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Entry version 150 (16 Oct 2019)
Sequence version 3 (27 Jul 2011)
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Protein

C-type mannose receptor 2

Gene

Mrc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandCalcium, Lectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-type mannose receptor 2
Alternative name(s):
Lectin lambda
Macrophage mannose receptor 2
CD_antigen: CD280
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mrc2
Synonyms:Kiaa0709
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107818 Mrc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 1413ExtracellularSequence analysisAdd BLAST1383
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1414 – 1434HelicalSequence analysisAdd BLAST21
Topological domaini1435 – 1479CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show impaired mammary tumor growth. Tumors from mice lacking Mrc2 display an abrogation of cellular collagen uptake, a fibrotic state characterized by the accumulation of both basement membrane and interstitial collagens, and an overall tumor size reduction, despite the collagen accumulation. Fibroblasts from mice lacking Mrc2 display a severe impairment of internalization of collagen IV and V and thus, exhibit a general deficiency in uptake and delivery of collagens to vesicular compartments. Fibroblasts also have diminished initial adhesion to collagen as well as impaired migration on fibrillar collagen. Mice with a targeted deletion of Mrc2 exon 2-6 are phenotypically normal, healthy and fertile. This deletion resulted in expression of a protein that lacks the ricin B-type lectin domain, the fibronectin type-II domain and the first C-type lectin domain. Fibroblasts from these mice display C-type lectin activity, but have a defect in collagen-binding and internalization, and an impaired migratory phenotype.4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004607931 – 1479C-type mannose receptor 2Add BLAST1449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi92 ↔ 111By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi186 ↔ 212By similarity
Disulfide bondi200 ↔ 227By similarity
Disulfide bondi265 ↔ 358By similarity
Disulfide bondi334 ↔ 350By similarity
Glycosylationi363N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi409 ↔ 503By similarity
Disulfide bondi480 ↔ 495By similarity
Disulfide bondi617 ↔ 634By similarity
Disulfide bondi703 ↔ 807By similarity
Disulfide bondi784 ↔ 799By similarity
Disulfide bondi852 ↔ 949By similarity
Disulfide bondi926 ↔ 941By similarity
Glycosylationi1028N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1077 ↔ 1097By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Disulfide bondi1219 ↔ 1233By similarity
Glycosylationi1348N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1367 ↔ 1382By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q64449

PeptideAtlas

More...
PeptideAtlasi
Q64449

PRoteomics IDEntifications database

More...
PRIDEi
Q64449

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2240

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q64449

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q64449

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, lung and kidney, but little or no expression in brain, thymus or adult liver. Expressed at highly endothelialized sites such as those in choroid plexus and kidney glomerulai as well as in chondrocytes in cartilaginous regions of the embryo.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed at day 7 of embryonic development and detected throughout the later stages of embryonic development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020695 Expressed in 226 organ(s), highest expression level in molar tooth

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q64449 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q64449 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex.

Interacts with collagen V and with C-terminal region of type I collagen/COL1A1 (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097909

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q64449

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 190Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST154
Domaini181 – 229Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Domaini243 – 359C-type lectin 1PROSITE-ProRule annotationAdd BLAST117
Domaini388 – 504C-type lectin 2PROSITE-ProRule annotationAdd BLAST117
Domaini527 – 643C-type lectin 3PROSITE-ProRule annotationAdd BLAST117
Domaini677 – 808C-type lectin 4PROSITE-ProRule annotationAdd BLAST132
Domaini831 – 950C-type lectin 5PROSITE-ProRule annotationAdd BLAST120
Domaini978 – 1106C-type lectin 6PROSITE-ProRule annotationAdd BLAST129
Domaini1131 – 1242C-type lectin 7PROSITE-ProRule annotationAdd BLAST112
Domaini1271 – 1391C-type lectin 8PROSITE-ProRule annotationAdd BLAST121

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner (By similarity).By similarity
Fibronectin type-II domain mediates collagen-binding.By similarity
Ricin B-type lectin domain contacts with the second C-type lectin domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDF3 Eukaryota
ENOG410XQ89 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182821

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231191

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q64449

KEGG Orthology (KO)

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KOi
K06560

Identification of Orthologs from Complete Genome Data

More...
OMAi
HNFDRSN

Database of Orthologous Groups

More...
OrthoDBi
29241at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316663

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03590 CLECT_DC-SIGN_like, 1 hit
cd00062 FN2, 1 hit
cd00161 RICIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 3 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q64449-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPIRPALAP WPRHLLRCVL LLGGLRLGHP ADSAAALLEP DVFLIFSQGM
60 70 80 90 100
QGCLEAQGVQ VRVTPVCNAS LPAQRWKWVS RNRLFNLGAT QCLGTGWPVT
110 120 130 140 150
NTTVSLGMYE CDREALSLRW QCRTLGDQLS LLLGARASNA SKPGTLERGD
160 170 180 190 200
QTRSGHWNIY GSEEDLCARP YYEVYTIQGN SHGKPCTIPF KYDNQWFHGC
210 220 230 240 250
TSTGREDGHL WCATTQDYGK DERWGFCPIK SNDCETFWDK DQLTDSCYQF
260 270 280 290 300
NFQSTLSWRE AWASCEQQGA DLLSITEIHE QTYINGLLTG YSSTLWIGLN
310 320 330 340 350
DLDTSGGWQW SDNSPLKYLN WESDQPDNPG EENCGVIRTE SSGGWQNHDC
360 370 380 390 400
SIALPYVCKK KPNATVEPIQ PDRWTNVKVE CDPSWQPFQG HCYRLQAEKR
410 420 430 440 450
SWQESKRACL RGGGDLLSIH SMAELEFITK QIKQEVEELW IGLNDLKLQM
460 470 480 490 500
NFEWSDGSLV SFTHWHPFEP NNFRDSLEDC VTIWGPEGRW NDSPCNQSLP
510 520 530 540 550
SICKKAGRLS QGAAEEDHGC RKGWTWHSPS CYWLGEDQVI YSDARRLCTD
560 570 580 590 600
HGSQLVTITN RFEQAFVSSL IYNWEGEYFW TALQDLNSTG SFRWLSGDEV
610 620 630 640 650
IYTHWNRDQP GYRRGGCVAL ATGSAMGLWE VKNCTSFRAR YICRQSLGTP
660 670 680 690 700
VTPELPGPDP TPSLTGSCPQ GWVSDPKLRH CYKVFSSERL QEKKSWIQAL
710 720 730 740 750
GVCRELGAQL LSLASYEEEH FVAHMLNKIF GESEPESHEQ HWFWIGLNRR
760 770 780 790 800
DPREGHSWRW SDGLGFSYHN FARSRHDDDD IRGCAVLDLA SLQWVPMQCQ
810 820 830 840 850
TQLDWICKIP RGVDVREPDI GRQGRLEWVR FQEAEYKFFE HHSSWAQAQR
860 870 880 890 900
ICTWFQADLT SVHSQAELDF LGQNLQKLSS DQEQHWWIGL HTLESDGRFR
910 920 930 940 950
WTDGSIINFI SWAPGKPRPI GKDKKCVYMT ARQEDWGDQR CHTALPYICK
960 970 980 990 1000
RSNSSGETQP QDLPPSALGG CPSGWNQFLN KCFRIQGQDP QDRVKWSEAQ
1010 1020 1030 1040 1050
FSCEQQEAQL VTIANPLEQA FITASLPNVT FDLWIGLHAS QRDFQWIEQE
1060 1070 1080 1090 1100
PLLYTNWAPG EPSGPSPAPS GTKPTSCAVI LHSPSAHFTG RWDDRSCTEE
1110 1120 1130 1140 1150
THGFICQKGT DPSLSPSPAA TPPAPGAELS YLNHTFRLLQ KPLRWKDALL
1160 1170 1180 1190 1200
LCESRNASLA HVPDPYTQAF LTQAARGLQT PLWIGLASEE GSRRYSWLSE
1210 1220 1230 1240 1250
EPLNYVSWQD EEPQHSGGCA YVDVDGTWRT TSCDTKLQGA VCGVSRGPPP
1260 1270 1280 1290 1300
RRINYRGSCP QGLADSSWIP FREHCYSFHM EVLLGHKEAL QRCQKAGGTV
1310 1320 1330 1340 1350
LSILDEMENV FVWEHLQTAE AQSRGAWLGM NFNPKGGTLV WQDNTAVNYS
1360 1370 1380 1390 1400
NWGPPGLGPS MLSHNSCYWI QSSSGLWRPG ACTNITMGVV CKLPRVEENS
1410 1420 1430 1440 1450
FLPSAALPES PVALVVVLTA VLLLLALMTA ALILYRRRQS AERGSFEGAR
1460 1470
YSRSSHSGPA EATEKNILVS DMEMNEQQE
Length:1,479
Mass (Da):167,074
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFC78624FE331E32
GO
Isoform 2 (identifier: Q64449-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-180: EVYTIQGN → GEGSIAKS
     181-1479: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):19,706
Checksum:iB83C2ABEC02029D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AAA9A2AAA9_MOUSE
C-type mannose receptor 2
Mrc2
1,053Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC52729 differs from that shown. Reason: Frameshift.Curated
The sequence BAC35672 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66V → F in AAC52729 (PubMed:8702911).Curated1
Sequence conflicti519G → D in AAC52729 (PubMed:8702911).Curated1
Sequence conflicti869D → G in AAC52729 (PubMed:8702911).Curated1
Sequence conflicti984R → Q in BAC98005 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017223173 – 180EVYTIQGN → GEGSIAKS in isoform 2. 1 Publication8
Alternative sequenceiVSP_017224181 – 1479Missing in isoform 2. 1 PublicationAdd BLAST1299

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U56734 mRNA Translation: AAC52729.1 Frameshift.
AK054150 mRNA Translation: BAC35672.1 Different initiation.
AL645471 Genomic DNA No translation available.
AL645572 Genomic DNA No translation available.
AL645684 Genomic DNA No translation available.
AK129195 mRNA Translation: BAC98005.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS25539.1 [Q64449-1]

Protein sequence database of the Protein Information Resource

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PIRi
T42710

NCBI Reference Sequences

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RefSeqi
NP_032652.3, NM_008626.3 [Q64449-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000100335; ENSMUSP00000097909; ENSMUSG00000020695 [Q64449-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
17534

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17534

UCSC genome browser

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UCSCi
uc007lxi.1 mouse [Q64449-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Endo180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56734 mRNA Translation: AAC52729.1 Frameshift.
AK054150 mRNA Translation: BAC35672.1 Different initiation.
AL645471 Genomic DNA No translation available.
AL645572 Genomic DNA No translation available.
AL645684 Genomic DNA No translation available.
AK129195 mRNA Translation: BAC98005.1
CCDSiCCDS25539.1 [Q64449-1]
PIRiT42710
RefSeqiNP_032652.3, NM_008626.3 [Q64449-1]

3D structure databases

SMRiQ64449
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097909

PTM databases

GlyConnecti2240
iPTMnetiQ64449
PhosphoSitePlusiQ64449

Proteomic databases

PaxDbiQ64449
PeptideAtlasiQ64449
PRIDEiQ64449

Genome annotation databases

EnsembliENSMUST00000100335; ENSMUSP00000097909; ENSMUSG00000020695 [Q64449-1]
GeneIDi17534
KEGGimmu:17534
UCSCiuc007lxi.1 mouse [Q64449-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9902
MGIiMGI:107818 Mrc2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410KDF3 Eukaryota
ENOG410XQ89 LUCA
GeneTreeiENSGT00950000182821
HOGENOMiHOG000231191
InParanoidiQ64449
KOiK06560
OMAiHNFDRSN
OrthoDBi29241at2759
TreeFamiTF316663

Enzyme and pathway databases

ReactomeiR-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Mrc2 mouse

Protein Ontology

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PROi
PR:Q64449

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020695 Expressed in 226 organ(s), highest expression level in molar tooth
ExpressionAtlasiQ64449 baseline and differential
GenevisibleiQ64449 MM

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
cd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits
SMARTiView protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 3 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRC2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q64449
Secondary accession number(s): A2AAB0, Q6ZQ64, Q8C6P0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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