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Protein

Serine/threonine-protein phosphatase 6 catalytic subunit

Gene

Ppp6c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Manganese 1By similarity1
Metal bindingi55Manganese 1By similarity1
Metal bindingi81Manganese 1By similarity1
Metal bindingi81Manganese 2By similarity1
Metal bindingi113Manganese 2By similarity1
Active sitei114Proton donorBy similarity1
Metal bindingi163Manganese 2By similarity1
Metal bindingi237Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Immunity, Innate immunity
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 catalytic subunit (EC:3.1.3.16)
Short name:
PP6C
Alternative name(s):
Protein phosphatase V
Short name:
PP-V
Gene namesi
Name:Ppp6c
Synonyms:Ppv
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi708460 Ppp6c

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588791 – 305Serine/threonine-protein phosphatase 6 catalytic subunitAdd BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ64620
PRIDEiQ64620

PTM databases

PhosphoSitePlusiQ64620

Expressioni

Tissue specificityi

Highest levels found in spleen, brain and lung.1 Publication

Gene expression databases

BgeeiENSRNOG00000015145 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ64620 RN

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 and PPP6R3 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ64620, 2 interactors
STRINGi10116.ENSRNOP00000021176

Structurei

3D structure databases

ProteinModelPortaliQ64620
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0373 Eukaryota
ENOG410XNR9 LUCA
GeneTreeiENSGT00550000074961
HOGENOMiHOG000172696
HOVERGENiHBG000216
InParanoidiQ64620
KOiK15498
OMAiNIQPVRT
OrthoDBiEOG091G0B6S
PhylomeDBiQ64620
TreeFamiTF105563

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q64620-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLDLDKYV EIARQCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV
60 70 80 90 100
CGDIHGQFYD LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK
110 120 130 140 150
AKWPDRITLL RGNHESRQIT QVYGFYDECQ TKYGNANAWR YCTKVFDMLT
160 170 180 190 200
VAALIDEQIL CVHGGLSPDI KTLDQIRTIE RNQEIPHKGA FCDLVWSDPE
210 220 230 240 250
DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV HEGYKFMFDE
260 270 280 290 300
KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT

TPYFL
Length:305
Mass (Da):35,159
Last modified:January 15, 2008 - v2
Checksum:i662969DE1B2EF490
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72P → L in CAA54453 (PubMed:8077208).Curated1
Sequence conflicti87Y → H in CAA54453 (PubMed:8077208).Curated1
Sequence conflicti91E → V in CAA54453 (PubMed:8077208).Curated1
Sequence conflicti285F → N in CAA54453 (PubMed:8077208).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77236 mRNA Translation: CAA54453.1
BC078747 mRNA Translation: AAH78747.1
PIRiB55346
RefSeqiNP_598273.2, NM_133589.2
UniGeneiRn.9573

Genome annotation databases

EnsembliENSRNOT00000021176; ENSRNOP00000021176; ENSRNOG00000015145
GeneIDi171121
KEGGirno:171121
UCSCiRGD:708460 rat

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77236 mRNA Translation: CAA54453.1
BC078747 mRNA Translation: AAH78747.1
PIRiB55346
RefSeqiNP_598273.2, NM_133589.2
UniGeneiRn.9573

3D structure databases

ProteinModelPortaliQ64620
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64620, 2 interactors
STRINGi10116.ENSRNOP00000021176

PTM databases

PhosphoSitePlusiQ64620

Proteomic databases

PaxDbiQ64620
PRIDEiQ64620

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021176; ENSRNOP00000021176; ENSRNOG00000015145
GeneIDi171121
KEGGirno:171121
UCSCiRGD:708460 rat

Organism-specific databases

CTDi5537
RGDi708460 Ppp6c

Phylogenomic databases

eggNOGiKOG0373 Eukaryota
ENOG410XNR9 LUCA
GeneTreeiENSGT00550000074961
HOGENOMiHOG000172696
HOVERGENiHBG000216
InParanoidiQ64620
KOiK15498
OMAiNIQPVRT
OrthoDBiEOG091G0B6S
PhylomeDBiQ64620
TreeFamiTF105563

Enzyme and pathway databases

ReactomeiR-RNO-204005 COPII-mediated vesicle transport

Miscellaneous databases

PROiPR:Q64620

Gene expression databases

BgeeiENSRNOG00000015145 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ64620 RN

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPP6_RAT
AccessioniPrimary (citable) accession number: Q64620
Secondary accession number(s): Q6AZ47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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