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Protein

Cytochrome P450 4B1

Gene

Cyp4b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for mutagenic activation of 3-methoxy-4-aminoazobenzene (3-MeO-AAB); a potent procarcinogen. Also active on 2-aminofluorene and 2-aminoanthracene.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315Heme (covalent; via 1 link)By similarity1
Metal bindingi453Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211979 Eicosanoids
R-MMU-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4B1 (EC:1.14.14.1)
Alternative name(s):
CYPIVB1
Gene namesi
Name:Cyp4b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:103225 Cyp4b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518201 – 511Cytochrome P450 4B1Add BLAST511

Proteomic databases

MaxQBiQ64462
PaxDbiQ64462
PRIDEiQ64462

PTM databases

iPTMnetiQ64462
PhosphoSitePlusiQ64462

Expressioni

Tissue specificityi

Present abundantly in renal microsomes of male mice but not in those of female mice. Also present in pulmonary microsomes of male and female mice. Not found in liver.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000028713 Expressed in 168 organ(s), highest expression level in proximal tubule
ExpressionAtlasiQ64462 baseline and differential
GenevisibleiQ64462 MM

Interactioni

Protein-protein interaction databases

IntActiQ64462, 3 interactors
MINTiQ64462
STRINGi10090.ENSMUSP00000099768

Structurei

3D structure databases

ProteinModelPortaliQ64462
SMRiQ64462
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiQ64462
KOiK07426
OMAiAHPLWLG
OrthoDBiEOG091G06KN
PhylomeDBiQ64462
TreeFamiTF105088

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q64462-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSFLSPSL SRLGLWASVV ILMVTVLKLL SLLFRRQKLA RALDSFPGPP
60 70 80 90 100
KHWLFGHALE IQKTGGLDKV VTWTEQFPYA HPLWLGQFIV FLNIYEPDYA
110 120 130 140 150
KAVYSRGDPK AAYVYDFFLQ WIGKGLLVLE GPKWFQHRKL LTPGFHYDVL
160 170 180 190 200
KPYVAIFAES TRVMLDKWEK KASENKSFDI FCDVGHMALD TLMKCTFGKG
210 220 230 240 250
DSGLSHSDNS YYLAVSDLTL LMQQRIDSFQ YHNDFIYWLT PHGRRFLRAC
260 270 280 290 300
QIAHDHTDHV IRQRKAALQD EKEQKKLQER RHLDFLDILL GARDESGIKL
310 320 330 340 350
SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPMHQQR CREEVREILG
360 370 380 390 400
DRDSFQWDDL AQMTYLTMCM KECFRLYPPV PQVYRQLSKP VTFVDGRSLP
410 420 430 440 450
AGSLISLHIY ALHRNSAVWP DPEVFDPLRF SPENMTGRHP FAFMPFSAGP
460 470 480 490 500
RNCIGQQFAM NEMKVVTALC LLRFEFSPDP SKIPIKVPQL ILRSKNGIHL
510
YLKPLGPGSG K
Length:511
Mass (Da):58,900
Last modified:November 1, 1996 - v1
Checksum:i35463ACDFFE6328B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YY50A0A0A6YY50_MOUSE
Cytochrome P450 4B1
Cyp4b1
208Annotation score:
F6X6A4F6X6A4_MOUSE
Cytochrome P450 4B1
Cyp4b1
375Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50834 mRNA Translation: BAA09446.1
BC008996 mRNA Translation: AAH08996.1
CCDSiCCDS18493.1
PIRiS66472
RefSeqiNP_031849.1, NM_007823.2
UniGeneiMm.1840

Genome annotation databases

EnsembliENSMUST00000102707; ENSMUSP00000099768; ENSMUSG00000028713
GeneIDi13120
KEGGimmu:13120
UCSCiuc008ufc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50834 mRNA Translation: BAA09446.1
BC008996 mRNA Translation: AAH08996.1
CCDSiCCDS18493.1
PIRiS66472
RefSeqiNP_031849.1, NM_007823.2
UniGeneiMm.1840

3D structure databases

ProteinModelPortaliQ64462
SMRiQ64462
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64462, 3 interactors
MINTiQ64462
STRINGi10090.ENSMUSP00000099768

PTM databases

iPTMnetiQ64462
PhosphoSitePlusiQ64462

Proteomic databases

MaxQBiQ64462
PaxDbiQ64462
PRIDEiQ64462

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102707; ENSMUSP00000099768; ENSMUSG00000028713
GeneIDi13120
KEGGimmu:13120
UCSCiuc008ufc.1 mouse

Organism-specific databases

CTDi1580
MGIiMGI:103225 Cyp4b1

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiQ64462
KOiK07426
OMAiAHPLWLG
OrthoDBiEOG091G06KN
PhylomeDBiQ64462
TreeFamiTF105088

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211979 Eicosanoids
R-MMU-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)

Miscellaneous databases

PROiPR:Q64462
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028713 Expressed in 168 organ(s), highest expression level in proximal tubule
ExpressionAtlasiQ64462 baseline and differential
GenevisibleiQ64462 MM

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP4B1_MOUSE
AccessioniPrimary (citable) accession number: Q64462
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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