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Protein

AKT-interacting protein

Gene

Aktip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).By similarity

Caution

Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.Curated

GO - Biological processi

Keywordsi

Biological processApoptosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AKT-interacting protein
Alternative name(s):
FT1
Fused toes protein
Gene namesi
Name:Aktip
Synonyms:Fif, Ft1, Fts
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:3693832 Aktip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Aktip are a cause of embryonic death in homozygous animals. Death occurs at about 10 days of development. Symptoms include loss of left-right asymmetry, malformation of the developing brain and of the spinal cord, syndactyly and polydactyly. Heterozygous animals are characterized by polydactyly and thymic hyperplasia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826101 – 292AKT-interacting proteinAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ64362
PaxDbiQ64362
PRIDEiQ64362

PTM databases

iPTMnetiQ64362
PhosphoSitePlusiQ64362

Expressioni

Tissue specificityi

Ubiquitous. Highest expression in kidney, testis and brain and lowest in spleen and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000031667 Expressed in 311 organ(s), highest expression level in spinal cord
ExpressionAtlasiQ64362 baseline and differential
GenevisibleiQ64362 MM

Interactioni

Subunit structurei

Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105238

Structurei

3D structure databases

ProteinModelPortaliQ64362
SMRiQ64362
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0429 Eukaryota
ENOG410ZQ9Z LUCA
GeneTreeiENSGT00390000010125
HOGENOMiHOG000033885
HOVERGENiHBG095637
InParanoidiQ64362
OrthoDBiEOG091G0C08
PhylomeDBiQ64362
TreeFamiTF314386

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q64362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPLWSMSAG SVRKRAEGEE KTLAGDVKTS PPRSAPKKQL PSIPKNALPI
60 70 80 90 100
AKPTSPAPAA QSTNGTHASY GPFYLEYSLL AEFTLVVKQK LPGVYVQPSY
110 120 130 140 150
RSALVWFGVI FIRHGLYQDG VFKFTVYIPD NYPDGDCPRL LFDIPVFHPL
160 170 180 190 200
VDPTSGELDV KRAFAKWRRN HNHIWQVLMY ARRVFYKIDT TSPLNPEAAV
210 220 230 240 250
LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP WNPSVHDEAR
260 270 280 290
EKMLTQKKPD EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT
Length:292
Mass (Da):32,942
Last modified:November 1, 1996 - v1
Checksum:iA5FFC7F9053B1E3B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z632D3Z632_MOUSE
AKT-interacting protein
Aktip Fts, mCG_1907
258Annotation score:
D3Z2J4D3Z2J4_MOUSE
AKT-interacting protein
Aktip
292Annotation score:
A0A1B0GS90A0A1B0GS90_MOUSE
AKT-interacting protein
Aktip
51Annotation score:
A0A1B0GSS3A0A1B0GSS3_MOUSE
AKT-interacting protein
Aktip
55Annotation score:
A0A1B0GS26A0A1B0GS26_MOUSE
AKT-interacting protein
Aktip
32Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67963 mRNA Translation: CAA91902.1
X71978 mRNA Translation: CAA50800.1
AK146459 mRNA Translation: BAE27187.1
AK158704 mRNA Translation: BAE34620.1
CH466525 Genomic DNA Translation: EDL11072.1
CH466525 Genomic DNA Translation: EDL11073.1
BC008130 mRNA Translation: AAH08130.1
CCDSiCCDS22519.1
PIRiS33513
RefSeqiNP_001289195.1, NM_001302266.1
NP_001289196.1, NM_001302267.1
NP_001289197.1, NM_001302268.1
NP_001289266.1, NM_001302337.1
NP_034371.1, NM_010241.5
XP_017168061.1, XM_017312572.1
XP_017168062.1, XM_017312573.1
UniGeneiMm.324588
Mm.487955

Genome annotation databases

EnsembliENSMUST00000109609; ENSMUSP00000105238; ENSMUSG00000031667
ENSMUST00000120213; ENSMUSP00000112375; ENSMUSG00000031667
ENSMUST00000120349; ENSMUSP00000113769; ENSMUSG00000031667
ENSMUST00000125257; ENSMUSP00000119277; ENSMUSG00000031667
GeneIDi14339
KEGGimmu:14339
UCSCiuc009msl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67963 mRNA Translation: CAA91902.1
X71978 mRNA Translation: CAA50800.1
AK146459 mRNA Translation: BAE27187.1
AK158704 mRNA Translation: BAE34620.1
CH466525 Genomic DNA Translation: EDL11072.1
CH466525 Genomic DNA Translation: EDL11073.1
BC008130 mRNA Translation: AAH08130.1
CCDSiCCDS22519.1
PIRiS33513
RefSeqiNP_001289195.1, NM_001302266.1
NP_001289196.1, NM_001302267.1
NP_001289197.1, NM_001302268.1
NP_001289266.1, NM_001302337.1
NP_034371.1, NM_010241.5
XP_017168061.1, XM_017312572.1
XP_017168062.1, XM_017312573.1
UniGeneiMm.324588
Mm.487955

3D structure databases

ProteinModelPortaliQ64362
SMRiQ64362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105238

PTM databases

iPTMnetiQ64362
PhosphoSitePlusiQ64362

Proteomic databases

MaxQBiQ64362
PaxDbiQ64362
PRIDEiQ64362

Protocols and materials databases

DNASUi14339
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109609; ENSMUSP00000105238; ENSMUSG00000031667
ENSMUST00000120213; ENSMUSP00000112375; ENSMUSG00000031667
ENSMUST00000120349; ENSMUSP00000113769; ENSMUSG00000031667
ENSMUST00000125257; ENSMUSP00000119277; ENSMUSG00000031667
GeneIDi14339
KEGGimmu:14339
UCSCiuc009msl.2 mouse

Organism-specific databases

CTDi64400
MGIiMGI:3693832 Aktip

Phylogenomic databases

eggNOGiKOG0429 Eukaryota
ENOG410ZQ9Z LUCA
GeneTreeiENSGT00390000010125
HOGENOMiHOG000033885
HOVERGENiHBG095637
InParanoidiQ64362
OrthoDBiEOG091G0C08
PhylomeDBiQ64362
TreeFamiTF314386

Miscellaneous databases

PROiPR:Q64362
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031667 Expressed in 311 organ(s), highest expression level in spinal cord
ExpressionAtlasiQ64362 baseline and differential
GenevisibleiQ64362 MM

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKTIP_MOUSE
AccessioniPrimary (citable) accession number: Q64362
Secondary accession number(s): Q3TYE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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