UniProtKB - Q643R3 (LPCT4_HUMAN)

BLAST

>sp|Q643R3|LPCT4_HUMAN Lysophospholipid acyltransferase LPCAT4 OS=Homo sapiens OX=9606 GN=LPCAT4 PE=1 SV=1
MSQGSPGDWAPLDPTPGPPASPNPFVHELHLSRLQRVKFCLLGALLAPIRVLLAFIVLFL
LWPFAWLQVAGLSEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLQ
APVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRR
VVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTT
SWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYHPSPEESRDPTLYANNVQRVMAQALGIP
ATECEFVGSLPVIVVGRLKVALEPQLWELGKVLRKAGLSAGYVDAGAEPGRSRMISQEEF
ARQLQLSDPQTVAGAFGYFQQDTKGLVDFRDVALALAALDGGRSLEELTRLAFELFAEEQ
AEGPNRLLYKDGFSTILHLLLGSPHPAATALHAELCQAGSSQGLSLCQFQNFSLHDPLYG
KLFSTYLRPPHTSRGTSQTPNASSPGNPTALANGTVQAPKQKGD

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History
Entry version 136 (12 Sep 2018)
Sequence version 1 (25 Oct 2004)
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Protein

Lysophospholipid acyltransferase LPCAT4

Gene

LPCAT4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.1 Publication

Catalytic activityⁱ

Acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine.1 Publication

Acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine.1 Publication

Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.1 Publication

Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.1 Publication

Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylserine.1 Publication

Kineticsⁱ

V_max=
270 pmol/min/mg enzyme with lysophosphatidylethanolamine and oleoyl-CoA as substrates
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2."
  Cao J., Shan D., Revett T., Li D., Wu L., Liu W., Tobin J.F., Gimeno R.E.
  J. Biol. Chem. 283:19049-19057(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBSTRATE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Pathwayⁱ: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

GO - Molecular functionⁱ

1-acylglycerol-3-phosphate O-acyltransferase activity Source: Reactome
1-acylglycerophosphocholine O-acyltransferase activity Source: UniProtKB-EC
1-alkenylglycerophosphoethanolamine O-acyltransferase activity Source: UniProtKB-EC
1-alkylglycerophosphocholine O-acetyltransferase activity Source: UniProtKB-EC
2-acylglycerol-3-phosphate O-acyltransferase activity Source: Reactome
lysophospholipid acyltransferase activity
Source: MGI
Inferred from direct assayⁱ
- 18458083

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phosphatidic acid biosynthetic process Source: Reactome
phosphatidylcholine acyl-chain remodeling Source: Reactome
phosphatidylethanolamine acyl-chain remodeling Source: Reactome
phosphatidylglycerol acyl-chain remodeling Source: Reactome
phosphatidylserine acyl-chain remodeling Source: Reactome
phospholipid metabolic process
Source: MGI
Inferred from direct assayⁱ
- 18458083

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS16664-MONOMER
BRENDAⁱ	2.3.1.23 2681 2.3.1.51 2681
Reactomeⁱ	R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482801 Acyl chain remodelling of PS R-HSA-1482839 Acyl chain remodelling of PE R-HSA-1482925 Acyl chain remodelling of PG R-HSA-1483166 Synthesis of PA
UniPathwayⁱ	UPA00085

Chemistry databases

SwissLipidsⁱ	SLP:000000294

SwissLipidsⁱ

SLP:000000294

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lysophospholipid acyltransferase LPCAT4 Alternative name(s): 1-acylglycerol-3-phosphate O-acyltransferase 7 Short name: 1-AGP acyltransferase 7 Short name: 1-AGPAT 7 1-acylglycerophosphocholine O-acyltransferase (EC:2.3.1.23) 1-acylglycerophosphoserine O-acyltransferase (EC:2.3.1.n6) 1-alkenylglycerophosphoethanolamine O-acyltransferase (EC:2.3.1.121) 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67) Acyltransferase-like 3 Lysophosphatidylcholine acyltransferase 4 Lysophosphatidylethanolamine acyltransferase 2 (EC:2.3.1.n7) Plasmalogen synthase
Gene namesⁱ	Name:LPCAT4 Synonyms:AGPAT7, AYTL3, LPEAT2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176454.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30059 LPCAT4
MIMⁱ	612039 gene
neXtProtⁱ	NX_Q643R3

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	40 – 62	HelicalSequence analysisAdd BLAST		23
Transmembraneⁱ	87 – 107	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	254531
Open Targets More...OpenTargetsⁱ	ENSG00000176454
PharmGKBⁱ	PA162394297

Polymorphism and mutation databases

BioMutaⁱ	LPCAT4
DMDMⁱ	74736281

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000247054	1 – 524	Lysophospholipid acyltransferase LPCAT4Add BLAST		524

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	152	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q643R3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q643R3
PaxDbⁱ	Q643R3
PeptideAtlas More...PeptideAtlasⁱ	Q643R3
PRIDEⁱ	Q643R3
ProteomicsDBⁱ	65914

PTM databases

iPTMnetⁱ	Q643R3
PhosphoSitePlusⁱ	Q643R3
SwissPalmⁱ	Q643R3

Expressionⁱ

Tissue specificityⁱ

Widely expressed with predominant level in brain.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000176454 Expressed in 227 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_LPCAT4
ExpressionAtlasⁱ	Q643R3 baseline and differential
Genevisibleⁱ	Q643R3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030719

HPAⁱ

HPA030719

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	129039, 13 interactors
STRINGⁱ	9606.ENSP00000317300

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q643R3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	129 – 134	HXXXXD motif		6

Sequence similaritiesⁱ

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4666 Eukaryota ENOG410XSIQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004914
HOGENOMⁱ	HOG000234374
InParanoidⁱ	Q643R3
KEGG Orthology (KO) More...KOⁱ	K13512
OMAⁱ	LRPPHTS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09LH
PhylomeDBⁱ	Q643R3
TreeFamⁱ	TF323244

Family and domain databases

InterProⁱ	View protein in InterPro IPR002123 Plipid/glycerol_acylTrfase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit
SMARTⁱ	View protein in SMART SM00563 PlsC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q643R3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQGSPGDWA PLDPTPGPPA SPNPFVHELH LSRLQRVKFC LLGALLAPIR 
        60         70         80         90        100
VLLAFIVLFL LWPFAWLQVA GLSEEQLQEP ITGWRKTVCH NGVLGLSRLL 
       110        120        130        140        150
FFLLGFLRIR VRGQRASRLQ APVLVAAPHS TFFDPIVLLP CDLPKVVSRA 
       160        170        180        190        200
ENLSVPVIGA LLRFNQAILV SRHDPASRRR VVEEVRRRAT SGGKWPQVLF 
       210        220        230        240        250
FPEGTCSNKK ALLKFKPGAF IAGVPVQPVL IRYPNSLDTT SWAWRGPGVL 
       260        270        280        290        300
KVLWLTASQP CSIVDVEFLP VYHPSPEESR DPTLYANNVQ RVMAQALGIP 
       310        320        330        340        350
ATECEFVGSL PVIVVGRLKV ALEPQLWELG KVLRKAGLSA GYVDAGAEPG 
       360        370        380        390        400
RSRMISQEEF ARQLQLSDPQ TVAGAFGYFQ QDTKGLVDFR DVALALAALD 
       410        420        430        440        450
GGRSLEELTR LAFELFAEEQ AEGPNRLLYK DGFSTILHLL LGSPHPAATA 
       460        470        480        490        500
LHAELCQAGS SQGLSLCQFQ NFSLHDPLYG KLFSTYLRPP HTSRGTSQTP 
       510        520 
NASSPGNPTA LANGTVQAPK QKGD

Length:524

Mass (Da):57,219

Last modified:October 25, 2004 - v1

Checksum:ⁱ3A2A12656E1241BC

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DGT4	A0A0C4DGT4_HUMAN	Lysophospholipid acyltransferase LP... Lysophospholipid acyltransferase LPCAT4	LPCAT4	351	Annotation score:
H3BMK4	H3BMK4_HUMAN	Lysophospholipid acyltransferase LP... Lysophospholipid acyltransferase LPCAT4	LPCAT4	84	Annotation score:

Sequence cautionⁱ

The sequence AAC19156 differs from that shown. Probable cloning artifact.Curated

The sequence AAC19156 differs from that shown. Reason: Frameshift at position 328.Curated

The sequence AAN33178 differs from that shown. Reason: Frameshift at position 198.Curated

The sequence AAP97722 differs from that shown. Reason: Frameshift at positions 188 and 198.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY734233 mRNA Translation: AAU34184.1 AF529233 mRNA Translation: AAP97722.1 Frameshift. AF542964 mRNA Translation: AAN33178.1 Frameshift. AK290273 mRNA Translation: BAF82962.1 CH471125 Genomic DNA Translation: EAW92306.1 BC024892 mRNA Translation: AAH24892.2 BC092463 mRNA Translation: AAH92463.1 AF007155 mRNA Translation: AAC19156.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32191.1
NCBI Reference Sequences More...RefSeqⁱ	NP_705841.2, NM_153613.2
UniGeneⁱ	Hs.352614

Genome annotation databases

Ensemblⁱ	ENST00000314891; ENSP00000317300; ENSG00000176454
GeneIDⁱ	254531
KEGGⁱ	hsa:254531
UCSC genome browser More...UCSCⁱ	uc001zig.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q643R3	LPCAT4 protein (Fragment)		HUMAN		397	UniRef100_Q643R3

Protein	Similar proteins		Species	Score	Length	Source
Q643R3	Lysophospholipid acyltransferase LPCAT4		MOUSE		524	UniRef90_Q643R3
LPCAT4 protein (Fragment)		HUMAN		397
Uncharacterized protein		RABIT		525
Uncharacterized protein		MACMU		524
Uncharacterized protein		MACFA		524
+66

Protein	Similar proteins		Species	Score	Length	Source
Q643R3	Lysophospholipid acyltransferase LPCAT4		MOUSE		524	UniRef50_Q643R3
LPCAT4 protein (Fragment)		HUMAN		397
Uncharacterized protein		RABIT		525
lysophospholipid acyltransferase LPCAT4		MESAU		524
Lysophosphatidylcholine acyltransferase 4		CALJA		524
+67

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY734233 mRNA Translation: AAU34184.1 AF529233 mRNA Translation: AAP97722.1 Frameshift. AF542964 mRNA Translation: AAN33178.1 Frameshift. AK290273 mRNA Translation: BAF82962.1 CH471125 Genomic DNA Translation: EAW92306.1 BC024892 mRNA Translation: AAH24892.2 BC092463 mRNA Translation: AAH92463.1 AF007155 mRNA Translation: AAC19156.1 Sequence problems.
CCDSⁱ	CCDS32191.1
RefSeqⁱ	NP_705841.2, NM_153613.2
UniGeneⁱ	Hs.352614

3D structure databases

ProteinModelPortalⁱ	Q643R3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129039, 13 interactors
STRINGⁱ	9606.ENSP00000317300

Chemistry databases

SwissLipidsⁱ	SLP:000000294

SwissLipidsⁱ

SLP:000000294

PTM databases

iPTMnetⁱ	Q643R3
PhosphoSitePlusⁱ	Q643R3
SwissPalmⁱ	Q643R3

Polymorphism and mutation databases

BioMutaⁱ	LPCAT4
DMDMⁱ	74736281

Proteomic databases

EPDⁱ	Q643R3
MaxQBⁱ	Q643R3
PaxDbⁱ	Q643R3
PeptideAtlasⁱ	Q643R3
PRIDEⁱ	Q643R3
ProteomicsDBⁱ	65914

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000314891; ENSP00000317300; ENSG00000176454
GeneIDⁱ	254531
KEGGⁱ	hsa:254531
UCSCⁱ	uc001zig.4 human

Organism-specific databases

CTDⁱ	254531
DisGeNETⁱ	254531
EuPathDBⁱ	HostDB:ENSG00000176454.13
GeneCardsⁱ	LPCAT4
HGNCⁱ	HGNC:30059 LPCAT4
HPAⁱ	HPA030719
MIMⁱ	612039 gene
neXtProtⁱ	NX_Q643R3
OpenTargetsⁱ	ENSG00000176454
PharmGKBⁱ	PA162394297
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4666 Eukaryota ENOG410XSIQ LUCA
GeneTreeⁱ	ENSGT00390000004914
HOGENOMⁱ	HOG000234374
InParanoidⁱ	Q643R3
KOⁱ	K13512
OMAⁱ	LRPPHTS
OrthoDBⁱ	EOG091G09LH
PhylomeDBⁱ	Q643R3
TreeFamⁱ	TF323244

Enzyme and pathway databases

UniPathwayⁱ	UPA00085
BioCycⁱ	MetaCyc:HS16664-MONOMER
BRENDAⁱ	2.3.1.23 2681 2.3.1.51 2681
Reactomeⁱ	R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482801 Acyl chain remodelling of PS R-HSA-1482839 Acyl chain remodelling of PE R-HSA-1482925 Acyl chain remodelling of PG R-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRSⁱ	LPCAT4 human
GenomeRNAiⁱ	254531
Protein Ontology More...PROⁱ	PR:Q643R3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000176454 Expressed in 227 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_LPCAT4
ExpressionAtlasⁱ	Q643R3 baseline and differential
Genevisibleⁱ	Q643R3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002123 Plipid/glycerol_acylTrfase
Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit
SMARTⁱ	View protein in SMART SM00563 PlsC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LPCT4_HUMAN
Accessionⁱ	Q643R3Primary (citable) accession number: Q643R3 Secondary accession number(s): A8K2K8 , O43412, Q7Z4P4, Q8IUL7, Q8TB38
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
	Last sequence update:	October 25, 2004
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q643R3 (LPCT4_HUMAN)

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Lysophospholipid acyltransferase LPCAT4

LPCAT4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phospholipid metabolism

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

Pathwayⁱ: phospholipid metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ