UniProtKB - Q64373 (B2CL1_MOUSE)
Bcl-2-like protein 1
Bcl2l1
Functioni
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
1 PublicationIsoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles (By similarity).
May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).
By similarityIsoform Bcl-X(S) promotes apoptosis.
By similarityGO - Molecular functioni
- BH3 domain binding Source: MGI
- BH domain binding Source: MGI
- clathrin binding Source: MGI
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: MGI
- GTPase binding Source: MGI
- identical protein binding Source: MGI
- MDM2/MDM4 family protein binding Source: MGI
- protein-containing complex binding Source: MGI
- protein heterodimerization activity Source: GO_Central
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: MGI
GO - Biological processi
- apoptotic process in bone marrow cell Source: MGI
- cell population proliferation Source: MGI
- cellular response to alkaloid Source: MGI
- cellular response to amino acid stimulus Source: MGI
- cellular response to gamma radiation Source: MGI
- defense response to virus Source: MGI
- extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
- fertilization Source: MGI
- germ cell development Source: MGI
- hepatocyte apoptotic process Source: MGI
- intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
- in utero embryonic development Source: MGI
- male gonad development Source: MGI
- mitochondrion morphogenesis Source: MGI
- negative regulation of anoikis Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: UniProtKB
- negative regulation of execution phase of apoptosis Source: UniProtKB
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
- negative regulation of intrinsic apoptotic signaling pathway Source: MGI
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of protein localization to plasma membrane Source: MGI
- neuron apoptotic process Source: MGI
- ovarian follicle development Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of ATP biosynthetic process Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of synaptic vesicle clustering Source: MGI
- positive regulation of synaptic vesicle endocytosis Source: MGI
- positive regulation of synaptic vesicle exocytosis Source: MGI
- regulation of apoptotic process Source: MGI
- regulation of cytokinesis Source: UniProtKB
- regulation of growth Source: MGI
- regulation of long-term synaptic depression Source: MGI
- regulation of mitochondrial membrane permeability Source: MGI
- regulation of mitochondrial membrane potential Source: MGI
- release of cytochrome c from mitochondria Source: MGI
- response to cycloheximide Source: MGI
- response to cytokine Source: MGI
- response to ischemia Source: MGI
- response to radiation Source: MGI
- response to virus Source: MGI
- spermatogenesis Source: MGI
- suppression by virus of host apoptotic process Source: MGI
- synaptic vesicle recycling via endosome Source: MGI
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
Reactomei | R-MMU-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-MMU-844455, The NLRP1 inflammasome R-MMU-9648002, RAS processing |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-like protein 1Short name: Bcl2-L-1 Alternative name(s): Apoptosis regulator Bcl-X |
Gene namesi | Name:Bcl2l1 Synonyms:Bcl2l, Bclx |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88139, Bcl2l1 |
VEuPathDBi | HostDB:ENSMUSG00000007659 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Mitochondrion
- Mitochondrion membrane 1 Publication; Single-pass membrane protein 1 Publication
Nucleus
- Nucleus membrane By similarity; Single-pass membrane protein By similarity; Cytoplasmic side By similarity
Note: Localizes to the centrosome when phosphorylated at Ser-49.
Cytoplasm and Cytosol
- cytosol By similarity
Mitochondrion
Other locations
- synaptic vesicle membrane By similarity
Note: After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner.By similarity
Cytoplasm and Cytosol
Cytoskeleton
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: MGI
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Mitochondrion
- mitochondrial envelope Source: MGI
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrial membrane Source: MGI
- mitochondrial outer membrane Source: MGI
- mitochondrion Source: MGI
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- Bcl-2 family protein complex Source: MGI
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
- presynapse Source: MGI
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 210 – 226 | HelicalSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane, Nucleus, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143063 | 1 – 233 | Bcl-2-like protein 1Add BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | Phosphoserine; by PLK3By similarity | 1 | |
Modified residuei | 62 | Phosphoserine; by CDK1By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q64373 |
PaxDbi | Q64373 |
PRIDEi | Q64373 |
ProteomicsDBi | 273510 [Q64373-1] 273511 [Q64373-2] 273512 [Q64373-3] 273513 [Q64373-4] |
PTM databases
iPTMneti | Q64373 |
PhosphoSitePlusi | Q64373 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000007659, Expressed in bone marrow and 312 other tissues |
ExpressionAtlasi | Q64373, baseline and differential |
Genevisiblei | Q64373, MM |
Interactioni
Subunit structurei
Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity.
Interacts with BAD.
Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity.
Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3.
Interacts with HEBP2. Isoform Bcl-X(L) interacts with BOP.
Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF.
Interacts with ATP5F1A and ATP5F1B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F1F0 ATP synthase (By similarity).
Interacts with VDAC1 (By similarity). Isoform Bcl-X(L) interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV.
Interacts with BCL2L11 (via BH3) (PubMed:27013495, PubMed:14499110).
Interacts with RNF183 (By similarity).
Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771).
Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and BCL2L1 is impaired in the absence of GIMAP5 (PubMed:21502331).
Interacts with CLU (isoform 4); this interaction releases and activates BAX and promotes cell death (By similarity).
By similarity4 PublicationsBinary interactionsi
Q64373
With | #Exp. | IntAct |
---|---|---|
E [P59637] from Severe acute respiratory syndrome coronavirus. | 2 | EBI-526361,EBI-25487741 |
Isoform Bcl-X(L) [Q64373-1]
With | #Exp. | IntAct |
---|---|---|
Bad [Q61337] | 2 | EBI-526380,EBI-400328 |
GO - Molecular functioni
- BH3 domain binding Source: MGI
- BH domain binding Source: MGI
- clathrin binding Source: MGI
- GTPase binding Source: MGI
- identical protein binding Source: MGI
- MDM2/MDM4 family protein binding Source: MGI
- protein heterodimerization activity Source: GO_Central
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198323, 25 interactors |
ComplexPortali | CPX-2021, BAD:BCL-XL complex [Q64373-1] CPX-2025, BIM:BCL-XL complex [Q64373-1] CPX-2029, PUMA:BCL-XL complex [Q64373-1] CPX-2037, BID:BCL-XL complex [Q64373-1] CPX-299, BCL-XL complex [Q64373-1] |
CORUMi | Q64373 |
ELMi | Q64373 |
IntActi | Q64373, 9 interactors |
STRINGi | 10090.ENSMUSP00000007803 |
Chemistry databases
BindingDBi | Q64373 |
Miscellaneous databases
RNActi | Q64373, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q64373 |
SMRi | Q64373 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q64373 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 73 | DisorderedSequence analysisAdd BLAST | 47 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 4 – 24 | BH4Add BLAST | 21 | |
Motifi | 86 – 100 | BH3Add BLAST | 15 | |
Motifi | 129 – 148 | BH1Add BLAST | 20 | |
Motifi | 180 – 195 | BH2Add BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 32 – 46 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4728, Eukaryota |
GeneTreei | ENSGT01020000230347 |
InParanoidi | Q64373 |
OMAi | RIASWMT |
PhylomeDBi | Q64373 |
TreeFami | TF315834 |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
DisProti | DP02817 |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013279, Apop_reg_BclX IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR004725, Bcl2/BclX IPR020717, Bcl2_BH1_motif_CS IPR020726, Bcl2_BH2_motif_CS IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF12, PTHR11256:SF12, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01864, APOPREGBCLX PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
TIGRFAMsi | TIGR00865, bcl-2, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01258, BH2, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEAERETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL
160 170 180 190 200
CVESVDKEMQ VLVSRIASWM ATYLNDHLEP WIQENGGWDT FVDLYGNNAA
210 220 230
AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK
The sequence of this isoform differs from the canonical sequence as follows:
126-188: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
189-233: DTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK → VRTTPLVCPPLACVSLLCEHP
The sequence of this isoform differs from the canonical sequence as follows:
194-233: LYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK → GHDCGWCGSAGLTLQSEVTRH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9QWX2 | Q9QWX2_MOUSE | Apoptosis regulator Bcl-X | Bcl2l1 Bcl2l | 188 | Annotation score: | ||
A2AHX9 | A2AHX9_MOUSE | Apoptosis regulator Bcl-X | Bcl2l1 | 154 | Annotation score: | ||
A2AHX8 | A2AHX8_MOUSE | Bcl-2-like protein 1 | Bcl2l1 | 96 | Annotation score: | ||
A2AHX7 | A2AHX7_MOUSE | Bcl-2-like protein 1 | Bcl2l1 | 78 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 207 – 209 | QER → KEG in AAC53459 (PubMed:9390687).Curated | 3 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000517 | 126 – 188 | Missing in isoform Bcl-X(S). CuratedAdd BLAST | 63 | |
Alternative sequenceiVSP_000518 | 189 – 233 | DTFVD…LFSRK → VRTTPLVCPPLACVSLLCEH P in isoform Bcl-X(beta). CuratedAdd BLAST | 45 | |
Alternative sequenceiVSP_000519 | 194 – 233 | LYGNN…LFSRK → GHDCGWCGSAGLTLQSEVTR H in isoform Bcl-X(delta-TM). CuratedAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83574 mRNA Translation: CAA58557.1 L35049 mRNA Translation: AAA51039.1 L35048 mRNA Translation: AAA51040.1 U10102 mRNA Translation: AAA82174.1 U10101 mRNA Translation: AAA82173.1 U10100 mRNA Translation: AAA82172.1 U51278 mRNA Translation: AAC53459.1 U51279 mRNA Translation: AAC53460.1 U78031, U78030 Genomic DNA Translation: AAB96881.1 |
CCDSi | CCDS16899.1 [Q64373-1] |
PIRi | I49055 I49056 I49057 |
RefSeqi | NP_001276645.1, NM_001289716.1 [Q64373-1] NP_001276646.1, NM_001289717.1 [Q64373-1] NP_033873.3, NM_009743.5 [Q64373-1] XP_006498672.1, XM_006498609.3 XP_006498674.1, XM_006498611.3 [Q64373-1] XP_006498675.1, XM_006498612.2 [Q64373-1] XP_011237562.1, XM_011239260.2 [Q64373-1] |
Genome annotation databases
Ensembli | ENSMUST00000007803; ENSMUSP00000007803; ENSMUSG00000007659 [Q64373-1] ENSMUST00000109820; ENSMUSP00000105445; ENSMUSG00000007659 [Q64373-1] ENSMUST00000134902; ENSMUSP00000134614; ENSMUSG00000007659 [Q64373-3] ENSMUST00000140436; ENSMUSP00000134596; ENSMUSG00000007659 [Q64373-3] |
GeneIDi | 12048 |
KEGGi | mmu:12048 |
UCSCi | uc008ngi.2, mouse [Q64373-2] uc008ngj.2, mouse [Q64373-1] uc008ngn.2, mouse [Q64373-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83574 mRNA Translation: CAA58557.1 L35049 mRNA Translation: AAA51039.1 L35048 mRNA Translation: AAA51040.1 U10102 mRNA Translation: AAA82174.1 U10101 mRNA Translation: AAA82173.1 U10100 mRNA Translation: AAA82172.1 U51278 mRNA Translation: AAC53459.1 U51279 mRNA Translation: AAC53460.1 U78031, U78030 Genomic DNA Translation: AAB96881.1 |
CCDSi | CCDS16899.1 [Q64373-1] |
PIRi | I49055 I49056 I49057 |
RefSeqi | NP_001276645.1, NM_001289716.1 [Q64373-1] NP_001276646.1, NM_001289717.1 [Q64373-1] NP_033873.3, NM_009743.5 [Q64373-1] XP_006498672.1, XM_006498609.3 XP_006498674.1, XM_006498611.3 [Q64373-1] XP_006498675.1, XM_006498612.2 [Q64373-1] XP_011237562.1, XM_011239260.2 [Q64373-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PQ0 | X-ray | 2.20 | A | 1-196 | [»] | |
1PQ1 | X-ray | 1.65 | A | 1-196 | [»] | |
2BZW | X-ray | 2.30 | A | 1-211 | [»] | |
3IHC | X-ray | 1.85 | A | 1-196 | [»] | |
3IHD | X-ray | 1.88 | A | 1-196 | [»] | |
3IHE | X-ray | 3.00 | A | 1-196 | [»] | |
3IHF | X-ray | 2.28 | A/B/C/D | 1-196 | [»] | |
3IIG | X-ray | 2.30 | A | 1-196 | [»] | |
3IIH | X-ray | 2.75 | A | 1-196 | [»] | |
3ILB | X-ray | 2.38 | A/N | 1-196 | [»] | |
3ILC | X-ray | 1.64 | A | 1-196 | [»] | |
4YJ4 | X-ray | 2.10 | A | 1-196 | [»] | |
4YK9 | X-ray | 1.70 | A/F | 2-196 | [»] | |
5C3G | X-ray | 2.45 | A | 1-26 | [»] | |
BMRBi | Q64373 | |||||
SMRi | Q64373 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198323, 25 interactors |
ComplexPortali | CPX-2021, BAD:BCL-XL complex [Q64373-1] CPX-2025, BIM:BCL-XL complex [Q64373-1] CPX-2029, PUMA:BCL-XL complex [Q64373-1] CPX-2037, BID:BCL-XL complex [Q64373-1] CPX-299, BCL-XL complex [Q64373-1] |
CORUMi | Q64373 |
ELMi | Q64373 |
IntActi | Q64373, 9 interactors |
STRINGi | 10090.ENSMUSP00000007803 |
Chemistry databases
BindingDBi | Q64373 |
ChEMBLi | CHEMBL3309112 |
PTM databases
iPTMneti | Q64373 |
PhosphoSitePlusi | Q64373 |
Proteomic databases
MaxQBi | Q64373 |
PaxDbi | Q64373 |
PRIDEi | Q64373 |
ProteomicsDBi | 273510 [Q64373-1] 273511 [Q64373-2] 273512 [Q64373-3] 273513 [Q64373-4] |
Protocols and materials databases
Antibodypediai | 3430, 2000 antibodies from 52 providers |
DNASUi | 12048 |
Genome annotation databases
Ensembli | ENSMUST00000007803; ENSMUSP00000007803; ENSMUSG00000007659 [Q64373-1] ENSMUST00000109820; ENSMUSP00000105445; ENSMUSG00000007659 [Q64373-1] ENSMUST00000134902; ENSMUSP00000134614; ENSMUSG00000007659 [Q64373-3] ENSMUST00000140436; ENSMUSP00000134596; ENSMUSG00000007659 [Q64373-3] |
GeneIDi | 12048 |
KEGGi | mmu:12048 |
UCSCi | uc008ngi.2, mouse [Q64373-2] uc008ngj.2, mouse [Q64373-1] uc008ngn.2, mouse [Q64373-3] |
Organism-specific databases
CTDi | 598 |
MGIi | MGI:88139, Bcl2l1 |
VEuPathDBi | HostDB:ENSMUSG00000007659 |
Phylogenomic databases
eggNOGi | KOG4728, Eukaryota |
GeneTreei | ENSGT01020000230347 |
InParanoidi | Q64373 |
OMAi | RIASWMT |
PhylomeDBi | Q64373 |
TreeFami | TF315834 |
Enzyme and pathway databases
Reactomei | R-MMU-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-MMU-844455, The NLRP1 inflammasome R-MMU-9648002, RAS processing |
Miscellaneous databases
BioGRID-ORCSi | 12048, 14 hits in 64 CRISPR screens |
ChiTaRSi | Bcl2l1, mouse |
EvolutionaryTracei | Q64373 |
PROi | PR:Q64373 |
RNActi | Q64373, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000007659, Expressed in bone marrow and 312 other tissues |
ExpressionAtlasi | Q64373, baseline and differential |
Genevisiblei | Q64373, MM |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
DisProti | DP02817 |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR013279, Apop_reg_BclX IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR004725, Bcl2/BclX IPR020717, Bcl2_BH1_motif_CS IPR020726, Bcl2_BH2_motif_CS IPR020728, Bcl2_BH3_motif_CS IPR003093, Bcl2_BH4 IPR020731, Bcl2_BH4_motif_CS |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF12, PTHR11256:SF12, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit PF02180, BH4, 1 hit |
PRINTSi | PR01864, APOPREGBCLX PR01862, BCL2FAMILY |
SMARTi | View protein in SMART SM00337, BCL, 1 hit SM00265, BH4, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
TIGRFAMsi | TIGR00865, bcl-2, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit PS01080, BH1, 1 hit PS01258, BH2, 1 hit PS01259, BH3, 1 hit PS01260, BH4_1, 1 hit PS50063, BH4_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2CL1_MOUSE | |
Accessioni | Q64373Primary (citable) accession number: Q64373 Secondary accession number(s): O35844 Q61338 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 201 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families