Bcl-2-like protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• BH3 domain binding Source: MGI
• BH domain binding Source: MGI
• clathrin binding Source: MGI
• cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: MGI
• GTPase binding Source: MGI
• identical protein binding Source: MGI
• MDM2/MDM4 family protein binding Source: MGI
• protein-containing complex binding Source: MGI
• protein heterodimerization activity Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Bcl-XL and Bcl-2 repress a common pathway of cell death."
    Chao D.T., Linette G.P., Boise L.H., White L.S., Thompson C.B., Korsmeyer S.J.
    J. Exp. Med. 182:821-828(1995) [PubMed] [Europe PMC] [Abstract]
  • "Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death."
    Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., Korsmeyer S.J.
    Cell 80:285-291(1995) [PubMed] [Europe PMC] [Abstract]
  • "BID: a novel BH3 domain-only death agonist."
    Wang K., Yin X.-M., Chao D.T., Milliman C.L., Korsmeyer S.J.
    Genes Dev. 10:2859-2869(1996) [PubMed] [Europe PMC] [Abstract]
  • "Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL."
    Simonian P.L., Grillot D.A., Merino R., Nunez G.
    J. Biol. Chem. 271:22764-22772(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: MGI
• transcription factor binding Source: MGI

GO - Biological processⁱ

• apoptotic process in bone marrow cell Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death."
    Roth K.A., Kuan C., Haydar T.F., D'Sa-Eipper C., Shindler K.S., Zheng T.S., Kuida K., Flavell R.A., Rakic P.
    Proc. Natl. Acad. Sci. U.S.A. 97:466-471(2000) [PubMed] [Europe PMC] [Abstract]
• cell population proliferation Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene."
    Tzung S.P., Fausto N., Hockenbery D.M.
    Am. J. Pathol. 150:1985-1995(1997) [PubMed] [Europe PMC] [Abstract]
• cellular process regulating host cell cycle in response to virus Source: MGIInferred from mutant phenotypeⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to alkaloid Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to amino acid stimulus Source: MGIInferred from mutant phenotypeⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to gamma radiation Source: MGIInferred from mutant phenotypeⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• extrinsic apoptotic signaling pathway in absence of ligand Source: MGIInferred from mutant phenotypeⁱ
  • "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad."
    Ayllon V., Cayla X., Garcia A., Fleischer A., Rebollo A.
    Eur. J. Immunol. 32:1847-1855(2002) [PubMed] [Europe PMC] [Abstract]
• fertilization Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis."
    Rucker E.B., Dierisseau P., Wagner K.U., Garrett L., Wynshaw-Boris A., Flaws J.A., Hennighausen L.
    Mol. Endocrinol. 14:1038-1052(2000) [PubMed] [Europe PMC] [Abstract]
• germ cell development Source: MGIInferred from mutant phenotypeⁱ
  • "Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis."
    Rucker E.B., Dierisseau P., Wagner K.U., Garrett L., Wynshaw-Boris A., Flaws J.A., Hennighausen L.
    Mol. Endocrinol. 14:1038-1052(2000) [PubMed] [Europe PMC] [Abstract]
• hepatocyte apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death."
    Roth K.A., Kuan C., Haydar T.F., D'Sa-Eipper C., Shindler K.S., Zheng T.S., Kuida K., Flavell R.A., Rakic P.
    Proc. Natl. Acad. Sci. U.S.A. 97:466-471(2000) [PubMed] [Europe PMC] [Abstract]
• intrinsic apoptotic signaling pathway in response to DNA damage Source: MGIInferred from mutant phenotypeⁱ
  • "c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL."
    Maclean K.H., Keller U.B., Rodriguez-Galindo C., Nilsson J.A., Cleveland J.L.
    Mol. Cell. Biol. 23:7256-7270(2003) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death."
    Roth K.A., Kuan C., Haydar T.F., D'Sa-Eipper C., Shindler K.S., Zheng T.S., Kuida K., Flavell R.A., Rakic P.
    Proc. Natl. Acad. Sci. U.S.A. 97:466-471(2000) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: MGIInferred from mutant phenotypeⁱ
  • "Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis."
    Rucker E.B., Dierisseau P., Wagner K.U., Garrett L., Wynshaw-Boris A., Flaws J.A., Hennighausen L.
    Mol. Endocrinol. 14:1038-1052(2000) [PubMed] [Europe PMC] [Abstract]
• mitochondrion morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Bcl-2 family interaction with the mitochondrial morphogenesis machinery."
    Cleland M.M., Norris K.L., Karbowski M., Wang C., Suen D.F., Jiao S., George N.M., Luo X., Li Z., Youle R.J.
    Cell Death Differ. 18:235-247(2011) [PubMed] [Europe PMC] [Abstract]
• mitotic cell cycle checkpoint Source: UniProtKB
• negative regulation of anoikis Source: MGI
• negative regulation of apoptotic process Source: MGIInferred from direct assayⁱ
  • "Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity."
    Dramsi S., Scheid M.P., Maiti A., Hojabrpour P., Chen X., Schubert K., Goodlett D.R., Aebersold R., Duronio V.
    J. Biol. Chem. 277:6399-6405(2002) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the lifespan in dendritic cell subsets."
    Chen M., Huang L., Shabier Z., Wang J.
    Mol. Immunol. 44:2558-2565(2007) [PubMed] [Europe PMC] [Abstract]
  • "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins."
    Chen G., Cizeau J., Vande Velde C., Park J.H., Bozek G., Bolton J., Shi L., Dubik D., Greenberg A.
    J. Biol. Chem. 274:7-10(1999) [PubMed] [Europe PMC] [Abstract]
  • Ref.2

    "bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria."
    Gonzalez-Garcia M., Perez-Ballestero R., Ding L., Duan L., Boise L.H., Thompson C.B., Nunez G.
    Development 120:3033-3042(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BCL-X(L) AND BCL-X(BETA)), DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • "Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells."
    Heermeier K., Benedict M., Li M., Furth P., Nunez G., Hennighausen L.
    Mech. Dev. 56:197-207(1996) [PubMed] [Europe PMC] [Abstract]
• negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: UniProtKB
• negative regulation of execution phase of apoptosis Source: UniProtKB
• negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGIInferred from sequence orthologyⁱ
  • "Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells."
    Urresti J., Ruiz-Meana M., Coccia E., Arevalo J.C., Castellano J., Fernandez-Sanz C., Galenkamp K.M., Planells-Ferrer L., Moubarak R.S., Llecha-Cano N., Reix S., Garcia-Dorado D., Barneda-Zahonero B., Comella J.X.
    J. Biol. Chem. 291:1221-1234(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of intrinsic apoptotic signaling pathway Source: MGI
• negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
• negative regulation of neuron apoptotic process Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
  • "bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death."
    Gonzalez-Garcia M., Garcia I., Ding L., O'Shea S., Boise L.H., Thompson C.B., Nunez G.
    Proc. Natl. Acad. Sci. U.S.A. 92:4304-4308(1995) [PubMed] [Europe PMC] [Abstract]
  • "Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors."
    Middleton G., Nunez G., Davies A.M.
    Development 122:695-701(1996) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein localization to plasma membrane Source: MGI
• negative regulation of release of cytochrome c from mitochondria Source: MGI
• neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death."
    Roth K.A., Kuan C., Haydar T.F., D'Sa-Eipper C., Shindler K.S., Zheng T.S., Kuida K., Flavell R.A., Rakic P.
    Proc. Natl. Acad. Sci. U.S.A. 97:466-471(2000) [PubMed] [Europe PMC] [Abstract]
• ovarian follicle development Source: MGIInferred from mutant phenotypeⁱ
  • "Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis."
    Rucker E.B., Dierisseau P., Wagner K.U., Garrett L., Wynshaw-Boris A., Flaws J.A., Hennighausen L.
    Mol. Endocrinol. 14:1038-1052(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: MGIInferred from direct assayⁱ
  • "Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells."
    Heermeier K., Benedict M., Li M., Furth P., Nunez G., Hennighausen L.
    Mech. Dev. 56:197-207(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ATP biosynthetic process Source: MGI
• positive regulation of cell population proliferation Source: MGIInferred from direct assayⁱ
  • "Regulation of the lifespan in dendritic cell subsets."
    Chen M., Huang L., Shabier Z., Wang J.
    Mol. Immunol. 44:2558-2565(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synaptic vesicle clustering Source: MGI
• positive regulation of synaptic vesicle endocytosis Source: MGI
• positive regulation of synaptic vesicle exocytosis Source: MGI
• regulation of apoptotic process Source: MGI
• regulation of cytokinesis Source: UniProtKB
• regulation of growth Source: MGIInferred from mutant phenotypeⁱ
  • "Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis."
    Rucker E.B., Dierisseau P., Wagner K.U., Garrett L., Wynshaw-Boris A., Flaws J.A., Hennighausen L.
    Mol. Endocrinol. 14:1038-1052(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of long-term synaptic depression Source: MGI
• regulation of mitochondrial membrane permeability Source: MGI
• regulation of mitochondrial membrane potential Source: MGI
• release of cytochrome c from mitochondria Source: MGIInferred from genetic interactionⁱ
  • "A stapled BID BH3 helix directly binds and activates BAX."
    Walensky L.D., Pitter K., Morash J., Oh K.J., Barbuto S., Fisher J., Smith E., Verdine G.L., Korsmeyer S.J.
    Mol. Cell 24:199-210(2006) [PubMed] [Europe PMC] [Abstract]
• response to cycloheximide Source: MGIInferred from direct assayⁱ
  • "Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene."
    Tzung S.P., Fausto N., Hockenbery D.M.
    Am. J. Pathol. 150:1985-1995(1997) [PubMed] [Europe PMC] [Abstract]
• response to cytokine Source: MGIInferred from sequence orthologyⁱ
  • "The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression."
    Li L., Krajewski S., Reed J.C., Choi Y.S.
    Cell. Immunol. 178:33-41(1997) [PubMed] [Europe PMC] [Abstract]
• response to ischemia Source: MGI
• response to radiation Source: MGIInferred from mutant phenotypeⁱ
  • "c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL."
    Maclean K.H., Keller U.B., Rodriguez-Galindo C., Nilsson J.A., Cleveland J.L.
    Mol. Cell. Biol. 23:7256-7270(2003) [PubMed] [Europe PMC] [Abstract]
• response to virus Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: MGIInferred from genetic interactionⁱ
  • "Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis."
    Rucker E.B., Dierisseau P., Wagner K.U., Garrett L., Wynshaw-Boris A., Flaws J.A., Hennighausen L.
    Mol. Endocrinol. 14:1038-1052(2000) [PubMed] [Europe PMC] [Abstract]
• suppression by virus of host apoptotic process Source: MGIInferred from sequence orthologyⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• synaptic vesicle recycling via endosome Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• BH3 domain binding Source: MGI
• BH domain binding Source: MGI
• clathrin binding Source: MGI
• GTPase binding Source: MGI
• identical protein binding Source: MGI
• MDM2/MDM4 family protein binding Source: MGI
• protein heterodimerization activity Source: MGIInferred from physical interactionⁱ
  • "Bcl-XL and Bcl-2 repress a common pathway of cell death."
    Chao D.T., Linette G.P., Boise L.H., White L.S., Thompson C.B., Korsmeyer S.J.
    J. Exp. Med. 182:821-828(1995) [PubMed] [Europe PMC] [Abstract]
  • "Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death."
    Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., Korsmeyer S.J.
    Cell 80:285-291(1995) [PubMed] [Europe PMC] [Abstract]
  • "BID: a novel BH3 domain-only death agonist."
    Wang K., Yin X.-M., Chao D.T., Milliman C.L., Korsmeyer S.J.
    Genes Dev. 10:2859-2869(1996) [PubMed] [Europe PMC] [Abstract]
  • "Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL."
    Simonian P.L., Grillot D.A., Merino R., Nunez G.
    J. Biol. Chem. 271:22764-22772(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: MGI
• transcription factor binding Source: MGI

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEAERETPSA 
        60         70         80         90        100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR 
       110        120        130        140        150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL 
       160        170        180        190        200
CVESVDKEMQ VLVSRIASWM ATYLNDHLEP WIQENGGWDT FVDLYGNNAA 
       210        220        230 
AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK                   

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEAERETPSA 
        60         70         80         90        100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR 
       110        120        130        140        150
YRRAFSDLTS QLHITPGTAY QSFEQDTFVD LYGNNAAAES RKGQERFNRW 
       160        170
FLTGMTVAGV VLLGSLFSRK                                  

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEAERETPSA 
        60         70         80         90        100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR 
       110        120        130        140        150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL 
       160        170        180        190        200
CVESVDKEMQ VLVSRIASWM ATYLNDHLEP WIQENGGWVR TTPLVCPPLA 

CVSLLCEHP                                              

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEAERETPSA 
        60         70         80         90        100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR 
       110        120        130        140        150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL 
       160        170        180        190        200
CVESVDKEMQ VLVSRIASWM ATYLNDHLEP WIQENGGWDT FVDGHDCGWC 
       210 
GSAGLTLQSE VTRH                                        

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references