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Protein

Cytochrome P450 2C29

Gene

Cyp2c29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions
R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-MMU-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKiQ64458

Chemistry databases

SwissLipidsiSLP:000001668

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C29 (EC:1.14.14.1)
Alternative name(s):
Aldehyde oxygenase
CYPIIC29
Cytochrome P-450 MUT-2
Gene namesi
Name:Cyp2c29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:103238 Cyp2c29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517171 – 490Cytochrome P450 2C29Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249N6-acetyllysineCombined sources1
Modified residuei252N6-acetyllysineCombined sources1
Modified residuei375N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ64458
PaxDbiQ64458
PeptideAtlasiQ64458
PRIDEiQ64458

PTM databases

iPTMnetiQ64458
PhosphoSitePlusiQ64458
SwissPalmiQ64458

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000003053
ExpressionAtlasiQ64458 baseline and differential
GenevisibleiQ64458 MM

Interactioni

Protein-protein interaction databases

IntActiQ64458, 3 interactors
MINTiQ64458
STRINGi10090.ENSMUSP00000003137

Structurei

3D structure databases

ProteinModelPortaliQ64458
SMRiQ64458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ64458
KOiK07413
OMAiTAHIGMI
OrthoDBiEOG091G0BT8
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008068 Cyt_P450_E_grp-I_CYP2B-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01685 EP450ICYP2B
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q64458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVVFLALT LSCLILLSLW RQSSGRGKLP PGPTPLPIIG NFLQIDVKNI
60 70 80 90 100
SQSFTNFSKA YGPVFTLYLG SKPTVILHGY EAVKEALIDR GEEFAGRGSF
110 120 130 140 150
PMAEKIIKGF GVVFSNGNRW KEMRRFTLMT LRNLGMGKRN IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQNRFDYK DKEFLILMDK
210 220 230 240 250
INENVKILSS PWLQVCNSFP SLIDYCPGSH HKIVKNFNYL KSYLLEKIKE
260 270 280 290 300
HKESLDVTNP RDFIDYYLIK QKQVNHIEQS EFSLENLAST INDLFGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKYPDVT AKVQEEIDRV VGRHRSPCMQ DRSHMPYTDA
360 370 380 390 400
MIHEVQRFID LLPTSLPHAV TCDIKFRKYL IPKGTTVITS LSSVLHDSKE
410 420 430 440 450
FPNPEMFDPG HFLNGNGNFK KSDYFMPFST GKRICAGEGL ARMELFLILT
460 470 480 490
TILQNFKLKS LVHPKEIDIT PVMNGFASLP PPYQLCFIPL
Length:490
Mass (Da):55,716
Last modified:July 27, 2011 - v2
Checksum:i17D6FF46002E169A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106I → M in AAH19908 (PubMed:15489334).Curated1
Sequence conflicti415G → A in BAA04555 (PubMed:8130255).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17674 mRNA Translation: BAA04555.1
AC120840 Genomic DNA No translation available.
AC139233 Genomic DNA No translation available.
BC019908 mRNA Translation: AAH19908.1
CCDSiCCDS29793.1
PIRiI49610
RefSeqiNP_031841.3, NM_007815.3
UniGeneiMm.20764

Genome annotation databases

EnsembliENSMUST00000003137; ENSMUSP00000003137; ENSMUSG00000003053
GeneIDi13095
KEGGimmu:13095
UCSCiuc008hjz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCP2CT_MOUSE
AccessioniPrimary (citable) accession number: Q64458
Secondary accession number(s): E9QMD8, Q8WUN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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