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Protein

Receptor-type tyrosine-protein phosphatase delta

Gene

Ptprd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically (PubMed:25908590). Involved in pre-synaptic differentiation through interaction with SLITRK2 (PubMed:25989451).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei266Required for interaction with IL1RAP1 Publication1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1521SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1553Phosphocysteine intermediateBy similarity1
Binding sitei1597SubstrateBy similarity1
Active sitei1844Phosphocysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-388844 Receptor-type tyrosine-protein phosphatases
R-MMU-8849932 Synaptic adhesion-like molecules

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase delta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase delta
Short name:
R-PTP-delta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ptprd
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97812 Ptprd

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1266ExtracellularSequence analysisAdd BLAST1246
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1267 – 1287HelicalSequence analysisAdd BLAST21
Topological domaini1288 – 1912CytoplasmicSequence analysisAdd BLAST625

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi68R → A: Reduces affinity with IL1RAPL1. Reduces the synaptogenic activity to ~7%. 1 Publication1
Mutagenesisi189R → A: Decreases affinity for interaction with IL1RAPL1. 1 Publication1
Mutagenesisi229R → E: Abolishes interaction with SLITRK2. 1 Publication1
Mutagenesisi266Y → A: No effect on interaction with SLITRK2. Decreases the affinity for IL1RAPL1. Abolishes interaction with IL1RAP. 2 Publications1
Mutagenesisi279E → A: Decreases affinity for IL1RAP. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002543821 – 1912Receptor-type tyrosine-protein phosphatase deltaAdd BLAST1892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 98PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi147 ↔ 207PROSITE-ProRule annotationCombined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysisCombined sources2 Publications1
Disulfide bondi257 ↔ 302PROSITE-ProRule annotationCombined sources2 Publications
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysisCombined sources2 Publications1
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi832N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1181 – 1182CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q64487

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q64487

PeptideAtlas

More...
PeptideAtlasi
Q64487

PRoteomics IDEntifications database

More...
PRIDEi
Q64487

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q64487

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q64487

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, kidney, heart, and some B-cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028399 Expressed in 321 organ(s), highest expression level in ear

CleanEx database of gene expression profiles

More...
CleanExi
MM_PTPRD

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q64487 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q64487 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity). Interacts (via extracellular domain) with SLITRK4 (via LRR 1 and 2 repeats) (PubMed:25989451). Interacts with SLITRK2; induces presynaptic differentiation (PubMed:25989451). Interacts (via the second immunoglobilin domain) with IL1RAPL1 (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons and synapse formation. Isoform G, isoform H, isoform I, isoform J, and isoform K do not interact with IL1RAPL1 (PubMed:25908590, PubMed:21940441). Interacts (via the third immunoglobilin domain) with IL1RAP (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (PubMed:25908590).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Il1rapl1P598236EBI-771834,EBI-5452114

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
202495, 1 interactor

Protein interaction database and analysis system

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IntActi
Q64487, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000133468

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11912
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q64487

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q64487

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 114Ig-like C2-type 1Add BLAST91
Domaini126 – 224Ig-like C2-type 2Add BLAST99
Domaini236 – 318Ig-like C2-type 3Add BLAST83
Domaini325 – 415Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini420 – 516Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini518 – 607Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini612 – 709Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini714 – 822Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST109
Domaini823 – 916Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini921 – 1016Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini1020 – 1106Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST87
Domaini1357 – 1612Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1644 – 1903Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni181 – 189Mini-exon peptide A9; sufficient for interaction with IL1RAPL12 Publications9
Regioni227 – 230Mini-exon peptide B; required for interaction with SLITRK2 and in the function in pre-synaptic differentiation; Acts as an adjustable linker to control relative positions and orientations of the PTPRD second and third immunoglobilin domains for their simultaneous interactions with the first immunoglobilin domain of IL1RAPL1 and IL1RAP; Modulates affinity for IL1RAPL1 and IL1RAP2 Publications4
Regioni1553 – 1559Substrate bindingBy similarity7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000153617

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000010250

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053758

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q64487

KEGG Orthology (KO)

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KOi
K06777

Identification of Orthologs from Complete Genome Data

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OMAi
EVWWEPV

Database of Orthologous Groups

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OrthoDBi
EOG091G11WG

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 11 hits
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits
SSF52799 SSF52799, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 12 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform D (identifier: Q64487-4) [UniParc]FASTAAdd to basket
Also known as: delta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPVARPLSL LLTFFLCACA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG
260 270 280 290 300
GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY
310 320 330 340 350
TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP
360 370 380 390 400
VSYYIIQHKP KNSEEPYKEI DGIATTRYSV AGLSPYSDYE FRVVAVNNIG
410 420 430 440 450
RGPASEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG
460 470 480 490 500
YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD
510 520 530 540 550
GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIASYELV
560 570 580 590 600
YRDGDQGEEQ RITIEPGTSY RLQGLKPNSL YYFRLSARSP QGLGASTAEI
610 620 630 640 650
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSLKYA
660 670 680 690 700
AVDGEDFKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL
710 720 730 740 750
SVLIRTDEDV PSGPPRKVEV EAVNATAVKV SWRSPVPNKQ HGQIRGYQVH
760 770 780 790 800
YVKMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV
810 820 830 840 850
TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF
860 870 880 890 900
GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK
910 920 930 940 950
VGFGEEMVKE ISVPEEIPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGV
960 970 980 990 1000
ITKYTLLYRD INVPLLPMEH LIVPADTSMT LTGLKSDTTY DVKVRAHTSK
1010 1020 1030 1040 1050
GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF
1060 1070 1080 1090 1100
KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT
1110 1120 1130 1140 1150
AKTAPDVLRT KPAFIGKTNL DGMITVQLPD VPANENIKGY YIIIVPLKKS
1160 1170 1180 1190 1200
RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP
1210 1220 1230 1240 1250
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMDHAESKM YATSPYSDPV
1260 1270 1280 1290 1300
VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESESR
1310 1320 1330 1340 1350
KSSLPNSKEV PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK
1360 1370 1380 1390 1400
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
1410 1420 1430 1440 1450
AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT
1460 1470 1480 1490 1500
VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL
1510 1520 1530 1540 1550
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV
1560 1570 1580 1590 1600
VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED
1610 1620 1630 1640 1650
QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR
1660 1670 1680 1690 1700
LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI
1710 1720 1730 1740 1750
NASFLDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG
1760 1770 1780 1790 1800
REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
1810 1820 1830 1840 1850
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR
1860 1870 1880 1890 1900
TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFCYRAA
1910
LEYLGSFDHY AT
Length:1,912
Mass (Da):214,410
Last modified:May 16, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDEF494AA5A2CE814
GO
Isoform C (identifier: Q64487-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.
     775-783: Missing.

Show »
Length:1,893
Mass (Da):212,139
Checksum:i75E8EA527026E69B
GO
Isoform A (identifier: Q64487-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCLTSCFILASHMLSCDLVFVP
     2-230: Missing.
     608-1018: Missing.
     1019-1019: V → M

Show »
Length:1,293
Mass (Da):146,050
Checksum:iBB720DA7CCF34DD6
GO
Isoform B (identifier: Q64487-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCLTSCFILASHMLSCDLVFVP
     2-230: Missing.
     775-783: Missing.

Show »
Length:1,695
Mass (Da):190,371
Checksum:i386F0DB5ACDD4C89
GO
Isoform E (identifier: Q64487-5) [UniParc]FASTAAdd to basket
Also known as: delta-DelB

The sequence of this isoform differs from the canonical sequence as follows:
     227-230: Missing.

Show »
Length:1,908
Mass (Da):213,882
Checksum:iD95358289FF1576B
GO
Isoform F (identifier: Q64487-6) [UniParc]FASTAAdd to basket
Also known as: deltaA6

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.

Show »
Length:1,909
Mass (Da):214,080
Checksum:iA4103C1071DB834A
GO
Isoform G (identifier: Q64487-7) [UniParc]FASTAAdd to basket
Also known as: deltaA6-DelB

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.
     227-230: Missing.

Show »
Length:1,905
Mass (Da):213,553
Checksum:iB2A43376C7BFBA17
GO
Isoform H (identifier: Q64487-8) [UniParc]FASTAAdd to basket
Also known as: deltaA3

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.

Show »
Length:1,906
Mass (Da):213,828
Checksum:i5CD10161556D78FC
GO
Isoform I (identifier: Q64487-9) [UniParc]FASTAAdd to basket
Also known as: deltaA3-DelB

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.

Show »
Length:1,902
Mass (Da):213,300
Checksum:iE612C8C07FCF9632
GO
Isoform J (identifier: Q64487-10) [UniParc]FASTAAdd to basket
Also known as: delta-DelA

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.

Show »
Length:1,903
Mass (Da):213,499
Checksum:i978F592FB8113D1A
GO
Isoform K (identifier: Q64487-11) [UniParc]FASTAAdd to basket
Also known as: delta-DelAB

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.
     227-230: Missing.

Show »
Length:1,899
Mass (Da):212,971
Checksum:iEB6E8D26E1900A38
GO
Isoform L (identifier: Q64487-12) [UniParc]FASTAAdd to basket
Also known as: delta A

The sequence of this isoform differs from the canonical sequence as follows:
     608-1018: Missing.
     1019-1019: V → M

Show »
Length:1,501
Mass (Da):168,928
Checksum:i141D4F9E90F088AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9EJA3B9EJA3_MOUSE
Protein tyrosine phosphatase, recep...
Ptprd
1,508Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q7I7E9Q7I7_MOUSE
Receptor-type tyrosine-protein phos...
Ptprd
1,505Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UYU6G3UYU6_MOUSE
Receptor-type tyrosine-protein phos...
Ptprd
1,495Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWK6G3UWK6_MOUSE
Receptor-type tyrosine-protein phos...
Ptprd
1,505Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PVW8E9PVW8_MOUSE
Receptor-type tyrosine-protein phos...
Ptprd
1,506Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UY75G3UY75_MOUSE
Receptor-type tyrosine-protein phos...
Ptprd
1,890Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UX60G3UX60_MOUSE
Receptor-type tyrosine-protein phos...
Ptprd
1,502Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SPA9Q5SPA9_MOUSE
Receptor-type tyrosine-protein phos...
Ptprd
1,254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLZ1A0A1D5RLZ1_MOUSE
Receptor-type tyrosine-protein phos...
Ptprd
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UYR6G3UYR6_MOUSE
Receptor-type tyrosine-protein phos...
Ptprd
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA03004 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5A → R in BAA03004 (PubMed:8355697).Curated1
Sequence conflicti349E → G in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti416A → T in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti551Y → D in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti588R → T in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti657F → Y in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti663 – 666LGIP → IGNS in BAA03005 (PubMed:8355697).Curated4
Sequence conflicti696G → W in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti761 – 763GQP → SA in BAA03005 (PubMed:8355697).Curated3
Sequence conflicti822A → S in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti852Missing in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti1001G → R in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti1004P → A in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti1046 – 1055SAMPFKILYD → PAILSKFFMMM in BAA03003 (PubMed:8355697).Curated10
Sequence conflicti1084V → A in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti1298E → D in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti1447 – 1448RS → E in BAA03003 (PubMed:8355697).Curated2
Sequence conflicti1491 – 1502ATYCV…FALYK → HILCPDICTLN in BAA03003 (PubMed:8355697).CuratedAdd BLAST12
Sequence conflicti1510E → K in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti1531 – 1542FLAFL…VKTCN → VPSFLTESQNLH in BAA03003 (PubMed:8355697).CuratedAdd BLAST12
Sequence conflicti1684T → G in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti1786 – 1795EFKVTDARDG → NSRSRMPGI in BAA03003 (PubMed:8355697).Curated10

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0435451M → MCLTSCFILASHMLSCDLVF VP in isoform A and isoform B. 1 Publication1
Alternative sequenceiVSP_0435462 – 230Missing in isoform A and isoform B. 1 PublicationAdd BLAST229
Alternative sequenceiVSP_043547181 – 189Missing in isoform J and isoform K. Curated9
Alternative sequenceiVSP_043548181 – 183Missing in isoform F and isoform G. Curated3
Alternative sequenceiVSP_043549184 – 189Missing in isoform C, isoform H and isoform I. Curated6
Alternative sequenceiVSP_043550227 – 230Missing in isoform C, isoform E, isoform G, isoform I and isoform K. Curated4
Alternative sequenceiVSP_043551608 – 1018Missing in isoform A and isoform L. 2 PublicationsAdd BLAST411
Alternative sequenceiVSP_043552775 – 783Missing in isoform B and isoform C. Curated9
Alternative sequenceiVSP_0435531019V → M in isoform A and isoform L. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D13903 mRNA Translation: BAA03003.1
D13905 mRNA Translation: BAA03005.1
D13904 mRNA Translation: BAA03004.1 Different initiation.
AF326559 mRNA Translation: AAL37405.1
AF326560 mRNA Translation: AAL37406.1
AL844848 Genomic DNA No translation available.
AL845517 Genomic DNA No translation available.
AL929181 Genomic DNA No translation available.
Z23051 mRNA Translation: CAA80586.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C54689
D54689

NCBI Reference Sequences

More...
RefSeqi
NP_035341.2, NM_011211.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.184021
Mm.403663
Mm.477158
Mm.489057

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000107289; ENSMUSP00000102910; ENSMUSG00000028399 [Q64487-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19266

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19266

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13903 mRNA Translation: BAA03003.1
D13905 mRNA Translation: BAA03005.1
D13904 mRNA Translation: BAA03004.1 Different initiation.
AF326559 mRNA Translation: AAL37405.1
AF326560 mRNA Translation: AAL37406.1
AL844848 Genomic DNA No translation available.
AL845517 Genomic DNA No translation available.
AL929181 Genomic DNA No translation available.
Z23051 mRNA Translation: CAA80586.1
PIRiC54689
D54689
RefSeqiNP_035341.2, NM_011211.3
UniGeneiMm.184021
Mm.403663
Mm.477158
Mm.489057

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Y61X-ray3.36A21-411[»]
4YFDX-ray3.25A21-511[»]
4YFEX-ray1.97A/B321-511[»]
4YFGX-ray3.49A/B21-511[»]
4YH7X-ray4.40A21-1265[»]
5XWTX-ray4.18A/C20-410[»]
5XWUX-ray3.16A/C20-321[»]
5Y32X-ray2.70A21-318[»]
ProteinModelPortaliQ64487
SMRiQ64487
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202495, 1 interactor
IntActiQ64487, 5 interactors
STRINGi10090.ENSMUSP00000133468

PTM databases

iPTMnetiQ64487
PhosphoSitePlusiQ64487

Proteomic databases

MaxQBiQ64487
PaxDbiQ64487
PeptideAtlasiQ64487
PRIDEiQ64487

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107289; ENSMUSP00000102910; ENSMUSG00000028399 [Q64487-4]
GeneIDi19266
KEGGimmu:19266

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5789
MGIiMGI:97812 Ptprd

Phylogenomic databases

GeneTreeiENSGT00940000153617
HOGENOMiHOG000010250
HOVERGENiHBG053758
InParanoidiQ64487
KOiK06777
OMAiEVWWEPV
OrthoDBiEOG091G11WG

Enzyme and pathway databases

ReactomeiR-MMU-388844 Receptor-type tyrosine-protein phosphatases
R-MMU-8849932 Synaptic adhesion-like molecules

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ptprd mouse

Protein Ontology

More...
PROi
PR:Q64487

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028399 Expressed in 321 organ(s), highest expression level in ear
CleanExiMM_PTPRD
ExpressionAtlasiQ64487 baseline and differential
GenevisibleiQ64487 MM

Family and domain databases

CDDicd00063 FN3, 8 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRD_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q64487
Secondary accession number(s): G3X9S7
, Q64486, Q64488, Q64495, Q8VBV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 16, 2012
Last modified: December 5, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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