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Protein

Taste receptor type 2 member 46

Gene

TAS2R46

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

  • bitter taste receptor activity Source: GO_Central
  • G protein-coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 46
Short name:
T2R46
Gene namesi
Name:TAS2R46
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1ExtracellularSequence analysis1
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini23 – 46CytoplasmicSequence analysisAdd BLAST24
Transmembranei47 – 67Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini68 – 86ExtracellularSequence analysisAdd BLAST19
Transmembranei87 – 107Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini108 – 126CytoplasmicSequence analysisAdd BLAST19
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 178ExtracellularSequence analysisAdd BLAST31
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 229CytoplasmicSequence analysisAdd BLAST30
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 258ExtracellularSequence analysis8
Transmembranei259 – 279Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini280 – 308CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000823191 – 308Taste receptor type 2 member 46Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000032127 Expressed in 5 organ(s), highest expression level in lung

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000040193

Structurei

3D structure databases

ProteinModelPortaliQ645T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9F7 Eukaryota
ENOG4111BEG LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ645T4
KOiK08474
OMAiFCQAIIF
OrthoDBiEOG091G0HMB
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q645T4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITFLSITFS ILVGVIFVIG NFANGFIALV NSIEWVKRQK ISFADQILTG
60 70 80 90 100
LAVSRVGLLW VLLLHLYATE FNLAFYSVEV RITAYNVWIV TNHFSNWLST
110 120 130 140 150
SLSMFYLLKI ATFSNLIFLH LKRKVKSVIL VTLLGPLLFL VCHLFVMNMN
160 170 180 190 200
HIVWRKEYEG NITWRIKLRS AMYLSNVTVT MLANLIPLTL TLMSFLLLIC
210 220 230 240 250
SLCKHLKKMQ VHGKGSQDPS TKVHIKALQT VTSFLLLCAI YFLSMILSVW
260 270 280 290 300
NFELEKKPVF MFCQAVIFSY PSTHPLILIW GNKKLKQIFL SVLWNVRYWV

KGQKPSSP
Length:308
Mass (Da):35,462
Last modified:October 25, 2004 - v1
Checksum:i985576F9F5142858
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1I7Q492A0A1I7Q492_MACMU
Taste receptor type 2
TAS2R46
312Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY725005 Genomic DNA Translation: AAU21185.1
RefSeqiNP_001074226.1, NM_001080757.2
XP_015006561.1, XM_015151075.1
XP_015006562.1, XM_015151076.1
XP_015006563.1, XM_015151077.1
UniGeneiMmu.16492

Genome annotation databases

EnsembliENSMMUT00000059015; ENSMMUP00000054721; ENSMMUG00000040119
GeneIDi694814
KEGGimcc:694814

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY725005 Genomic DNA Translation: AAU21185.1
RefSeqiNP_001074226.1, NM_001080757.2
XP_015006561.1, XM_015151075.1
XP_015006562.1, XM_015151076.1
XP_015006563.1, XM_015151077.1
UniGeneiMmu.16492

3D structure databases

ProteinModelPortaliQ645T4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000040193

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000059015; ENSMMUP00000054721; ENSMMUG00000040119
GeneIDi694814
KEGGimcc:694814

Organism-specific databases

CTDi259292

Phylogenomic databases

eggNOGiENOG410J9F7 Eukaryota
ENOG4111BEG LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG060698
InParanoidiQ645T4
KOiK08474
OMAiFCQAIIF
OrthoDBiEOG091G0HMB
TreeFamiTF335891

Gene expression databases

BgeeiENSMMUG00000032127 Expressed in 5 organ(s), highest expression level in lung

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT2R46_MACMU
AccessioniPrimary (citable) accession number: Q645T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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