We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q64511 (TOP2B_MOUSE)
Protein
DNA topoisomerase 2-beta
Gene
Top2b
Organism
Mus musculus (Mouse)
Status
Functioni
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
By similarityMiscellaneous
Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
Catalytic activityi
- ATP-dependent breakage, passage and rejoining of double-stranded DNA.PROSITE-ProRule annotationBy similarity EC:5.6.2.2
Cofactori
Mg2+PROSITE-ProRule annotationBy similarity, Mn2+PROSITE-ProRule annotationBy similarity, Ca2+PROSITE-ProRule annotationBy similarityNote: Binds two Mg2+ per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn2+ or Ca2+.PROSITE-ProRule annotationBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 100 | ATPBy similarity | 1 | |
Binding sitei | 129 | ATPBy similarity | 1 | |
Metal bindingi | 470 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 550 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 550 | Magnesium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 552 | Magnesium 2PROSITE-ProRule annotation | 1 | |
Sitei | 813 | Transition state stabilizerBy similarity | 1 | |
Active sitei | 814 | O-(5'-phospho-DNA)-tyrosine intermediateBy similarity | 1 | |
Sitei | 865 | Important for DNA bending; intercalates between base pairs of target DNABy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 157 – 159 | ATPBy similarity | 3 | |
Nucleotide bindingi | 170 – 177 | ATPBy similarity | 8 | |
Nucleotide bindingi | 385 – 387 | ATPBy similarity | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- chromatin binding Source: MGI
- DNA binding Source: UniProtKB-KW
- DNA topoisomerase activity Source: UniProtKB
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Source: UniProtKB
- enzyme binding Source: MGI
- histone deacetylase binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- protein C-terminus binding Source: MGI
- protein heterodimerization activity Source: MGI
- protein kinase C binding Source: MGI
GO - Biological processi
- axonogenesis Source: MGI
- DNA topological change Source: UniProtKB
- forebrain development Source: MGI
- neuron migration Source: MGI
- positive regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: MGI
- resolution of meiotic recombination intermediates Source: GO_Central
- sister chromatid segregation Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Isomerase, Topoisomerase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-4615885, SUMOylation of DNA replication proteins |
Names & Taxonomyi
Protein namesi | Recommended name: DNA topoisomerase 2-beta (EC:5.6.2.2PROSITE-ProRule annotationBy similarity)Alternative name(s): DNA topoisomerase II, beta isozyme |
Gene namesi | Name:Top2b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98791, Top2b |
VEuPathDBi | HostDB:ENSMUSG00000017485 |
Subcellular locationi
Nucleus
- nucleolus By similarity
- nucleoplasm By similarity
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nucleolus Source: UniProtKB
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000145370 | 2 – 1612 | DNA topoisomerase 2-betaAdd BLAST | 1611 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 3 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 21 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 22 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 165 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 166 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 216 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 287 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 355 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 361 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 425 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 427 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 434 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 588 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 593 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 623 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 631 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 634 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 664 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 700 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1080 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1202 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1205 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1214 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1215 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1224 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1238 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1250 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1259 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1280 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 1311 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1315 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1324 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1328 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1330 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1332 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1346 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1358 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 1363 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1376 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1385 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1387 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1390 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1400 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1408 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 1411 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1427 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1428 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1439 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1441 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1443 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1448 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1453 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1460 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1477 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1509 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1511 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1513 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1537 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1539 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1562 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1563 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1568 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1596 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1600 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q64511 |
jPOSTi | Q64511 |
MaxQBi | Q64511 |
PaxDbi | Q64511 |
PeptideAtlasi | Q64511 |
PRIDEi | Q64511 |
ProteomicsDBi | 259155 |
PTM databases
iPTMneti | Q64511 |
PhosphoSitePlusi | Q64511 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000017485, Expressed in brain and 317 other tissues |
ExpressionAtlasi | Q64511, baseline and differential |
Genevisiblei | Q64511, MM |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with KIAA1210 (PubMed:28203736).
Interacts with PLSCR1 (By similarity).
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 498 | Interaction with DNAPROSITE-ProRule annotation | 1 | |
Sitei | 501 | Interaction with DNAPROSITE-ProRule annotation | 1 | |
Sitei | 670 | Interaction with DNAPROSITE-ProRule annotation | 1 | |
Sitei | 671 | Interaction with DNAPROSITE-ProRule annotation | 1 | |
Sitei | 732 | Interaction with DNAPROSITE-ProRule annotation | 1 | |
Sitei | 766 | Interaction with DNAPROSITE-ProRule annotation | 1 | |
Sitei | 940 | Interaction with DNAPROSITE-ProRule annotation | 1 |
Binary interactionsi
Q64511
With | #Exp. | IntAct |
---|---|---|
Aicda [Q9WVE0] | 3 | EBI-2325586,EBI-3835567 |
GO - Molecular functioni
- enzyme binding Source: MGI
- histone deacetylase binding Source: MGI
- protein C-terminus binding Source: MGI
- protein heterodimerization activity Source: MGI
- protein kinase C binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204277, 16 interactors |
IntActi | Q64511, 7 interactors |
MINTi | Q64511 |
STRINGi | 10090.ENSMUSP00000017629 |
Miscellaneous databases
RNActi | Q64511, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 464 – 581 | ToprimPROSITE-ProRule annotationAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 351 – 353 | Interaction with DNABy similarity | 3 | |
Regioni | 999 – 1008 | Interaction with DNABy similarity | 10 | |
Regioni | 1098 – 1128 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1245 – 1586 | DisorderedSequence analysisAdd BLAST | 342 | |
Regioni | 1493 – 1499 | Interaction with PLSCR1By similarity | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1098 – 1117 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1245 – 1261 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1288 – 1302 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1318 – 1362 | Basic and acidic residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 1376 – 1390 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1428 – 1444 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1488 – 1508 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the type II topoisomerase family.Curated
Phylogenomic databases
eggNOGi | KOG0355, Eukaryota |
GeneTreei | ENSGT00940000157921 |
HOGENOMi | CLU_001935_1_0_1 |
InParanoidi | Q64511 |
OMAi | TWTQDFK |
OrthoDBi | 117851at2759 |
PhylomeDBi | Q64511 |
TreeFami | TF105282 |
Family and domain databases
CDDi | cd00187, TOP4c, 1 hit cd03365, TOPRIM_TopoIIA, 1 hit |
Gene3Di | 1.10.268.10, 1 hit 3.30.230.10, 1 hit 3.30.565.10, 1 hit 3.40.50.670, 1 hit 3.90.199.10, 1 hit |
InterProi | View protein in InterPro IPR012542, DTHCT IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR028467, Top2b IPR001241, Topo_IIA IPR013760, Topo_IIA-like_dom_sf IPR013758, Topo_IIA_A/C_ab IPR013757, Topo_IIA_A_a_sf IPR013759, Topo_IIA_B_C IPR013506, Topo_IIA_bsu_dom2 IPR002205, Topo_IIA_dom_A IPR018522, TopoIIA_CS IPR031660, TOPRIM_C IPR006171, TOPRIM_domain IPR034157, TOPRIM_TopoII |
PANTHERi | PTHR10169:SF36, PTHR10169:SF36, 1 hit |
Pfami | View protein in Pfam PF00204, DNA_gyraseB, 1 hit PF00521, DNA_topoisoIV, 1 hit PF08070, DTHCT, 1 hit PF02518, HATPase_c, 1 hit PF01751, Toprim, 1 hit PF16898, TOPRIM_C, 1 hit |
SMARTi | View protein in SMART SM00433, TOP2c, 1 hit SM00434, TOP4c, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit SSF56719, SSF56719, 1 hit |
PROSITEi | View protein in PROSITE PS00177, TOPOISOMERASE_II, 1 hit PS50880, TOPRIM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q64511-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKSSLAGSD GALTWVNNAT KKEELETANK NDSTKKLSVE RVYQKKTQLE
60 70 80 90 100
HILLRPDTYI GSVEPLTQLM WVYDEDVGMN CREVTFVPGL YKIFDEILVN
110 120 130 140 150
AADNKQRDKN MTCIKVSIDP ESNIISIWNN GKGIPVVEHK VEKVYVPALI
160 170 180 190 200
FGQLLTSSNY DDDEKKVTGG RNGYGAKLCN IFSTKFTVET ACKEYKHSFK
210 220 230 240 250
QTWMNNMMKT SEAKIKHFDG EDYTCITFQP DLSKFKMEKL DKDIVALMTR
260 270 280 290 300
RAYDLAGSCK GVKVMFNGKK LPVNGFRSYV DLYVKDKLDE TGVALKVIHE
310 320 330 340 350
LANERWDVCL TLSEKGFQQI SFVNSIATTK GGRHVDYVVD QVVSKLIEVV
360 370 380 390 400
KKKNKAGVSV KPFQVKNHIW VFINCLIENP TFDSQTKENM TLQPKSFGSK
410 420 430 440 450
CQLSEKFFKA ASNCGIVESI LNWVKFKAQT QLNKKCSSVK YSKIKGIPKL
460 470 480 490 500
DDANDAGGKH SLECTLILTE GDSAKSLAVS GLGVIGRDRY GVFPLRGKIL
510 520 530 540 550
NVREASHKQI MENAEINNII KIVGLQYKKS YDDAESLKTL RYGKIMIMTD
560 570 580 590 600
QDQDGSHIKG LLINFIHHNW PSLLKHGFLE EFITPIVKAS KNKQELSFYS
610 620 630 640 650
IPEFDEWKKH IENQKAWKIK YYKGLGTSTA KEAKEYFADM ERHRILFRYA
660 670 680 690 700
GPEDDAAITL AFSKKKIDDR KEWLTNFMED RRQRRLHGLP EQFLYGTATK
710 720 730 740 750
HLTYNDFINK ELILFSNSDN ERSIPSLVDG FKPGQRKVLF TCFKRNDKRE
760 770 780 790 800
VKVAQLAGSV AEMSAYHHGE QALMMTIVNL AQNFVGSNNI NLLQPIGQFG
810 820 830 840 850
TRLHGGKDAA SPRYIFTMLS SLARLLFPAV DDNLLKFLYD DNQRVEPEWY
860 870 880 890 900
IPIIPMVLIN GAEGIGTGWA CKLPNYDARE IVNNVRRMLE GLDPHPMLPN
910 920 930 940 950
YKNFKGTIQE LGQNQYAVSG EIFVVDRNTV EITELPVRTW TQVYKEQVLE
960 970 980 990 1000
PMLNGTDKTP ALISDYKEYH TDTTVKFVVK MTEEKLAQAE AAGLHKVFKL
1010 1020 1030 1040 1050
QTTLTCNSMV LFDHMGCLKK YETVQDILKE FFDLRLSYYG LRKEWLVGML
1060 1070 1080 1090 1100
GAESTKLNNQ ARFILEKIQG KITIENRSKK DLIQMLVQRG YESDPVKAWK
1110 1120 1130 1140 1150
EAQEKAAEEE DSQNQHDDSS SDSGTPSGPD FNYILNMSLW SLTKEKVEEL
1160 1170 1180 1190 1200
IKQRDTKGRE VNDLKRKSPS DLWKEDLAAF VEELDKVEAQ EREDILAGMS
1210 1220 1230 1240 1250
GKAIKGKVGK PKVKKLQLEE TMPSPYGRRI VPEITAMKAD ASRKLLKKKK
1260 1270 1280 1290 1300
GDPDTTVVKV EFDEEFSGTP AEGTGEETLT PSAPVNKGPK PKREKKEPGT
1310 1320 1330 1340 1350
RVRKTPTSTG KTNAKKVKKR NPWSDDESKS ESDLEEAEPV VIPRDSLLRR
1360 1370 1380 1390 1400
AAAERPKYTF DFSEEEDDDA AAADDSNDLE ELKVKASPIT NDGEDEFVPS
1410 1420 1430 1440 1450
DGLDKDEYAF SSGKSKATPE KSSNDKKSQD FGNLFSFPSY SQKSEDDSAK
1460 1470 1480 1490 1500
FDSNEEDTAS VFAPSFGLKQ TDKLPSKTVA AKKGKPPSDT APKAKRAPKQ
1510 1520 1530 1540 1550
KKIVETINSD SDSEFGIPKK TTTPKGKGRG AKKRKASGSE NEGDYNPGRK
1560 1570 1580 1590 1600
PSKTASKKPK KTSFDQDSDV DIFPSDFTSE PPALPRTGRA RKEVKYFAES
1610
DEEEDVDFAM FN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6XX57 | F6XX57_MOUSE | DNA topoisomerase 2-beta | Top2b | 348 | Annotation score: | ||
F6U5K2 | F6U5K2_MOUSE | DNA topoisomerase 2-beta | Top2b | 230 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | V → A in BAA07236 (Ref. 1) Curated | 1 | |
Sequence conflicti | 1434 | L → P in BAA07236 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38046 mRNA Translation: BAA07236.1 BC041106 mRNA Translation: AAH41106.1 BC054541 mRNA Translation: AAH54541.1 |
CCDSi | CCDS26833.1 |
RefSeqi | NP_033435.2, NM_009409.2 |
Genome annotation databases
Ensembli | ENSMUST00000017629; ENSMUSP00000017629; ENSMUSG00000017485 |
GeneIDi | 21974 |
KEGGi | mmu:21974 |
UCSCi | uc007shc.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38046 mRNA Translation: BAA07236.1 BC041106 mRNA Translation: AAH41106.1 BC054541 mRNA Translation: AAH54541.1 |
CCDSi | CCDS26833.1 |
RefSeqi | NP_033435.2, NM_009409.2 |
3D structure databases
SMRi | Q64511 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204277, 16 interactors |
IntActi | Q64511, 7 interactors |
MINTi | Q64511 |
STRINGi | 10090.ENSMUSP00000017629 |
Chemistry databases
ChEMBLi | CHEMBL5564 |
PTM databases
iPTMneti | Q64511 |
PhosphoSitePlusi | Q64511 |
Proteomic databases
EPDi | Q64511 |
jPOSTi | Q64511 |
MaxQBi | Q64511 |
PaxDbi | Q64511 |
PeptideAtlasi | Q64511 |
PRIDEi | Q64511 |
ProteomicsDBi | 259155 |
Protocols and materials databases
Antibodypediai | 3893, 294 antibodies from 36 providers |
DNASUi | 21974 |
Genome annotation databases
Ensembli | ENSMUST00000017629; ENSMUSP00000017629; ENSMUSG00000017485 |
GeneIDi | 21974 |
KEGGi | mmu:21974 |
UCSCi | uc007shc.1, mouse |
Organism-specific databases
CTDi | 7155 |
MGIi | MGI:98791, Top2b |
VEuPathDBi | HostDB:ENSMUSG00000017485 |
Phylogenomic databases
eggNOGi | KOG0355, Eukaryota |
GeneTreei | ENSGT00940000157921 |
HOGENOMi | CLU_001935_1_0_1 |
InParanoidi | Q64511 |
OMAi | TWTQDFK |
OrthoDBi | 117851at2759 |
PhylomeDBi | Q64511 |
TreeFami | TF105282 |
Enzyme and pathway databases
Reactomei | R-MMU-4615885, SUMOylation of DNA replication proteins |
Miscellaneous databases
BioGRID-ORCSi | 21974, 3 hits in 65 CRISPR screens |
ChiTaRSi | Top2b, mouse |
PROi | PR:Q64511 |
RNActi | Q64511, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000017485, Expressed in brain and 317 other tissues |
ExpressionAtlasi | Q64511, baseline and differential |
Genevisiblei | Q64511, MM |
Family and domain databases
CDDi | cd00187, TOP4c, 1 hit cd03365, TOPRIM_TopoIIA, 1 hit |
Gene3Di | 1.10.268.10, 1 hit 3.30.230.10, 1 hit 3.30.565.10, 1 hit 3.40.50.670, 1 hit 3.90.199.10, 1 hit |
InterProi | View protein in InterPro IPR012542, DTHCT IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR028467, Top2b IPR001241, Topo_IIA IPR013760, Topo_IIA-like_dom_sf IPR013758, Topo_IIA_A/C_ab IPR013757, Topo_IIA_A_a_sf IPR013759, Topo_IIA_B_C IPR013506, Topo_IIA_bsu_dom2 IPR002205, Topo_IIA_dom_A IPR018522, TopoIIA_CS IPR031660, TOPRIM_C IPR006171, TOPRIM_domain IPR034157, TOPRIM_TopoII |
PANTHERi | PTHR10169:SF36, PTHR10169:SF36, 1 hit |
Pfami | View protein in Pfam PF00204, DNA_gyraseB, 1 hit PF00521, DNA_topoisoIV, 1 hit PF08070, DTHCT, 1 hit PF02518, HATPase_c, 1 hit PF01751, Toprim, 1 hit PF16898, TOPRIM_C, 1 hit |
SMARTi | View protein in SMART SM00433, TOP2c, 1 hit SM00434, TOP4c, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit SSF56719, SSF56719, 1 hit |
PROSITEi | View protein in PROSITE PS00177, TOPOISOMERASE_II, 1 hit PS50880, TOPRIM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TOP2B_MOUSE | |
Accessioni | Q64511Primary (citable) accession number: Q64511 Secondary accession number(s): Q7TQG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | September 27, 2005 | |
Last modified: | February 23, 2022 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families