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UniProtKB - Q64481 (CP3AG_MOUSE)
Protein
Cytochrome P450 3A16
Gene
Cyp3a16
Organism
Mus musculus (Mouse)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 443 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- demethylase activity Source: MGI
- estrogen 16-alpha-hydroxylase activity Source: MGI
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: MGI
- oxidoreductase activity Source: MGI
- retinoic acid 4-hydroxylase activity Source: MGI
- steroid hydroxylase activity Source: GO_Central
- testosterone 6-beta-hydroxylase activity Source: MGI
GO - Biological processi
- oxidative demethylation Source: GO_Central
- steroid metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-211981, Xenobiotics R-MMU-5423646, Aflatoxin activation and detoxification |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp3a16 Synonyms:Cyp3a-16 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106099, Cyp3a16 |
VEuPathDBi | HostDB:ENSMUSG00000038656 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051799 | 1 – 504 | Cytochrome P450 3A16Add BLAST | 504 |
Proteomic databases
EPDi | Q64481 |
jPOSTi | Q64481 |
MaxQBi | Q64481 |
PaxDbi | Q64481 |
PRIDEi | Q64481 |
ProteomicsDBi | 284000 |
PTM databases
iPTMneti | Q64481 |
PhosphoSitePlusi | Q64481 |
Expressioni
Developmental stagei
Fetal- and puberty-specific.
Inductioni
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Gene expression databases
Bgeei | ENSMUSG00000038656, Expressed in liver and 28 other tissues |
Genevisiblei | Q64481, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031633 |
Miscellaneous databases
RNActi | Q64481, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00950000182958 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q64481 |
OMAi | HNTIARL |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q64481 |
TreeFami | TF105087 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q64481-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLFSALSLD TLVLLAIILV LLYRYGTCTH GLFKKQGIPG PKPLPFLGTV
60 70 80 90 100
LNYYKGLWKF DMECYEKYGK TWGLFDGQIP LFVITDPETI KNVLVKECFS
110 120 130 140 150
VFTNRQDFFP VGIMSKSISL AKDEEWKRYR ALLSPTFTSG NLKEMFPVIE
160 170 180 190 200
QYGDILVKYL RQEAEKGKPV AVKDVLGAYS MDVIISTTFG VNIDSLNNPE
210 220 230 240 250
DPFVENAKKV LRFDYFDPLS LSVALFPFLT PIYEMLNICM FPKDSIEFFK
260 270 280 290 300
KFVDRMTENR LDSKQKHRVD FIYLMMEAYN KSKDKDSHKA LSEIEITAQS
310 320 330 340 350
IIFIFAGYET TSSILSFTVY SLATHPDIQK KLQEEIDEAL PNKAPPTYDT
360 370 380 390 400
VMAMEYLDMV LNETLRLYPI TNRLQRVCKK DVEINGIYIP KGSTVIIPSY
410 420 430 440 450
VLHHDPQHWP EPEEFQPERF SKENKGSIDP YVYLPFGNGP RNCIGMRFAL
460 470 480 490 500
MNMKLALIKV LQNFSFQPCK ETQIPLKLSR ELLLQPVKPI VLKVVPRDAV
ITGA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | C → Y in BAA05133 (PubMed:7813478).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26137 mRNA Translation: BAA05133.1 AC115895 Genomic DNA No translation available. |
CCDSi | CCDS19862.1 |
PIRi | S50892 |
RefSeqi | NP_031846.2, NM_007820.2 |
Genome annotation databases
Ensembli | ENSMUST00000031633; ENSMUSP00000031633; ENSMUSG00000038656 |
GeneIDi | 13114 |
KEGGi | mmu:13114 |
UCSCi | uc009amv.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26137 mRNA Translation: BAA05133.1 AC115895 Genomic DNA No translation available. |
CCDSi | CCDS19862.1 |
PIRi | S50892 |
RefSeqi | NP_031846.2, NM_007820.2 |
3D structure databases
SMRi | Q64481 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031633 |
Chemistry databases
ChEMBLi | CHEMBL3637781 |
PTM databases
iPTMneti | Q64481 |
PhosphoSitePlusi | Q64481 |
Proteomic databases
EPDi | Q64481 |
jPOSTi | Q64481 |
MaxQBi | Q64481 |
PaxDbi | Q64481 |
PRIDEi | Q64481 |
ProteomicsDBi | 284000 |
Protocols and materials databases
DNASUi | 13114 |
Genome annotation databases
Ensembli | ENSMUST00000031633; ENSMUSP00000031633; ENSMUSG00000038656 |
GeneIDi | 13114 |
KEGGi | mmu:13114 |
UCSCi | uc009amv.2, mouse |
Organism-specific databases
CTDi | 13114 |
MGIi | MGI:106099, Cyp3a16 |
VEuPathDBi | HostDB:ENSMUSG00000038656 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00950000182958 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q64481 |
OMAi | HNTIARL |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q64481 |
TreeFami | TF105087 |
Enzyme and pathway databases
Reactomei | R-MMU-211981, Xenobiotics R-MMU-5423646, Aflatoxin activation and detoxification |
Miscellaneous databases
BioGRID-ORCSi | 13114, 3 hits in 67 CRISPR screens |
PROi | PR:Q64481 |
RNActi | Q64481, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038656, Expressed in liver and 28 other tissues |
Genevisiblei | Q64481, MM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP3AG_MOUSE | |
Accessioni | Q64481Primary (citable) accession number: Q64481 Secondary accession number(s): E9QP65 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families