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Protein

ATP-binding cassette sub-family G member 1

Gene

Abcg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 125ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369062 ABC transporters in lipid homeostasis
R-MMU-8964058 HDL remodeling

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 1
Alternative name(s):
ATP-binding cassette transporter 8
White protein homolog
Gene namesi
Name:Abcg1
Synonyms:Abc8, Wht1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:107704 Abcg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 414CytoplasmicSequence analysisAdd BLAST414
Transmembranei415 – 433HelicalSequence analysisAdd BLAST19
Topological domaini434 – 444ExtracellularSequence analysisAdd BLAST11
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 494CytoplasmicSequence analysisAdd BLAST29
Transmembranei495 – 513HelicalSequence analysisAdd BLAST19
Topological domaini514 – 521ExtracellularSequence analysis8
Transmembranei522 – 543HelicalSequence analysisAdd BLAST22
Topological domaini544 – 555CytoplasmicSequence analysisAdd BLAST12
Transmembranei556 – 574HelicalSequence analysisAdd BLAST19
Topological domaini575 – 637ExtracellularSequence analysisAdd BLAST63
Transmembranei638 – 657HelicalSequence analysisAdd BLAST20
Topological domaini658 – 666CytoplasmicSequence analysis9

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933851 – 666ATP-binding cassette sub-family G member 1Add BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi30S-palmitoyl cysteineBy similarity1
Lipidationi154S-palmitoyl cysteineBy similarity1
Lipidationi315S-palmitoyl cysteineBy similarity1
Lipidationi394S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ64343
PaxDbiQ64343
PRIDEiQ64343

PTM databases

iPTMnetiQ64343
PhosphoSitePlusiQ64343
SwissPalmiQ64343

Expressioni

Tissue specificityi

Expressed mainly in brain, thymus, lung, adrenals, spleen and placenta. Little or no expression in liver, kidney, heart, muscle or testes.

Inductioni

Strongly induced in macrophage cell line RAW 264.7 during cholesterol influx. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Down-regulated by endotoxins or cytokines (TNF and IL1) in J-774 macrophages.1 Publication

Gene expression databases

BgeeiENSMUSG00000024030 Expressed in 292 organ(s), highest expression level in thymus
ExpressionAtlasiQ64343 baseline and differential
GenevisibleiQ64343 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ64343
STRINGi10090.ENSMUSP00000024829

Structurei

3D structure databases

ProteinModelPortaliQ64343
SMRiQ64343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 317ABC transporterPROSITE-ProRule annotationAdd BLAST241
Domaini403 – 661ABC transmembrane type-2Add BLAST259

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00740000114855
HOGENOMiHOG000236364
HOVERGENiHBG103052
InParanoidiQ64343
KOiK05679
OMAiQGQCIYR
OrthoDBiEOG091G050S
PhylomeDBiQ64343
TreeFamiTF105210

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR020064 ABCG1
IPR027417 P-loop_NTPase
IPR005284 Pigment_permease/Abcg
PANTHERiPTHR19241:SF177 PTHR19241:SF177, 1 hit
PfamiView protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00955 3a01204, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q64343-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACLMAAFSV GTAMNASSYS AAMTEPKSVC VSVDEVVSSN VDEVETDLLN
60 70 80 90 100
GHLKKVDNNF TEAQRFSSLP RRAAVNIEFK DLSYSVPEGP WWKKKGYKTL
110 120 130 140 150
LKGISGKFNS GELVAIMGPS GAGKSTLMNI LAGYRETGMK GAVLINGMPR
160 170 180 190 200
DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV SAHLKLQEKD EGRREMVKEI
210 220 230 240 250
LTALGLLPCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF DEPTSGLDSA
260 270 280 290 300
SCFQVVSLMK GLAQGGRSIV CTIHQPSAKL FELFDQLYVL SQGQCVYRGK
310 320 330 340 350
VSNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD
360 370 380 390 400
ADYKRDLGGD TDVNPFLWHR PAEEDSASME GCHSFSASCL TQFCILFKRT
410 420 430 440 450
FLSIMRDSVL THLRITSHIG IGLLIGLLYL GIGNEAKKVL SNSGFLFFSM
460 470 480 490 500
LFLMFAALMP TVLTFPLEMS VFLREHLNYW YSLKAYYLAK TMADVPFQIM
510 520 530 540 550
FPVAYCSIVY WMTSQPSDAV RFVLFAALGT MTSLVAQSLG LLIGAASTSL
560 570 580 590 600
QVATFVGPVT AIPVLLFSGF FVSFDTIPAY LQWMSYISYV RYGFEGVILS
610 620 630 640 650
IYGLDREDLH CDIAETCHFQ KSEAILRELD VENAKLYLDF IVLGIFFISL
660
RLIAYFVLRY KIRAER
Length:666
Mass (Da):74,033
Last modified:November 1, 1997 - v1
Checksum:iEDDC6AFBD43950B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34920 mRNA Translation: AAB47738.1
Z48745 mRNA Translation: CAA88636.1
AF323659 mRNA Translation: AAK27442.1
CCDSiCCDS28602.1
RefSeqiNP_033723.1, NM_009593.2
UniGeneiMm.15691
Mm.470747

Genome annotation databases

EnsembliENSMUST00000024829; ENSMUSP00000024829; ENSMUSG00000024030
GeneIDi11307
KEGGimmu:11307
UCSCiuc008buj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34920 mRNA Translation: AAB47738.1
Z48745 mRNA Translation: CAA88636.1
AF323659 mRNA Translation: AAK27442.1
CCDSiCCDS28602.1
RefSeqiNP_033723.1, NM_009593.2
UniGeneiMm.15691
Mm.470747

3D structure databases

ProteinModelPortaliQ64343
SMRiQ64343
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ64343
STRINGi10090.ENSMUSP00000024829

PTM databases

iPTMnetiQ64343
PhosphoSitePlusiQ64343
SwissPalmiQ64343

Proteomic databases

MaxQBiQ64343
PaxDbiQ64343
PRIDEiQ64343

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024829; ENSMUSP00000024829; ENSMUSG00000024030
GeneIDi11307
KEGGimmu:11307
UCSCiuc008buj.2 mouse

Organism-specific databases

CTDi9619
MGIiMGI:107704 Abcg1

Phylogenomic databases

eggNOGiKOG0061 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00740000114855
HOGENOMiHOG000236364
HOVERGENiHBG103052
InParanoidiQ64343
KOiK05679
OMAiQGQCIYR
OrthoDBiEOG091G050S
PhylomeDBiQ64343
TreeFamiTF105210

Enzyme and pathway databases

ReactomeiR-MMU-1369062 ABC transporters in lipid homeostasis
R-MMU-8964058 HDL remodeling

Miscellaneous databases

PROiPR:Q64343
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024030 Expressed in 292 organ(s), highest expression level in thymus
ExpressionAtlasiQ64343 baseline and differential
GenevisibleiQ64343 MM

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR020064 ABCG1
IPR027417 P-loop_NTPase
IPR005284 Pigment_permease/Abcg
PANTHERiPTHR19241:SF177 PTHR19241:SF177, 1 hit
PfamiView protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00955 3a01204, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABCG1_MOUSE
AccessioniPrimary (citable) accession number: Q64343
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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