UniProtKB - Q64455 (PTPRJ_MOUSE)

BLAST

>sp|Q64455|PTPRJ_MOUSE Receptor-type tyrosine-protein phosphatase eta OS=Mus musculus OX=10090 GN=Ptprj PE=1 SV=2
MKPAARETRTPPRSPGLRWALLPLLLLLRQGQVLCAGAAPNPIFDIEAVVSPTSVLLTWK
HNDSGASECRIENKMESNLTFPVKNQTSCNITGLSPGTSYTFSIISVTTNETLNKTITTE
PWPVSDLHVTSVGVTQARLTWSNANGTASYRMLIEELTTHSSVNISGLKPGTNNSFAFPE
SNETQADFAVAEEVPDANGTKRIPVTNLSQLHKNSLVSVDPPSGQDPSLTEILLTDLKPD
TQYNATIYSQAANGTEGQPRNKVFKTNSTQVSDVRAMNISASSMTLTWKSNYDGSRTSIV
YKIHVAGGTHSVNQTVNKTEAIILGLSSSTLYNITVHPFLGQTEGTPGFLQVYTSPDQVS
DFRVTNVSTRAIGLAWRSNDSKSFEIFIKQDGGEKHRNASTGNQSYMVEDLKPGTSYHFE
IIPRGPDGTEGLSSTVNGSTDPSAVTDIRVVNISTTEMQLEWQNTDDASGYTYHLVLESK
SGSIIRTNSSQKWITVGSLTPGTLYNVTIFPEVDQIQGISNSITQYTRPSSVSHIEVNTT
TTTAAIRWKNEDAASASYAYSVLILKTGDGSNVTSNFTKDPSILIPELIPGVSYTVKILT
QVGDGTTSLVPGWNLFCTEPEPVTSFHCEVVPKEPALVLKWACPFGMYTGFELGVRSDSW
DNMTRLENCTSDDDTECRTEVAYLNFSTSYNISIATLSCGKMALPAQNICTTGITDPPTP
DGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAAQPSADVLKYTYEDFKRGAS
DTYVTYLIRIEEKGQSQGLSEVLNYEIDVGNQSTTLGYYNGRLEPLGSYRACVAGFTNIT
YNLQNDGLINGDESYVSFSPYSEAVFLPQDPGVICGAVFGCIFGALAITAVGGFIFWRKK
RTDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYT
AEIAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
LKDFWRMVWEKNVYAIVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEVVLPEWTI
RDFVVKNMQNSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPESPILVHC
SAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDII
RAQKDSKVDLIYQNTTAMTIYENLEPVSMFGKTNGYIA

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History
Entry version 158 (12 Sep 2018)
Sequence version 2 (15 Dec 2009)
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Protein

Receptor-type tyrosine-protein phosphatase eta

Gene

Ptprj

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. May be involved in the mechanism of contact inhibition of cell growth. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.7 Publications

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	1106	SubstrateBy similarity	1
Active siteⁱ	1140	Phosphocysteine intermediatePROSITE-ProRule annotation	1
Binding siteⁱ	1184	SubstrateBy similarity	1

GO - Molecular functionⁱ

beta-catenin binding Source: MGI
delta-catenin binding Source: MGI
gamma-catenin binding Source: MGI
identical protein binding Source: MGI
mitogen-activated protein kinase binding Source: MGI
phosphatase activity Source: UniProtKB
platelet-derived growth factor receptor binding Source: MGI
protein kinase binding Source: MGI
protein tyrosine phosphatase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12771128

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19246339
heart development
Source: MGI
Inferred from mutant phenotypeⁱ
- 12588999
negative regulation of cell growth Source: MGI
negative regulation of cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 12833140
negative regulation of cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12771128
negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
negative regulation of MAP kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12833140
negative regulation of platelet-derived growth factor receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 12833140
negative regulation of protein kinase B signaling Source: UniProtKB
negative regulation of signaling receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12771128
negative regulation of T cell receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 12913111
negative regulation of vascular permeability Source: MGI
oligodendrocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 19139271
peptidyl-tyrosine dephosphorylation Source: MGI
platelet-derived growth factor receptor signaling pathway Source: UniProtKB
positive chemotaxis Source: MGI
positive regulation of cell adhesion Source: MGI
positive regulation of cell-matrix adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 12833140
positive regulation of focal adhesion assembly Source: UniProtKB
positive regulation of macrophage chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 19268662
positive regulation of platelet activation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19246339
positive regulation of protein kinase B signaling Source: MGI
regulation of cell adhesion Source: MGI
vasculogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 12588999

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor-type tyrosine-protein phosphatase eta (EC:3.1.3.48) Short name: Protein-tyrosine phosphatase eta Short name: R-PTP-eta Alternative name(s): HPTP beta-like tyrosine phosphatase Protein-tyrosine phosphatase receptor type J Short name: R-PTP-J Susceptibility to colon cancer 1 CD_antigen: CD148
Gene namesⁱ	Name:Ptprj Synonyms:Byp, Scc1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:104574 Ptprj

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	29 – 876	ExtracellularSequence analysisAdd BLAST	848
Transmembraneⁱ	877 – 897	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	898 – 1238	CytoplasmicSequence analysisAdd BLAST	341

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1106	D → A: Substrate trapping with much higher affinity for substrate. 1 Publication		1
Mutagenesisⁱ	1140	C → S: Catalytically inactive and substrate trapping with higher affinity for substrate. 2 Publications		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_0000025445	29 – 1238	Receptor-type tyrosine-protein phosphatase etaAdd BLAST		1210

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	62	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	78	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	85	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	90	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	110	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	145	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	164	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	173	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	182	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	198	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	207	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	244	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	253	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	267	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	278	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	313	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	317	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	333	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	366	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	379	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	398	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	403	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	437	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	452	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	488	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	506	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	538	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	572	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	576	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	662	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	668	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	685	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	691	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	725	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	811	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	838	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	910	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q64455
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q64455
PaxDbⁱ	Q64455
PRIDEⁱ	Q64455

PTM databases

iPTMnetⁱ	Q64455
PhosphoSitePlusⁱ	Q64455

Expressionⁱ

Tissue specificityⁱ

Expressed at high levels in brain, kidney, spleen and intestine, and at lower levels in liver, lung, thymus and heart. Expressed at a high level in the myeloid cell line FDC-P2, and at a lower level in the pre-B lymphoid cell line WEHI-231 and the T hybridoma cell line HB21.7.31. Not expressed in the fibroblast cell line NIH3T3 or the erythroid cell line F5-5. Expressed in macrophages.3 Publications

Developmental stageⁱ

Expressed at 11.5 dpc in presumptive macrophages concentrated in the liver and scattered throughout the embryonic mesenchyme. Expressed at 11.5 and 12.5 dpc in the developing eye and in the ganglia and processes of cranial and spinal nerves constituting the PNS.1 Publication

Gene expression databases

CleanExⁱ	MM_PTPRJ

CleanExⁱ

MM_PTPRJ

Interactionⁱ

Subunit structureⁱ

Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with FLT3 (phosphorylated). Interacts with GAB1 and GRB2 (By similarity).By similarity

GO - Molecular functionⁱ

beta-catenin binding Source: MGI
delta-catenin binding Source: MGI
gamma-catenin binding Source: MGI
identical protein binding Source: MGI
mitogen-activated protein kinase binding Source: MGI
platelet-derived growth factor receptor binding Source: MGI
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q64455, 1 interactor
STRINGⁱ	10090.ENSMUSP00000129592

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q64455
SMRⁱ	Q64455
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	39 – 122	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	170 – 266	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	97
Domainⁱ	270 – 358	Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST	89
Domainⁱ	359 – 443	Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST	85
Domainⁱ	444 – 527	Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	528 – 621	Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST	94
Domainⁱ	622 – 718	Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST	97
Domainⁱ	717 – 803	Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST	87
Domainⁱ	942 – 1199	Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST	258

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1140 – 1146	Substrate bindingBy similarity		7

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0791 Eukaryota COG5599 LUCA
HOGENOMⁱ	HOG000232054
HOVERGENⁱ	HBG053761
InParanoidⁱ	Q64455
KEGG Orthology (KO) More...KOⁱ	K05698

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 5 hits
Gene3Dⁱ	2.60.40.10, 5 hits 3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041 fn3, 3 hits PF00102 Y_phosphatase, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00060 FN3, 8 hits SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 5 hits SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 6 hits PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q64455-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKPAARETRT PPRSPGLRWA LLPLLLLLRQ GQVLCAGAAP NPIFDIEAVV 
        60         70         80         90        100
SPTSVLLTWK HNDSGASECR IENKMESNLT FPVKNQTSCN ITGLSPGTSY 
       110        120        130        140        150
TFSIISVTTN ETLNKTITTE PWPVSDLHVT SVGVTQARLT WSNANGTASY 
       160        170        180        190        200
RMLIEELTTH SSVNISGLKP GTNNSFAFPE SNETQADFAV AEEVPDANGT 
       210        220        230        240        250
KRIPVTNLSQ LHKNSLVSVD PPSGQDPSLT EILLTDLKPD TQYNATIYSQ 
       260        270        280        290        300
AANGTEGQPR NKVFKTNSTQ VSDVRAMNIS ASSMTLTWKS NYDGSRTSIV 
       310        320        330        340        350
YKIHVAGGTH SVNQTVNKTE AIILGLSSST LYNITVHPFL GQTEGTPGFL 
       360        370        380        390        400
QVYTSPDQVS DFRVTNVSTR AIGLAWRSND SKSFEIFIKQ DGGEKHRNAS 
       410        420        430        440        450
TGNQSYMVED LKPGTSYHFE IIPRGPDGTE GLSSTVNGST DPSAVTDIRV 
       460        470        480        490        500
VNISTTEMQL EWQNTDDASG YTYHLVLESK SGSIIRTNSS QKWITVGSLT 
       510        520        530        540        550
PGTLYNVTIF PEVDQIQGIS NSITQYTRPS SVSHIEVNTT TTTAAIRWKN 
       560        570        580        590        600
EDAASASYAY SVLILKTGDG SNVTSNFTKD PSILIPELIP GVSYTVKILT 
       610        620        630        640        650
QVGDGTTSLV PGWNLFCTEP EPVTSFHCEV VPKEPALVLK WACPFGMYTG 
       660        670        680        690        700
FELGVRSDSW DNMTRLENCT SDDDTECRTE VAYLNFSTSY NISIATLSCG 
       710        720        730        740        750
KMALPAQNIC TTGITDPPTP DGSPNITSVS HNSVKVKFSG FEASHGPIKA 
       760        770        780        790        800
YAVILTTGEA AQPSADVLKY TYEDFKRGAS DTYVTYLIRI EEKGQSQGLS 
       810        820        830        840        850
EVLNYEIDVG NQSTTLGYYN GRLEPLGSYR ACVAGFTNIT YNLQNDGLIN 
       860        870        880        890        900
GDESYVSFSP YSEAVFLPQD PGVICGAVFG CIFGALAITA VGGFIFWRKK 
       910        920        930        940        950
RTDAKNNEVS FSQIKPKKSK LIRVENFEAY FKKQQADSNC GFAEEYEDLK 
       960        970        980        990       1000
LIGISLPKYT AEIAENRGKN RYNNVLPYDI SRVKLSVQTH STDDYINANY 
      1010       1020       1030       1040       1050
MPGYHSKKDF IATQGPLPNT LKDFWRMVWE KNVYAIVMLT KCVEQGRTKC 
      1060       1070       1080       1090       1100
EEYWPSKQAQ DYGDITVAMT SEVVLPEWTI RDFVVKNMQN SESHPLRQFH 
      1110       1120       1130       1140       1150
FTSWPDHGVP DTTDLLINFR YLVRDYMKQI PPESPILVHC SAGVGRTGTF 
      1160       1170       1180       1190       1200
IAIDRLIYQI ENENTVDVYG IVYDLRMHRP LMVQTEDQYV FLNQCVLDII 
      1210       1220       1230 
RAQKDSKVDL IYQNTTAMTI YENLEPVSMF GKTNGYIA

Length:1,238

Mass (Da):136,769

Last modified:December 15, 2009 - v2

Checksum:ⁱE525D346A2C60335

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9Q4S7	E9Q4S7_MOUSE	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase eta	Ptprj	1,350	Annotation score:
A2AWF9	A2AWF9_MOUSE	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase eta	Ptprj	1,299	Annotation score:
A2AWF8	A2AWF8_MOUSE	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase eta	Ptprj	1,164	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	175	S → T in BAA08146 (PubMed:8549806).Curated	1
Sequence conflictⁱ	175	S → T in AAK96030 (PubMed:12089527).Curated	1
Sequence conflictⁱ	175	S → T in AAK98640 (PubMed:12089527).Curated	1
Sequence conflictⁱ	211	L → P in AAK98640 (PubMed:12089527).Curated	1
Sequence conflictⁱ	217	V → A in AAK98640 (PubMed:12089527).Curated	1
Sequence conflictⁱ	463	Q → H in BAE27842 (PubMed:16141072).Curated	1
Sequence conflictⁱ	553	A → T in AAK98640 (PubMed:12089527).Curated	1
Sequence conflictⁱ	622	P → S in AAK98640 (PubMed:12089527).Curated	1
Sequence conflictⁱ	1061	D → E in AAK98640 (PubMed:12089527).Curated	1
Sequence conflictⁱ	1126	Y → D in AAN11409 (PubMed:12089527).Curated	1
Sequence conflictⁱ	1133	E → K in AAN11409 (PubMed:12089527).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D45212 mRNA Translation: BAA08146.1 AY038877, AY038861 Genomic DNA Translation: AAN11409.1 AY038891 mRNA Translation: AAK96030.1 AY039232 mRNA Translation: AAK98640.1 DQ133576 mRNA Translation: ABA07808.1 AK147318 mRNA Translation: BAE27842.1 AK147556 mRNA Translation: BAE27993.1
PIRⁱ	S68700
NCBI Reference Sequences More...RefSeqⁱ	NP_033008.3, NM_008982.5
UniGeneⁱ	Mm.330393

Genome annotation databases

GeneIDⁱ	19271
KEGGⁱ	mmu:19271

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q64455	Receptor-type tyrosine-protein phosphatase eta		MOUSE		1350	UniRef100_Q64455
Receptor-type tyrosine-protein phosphatase eta		MOUSE		1164

Protein	Similar proteins		Species	Score	Length	Source
Q64455	Receptor-type tyrosine-protein phosphatase eta		MOUSE		1350	UniRef90_Q64455
UPI000A3149DE		MUSCR		1164
Receptor-type tyrosine-protein phosphatase eta		MOUSE		1164
Receptor-type tyrosine-protein phosphatase eta		MOUSE		1299
Protein tyrosine phosphatase (Fragment)		MOUSE		361
+3

Protein	Similar proteins		Species	Score	Length	Source
Q64455	Receptor-type tyrosine-protein phosphatase eta	)	HUMAN		1337	UniRef50_Q12913
Protein tyrosine phosphatase, receptor type, J		PANTR		1392
Uncharacterized protein		RHIRO		1337
PTPRJ isoform 1		PONAB		1337
Uncharacterized protein		RHIBE		1336
+225

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D45212 mRNA Translation: BAA08146.1 AY038877, AY038861 Genomic DNA Translation: AAN11409.1 AY038891 mRNA Translation: AAK96030.1 AY039232 mRNA Translation: AAK98640.1 DQ133576 mRNA Translation: ABA07808.1 AK147318 mRNA Translation: BAE27842.1 AK147556 mRNA Translation: BAE27993.1
PIRⁱ	S68700
RefSeqⁱ	NP_033008.3, NM_008982.5
UniGeneⁱ	Mm.330393

3D structure databases

ProteinModelPortalⁱ	Q64455
SMRⁱ	Q64455
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q64455, 1 interactor
STRINGⁱ	10090.ENSMUSP00000129592

PTM databases

iPTMnetⁱ	Q64455
PhosphoSitePlusⁱ	Q64455

Proteomic databases

EPDⁱ	Q64455
MaxQBⁱ	Q64455
PaxDbⁱ	Q64455
PRIDEⁱ	Q64455

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	19271
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	19271
KEGGⁱ	mmu:19271

Organism-specific databases

CTDⁱ	5795
MGIⁱ	MGI:104574 Ptprj

Phylogenomic databases

eggNOGⁱ	KOG0791 Eukaryota COG5599 LUCA
HOGENOMⁱ	HOG000232054
HOVERGENⁱ	HBG053761
InParanoidⁱ	Q64455
KOⁱ	K05698

Miscellaneous databases

ChiTaRSⁱ	Ptprj mouse
Protein Ontology More...PROⁱ	PR:Q64455
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_PTPRJ

CleanExⁱ

MM_PTPRJ

Family and domain databases

CDDⁱ	cd00063 FN3, 5 hits
Gene3Dⁱ	2.60.40.10, 5 hits 3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfamⁱ	View protein in Pfam PF00041 fn3, 3 hits PF00102 Y_phosphatase, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00060 FN3, 8 hits SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 5 hits SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 6 hits PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTPRJ_MOUSE
Accessionⁱ	Q64455Primary (citable) accession number: Q64455 Secondary accession number(s): Q3UH64 , Q3UHL5, Q541R5, Q8CIW9, Q8K3Q2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	December 15, 2009
	Last modified:	September 12, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q64455 (PTPRJ_MOUSE)

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Receptor-type tyrosine-protein phosphatase eta

Ptprj

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ