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Entry version 164 (22 Apr 2020)
Sequence version 2 (15 Mar 2004)
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Protein

Tyrosine-protein phosphatase non-receptor type 13

Gene

Ptpn13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2345SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2375Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei2419SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1660499 Synthesis of PIPs at the plasma membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 13 (EC:3.1.3.48By similarity)
Alternative name(s):
PTP36
Protein tyrosine phosphatase DPZPTP
Protein tyrosine phosphatase PTP-BL
Protein-tyrosine phosphatase RIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ptpn13
Synonyms:Ptp14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:103293 Ptpn13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194361 – 2453Tyrosine-protein phosphatase non-receptor type 13Add BLAST2453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei240PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei883PhosphoserineCombined sources1
Modified residuei890PhosphoserineCombined sources1
Modified residuei901PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1
Modified residuei907PhosphoserineCombined sources1
Modified residuei1021PhosphoserineBy similarity1
Modified residuei1025PhosphoserineBy similarity1
Modified residuei1076PhosphoserineBy similarity1
Modified residuei1221PhosphoserineCombined sources1
Modified residuei1270PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q64512

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q64512

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q64512

PRoteomics IDEntifications database

More...
PRIDEi
Q64512

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q64512

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q64512

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in kidney and, to a lesser extent, in lung, heart, brain and testis.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the first PDZ domain) with PLEKHA1 and PLEKHA2.

Interacts (via the second PDZ domain) with TNFRSF6 (Fas receptor) (via C-terminus) (By similarity).

Interacts (via the second PDZ domain) with TRIP6 (via the third LIM domain and C-terminus) (PubMed:10826496).

Interacts (via the third PDZ domain) with NGFR (via C-terminal SVP motif) and PKN2 (via C-terminus) (By similarity).

Interacts (via the second or fourth PDZ domains) with PDLIM4 (via C-terminus only or via combined C-terminus and LIM domain, but not LIM domain only) (PubMed:9487134, PubMed:15663004).

Found in a complex with PDLIM4 and TRIP6 (PubMed:10826496).

Interacts with PDLIM4; this interaction results in dephosphorylation of SRC 'Tyr-419' by this protein leading to its inactivation (By similarity).

Interacts with BRD7 (PubMed:10526152).

Interacts with RAPGEF6.

Interacts with ARHGAP29.

Interacts with PIK3R2; dephosphorylates PIK3R2.

Interacts with FBXL2 (By similarity).

Interacts (via the FERM domain) with ENTR1 (PubMed:23108400).

Found in a complex with ENTR1, PTPN13 and GIT1 (PubMed:23108400).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
202479, 13 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q64512

Protein interaction database and analysis system

More...
IntActi
Q64512, 9 interactors

Molecular INTeraction database

More...
MINTi
Q64512

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000048119

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q64512 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12453
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q64512

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q64512

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 190KINDPROSITE-ProRule annotationAdd BLAST188
Domaini565 – 865FERMPROSITE-ProRule annotationAdd BLAST301
Domaini1084 – 1170PDZ 1PROSITE-ProRule annotationAdd BLAST87
Domaini1357 – 1442PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini1491 – 1579PDZ 3PROSITE-ProRule annotationAdd BLAST89
Domaini1764 – 1845PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini1857 – 1942PDZ 5PROSITE-ProRule annotationAdd BLAST86
Domaini2180 – 2434Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2375 – 2381Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili458 – 493Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 59Poly-Leu4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0792 Eukaryota
COG5599 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q64512

KEGG Orthology (KO)

More...
KOi
K02374

Database of Orthologous Groups

More...
OrthoDBi
411281at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q64512

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011019 KIND_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR012153 PTPN13
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 5 hits
PF00102 Y_phosphatase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000933 Tyr-Ptase_nr13, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935 BAND41
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00750 KIND, 1 hit
SM00228 PDZ, 5 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 5 hits
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit
PS51377 KIND, 1 hit
PS50106 PDZ, 5 hits
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q64512-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQEVFRRVS IADPAALGFI
60 70 80 90 100
ISPWSLLLLP SGSVSFTDEN VSNQDLRAST APEVLQSHSL TSLADVEKIH
110 120 130 140 150
IYSLGMTLYW GADHEVPQSQ PIKLGDHLNS ILLGMCEDVI YARVSVRTVL
160 170 180 190 200
DACSAHIRNS NCAPSFSNVK QLVKLVLGNI SGTDPLSRSS EQKPDRSQAI
210 220 230 240 250
RDRLRGKGLP TGRSSTSDAL DTHEAPLSQQ TFVNKGLSKS MGFLSIRDTR
260 270 280 290 300
DEEDYLKDTP SDNNSRHEDS ETFSSPYQFK TSTPQMDALS KKKTWASSMD
310 320 330 340 350
LLCAANRDIS GETGRYQRCD PKTVTGRTSI TPRKKEGRYS DGSIALDIFG
360 370 380 390 400
PQKVEPVIHT RELPTSTAVS SALDRIRERQ QKLQVLREAM NVEEPVRRYK
410 420 430 440 450
TYHSDIFSIS SESPSVISSE SDFRQVRKSE ASKRFESSSG LPGVDETGQT
460 470 480 490 500
RPSRQYETSL EGNLINQDIM LRRQEEEMMQ LQARMALRQS RLSLYPGDTV
510 520 530 540 550
KASMLDISRD PLREMALETA MTQRKLRNFF GPEFVKMTVE PFVSLDLPRS
560 570 580 590 600
ILSQTKKGKS EDQRRKVNIR LLSGQRLELT CDTKTICKDV FDMVVAHIGL
610 620 630 640 650
VEHHLFALAT RKENEYFFVD PDLKLTKVAP EGWKEEPKRK GKAAVDFTLF
660 670 680 690 700
FRIKFFMDDV SLIQHDLTCH QYYLQLRKDL LDERVHCDDE AALLLASLAL
710 720 730 740 750
QAEYGDYQPE VHGVSYFRLE HYLPARVMEK LDVSYIKEEL PKLHNTYAGA
760 770 780 790 800
SEKETELEFL KVCQRLTEYG VHFHRVHPEK KSQTGILLGV CSKGVLVFEV
810 820 830 840 850
HNGVRALVLR FPWRETKKIS FSKKKITLQN TSDGIKHAFQ TDSSKACQYL
860 870 880 890 900
LHLCSSQHKF QLQMRARQSN QDAQDIERAS FRSLNLQAES VRGFNMGRAI
910 920 930 940 950
STGSLASSTI NKLAVRPLSV QAEILKRLSS SEWSLYQPLQ NSSKEKTDKA
960 970 980 990 1000
SWEEKPRGMS KSYHDLSQAS LCPHRKQVIN MEALPQAFAE LVGKPLYPMA
1010 1020 1030 1040 1050
RSDTESLAGL PKLDNSKSVA SLNRSPERRN HESDSSTEDP GQAYVVGMSL
1060 1070 1080 1090 1100
PSSGKSSSQV PFKDNDTLHK RWSIVSSPER EITLVNLKKD PKHGLGFQII
1110 1120 1130 1140 1150
GGEKMGRLDL GVFISAVTPG GPADLDGCLK PGDRLISVNS VSLEGVSHHA
1160 1170 1180 1190 1200
AVDILQNAPE DVTLVISQPK EKPSKVPSTP VHFANGMKSY TKKPAYMQDS
1210 1220 1230 1240 1250
AMDPSEDQPW PRGTLRHIPE SPFGLSGGLR EGSLSSQDSR TESASLSQSQ
1260 1270 1280 1290 1300
VNGFFASHLG DRGWQEPQHS SPSPSVTTKV NEKTFSDSNR SKAKRRGISD
1310 1320 1330 1340 1350
LIEHLDCADS DKDDSTYTSS QDHQTSKQEP SSSLSTSNKT SFPTSSASPP
1360 1370 1380 1390 1400
KPGDTFEVEL AKTDGSLGIS VTGGVNTSVR HGGIYVKAII PKGAAESDGR
1410 1420 1430 1440 1450
IHKGDRVLAV NGVSLEGATH KQAVETLRNT GQVVHLLLEK GQVPTSRERD
1460 1470 1480 1490 1500
PAGPQSPPPD QDAQRQAPEK VAKQTPHVKD YSFVTEDNTF EVKLFKNSSG
1510 1520 1530 1540 1550
LGFSFSREDN LIPEQINGSI VRVKKLFPGQ PAAESGKIDV GDVILKVNGA
1560 1570 1580 1590 1600
PLKGLSQQDV ISALRGTAPE VSLLLCRPAP GVLPEIDTTF LNPLYSPANS
1610 1620 1630 1640 1650
FLNSSKETSQ PSSSVEQGAS SDDNGVSGKT KNHCRAPSRR ESYSDHSESG
1660 1670 1680 1690 1700
EDDSVRAPAK MPNVTRVAAF PHEAPRSQEE SICAMFYLPR KIPGKLESES
1710 1720 1730 1740 1750
SHPPPLDVSP GQTCQPPAEC APSDATGKHF THLASQLSKE ENITTLKNDL
1760 1770 1780 1790 1800
GNHLEDSELE VELLITLVKS EKGSLGFTVT KGSQSIGCYV HDVIQDPAKG
1810 1820 1830 1840 1850
DGRLKAGDRL IKVNDTDVTN MTHTDAVNLL RAAPKTVRLV LGRILELPRM
1860 1870 1880 1890 1900
PVFPHLLPDI TVTCHGEELG FSLSGGQGSP HGVVYISDIN PRSAAAVDGS
1910 1920 1930 1940 1950
LQLLDIIHYV NGVSTQGMTL EDANRALDLS LPSVVLKVTR DGCPVVPTTR
1960 1970 1980 1990 2000
AAISAPRFTK ANGLTSMEPS GQPALMPKNS FSKVNGEGVH EAVCPAGEGS
2010 2020 2030 2040 2050
SSQMKESAGL TETKESNSRD DDIYDDPQEA EVIQSLLDVV DEEAQNLLNQ
2060 2070 2080 2090 2100
RHATRRACSP DPLRTNGEAP EEGDTDYDGS PLPEDVPESV SSGEGKVDLA
2110 2120 2130 2140 2150
SLTAASQEEK PIEEDATQES RNSTTETTDG EDSSKDPPFL TNEELAALPV
2160 2170 2180 2190 2200
VRVPPSGKYT GTQLQATIRT LQGLLDQGIP SKELENLQEL KPLDQCLIGQ
2210 2220 2230 2240 2250
TKENRRKNRY KNILPYDTTR VPLGDEGGYI NASFIRIPVG TQEFVYIACQ
2260 2270 2280 2290 2300
GPLPTTVGDF WQMVWEQNST VIAMMTQEVE GEKIKCQRYW PSILGTTTMA
2310 2320 2330 2340 2350
NERLRLALLR MQQLKGFIVR VMALEDIQTG EVRHISHLNF TAWPDHDTPS
2360 2370 2380 2390 2400
QPDDLLTFIS YMRHIRRSGP VITHCSAGIG RSGTLICIDV VLGLISQDLE
2410 2420 2430 2440 2450
FDISDLVRCM RLQRHGMVQT EGQYVFCYQV ILYVLTHLQA EEQKAQQPGL

PQP
Length:2,453
Mass (Da):270,334
Last modified:March 15, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53396F27AE2582F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8B1G5E8B1_MOUSE
Tyrosine-protein phosphatase non-re...
Ptpn13
2,451Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGH9A0A0G2JGH9_MOUSE
Tyrosine-protein phosphatase non-re...
Ptpn13
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79 – 81STA → FTG in BAA12158 (PubMed:7843407).Curated3
Sequence conflicti156 – 168HIRNS…PSFSN → TSGTASRAFVSY (PubMed:7843407).CuratedAdd BLAST13
Sequence conflicti233V → L in BAA12158 (PubMed:7843407).Curated1
Sequence conflicti306N → I in BAA12158 (PubMed:7843407).Curated1
Sequence conflicti322K → E in BAA12158 (PubMed:7843407).Curated1
Sequence conflicti381Q → K in BAA12158 (PubMed:7843407).Curated1
Sequence conflicti822S → L in BAA12158 (PubMed:7843407).Curated1
Sequence conflicti1233S → T in BAA05885 (PubMed:8074693).Curated1
Sequence conflicti1449R → Q in BAA12158 (PubMed:7843407).Curated1
Sequence conflicti1474 – 1489QTPHV…TEDNT → KHPMSKTTALLLKII in CAA83650 (PubMed:8749712).CuratedAdd BLAST16
Sequence conflicti1622D → H in BAA12158 (PubMed:7843407).Curated1
Sequence conflicti1872S → P in CAA83650 (PubMed:8749712).Curated1
Sequence conflicti1979N → I in BAA05885 (PubMed:8074693).Curated1
Sequence conflicti2078D → N in BAA12158 (PubMed:7843407).Curated1
Sequence conflicti2233S → T in BAA12158 (PubMed:7843407).Curated1
Sequence conflicti2448 – 2452PGLPQ → GSHSDAEQPPKAPP in CAA83650 (PubMed:8749712).Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z32740 mRNA Translation: CAA83650.1
D83966 mRNA Translation: BAA12158.1
D28529 mRNA Translation: BAA05885.1
Z23059 mRNA Translation: CAA80594.1

Protein sequence database of the Protein Information Resource

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PIRi
S40290
S71625

NCBI Reference Sequences

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RefSeqi
NP_035334.2, NM_011204.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
19249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19249

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32740 mRNA Translation: CAA83650.1
D83966 mRNA Translation: BAA12158.1
D28529 mRNA Translation: BAA05885.1
Z23059 mRNA Translation: CAA80594.1
PIRiS40290
S71625
RefSeqiNP_035334.2, NM_011204.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GM1NMR-A1351-1444[»]
1OZINMR-A1351-1444[»]
1VJ6NMR-A1351-1444[»]
6GBDNMR-A1475-1588[»]
6GBENMR-A1475-1588[»]
SMRiQ64512
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi202479, 13 interactors
ELMiQ64512
IntActiQ64512, 9 interactors
MINTiQ64512
STRINGi10090.ENSMUSP00000048119

PTM databases

iPTMnetiQ64512
PhosphoSitePlusiQ64512

Proteomic databases

jPOSTiQ64512
MaxQBiQ64512
PaxDbiQ64512
PRIDEiQ64512

Genome annotation databases

GeneIDi19249
KEGGimmu:19249

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5783
MGIiMGI:103293 Ptpn13

Phylogenomic databases

eggNOGiKOG0792 Eukaryota
COG5599 LUCA
InParanoidiQ64512
KOiK02374
OrthoDBi411281at2759
PhylomeDBiQ64512

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ptpn13 mouse
EvolutionaryTraceiQ64512

Protein Ontology

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PROi
PR:Q64512
RNActiQ64512 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011019 KIND_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR012153 PTPN13
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 5 hits
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000933 Tyr-Ptase_nr13, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00750 KIND, 1 hit
SM00228 PDZ, 5 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 5 hits
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS51377 KIND, 1 hit
PS50106 PDZ, 5 hits
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTN13_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q64512
Secondary accession number(s): Q61494, Q62135, Q64499
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: April 22, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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