bowman glands.
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1651, Eukaryota |
InParanoidi | Q64625 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q64625 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q64625-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQQFWGPCL FSLFMAVLAQ ETLDPQKSKV DCNKGVAGTV YEYGANTLDG
60 70 80 90 100
GEYVQFQQYA GKHILFVNVA SFCGLTATYP ELNTLQEELR PFNVSVLGFP
110 120 130 140 150
CNQFGKQEPG KNSEILLGLK YVRPGGGFVP NFQLFEKGDV NGDNEQKVFS
160 170 180 190 200
FLKSSCPPTS ELLGSPEHLF WDPMKVHDIR WNFEKFLVGP DGAPVMRWFH
210 220
QTPVRVVQSD IMEYLNQTRT Q
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3ZH29 | D3ZH29_RAT | Glutathione peroxidase | Gpx6 | 220 | Annotation score: | ||
A0A0G2JXN4 | A0A0G2JXN4_RAT | Glutathione peroxidase | Gpx6 | 204 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76733 mRNA Translation: AAA42094.1 |
PIRi | B40464 |
RefSeqi | NP_671694.1, NM_147165.1 |
Genome annotation databases
GeneIDi | 259233 |
KEGGi | rno:259233 |
UCSCi | RGD:628789, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76733 mRNA Translation: AAA42094.1 |
PIRi | B40464 |
RefSeqi | NP_671694.1, NM_147165.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000055070 |
Protein family/group databases
PeroxiBasei | 3736, RnoGPx06 |
Proteomic databases
PaxDbi | Q64625 |
PRIDEi | Q64625 |
Genome annotation databases
GeneIDi | 259233 |
KEGGi | rno:259233 |
UCSCi | RGD:628789, rat |
Organism-specific databases
CTDi | 257202 |
RGDi | 628789, Gpx6 |
Phylogenomic databases
eggNOGi | KOG1651, Eukaryota |
InParanoidi | Q64625 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q64625 |
Enzyme and pathway databases
Reactomei | R-RNO-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
PROi | PR:Q64625 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX6_RAT | |
Accessioni | Q64625Primary (citable) accession number: Q64625 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families