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Protein

Lysophospholipid acyltransferase LPCAT4

Gene

LPCAT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.1 Publication

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine.1 Publication
Acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine.1 Publication
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.1 Publication
Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.1 Publication
Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylserine.1 Publication

Kineticsi

  1. KM=80 µM for lysophosphatidylethanolamine1 Publication
  2. KM=20 µM for oleoyl-CoA1 Publication
  1. Vmax=270 pmol/min/mg enzyme with lysophosphatidylethanolamine and oleoyl-CoA as substrates1 Publication

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS16664-MONOMER
BRENDAi2.3.1.23 2681
2.3.1.51 2681
ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA
UniPathwayi
UPA00085

Chemistry databases

SwissLipidsiSLP:000000294

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipid acyltransferase LPCAT4
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 7
Short name:
1-AGP acyltransferase 7
Short name:
1-AGPAT 7
1-acylglycerophosphocholine O-acyltransferase (EC:2.3.1.23)
1-acylglycerophosphoserine O-acyltransferase (EC:2.3.1.n6)
1-alkenylglycerophosphoethanolamine O-acyltransferase (EC:2.3.1.121)
1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67)
Acyltransferase-like 3
Lysophosphatidylcholine acyltransferase 4
Lysophosphatidylethanolamine acyltransferase 2 (EC:2.3.1.n7)
Plasmalogen synthase
Gene namesi
Name:LPCAT4
Synonyms:AGPAT7, AYTL3, LPEAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000176454.13
HGNCiHGNC:30059 LPCAT4
MIMi612039 gene
neXtProtiNX_Q643R3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 62HelicalSequence analysisAdd BLAST23
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi254531
OpenTargetsiENSG00000176454
PharmGKBiPA162394297

Polymorphism and mutation databases

BioMutaiLPCAT4
DMDMi74736281

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470541 – 524Lysophospholipid acyltransferase LPCAT4Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ643R3
MaxQBiQ643R3
PaxDbiQ643R3
PeptideAtlasiQ643R3
PRIDEiQ643R3
ProteomicsDBi65914

PTM databases

iPTMnetiQ643R3
PhosphoSitePlusiQ643R3
SwissPalmiQ643R3

Expressioni

Tissue specificityi

Widely expressed with predominant level in brain.2 Publications

Gene expression databases

BgeeiENSG00000176454 Expressed in 227 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_LPCAT4
ExpressionAtlasiQ643R3 baseline and differential
GenevisibleiQ643R3 HS

Organism-specific databases

HPAiHPA030719

Interactioni

Protein-protein interaction databases

BioGridi129039, 13 interactors
STRINGi9606.ENSP00000317300

Structurei

3D structure databases

ProteinModelPortaliQ643R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 134HXXXXD motif6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4666 Eukaryota
ENOG410XSIQ LUCA
GeneTreeiENSGT00390000004914
HOGENOMiHOG000234374
InParanoidiQ643R3
KOiK13512
OMAiLRPPHTS
OrthoDBiEOG091G09LH
PhylomeDBiQ643R3
TreeFamiTF323244

Family and domain databases

InterProiView protein in InterPro
IPR002123 Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF01553 Acyltransferase, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q643R3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGSPGDWA PLDPTPGPPA SPNPFVHELH LSRLQRVKFC LLGALLAPIR
60 70 80 90 100
VLLAFIVLFL LWPFAWLQVA GLSEEQLQEP ITGWRKTVCH NGVLGLSRLL
110 120 130 140 150
FFLLGFLRIR VRGQRASRLQ APVLVAAPHS TFFDPIVLLP CDLPKVVSRA
160 170 180 190 200
ENLSVPVIGA LLRFNQAILV SRHDPASRRR VVEEVRRRAT SGGKWPQVLF
210 220 230 240 250
FPEGTCSNKK ALLKFKPGAF IAGVPVQPVL IRYPNSLDTT SWAWRGPGVL
260 270 280 290 300
KVLWLTASQP CSIVDVEFLP VYHPSPEESR DPTLYANNVQ RVMAQALGIP
310 320 330 340 350
ATECEFVGSL PVIVVGRLKV ALEPQLWELG KVLRKAGLSA GYVDAGAEPG
360 370 380 390 400
RSRMISQEEF ARQLQLSDPQ TVAGAFGYFQ QDTKGLVDFR DVALALAALD
410 420 430 440 450
GGRSLEELTR LAFELFAEEQ AEGPNRLLYK DGFSTILHLL LGSPHPAATA
460 470 480 490 500
LHAELCQAGS SQGLSLCQFQ NFSLHDPLYG KLFSTYLRPP HTSRGTSQTP
510 520
NASSPGNPTA LANGTVQAPK QKGD
Length:524
Mass (Da):57,219
Last modified:October 25, 2004 - v1
Checksum:i3A2A12656E1241BC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGT4A0A0C4DGT4_HUMAN
Lysophospholipid acyltransferase LP...
LPCAT4
351Annotation score:
H3BMK4H3BMK4_HUMAN
Lysophospholipid acyltransferase LP...
LPCAT4
84Annotation score:

Sequence cautioni

The sequence AAC19156 differs from that shown. Probable cloning artifact.Curated
The sequence AAC19156 differs from that shown. Reason: Frameshift at position 328.Curated
The sequence AAN33178 differs from that shown. Reason: Frameshift at position 198.Curated
The sequence AAP97722 differs from that shown. Reason: Frameshift at positions 188 and 198.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY734233 mRNA Translation: AAU34184.1
AF529233 mRNA Translation: AAP97722.1 Frameshift.
AF542964 mRNA Translation: AAN33178.1 Frameshift.
AK290273 mRNA Translation: BAF82962.1
CH471125 Genomic DNA Translation: EAW92306.1
BC024892 mRNA Translation: AAH24892.2
BC092463 mRNA Translation: AAH92463.1
AF007155 mRNA Translation: AAC19156.1 Sequence problems.
CCDSiCCDS32191.1
RefSeqiNP_705841.2, NM_153613.2
UniGeneiHs.352614

Genome annotation databases

EnsembliENST00000314891; ENSP00000317300; ENSG00000176454
GeneIDi254531
KEGGihsa:254531
UCSCiuc001zig.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY734233 mRNA Translation: AAU34184.1
AF529233 mRNA Translation: AAP97722.1 Frameshift.
AF542964 mRNA Translation: AAN33178.1 Frameshift.
AK290273 mRNA Translation: BAF82962.1
CH471125 Genomic DNA Translation: EAW92306.1
BC024892 mRNA Translation: AAH24892.2
BC092463 mRNA Translation: AAH92463.1
AF007155 mRNA Translation: AAC19156.1 Sequence problems.
CCDSiCCDS32191.1
RefSeqiNP_705841.2, NM_153613.2
UniGeneiHs.352614

3D structure databases

ProteinModelPortaliQ643R3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129039, 13 interactors
STRINGi9606.ENSP00000317300

Chemistry databases

SwissLipidsiSLP:000000294

PTM databases

iPTMnetiQ643R3
PhosphoSitePlusiQ643R3
SwissPalmiQ643R3

Polymorphism and mutation databases

BioMutaiLPCAT4
DMDMi74736281

Proteomic databases

EPDiQ643R3
MaxQBiQ643R3
PaxDbiQ643R3
PeptideAtlasiQ643R3
PRIDEiQ643R3
ProteomicsDBi65914

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314891; ENSP00000317300; ENSG00000176454
GeneIDi254531
KEGGihsa:254531
UCSCiuc001zig.4 human

Organism-specific databases

CTDi254531
DisGeNETi254531
EuPathDBiHostDB:ENSG00000176454.13
GeneCardsiLPCAT4
HGNCiHGNC:30059 LPCAT4
HPAiHPA030719
MIMi612039 gene
neXtProtiNX_Q643R3
OpenTargetsiENSG00000176454
PharmGKBiPA162394297
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4666 Eukaryota
ENOG410XSIQ LUCA
GeneTreeiENSGT00390000004914
HOGENOMiHOG000234374
InParanoidiQ643R3
KOiK13512
OMAiLRPPHTS
OrthoDBiEOG091G09LH
PhylomeDBiQ643R3
TreeFamiTF323244

Enzyme and pathway databases

UniPathwayi
UPA00085

BioCyciMetaCyc:HS16664-MONOMER
BRENDAi2.3.1.23 2681
2.3.1.51 2681
ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRSiLPCAT4 human
GenomeRNAii254531
PROiPR:Q643R3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176454 Expressed in 227 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_LPCAT4
ExpressionAtlasiQ643R3 baseline and differential
GenevisibleiQ643R3 HS

Family and domain databases

InterProiView protein in InterPro
IPR002123 Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF01553 Acyltransferase, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPCT4_HUMAN
AccessioniPrimary (citable) accession number: Q643R3
Secondary accession number(s): A8K2K8
, O43412, Q7Z4P4, Q8IUL7, Q8TB38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 25, 2004
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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