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Protein

Interferon-induced protein with tetratricopeptide repeats 3

Gene

Ifit3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2 (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI
  • RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein with tetratricopeptide repeats 3
Short name:
IFIT-3
Alternative name(s):
Glucocorticoid-attenuated response gene 49 protein
Short name:
GARG-49
Short name:
P49
IRG2
Gene namesi
Name:Ifit3
Synonyms:Garg49, Ifi49, Isg49
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1101055 Ifit3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063501 – 403Interferon-induced protein with tetratricopeptide repeats 3Add BLAST403

Proteomic databases

MaxQBiQ64345
PaxDbiQ64345
PRIDEiQ64345

PTM databases

iPTMnetiQ64345
PhosphoSitePlusiQ64345

Expressioni

Gene expression databases

BgeeiENSMUSG00000074896 Expressed in 22 organ(s), highest expression level in lung
ExpressionAtlasiQ64345 baseline and differential
GenevisibleiQ64345 MM

Interactioni

Subunit structurei

Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT2 (By similarity). Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58 (By similarity). Interacts with COPS5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200527, 1 interactor
IntActiQ64345, 1 interactor
STRINGi10090.ENSMUSP00000099889

Structurei

3D structure databases

ProteinModelPortaliQ64345
SMRiQ64345
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati94 – 127TPR 1Add BLAST34
Repeati136 – 169TPR 2Add BLAST34
Repeati172 – 206TPR 3Add BLAST35
Repeati241 – 274TPR 4Add BLAST34

Sequence similaritiesi

Belongs to the IFIT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000013876
HOGENOMiHOG000001558
HOVERGENiHBG066330
InParanoidiQ64345
OMAiANNYRWK
OrthoDBiEOG091G06GX
PhylomeDBiQ64345
TreeFamiTF342671

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR024122 Interferon-induced_IFIT3
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR10271:SF3 PTHR10271:SF3, 1 hit
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q64345-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEVNRESLE AILPQLKCHF TWNLFREGSM SSHMEDRVCN QVEHLNSEEK
60 70 80 90 100
ATMYDLLAYI KHLDGESKAA LECLGQAEDL RKSEHNDQSE IRRLVTWGNY
110 120 130 140 150
AWIYYHMGRL SEAQAYVDKV RQVCQKFANP YSMECPELEC EEGWTRLKCG
160 170 180 190 200
RNERAKMCFE KALEEKPKDP ECSSGMAIAM FRLEEKPEKQ FSVDALKQAM
210 220 230 240 250
ELNPQNQYLK VLLALKLLRM GEEAEGERLI KDALGKAPNQ TDVLQKAAQF
260 270 280 290 300
YKKKGNLDRA IELLGKALRS TVNNSPLYSL VMCRYREILE QLQNKGDADS
310 320 330 340 350
SERRQRMAEL RRLTMEFMQK TLQRRRSPLN SYSDLIDFPE VERCYQMVIS
360 370 380 390 400
KESPDVEEED LYERYCNLQE YHRKSEDLAA LECLLQFPRN ERSIEKEEVK

EQT
Length:403
Mass (Da):47,223
Last modified:November 1, 1996 - v1
Checksum:iAE5F5ED42F4F8F60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158C → Y in AAH03804 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43086 Genomic DNA Translation: AAC52627.1
L32974 mRNA Translation: AAA39329.1
BC003804 mRNA Translation: AAH03804.1
CCDSiCCDS29762.1
PIRiS71356
RefSeqiNP_034631.1, NM_010501.2
UniGeneiMm.426079

Genome annotation databases

EnsembliENSMUST00000102825; ENSMUSP00000099889; ENSMUSG00000074896
GeneIDi15959
KEGGimmu:15959
UCSCiuc008hgo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43086 Genomic DNA Translation: AAC52627.1
L32974 mRNA Translation: AAA39329.1
BC003804 mRNA Translation: AAH03804.1
CCDSiCCDS29762.1
PIRiS71356
RefSeqiNP_034631.1, NM_010501.2
UniGeneiMm.426079

3D structure databases

ProteinModelPortaliQ64345
SMRiQ64345
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200527, 1 interactor
IntActiQ64345, 1 interactor
STRINGi10090.ENSMUSP00000099889

PTM databases

iPTMnetiQ64345
PhosphoSitePlusiQ64345

Proteomic databases

MaxQBiQ64345
PaxDbiQ64345
PRIDEiQ64345

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102825; ENSMUSP00000099889; ENSMUSG00000074896
GeneIDi15959
KEGGimmu:15959
UCSCiuc008hgo.1 mouse

Organism-specific databases

CTDi3437
MGIiMGI:1101055 Ifit3

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000013876
HOGENOMiHOG000001558
HOVERGENiHBG066330
InParanoidiQ64345
OMAiANNYRWK
OrthoDBiEOG091G06GX
PhylomeDBiQ64345
TreeFamiTF342671

Miscellaneous databases

PROiPR:Q64345
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074896 Expressed in 22 organ(s), highest expression level in lung
ExpressionAtlasiQ64345 baseline and differential
GenevisibleiQ64345 MM

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR024122 Interferon-induced_IFIT3
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR10271:SF3 PTHR10271:SF3, 1 hit
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFIT3_MOUSE
AccessioniPrimary (citable) accession number: Q64345
Secondary accession number(s): Q99L62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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