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Protein

Alcohol dehydrogenase class 4 mu/sigma chain

Gene

Adh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi174Zinc 1; catalyticBy similarity1
Binding sitei223NADBy similarity1
Binding sitei228NADBy similarity1
Binding sitei369NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 204NADBy similarity6
Nucleotide bindingi292 – 294NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class 4 mu/sigma chain (EC:1.1.1.1)
Alternative name(s):
ADH-C2
Alcohol dehydrogenase 7
Alcohol dehydrogenase class IV mu/sigma chain
Gastric alcohol dehydrogenase
Retinol dehydrogenase
Gene namesi
Name:Adh7
Synonyms:Adh-3, Adh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:87926 Adh7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606921 – 374Alcohol dehydrogenase class 4 mu/sigma chainAdd BLAST374

Proteomic databases

PaxDbiQ64437
PeptideAtlasiQ64437
PRIDEiQ64437

PTM databases

iPTMnetiQ64437
PhosphoSitePlusiQ64437

Expressioni

Tissue specificityi

High expression in the stomach mucosa. Lower expression in eye, thymus, skin and ovary. Very low expression in small intestine, liver and uterus.

Gene expression databases

BgeeiENSMUSG00000055301 Expressed in 132 organ(s), highest expression level in cornea
ExpressionAtlasiQ64437 baseline and differential
GenevisibleiQ64437 MM

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087633

Structurei

3D structure databases

ProteinModelPortaliQ64437
SMRiQ64437
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiQ64437
KOiK13951
OMAiSNETYNE
OrthoDBiEOG091G08N3
TreeFamiTF300429

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR028635 Zinc_ADH_IV
PANTHERiPTHR43880:SF2 PTHR43880:SF2, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q64437-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTAGKVIKC KAAVLWGVNQ PFSIEEIEVA PPKAKEVRVK ILATGICRTD
60 70 80 90 100
DHIIKGSMVS KFPVIVGHEA VGVVESVGEG VTTVRPGDKV IPLFLPQCRE
110 120 130 140 150
CNACLNPEGN LCIRSDLTGR GVLADGTTRF TCKGKPVQHF MNTSTFTEYT
160 170 180 190 200
VLDESSVAKV DGAAPPEKAC LIGCGFSTGY GAAVKTAKVT PGSTCVVFGL
210 220 230 240 250
GGVGLSVIMG CKAAGASRII GIDINKDKFQ KALAVGATEC ISPKDSTKPI
260 270 280 290 300
SEVLSDMTGN TIQYTFEVIG RLETMVDALS SCHMNYGTSV VVGAPPSAKM
310 320 330 340 350
LTYDPMLLFT GRTWKGCVFG GWKSRDDVPK LVTEFLEKKF DLDQLITHTL
360 370
PFNNINEGFE LLYSGKSIRT VLTF
Length:374
Mass (Da):39,904
Last modified:July 27, 2011 - v2
Checksum:iD615119A23B41843
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120R → C in AAA76735 (PubMed:7738026).Curated1
Sequence conflicti120R → C in AAC53124 (PubMed:9126489).Curated1
Sequence conflicti262I → V in AAA76735 (PubMed:7738026).Curated1
Sequence conflicti262I → V in AAC53124 (PubMed:9126489).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20257 mRNA Translation: AAA76735.1
U76734
, U76728, U76729, U76730, U76727, U76731, U76733, U76732 Genomic DNA Translation: AAC53124.1
AC079682 Genomic DNA No translation available.
CCDSiCCDS38651.1
PIRiA56436
RefSeqiNP_033756.2, NM_009626.4
XP_006500982.1, XM_006500919.3
UniGeneiMm.8473

Genome annotation databases

EnsembliENSMUST00000090171; ENSMUSP00000087633; ENSMUSG00000055301
GeneIDi11529
KEGGimmu:11529
UCSCiuc008rnd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiADH7_MOUSE
AccessioniPrimary (citable) accession number: Q64437
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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