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Protein

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Gene

Cyp24a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has a role in maintaining calcium homeostasis. Catalyzes the adrenodoxin-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1-alpha,25-dihydroxyvitamin D3). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid.By similarity

Catalytic activityi

Calcitriol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O.By similarity
Calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = secalciferol + 2 oxidized adrenodoxin + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi462Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-196791 Vitamin D (calciferol) metabolism
R-MMU-211916 Vitamins

Names & Taxonomyi

Protein namesi
Recommended name:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (EC:1.14.15.16By similarity)
Short name:
24-OHase
Short name:
Vitamin D(3) 24-hydroxylase
Alternative name(s):
Cytochrome P450 24A1
Cytochrome P450-CC24
Gene namesi
Name:Cyp24a1
Synonyms:Cyp-24, Cyp24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88593 Cyp24a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000000361636 – 5141,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialAdd BLAST479

Proteomic databases

EPDiQ64441
PaxDbiQ64441
PRIDEiQ64441

PTM databases

iPTMnetiQ64441
PhosphoSitePlusiQ64441

Expressioni

Inductioni

By 1,25-dihydroxyvitamin D3 in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000038567 Expressed in 42 organ(s), highest expression level in metanephros
ExpressionAtlasiQ64441 baseline and differential
GenevisibleiQ64441 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047954

Structurei

3D structure databases

ProteinModelPortaliQ64441
SMRiQ64441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0159 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000276540
HOVERGENiHBG099053
InParanoidiQ64441
KOiK07436
OMAiEILWKGG
OrthoDBiEOG091G0MI3
PhylomeDBiQ64441
TreeFamiTF105094

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64441-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCPIDKRRP LIAFLRRLRD LGQPPRSVTS KAHVKRAPKE VPLCPLMTDG
60 70 80 90 100
ETRNVTSLPG PTNWPLLGSL LEIFWKGGLK KQHDTLAEYH KKYGQIFRMK
110 120 130 140 150
LGSFDSVHLG SPSLLEALYR TESAHPQRLE IKPWKAYRDH RNEAYGLMIL
160 170 180 190 200
EGQEWQRVRS AFQKKLMKPV EIMKLDKKIN EVLADFMGQI DELRDERGRI
210 220 230 240 250
QDLYSELNKW SFESICLVLY EKRFGLLQKD TEEEALTFIA AIKTMMSTFG
260 270 280 290 300
KMMVTPVELH KRLNTKVWQA HTLAWDTIFK SVKPCIDHRL ERYSQQPGAD
310 320 330 340 350
FLCDIYQQDH LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ
360 370 380 390 400
RLLREIQSVL PDNQTPRAED VRNMPYLKAC LKESMRLTPS VPFTTRTLDK
410 420 430 440 450
PTVLGEYTLP KGTVLTLNTQ VLGSSEDNFE DADKFRPERW LEKEKKINPF
460 470 480 490 500
AHLPFGVGKR MCIGRRLAEL QLHLALCWII QKYNIVATDS EPVEMLHLGI
510
LVPSRELPIA FCPR
Length:514
Mass (Da):59,453
Last modified:November 1, 1996 - v1
Checksum:i3D38BA9235177A42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49438 mRNA Translation: BAA08416.1
D89669 mRNA Translation: BAA21843.1
CCDSiCCDS17122.1
PIRiS60033
RefSeqiNP_034126.1, NM_009996.4
UniGeneiMm.6575

Genome annotation databases

EnsembliENSMUST00000038824; ENSMUSP00000047954; ENSMUSG00000038567
GeneIDi13081
KEGGimmu:13081
UCSCiuc008ocb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49438 mRNA Translation: BAA08416.1
D89669 mRNA Translation: BAA21843.1
CCDSiCCDS17122.1
PIRiS60033
RefSeqiNP_034126.1, NM_009996.4
UniGeneiMm.6575

3D structure databases

ProteinModelPortaliQ64441
SMRiQ64441
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047954

PTM databases

iPTMnetiQ64441
PhosphoSitePlusiQ64441

Proteomic databases

EPDiQ64441
PaxDbiQ64441
PRIDEiQ64441

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038824; ENSMUSP00000047954; ENSMUSG00000038567
GeneIDi13081
KEGGimmu:13081
UCSCiuc008ocb.1 mouse

Organism-specific databases

CTDi1591
MGIiMGI:88593 Cyp24a1

Phylogenomic databases

eggNOGiKOG0159 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000276540
HOVERGENiHBG099053
InParanoidiQ64441
KOiK07436
OMAiEILWKGG
OrthoDBiEOG091G0MI3
PhylomeDBiQ64441
TreeFamiTF105094

Enzyme and pathway databases

ReactomeiR-MMU-196791 Vitamin D (calciferol) metabolism
R-MMU-211916 Vitamins

Miscellaneous databases

PROiPR:Q64441
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038567 Expressed in 42 organ(s), highest expression level in metanephros
ExpressionAtlasiQ64441 baseline and differential
GenevisibleiQ64441 MM

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP24A_MOUSE
AccessioniPrimary (citable) accession number: Q64441
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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