UniProtKB - Q64347 (CLCN1_MOUSE)

BLAST

>sp|Q64347|CLCN1_MOUSE Chloride channel protein 1 OS=Mus musculus OX=10090 GN=Clcn1 PE=1 SV=3
MERSQSQRHGGEQSWWGSAPQYQYMPFEHCTSYGLPSENGGLQHRPRKDMGPRHNAHPTQ
IYGHQKEQYSYKAQDGGMPKKMGSSSTMDSLDEDHYSKCQDCVHRLGRVLRRKLGEDWIF
LVLLGLLMALVSWCMDYVSAKSLQAYKWTYAQMKPSLPLQYLAWVTFPLILILFSALFCQ
LISPQAVGSGIPEMKTILRGVVLKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIAS
ICAAVLSKFMSMFSGVYEQPYYYTDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVR
NYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAVIGICCGF
LGAVFVYLHRQVMLGVRKHKCLSQFLAKHRLLYPGIVTFVIASLTFPPGMGQFMAGELMP
REAISTLFDNNTWVKHIGDPQSLGQSAVWLHPQVNVIIIILLFFVMKFWMSIVATTMPIP
CGGFMPVFVLGAAFGRLVGEIMAMLFPEGILFDDIIYKILPGGYAVIGAAALTGAVSHTV
STAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSK
FTIFVEDIMVRDVKFVSASCTYGELRNLLQATTVKTLPLVDSKDSMILLGSVERSELQSL
LQRHLCAERRLKAAQDMARKLSELPYNGKAQLAGDWHPGGRPESFAFVDEDEDEDLSRKM
ELPLTPAPPPPSPPPPPSQFPIAPSNPEEPNGPLPSHKQPPEASDSADQRSSTFQRLLHC
LLGKAHSKKKKITQDSTDLVDNMSPEEIEAWEREQLSQPVCFDCCCIDQSPFQLVEQTTL
HKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSIR
KTPGGPPPPAEGWNVPEDGDGAPGREVMVPTMPETPVPPPSPEAPSCLAPARAEGELEEL
EMVGSLEPEEELADILHGPSLRSTDEEDEDELIL

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Format
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History
Entry version 147 (07 Nov 2018)
Sequence version 3 (18 May 2010)
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Protein

Chloride channel protein 1

Gene

Clcn1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Voltage-gated chloride channel (By similarity). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction (Probable) (PubMed:8119941).By similarity1 Publication1 Publication

Miscellaneous

The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	189	ChlorideBy similarity	1
Binding siteⁱ	484	Chloride; via amide nitrogenBy similarity	1
Binding siteⁱ	578	ChlorideBy similarity	1

GO - Molecular functionⁱ

protein homodimerization activity Source: UniProtKB
voltage-gated chloride channel activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chloride transmembrane transport Source: UniProtKB
chloride transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 2453798
muscle contraction Source: UniProtKB
neuronal action potential propagation
Source: MGI
Inferred from mutant phenotypeⁱ
- 2453798
regulation of ion transmembrane transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chloride channel, Ion channel, Voltage-gated channel
Biological process	Ion transport, Transport
Ligand	Chloride

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Chloride channel protein 1 Short name: ClC-1 Alternative name(s): Chloride channel protein, skeletal muscle
Gene namesⁱ	Name:Clcn1 Synonyms:Clc1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:88417 Clcn1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 118	CytoplasmicCuratedAdd BLAST	118
Transmembraneⁱ	119 – 150	HelicalBy similarityAdd BLAST	32
Topological domainⁱ	151 – 158	ExtracellularCurated	8
Transmembraneⁱ	159 – 179	HelicalBy similarityAdd BLAST	21
Topological domainⁱ	180 – 183	CytoplasmicCurated	4
Intramembraneⁱ	184 – 195	HelicalBy similarityAdd BLAST	12
Topological domainⁱ	196 – 208	CytoplasmicCuratedAdd BLAST	13
Transmembraneⁱ	209 – 228	HelicalBy similarityAdd BLAST	20
Transmembraneⁱ	229 – 246	HelicalBy similarityAdd BLAST	18
Topological domainⁱ	247 – 268	CytoplasmicCuratedAdd BLAST	22
Intramembraneⁱ	269 – 290	HelicalBy similarityAdd BLAST	22
Topological domainⁱ	291 – 301	CytoplasmicCuratedAdd BLAST	11
Transmembraneⁱ	302 – 321	HelicalBy similarityAdd BLAST	20
Topological domainⁱ	322 – 347	ExtracellularCuratedAdd BLAST	26
Transmembraneⁱ	348 – 376	HelicalBy similarityAdd BLAST	29
Topological domainⁱ	377 – 390	CytoplasmicCuratedAdd BLAST	14
Transmembraneⁱ	391 – 408	HelicalBy similarityAdd BLAST	18
Topological domainⁱ	409 – 414	ExtracellularCurated	6
Intramembraneⁱ	415 – 426	HelicalBy similarityAdd BLAST	12
Topological domainⁱ	427 – 457	ExtracellularCuratedAdd BLAST	31
Transmembraneⁱ	458 – 478	HelicalBy similarityAdd BLAST	21
Transmembraneⁱ	479 – 498	HelicalBy similarityAdd BLAST	20
Topological domainⁱ	499 – 521	ExtracellularCuratedAdd BLAST	23
Intramembraneⁱ	522 – 554	HelicalBy similarityAdd BLAST	33
Topological domainⁱ	555 – 557	ExtracellularCurated	3
Transmembraneⁱ	558 – 578	HelicalBy similarityAdd BLAST	21
Topological domainⁱ	579 – 994	CytoplasmicCuratedAdd BLAST	416

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	553	I → T: Causes myotonia. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000094430	1 – 994	Chloride channel protein 1Add BLAST		994

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	892	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q64347
PRIDEⁱ	Q64347

PTM databases

iPTMnetⁱ	Q64347
PhosphoSitePlusⁱ	Q64347

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in skeletal muscles.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000029862 Expressed in 79 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	MM_CLCN1
ExpressionAtlasⁱ	Q64347 baseline and differential

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

GO - Molecular functionⁱ

protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000031894

STRINGⁱ

10090.ENSMUSP00000031894

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q64347
SMRⁱ	Q64347
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	609 – 668	CBS 1PROSITE-ProRule annotationAdd BLAST		60
Domainⁱ	827 – 882	CBS 2PROSITE-ProRule annotationAdd BLAST		56

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	188 – 192	Selectivity filter part_1By similarity	5
Motifⁱ	230 – 234	Selectivity filter part_2By similarity	5
Motifⁱ	482 – 486	Selectivity filter part_3By similarity	5

Sequence similaritiesⁱ

Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily. [View classification]Curated

Keywords - Domainⁱ

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0476 Eukaryota COG0038 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119109
HOGENOMⁱ	HOG000231297
HOVERGENⁱ	HBG005332
InParanoidⁱ	Q64347
KEGG Orthology (KO) More...KOⁱ	K05010
OMAⁱ	HISKYNI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01RJ
PhylomeDBⁱ	Q64347
TreeFamⁱ	TF352264

Family and domain databases

Gene3Dⁱ	1.10.3080.10, 1 hit
InterProⁱ	View protein in InterPro IPR000644 CBS_dom IPR014743 Cl-channel_core IPR001807 Cl-channel_volt-gated IPR002243 Cl_channel-1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00654 Voltage_CLC, 1 hit
PRINTSⁱ	PR00762 CLCHANNEL PR01112 CLCHANNEL1
SUPFAMⁱ	SSF81340 SSF81340, 1 hit
PROSITEⁱ	View protein in PROSITE PS51371 CBS, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show all Align All

Q64347-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERSQSQRHG GEQSWWGSAP QYQYMPFEHC TSYGLPSENG GLQHRPRKDM 
        60         70         80         90        100
GPRHNAHPTQ IYGHQKEQYS YKAQDGGMPK KMGSSSTMDS LDEDHYSKCQ 
       110        120        130        140        150
DCVHRLGRVL RRKLGEDWIF LVLLGLLMAL VSWCMDYVSA KSLQAYKWTY 
       160        170        180        190        200
AQMKPSLPLQ YLAWVTFPLI LILFSALFCQ LISPQAVGSG IPEMKTILRG 
       210        220        230        240        250
VVLKEYLTLK AFVAKVVALT AGLGSGIPVG KEGPFVHIAS ICAAVLSKFM 
       260        270        280        290        300
SMFSGVYEQP YYYTDILTVG CAVGVGCCFG TPLGGVLFSI EVTSTYFAVR 
       310        320        330        340        350
NYWRGFFAAT FSAFVFRVLA VWNKDAVTIT ALFRTNFRMD FPFDLKELPA 
       360        370        380        390        400
FAVIGICCGF LGAVFVYLHR QVMLGVRKHK CLSQFLAKHR LLYPGIVTFV 
       410        420        430        440        450
IASLTFPPGM GQFMAGELMP REAISTLFDN NTWVKHIGDP QSLGQSAVWL 
       460        470        480        490        500
HPQVNVIIII LLFFVMKFWM SIVATTMPIP CGGFMPVFVL GAAFGRLVGE 
       510        520        530        540        550
IMAMLFPEGI LFDDIIYKIL PGGYAVIGAA ALTGAVSHTV STAVICFELT 
       560        570        580        590        600
GQIAHILPMM VAVILANMVA QSLQPSLYDS IIQVKKLPYL PDLGWNQLSK 
       610        620        630        640        650
FTIFVEDIMV RDVKFVSASC TYGELRNLLQ ATTVKTLPLV DSKDSMILLG 
       660        670        680        690        700
SVERSELQSL LQRHLCAERR LKAAQDMARK LSELPYNGKA QLAGDWHPGG 
       710        720        730        740        750
RPESFAFVDE DEDEDLSRKM ELPLTPAPPP PSPPPPPSQF PIAPSNPEEP 
       760        770        780        790        800
NGPLPSHKQP PEASDSADQR SSTFQRLLHC LLGKAHSKKK KITQDSTDLV 
       810        820        830        840        850
DNMSPEEIEA WEREQLSQPV CFDCCCIDQS PFQLVEQTTL HKTHTLFSLL 
       860        870        880        890        900
GLHLAYVTSM GKLRGVLALE ELQKAIEGHT KSGVQLRPPL ASFRNTTSIR 
       910        920        930        940        950
KTPGGPPPPA EGWNVPEDGD GAPGREVMVP TMPETPVPPP SPEAPSCLAP 
       960        970        980        990 
ARAEGELEEL EMVGSLEPEE ELADILHGPS LRSTDEEDED ELIL

Length:994

Mass (Da):109,794

Last modified:May 18, 2010 - v3

Checksum:ⁱ3C523C4325B279BF

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F6QI82	F6QI82_MOUSE	Chloride channel protein Chloride channel protein	Clcn1	923	Annotation score:
E9Q2N3	E9Q2N3_MOUSE	Chloride channel protein 1 Chloride channel protein 1	Clcn1	258	Annotation score:
F6X177	F6X177_MOUSE	Chloride channel protein 1 Chloride channel protein 1	Clcn1	289	Annotation score:
F7A9J6	F7A9J6_MOUSE	Chloride channel protein 1 Chloride channel protein 1	Clcn1	257	Annotation score:
F6QL23	F6QL23_MOUSE	Chloride channel protein 1 Chloride channel protein 1	Clcn1	229	Annotation score:
F7C9S1	F7C9S1_MOUSE	Chloride channel protein 1 Chloride channel protein 1	Clcn1	262	Annotation score:
F6VSA8	F6VSA8_MOUSE	Chloride channel protein 1 Chloride channel protein 1	Clcn1	104	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	65	Q → H in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	72	K → Q in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	76 – 78	GGM → RGI in CAB08359 (PubMed:9321463).Curated	3
Sequence conflictⁱ	82 – 83	MG → TD in CAB08359 (PubMed:9321463).Curated	2
Sequence conflictⁱ	88	M → V in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	243	A → T in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	483 – 484	GF → VN in CAB08359 (PubMed:9321463).Curated	2
Sequence conflictⁱ	585	K → E in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	620	C → S in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	631	A → T in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	746	N → H no nucleotide entry (PubMed:8119941).Curated	1
Sequence conflictⁱ	864	R → T in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	877	E → K in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	912	G → S in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	918 – 919	DG → GE in CAB08359 (PubMed:9321463).Curated	2
Sequence conflictⁱ	924	G → E in CAB08359 (PubMed:9321463).Curated	1
Sequence conflictⁱ	944	A → V no nucleotide entry (PubMed:8119941).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z95127 Z95149 Genomic DNA Translation: CAB08359.1 AK036735 mRNA Translation: BAC29557.1 CH466533 Genomic DNA Translation: EDL13488.1 BC114336 mRNA Translation: AAI14337.1 X62895 mRNA Translation: CAA44684.1 X62896 mRNA Translation: CAA44685.1 X62897 mRNA Translation: CAA44686.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39471.1
PIRⁱ	I48773
NCBI Reference Sequences More...RefSeqⁱ	NP_038519.1, NM_013491.2
UniGeneⁱ	Mm.386757

Genome annotation databases

Ensemblⁱ	ENSMUST00000031894; ENSMUSP00000031894; ENSMUSG00000029862
GeneIDⁱ	12723
KEGGⁱ	mmu:12723
UCSC genome browser More...UCSCⁱ	uc009bqs.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q64347	Chloride channel protein 1		MOUSE		258	UniRef100_Q64347
UPI0003D7840D		MOUSE		656

Protein	Similar proteins		Species	Score	Length	Source
Q64347	Chloride channel protein 1		RAT		994	UniRef90_Q64347
Chloride channel protein 1		MOUSE		258
Chloride channel protein		CRIGR		1005
Chloride channel protein		MESAU		992
UPI000A3168B4		MUSCR		997
+10

Protein	Similar proteins		Species	Score	Length	Source
Q64347	Chloride channel protein 1		RAT		994	UniRef50_Q64347
Chloride channel protein 1		MOUSE		258
Chloride channel protein		CRIGR		1005
Chloride channel protein		MESAU		992
chloride channel protein 1		URSMA		1092
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z95127 Z95149 Genomic DNA Translation: CAB08359.1 AK036735 mRNA Translation: BAC29557.1 CH466533 Genomic DNA Translation: EDL13488.1 BC114336 mRNA Translation: AAI14337.1 X62895 mRNA Translation: CAA44684.1 X62896 mRNA Translation: CAA44685.1 X62897 mRNA Translation: CAA44686.1
CCDSⁱ	CCDS39471.1
PIRⁱ	I48773
RefSeqⁱ	NP_038519.1, NM_013491.2
UniGeneⁱ	Mm.386757

3D structure databases

ProteinModelPortalⁱ	Q64347
SMRⁱ	Q64347
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000031894

STRINGⁱ

10090.ENSMUSP00000031894

PTM databases

iPTMnetⁱ	Q64347
PhosphoSitePlusⁱ	Q64347

Proteomic databases

PaxDbⁱ	Q64347
PRIDEⁱ	Q64347

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000031894; ENSMUSP00000031894; ENSMUSG00000029862
GeneIDⁱ	12723
KEGGⁱ	mmu:12723
UCSCⁱ	uc009bqs.1 mouse

Organism-specific databases

CTDⁱ	1180
MGIⁱ	MGI:88417 Clcn1

Phylogenomic databases

eggNOGⁱ	KOG0476 Eukaryota COG0038 LUCA
GeneTreeⁱ	ENSGT00760000119109
HOGENOMⁱ	HOG000231297
HOVERGENⁱ	HBG005332
InParanoidⁱ	Q64347
KOⁱ	K05010
OMAⁱ	HISKYNI
OrthoDBⁱ	EOG091G01RJ
PhylomeDBⁱ	Q64347
TreeFamⁱ	TF352264

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q64347
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029862 Expressed in 79 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	MM_CLCN1
ExpressionAtlasⁱ	Q64347 baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.3080.10, 1 hit
InterProⁱ	View protein in InterPro IPR000644 CBS_dom IPR014743 Cl-channel_core IPR001807 Cl-channel_volt-gated IPR002243 Cl_channel-1
Pfamⁱ	View protein in Pfam PF00654 Voltage_CLC, 1 hit
PRINTSⁱ	PR00762 CLCHANNEL PR01112 CLCHANNEL1
SUPFAMⁱ	SSF81340 SSF81340, 1 hit
PROSITEⁱ	View protein in PROSITE PS51371 CBS, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLCN1_MOUSE
Accessionⁱ	Q64347Primary (citable) accession number: Q64347 Secondary accession number(s): Q8BZ41, Q9QVY5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q64347 (CLCN1_MOUSE)

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Chloride channel protein 1

Clcn1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ