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Protein

Alcohol dehydrogenase 4

Gene

Adh4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the reduction of benzoquinones.

Miscellaneous

Has much lower enzymatic activity towards alcohols and aldehydes compared to human class II ADH. Strongly inhibited by omega-hydroxy fatty acids.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi179Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 49NADBy similarity2
Nucleotide bindingi204 – 209NADBy similarity6
Nucleotide bindingi297 – 299NADBy similarity3
Nucleotide bindingi320 – 322NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: RGD
  • alcohol dehydrogenase activity, zinc-dependent Source: InterPro
  • ethanol binding Source: RGD
  • NAD binding Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • aging Source: RGD
  • ethanol oxidation Source: RGD
  • ovulation cycle Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 4 (EC:1.1.1.1)
Alternative name(s):
ADH2
Alcohol dehydrogenase class II
Short name:
Alcohol dehydrogenase II
Gene namesi
Name:Adh4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71028 Adh4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606831 – 377Alcohol dehydrogenase 4Add BLAST377

Proteomic databases

PaxDbiQ64563
PRIDEiQ64563

PTM databases

CarbonylDBiQ64563

Expressioni

Tissue specificityi

Liver specific.

Interactioni

Subunit structurei

Dimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016891

Structurei

3D structure databases

ProteinModelPortaliQ64563
SMRiQ64563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiQ64563

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR028632 Zinc_ADH_II
PANTHERiPTHR43880:SF14 PTHR43880:SF14, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q64563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTQGKVITC KAAIAWKTDS PLCIEEIEVS PPKAHEVRIK VIATCVCPTD
60 70 80 90 100
INATNPKKKA LFPVVLGHEC AGIVESVGPG VTNFKPGDKV IPFFAPQCKK
110 120 130 140 150
CKLCLSPLTN LCGKLRNFKY PTIDQELMED RTSRFTSKER SIYHFMGVSS
160 170 180 190 200
FSQYTVVSEA NLARVDDEAN LERVCLIGCG FTSGYGAAIN TAKVTPGSAC
210 220 230 240 250
AVFGLGCVGL SAVIGCKIAG ASRIIAIDIN SEKFPKAKAL GATDCLNPRD
260 270 280 290 300
LDKPVQDVIT ELTGGGVDFS LDCAGTAQTL KAAVDCTVVG WGSCTVVGAK
310 320 330 340 350
VDEMNISTVD MILGRSVKGT FFGGWKSVDS VPNLVTDYKN KKFDLDLLVT
360 370
HALPFDKIND AIDLMNQGKS IRTILTF
Length:377
Mass (Da):40,277
Last modified:January 23, 2007 - v3
Checksum:i9944E04A86868CBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90710 mRNA Translation: CAA62241.1
PIRiS66286
UniGeneiRn.98159

Similar proteinsi

Entry informationi

Entry nameiADH4_RAT
AccessioniPrimary (citable) accession number: Q64563
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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