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Entry version 142 (08 May 2019)
Sequence version 1 (25 Oct 2004)
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Protein

Lysophospholipid acyltransferase LPCAT4

Gene

LPCAT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=80 µM for lysophosphatidylethanolamine1 Publication
  2. KM=20 µM for oleoyl-CoA1 Publication
  1. Vmax=270 pmol/min/mg enzyme with lysophosphatidylethanolamine and oleoyl-CoA as substrates1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS16664-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.23 2681
2.3.1.51 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00085

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000294

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophospholipid acyltransferase LPCAT4
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 7
Short name:
1-AGP acyltransferase 7
Short name:
1-AGPAT 7
1-acylglycerophosphocholine O-acyltransferase (EC:2.3.1.23)
1-acylglycerophosphoserine O-acyltransferase (EC:2.3.1.n6)
1-alkenylglycerophosphoethanolamine O-acyltransferase (EC:2.3.1.121)
1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67)
Acyltransferase-like 3
Lysophosphatidylcholine acyltransferase 4
Lysophosphatidylethanolamine acyltransferase 2 (EC:2.3.1.n7)
Plasmalogen synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LPCAT4
Synonyms:AGPAT7, AYTL3, LPEAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30059 LPCAT4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612039 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q643R3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 62HelicalSequence analysisAdd BLAST23
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
254531

Open Targets

More...
OpenTargetsi
ENSG00000176454

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162394297

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LPCAT4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736281

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470541 – 524Lysophospholipid acyltransferase LPCAT4Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q643R3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q643R3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q643R3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q643R3

PeptideAtlas

More...
PeptideAtlasi
Q643R3

PRoteomics IDEntifications database

More...
PRIDEi
Q643R3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65914

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q643R3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q643R3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q643R3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with predominant level in brain.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176454 Expressed in 227 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q643R3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q643R3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030719

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129039, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317300

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi129 – 134HXXXXD motif6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4666 Eukaryota
ENOG410XSIQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182744

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234374

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q643R3

KEGG Orthology (KO)

More...
KOi
K13512

Identification of Orthologs from Complete Genome Data

More...
OMAi
QMLMFPE

Database of Orthologous Groups

More...
OrthoDBi
1266853at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q643R3

TreeFam database of animal gene trees

More...
TreeFami
TF323244

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002123 Plipid/glycerol_acylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01553 Acyltransferase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00563 PlsC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q643R3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGSPGDWA PLDPTPGPPA SPNPFVHELH LSRLQRVKFC LLGALLAPIR
60 70 80 90 100
VLLAFIVLFL LWPFAWLQVA GLSEEQLQEP ITGWRKTVCH NGVLGLSRLL
110 120 130 140 150
FFLLGFLRIR VRGQRASRLQ APVLVAAPHS TFFDPIVLLP CDLPKVVSRA
160 170 180 190 200
ENLSVPVIGA LLRFNQAILV SRHDPASRRR VVEEVRRRAT SGGKWPQVLF
210 220 230 240 250
FPEGTCSNKK ALLKFKPGAF IAGVPVQPVL IRYPNSLDTT SWAWRGPGVL
260 270 280 290 300
KVLWLTASQP CSIVDVEFLP VYHPSPEESR DPTLYANNVQ RVMAQALGIP
310 320 330 340 350
ATECEFVGSL PVIVVGRLKV ALEPQLWELG KVLRKAGLSA GYVDAGAEPG
360 370 380 390 400
RSRMISQEEF ARQLQLSDPQ TVAGAFGYFQ QDTKGLVDFR DVALALAALD
410 420 430 440 450
GGRSLEELTR LAFELFAEEQ AEGPNRLLYK DGFSTILHLL LGSPHPAATA
460 470 480 490 500
LHAELCQAGS SQGLSLCQFQ NFSLHDPLYG KLFSTYLRPP HTSRGTSQTP
510 520
NASSPGNPTA LANGTVQAPK QKGD
Length:524
Mass (Da):57,219
Last modified:October 25, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A2A12656E1241BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGT4A0A0C4DGT4_HUMAN
Lysophospholipid acyltransferase LP...
LPCAT4
351Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMK4H3BMK4_HUMAN
Lysophospholipid acyltransferase LP...
LPCAT4
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC19156 differs from that shown. Probable cloning artifact.Curated
The sequence AAC19156 differs from that shown. Reason: Frameshift at position 328.Curated
The sequence AAN33178 differs from that shown. Reason: Frameshift at position 198.Curated
The sequence AAP97722 differs from that shown. Reason: Frameshift at positions 188 and 198.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY734233 mRNA Translation: AAU34184.1
AF529233 mRNA Translation: AAP97722.1 Frameshift.
AF542964 mRNA Translation: AAN33178.1 Frameshift.
AK290273 mRNA Translation: BAF82962.1
CH471125 Genomic DNA Translation: EAW92306.1
BC024892 mRNA Translation: AAH24892.2
BC092463 mRNA Translation: AAH92463.1
AF007155 mRNA Translation: AAC19156.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32191.1

NCBI Reference Sequences

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RefSeqi
NP_705841.2, NM_153613.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314891; ENSP00000317300; ENSG00000176454

Database of genes from NCBI RefSeq genomes

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GeneIDi
254531

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:254531

UCSC genome browser

More...
UCSCi
uc001zig.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY734233 mRNA Translation: AAU34184.1
AF529233 mRNA Translation: AAP97722.1 Frameshift.
AF542964 mRNA Translation: AAN33178.1 Frameshift.
AK290273 mRNA Translation: BAF82962.1
CH471125 Genomic DNA Translation: EAW92306.1
BC024892 mRNA Translation: AAH24892.2
BC092463 mRNA Translation: AAH92463.1
AF007155 mRNA Translation: AAC19156.1 Sequence problems.
CCDSiCCDS32191.1
RefSeqiNP_705841.2, NM_153613.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi129039, 15 interactors
STRINGi9606.ENSP00000317300

Chemistry databases

SwissLipidsiSLP:000000294

PTM databases

iPTMnetiQ643R3
PhosphoSitePlusiQ643R3
SwissPalmiQ643R3

Polymorphism and mutation databases

BioMutaiLPCAT4
DMDMi74736281

Proteomic databases

EPDiQ643R3
jPOSTiQ643R3
MaxQBiQ643R3
PaxDbiQ643R3
PeptideAtlasiQ643R3
PRIDEiQ643R3
ProteomicsDBi65914

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314891; ENSP00000317300; ENSG00000176454
GeneIDi254531
KEGGihsa:254531
UCSCiuc001zig.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
254531
DisGeNETi254531

GeneCards: human genes, protein and diseases

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GeneCardsi
LPCAT4
HGNCiHGNC:30059 LPCAT4
HPAiHPA030719
MIMi612039 gene
neXtProtiNX_Q643R3
OpenTargetsiENSG00000176454
PharmGKBiPA162394297

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4666 Eukaryota
ENOG410XSIQ LUCA
GeneTreeiENSGT00950000182744
HOGENOMiHOG000234374
InParanoidiQ643R3
KOiK13512
OMAiQMLMFPE
OrthoDBi1266853at2759
PhylomeDBiQ643R3
TreeFamiTF323244

Enzyme and pathway databases

UniPathwayiUPA00085
BioCyciMetaCyc:HS16664-MONOMER
BRENDAi2.3.1.23 2681
2.3.1.51 2681
ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LPCAT4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
254531

Protein Ontology

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PROi
PR:Q643R3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176454 Expressed in 227 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ643R3 baseline and differential
GenevisibleiQ643R3 HS

Family and domain databases

InterProiView protein in InterPro
IPR002123 Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF01553 Acyltransferase, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPCT4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q643R3
Secondary accession number(s): A8K2K8
, O43412, Q7Z4P4, Q8IUL7, Q8TB38
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 25, 2004
Last modified: May 8, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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