UniProtKB - Q64548 (RTN1_RAT)
Reticulon-1
Rtn1
Functioni
GO - Biological processi
- neuron differentiation Source: RGD
Names & Taxonomyi
Protein namesi | Recommended name: Reticulon-1Alternative name(s): Neuroendocrine-specific protein S-rex |
Gene namesi | Name:Rtn1 Synonyms:Nsp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620986, Rtn1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum Source: RGD
- endoplasmic reticulum membrane Source: RGD
- smooth endoplasmic reticulum Source: MGI
Golgi apparatus
- Golgi membrane Source: RGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 604 – 624 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 706 – 726 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168161 | 1 – 777 | Reticulon-1Add BLAST | 777 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Modified residuei | 68 | PhosphoserineCombined sources | 1 | |
Modified residuei | 210 | PhosphoserineCombined sources | 1 | |
Modified residuei | 241 | PhosphoserineCombined sources | 1 | |
Modified residuei | 325 | PhosphoserineCombined sources | 1 | |
Modified residuei | 348 | PhosphoserineCombined sources | 1 | |
Modified residuei | 350 | PhosphoserineCombined sources | 1 | |
Modified residuei | 485 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q64548 |
PRIDEi | Q64548 |
PTM databases
iPTMneti | Q64548 |
PhosphoSitePlusi | Q64548 |
SwissPalmi | Q64548 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSRNOG00000004794, Expressed in frontal cortex and 21 other tissues |
ExpressionAtlasi | Q64548, baseline and differential |
Genevisiblei | Q64548, RN |
Interactioni
Subunit structurei
Interacts with NDRG1.
Interacts with TMEM33.
Interacts with UGCG; regulates the ceramide glucosyltransferase activity of UGCG.
By similarityProtein-protein interaction databases
BioGRIDi | 250529, 5 interactors |
CORUMi | Q64548 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 590 – 777 | ReticulonPROSITE-ProRule annotationAdd BLAST | 188 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 610 – 613 | Poly-Leu | 4 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000155077 |
HOGENOMi | CLU_048580_2_1_1 |
InParanoidi | Q64548 |
OrthoDBi | 244299at2759 |
PhylomeDBi | Q64548 |
TreeFami | TF105431 |
Family and domain databases
InterProi | View protein in InterPro IPR003388, Reticulon |
Pfami | View protein in Pfam PF02453, Reticulon, 1 hit |
PROSITEi | View protein in PROSITE PS50845, RETICULON, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPPDLQDE PLSPANPGSQ LFGGRGEGEE ATPKGARPAQ QDGEPAWGSG
60 70 80 90 100
AGAGVVSSRG LCSGPARSPP VAMETASTGV AAVPDALDHS SSPTLKDGEG
110 120 130 140 150
ACYTSLISDI CYPPREDSAY FTGILQKENG HITTSESPEE LGTPGPSLPE
160 170 180 190 200
VPGTEPHGLL SSDSGIEMTP AESTEVNKIL ADPLDQMKAE ACKYIDITRP
210 220 230 240 250
QEAKGQEEQS PGLEDKDLDF KDKDSEVSTK PEGVHAPNQP SPVEGKLIKD
260 270 280 290 300
NLFEESTFAP YIDELSDEQH RMSLVTAPVK ITLTEIGPPV MTATHETIPE
310 320 330 340 350
KQDLCLKPSP DTVPTVTVSE PEDDSPGSVT PPSSGTEPSA AESQGKGSVS
360 370 380 390 400
EDELIAAIKE AKGLSYETTE SPRPVGQAAD RPKVKARSGL PTIPSSLDQE
410 420 430 440 450
ASSAESGDSE IELVSEDPMA SEDALPSGYV SFGHVSGPPP SPASPSIQYS
460 470 480 490 500
ILREEREAEL DSELIIESCD ASSASEESPK REQDSPPMKP GVLDAIREET
510 520 530 540 550
SSRATEERAP SHQGPVEPDP ILSFTPVTLQ SRPEPSSGDG APVPEPPKSQ
560 570 580 590 600
QQKPEEEAVS SSQSPAATEI PGPLGSDLVP PLPFFNKQKA IDLLYWRDIK
610 620 630 640 650
QTGIVFGSFL LLLFSLTQFS VVSVVAYLAL AALSATISFR IYKSVLQAVQ
660 670 680 690 700
KTDEGHPFKA YLELEITLSQ EQIQKYTDCL QLYVNSTLKE LRRLFLVQDL
710 720 730 740 750
VDSLKFAVLM WLLTYVGALF NGLTLLLMAV VSMFTLPVVY VKHQAQVDQY
760 770
LGLVRTHINT VVAKIQAKIP GAKRHAE
The sequence of this isoform differs from the canonical sequence as follows:
1-569: Missing.
570-589: IPGPLGSDLVPPLPFFNKQK → MQATADSTKMDCVWSNWKSQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R608 | M0R608_RAT | Reticulon | Rtn1 | 587 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005647 | 1 – 569 | Missing in isoform RTN1-S. 1 PublicationAdd BLAST | 569 | |
Alternative sequenceiVSP_005648 | 570 – 589 | IPGPL…FNKQK → MQATADSTKMDCVWSNWKSQ in isoform RTN1-S. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17604 mRNA Translation: AAC53046.1 U17603 mRNA Translation: AAC53045.1 |
RefSeqi | NP_446317.1, NM_053865.1 [Q64548-1] XP_008762912.1, XM_008764690.2 [Q64548-2] |
Genome annotation databases
Ensembli | ENSRNOT00000006373; ENSRNOP00000006373; ENSRNOG00000004794 [Q64548-2] |
GeneIDi | 116644 |
KEGGi | rno:116644 |
UCSCi | RGD:620986, rat [Q64548-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17604 mRNA Translation: AAC53046.1 U17603 mRNA Translation: AAC53045.1 |
RefSeqi | NP_446317.1, NM_053865.1 [Q64548-1] XP_008762912.1, XM_008764690.2 [Q64548-2] |
3D structure databases
SMRi | Q64548 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 250529, 5 interactors |
CORUMi | Q64548 |
PTM databases
iPTMneti | Q64548 |
PhosphoSitePlusi | Q64548 |
SwissPalmi | Q64548 |
Proteomic databases
jPOSTi | Q64548 |
PRIDEi | Q64548 |
Genome annotation databases
Ensembli | ENSRNOT00000006373; ENSRNOP00000006373; ENSRNOG00000004794 [Q64548-2] |
GeneIDi | 116644 |
KEGGi | rno:116644 |
UCSCi | RGD:620986, rat [Q64548-1] |
Organism-specific databases
CTDi | 6252 |
RGDi | 620986, Rtn1 |
Phylogenomic databases
GeneTreei | ENSGT00940000155077 |
HOGENOMi | CLU_048580_2_1_1 |
InParanoidi | Q64548 |
OrthoDBi | 244299at2759 |
PhylomeDBi | Q64548 |
TreeFami | TF105431 |
Miscellaneous databases
PROi | PR:Q64548 |
Gene expression databases
Bgeei | ENSRNOG00000004794, Expressed in frontal cortex and 21 other tissues |
ExpressionAtlasi | Q64548, baseline and differential |
Genevisiblei | Q64548, RN |
Family and domain databases
InterProi | View protein in InterPro IPR003388, Reticulon |
Pfami | View protein in Pfam PF02453, Reticulon, 1 hit |
PROSITEi | View protein in PROSITE PS50845, RETICULON, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RTN1_RAT | |
Accessioni | Q64548Primary (citable) accession number: Q64548 Secondary accession number(s): Q64547 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |