UDP-glucuronosyltransferase 1-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• glucuronate acceptor

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  + UDP-α-D-glucuronate

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  = acceptor β-D-glucuronoside

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  + H⁺

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  + UDP

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  EC:2.4.1.17
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  Source: Rhea

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  glucuronate acceptor

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  zoom

  +

  UDP-α-D-glucuronate

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  zoom

  =

  acceptor β-D-glucuronoside

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  zoom

  +

  H⁺

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  +

  UDP

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• enzyme binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex."
    Ishii Y., Iwanaga M., Nishimura Y., Takeda S., Ikushiro S., Nagata K., Yamazoe Y., Mackenzie P.I., Yamada H.
    Drug Metab. Pharmacokinet. 22:367-376(2007) [PubMed] [Europe PMC] [Abstract]
• enzyme inhibitor activity Source: Ensembl
• glucuronosyltransferase activity Source: RGDInferred from direct assayⁱ
  • "In vitro induction of bilirubin conjugation in primary rat hepatocyte culture."
    Jemnitz K., Lengyel G., Vereczkey L.
    Biochem. Biophys. Res. Commun. 291:29-33(2002) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: Ensembl
• protein homodimerization activity Source: Ensembl
• retinoic acid binding Source: Ensembl
• steroid binding Source: Ensembl

GO - Biological processⁱ

• acute-phase response Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Regulation of uridine diphosphate glucuronosyltransferase during the acute-phase response."
    Strasser S.I., Mashford M.L., Desmond P.V.
    J. Gastroenterol. Hepatol. 13:88-94(1998) [PubMed] [Europe PMC] [Abstract]
• animal organ regeneration Source: RGDInferred from expression patternⁱ
  • "Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats."
    Tian H., Ou J., Strom S.C., Venkataramanan R.
    Pharm. Res. 22:2007-2015(2005) [PubMed] [Europe PMC] [Abstract]
• bilirubin conjugation Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "In vitro induction of bilirubin conjugation in primary rat hepatocyte culture."
    Jemnitz K., Lengyel G., Vereczkey L.
    Biochem. Biophys. Res. Commun. 291:29-33(2002) [PubMed] [Europe PMC] [Abstract]
• biphenyl catabolic process Source: RGDInferred from direct assayⁱ
  • "UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat."
    Daidoji T., Gozu K., Iwano H., Inoue H., Yokota H.
    Drug Metab. Dispos. 33:1466-1476(2005) [PubMed] [Europe PMC] [Abstract]
• cellular glucuronidation Source: RGDInferred from direct assayⁱ
  • "Glucuronidation of retinoids by rat recombinant UDP: glucuronosyltransferase 1.1 (bilirubin UGT)."
    Radominska A., Little J.M., Lehman P.A., Samokyszyn V., Rios G.R., King C.D., Green M.D., Tephly T.R.
    Drug Metab. Dispos. 25:889-892(1997) [PubMed] [Europe PMC] [Abstract]
• cellular response to estradiol stimulus Source: RGDInferred from expression patternⁱ
  • "Sex hormones differentially regulate isoforms of UDP-glucuronosyltransferase."
    Strasser S.I., Smid S.A., Mashford M.L., Desmond P.V.
    Pharm. Res. 14:1115-1121(1997) [PubMed] [Europe PMC] [Abstract]
• cellular response to ethanol Source: RGDInferred from expression patternⁱ
  • "The expression of uridine diphosphate glucuronosyltransferase mRNA regulated by alcohol."
    Li Y., Wang K., Yu T., Zhao B., Li J., Zhang S., Zhao X.
    Zhonghua Gan Zang Bing Za Zhi 9:172-174(2001) [PubMed] [Europe PMC] [Abstract]
• cellular response to glucocorticoid stimulus Source: RGDInferred from expression patternⁱ
  • "The effect of hormones on the expression of five isoforms of UDP-glucuronosyltransferase in primary cultures of rat hepatocytes."
    Li Y.Q., Prentice D.A., Howard M.L., Mashford M.L., Desmond P.V.
    Pharm. Res. 16:191-197(1999) [PubMed] [Europe PMC] [Abstract]
• cellular response to hormone stimulus Source: RGDInferred from expression patternⁱ
  • "The effect of hormones on the expression of five isoforms of UDP-glucuronosyltransferase in primary cultures of rat hepatocytes."
    Li Y.Q., Prentice D.A., Howard M.L., Mashford M.L., Desmond P.V.
    Pharm. Res. 16:191-197(1999) [PubMed] [Europe PMC] [Abstract]
• cellular response to xenobiotic stimulus Source: RGDInferred from expression patternⁱ
  • "Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex."
    Emi Y., Ikushiro S., Iyanagi T.
    J. Biol. Chem. 271:3952-3958(1996) [PubMed] [Europe PMC] [Abstract]
• flavone metabolic process Source: Ensembl
• flavonoid glucuronidation Source: RGDInferred from direct assayⁱ
  • "The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1."
    King C.D., Green M.D., Rios G.R., Coffman B.L., Owens I.S., Bishop W.P., Tephly T.R.
    Arch. Biochem. Biophys. 332:92-100(1996) [PubMed] [Europe PMC] [Abstract]
• liver development Source: RGDInferred from expression patternⁱ
  • "Evolution of the activity of UGT1A1 throughout the development and adult life in a rat."
    Bustamante N., Cantarino M.H., Arahuetes R.M., Cubero F.J., Ortiz A.
    Life Sci. 78:1688-1695(2006) [PubMed] [Europe PMC] [Abstract]
  • "Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver."
    Kishi M., Emi Y., Sakaguchi M., Ikushiro S., Iyanagi T.
    Biochem. Biophys. Res. Commun. 377:815-819(2008) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "In vitro induction of bilirubin conjugation in primary rat hepatocyte culture."
    Jemnitz K., Lengyel G., Vereczkey L.
    Biochem. Biophys. Res. Commun. 291:29-33(2002) [PubMed] [Europe PMC] [Abstract]
• response to ethanol Source: RGDInferred from expression patternⁱ
  • "Ethanol-dependent induction of bilirubin UDP-glucuronosyl-transferase in rat liver is mediated by Kupffer cells."
    Kardon T., Mile V., Banhegyi G., Csala M., Burchell B., Mandl J., Braun L.
    Life Sci. 70:1205-1212(2002) [PubMed] [Europe PMC] [Abstract]
• response to glucocorticoid Source: RGDInferred from expression patternⁱ
  • "In vitro induction of bilirubin conjugation in primary rat hepatocyte culture."
    Jemnitz K., Lengyel G., Vereczkey L.
    Biochem. Biophys. Res. Commun. 291:29-33(2002) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: RGDInferred from expression patternⁱ
  • "Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats."
    Alkharfy K.M., Poloyac S.M., Congiu M., Desmond P.V., Frye R.F.
    Drug Metab Lett 2:248-255(2008) [PubMed] [Europe PMC] [Abstract]
• response to nutrient Source: RGDInferred from expression patternⁱ
  • "Influence of vitamin A status on the regulation of uridine (5'-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine."
    Haberkorn V., Heydel J.M., Mounie J., Artur Y., Goudonnet H.
    Br. J. Nutr. 85:289-297(2001) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation."
    Vansell N.R., Klaassen C.D.
    Drug Metab. Dispos. 30:240-246(2002) [PubMed] [Europe PMC] [Abstract]
• response to organic substance Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide."
    D'Andrea V., Perez L.M., Sanchez Pozzi E.J.
    Life Sci. 77:683-692(2005) [PubMed] [Europe PMC] [Abstract]
• response to starvation Source: RGDInferred from expression patternⁱ
  • "Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats."
    Braun L., Coffey M.J., Puskas F., Kardon T., Nagy G., Conley A.A., Burchell B., Mandl J.
    Biochem. J. 336:587-592(1998) [PubMed] [Europe PMC] [Abstract]
• response to steroid hormone Source: RGDInferred from expression patternⁱ
  • "Follicle-stimulating hormone, testosterone, and hypoxia differentially regulate UDP-glucuronosyltransferase 1 isoforms expression in rat sertoli and peritubular myoid cells."
    Magnanti M., Giuliani L., Gandini O., Gazzaniga P., Santiemma V., Ciotti M., Saccani G., Frati L., Agliano A.M.
    J. Steroid Biochem. Mol. Biol. 74:149-155(2000) [PubMed] [Europe PMC] [Abstract]
• xenobiotic glucuronidation Source: RGDInferred from direct assayⁱ
  • "The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1."
    King C.D., Green M.D., Rios G.R., Coffman B.L., Owens I.S., Bishop W.P., Tephly T.R.
    Arch. Biochem. Biophys. 332:92-100(1996) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• enzyme binding Source: RGDInferred from direct assayⁱ
  • "Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex."
    Ishii Y., Iwanaga M., Nishimura Y., Takeda S., Ikushiro S., Nagata K., Yamazoe Y., Mackenzie P.I., Yamada H.
    Drug Metab. Pharmacokinet. 22:367-376(2007) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: Ensembl
• protein homodimerization activity Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSVVCRSSCS LLLLPCLLLC VLGPSASHAG KLLVIPIDGS HWLSMLGVIQ 
        60         70         80         90        100
QLQQKGHEVV VIAPEASIHI KEGSFYTMRK YPVPFQNENV TAAFVELGRS 
       110        120        130        140        150
VFDQDPFLLR VVKTYNKVKR DSSMLLSGCS HLLHNAEFMA SLEQSHFDAL 
       160        170        180        190        200
LTDPFLPCGS IVAQYLSLPA VYFLNALPCS LDLEATQCPA PLSYVPKSLS 
       210        220        230        240        250
SNTDRMNFLQ RVKNMIIALT ENFLCRVVYS PYGSLATEIL QKEVTVKDLL 
       260        270        280        290        300
SPASIWLMRN DFVKDYPRPI MPNMVFIGGI NCLQKKALSQ EFEAYVNASG 
       310        320        330        340        350
EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN 
       360        370        380        390        400
TILVKWLPQN DLLGHPKARA FITHSGSHGI YEGICNGVPM VMMPLFGDQM 
       410        420        430        440        450
DNAKRMETRG AGVTLNVLEM TADDLENALK TVINNKSYKE NIMRLSSLHK 
       460        470        480        490        500
DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA HDLTWYQYHS LDVIGFLLAI 
       510        520        530 
VLTVVFIVYK SCAYGCRKCF GGKGRVKKSH KSKTH                 

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families