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Protein

Killer cell lectin-like receptor subfamily G member 1

Gene

Klrg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity, Innate immunity
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily G member 1
Alternative name(s):
Mast cell function-associated antigen
Gene namesi
Name:Klrg1
Synonyms:Mafa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi61978 Klrg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini56 – 188ExtracellularSequence analysisAdd BLAST133

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312581 – 188Killer cell lectin-like receptor subfamily G member 1Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 86PROSITE-ProRule annotation
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 183PROSITE-ProRule annotation
Disulfide bondi162 ↔ 175PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated in response to monoclonal antibody G63 binding and antigenic stimulation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ64335
PRIDEiQ64335

Expressioni

Tissue specificityi

Expressed in lung mast cells.2 Publications

Gene expression databases

BgeeiENSRNOG00000014918
GenevisibleiQ64335 RN

Interactioni

Subunit structurei

Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020094

Structurei

3D structure databases

ProteinModelPortaliQ64335
SMRiQ64335
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 184C-type lectinPROSITE-ProRule annotationAdd BLAST103

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 10ITIM motif6

Domaini

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00710000106527
HOGENOMiHOG000082429
HOVERGENiHBG103557
InParanoidiQ64335
KOiK10076
OMAiNSGWRWE
OrthoDBiEOG091G0MK5
PhylomeDBiQ64335
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q64335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNSIYSTL ELPAAPRVQD DSRWKVKAVL HRPCVSYLVM VALGLLTVIL
60 70 80 90 100
MSLLLYQRTL CCGSKGFMCS QCSRCPNLWM RNGSHCYYFS MEKRDWNSSL
110 120 130 140 150
KFCADKGSHL LTFPDNQGVN LFQEYVGEDF YWIGLRDIDG WRWEDGPALS
160 170 180
LSILSNSVVQ KCGTIHRCGL HASSCEVALQ WICEKVLP
Length:188
Mass (Da):21,356
Last modified:November 1, 1996 - v1
Checksum:i2CC8032D4D020B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79812 mRNA Translation: CAA56208.1
X97191
, X97192, X97193, X97194, X97195 Genomic DNA Translation: CAA65829.1
PIRiI59421
RefSeqiNP_113837.1, NM_031649.2
UniGeneiRn.10256

Genome annotation databases

EnsembliENSRNOT00000020094; ENSRNOP00000020094; ENSRNOG00000014918
GeneIDi58975
KEGGirno:58975
UCSCiRGD:61978 rat

Similar proteinsi

Entry informationi

Entry nameiKLRG1_RAT
AccessioniPrimary (citable) accession number: Q64335
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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