UniProtKB - Q64332 (SYN2_MOUSE)
Protein
Synapsin-2
Gene
Syn2
Organism
Mus musculus (Mouse)
Status
Functioni
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons.1 Publication
GO - Molecular functioni
- ATP binding Source: InterPro
- calcium-dependent protein binding Source: MGI
- identical protein binding Source: MGI
GO - Biological processi
- calcium-ion regulated exocytosis Source: UniProtKB
- neurotransmitter secretion Source: MGI
- synaptic vesicle clustering Source: SynGO
- synaptic vesicle cycle Source: SynGO
Enzyme and pathway databases
Reactomei | R-MMU-181429, Serotonin Neurotransmitter Release Cycle R-MMU-212676, Dopamine Neurotransmitter Release Cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Synapsin-2Alternative name(s): Synapsin II |
Gene namesi | Name:Syn2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103020, Syn2 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- extrinsic component of synaptic vesicle membrane Source: MGI
- glutamatergic synapse Source: MGI
- myelin sheath Source: UniProtKB
- postsynaptic density Source: MGI
- Schaffer collateral - CA1 synapse Source: SynGO
- SNARE complex Source: MGI
- synapse Source: MGI
- synaptic vesicle Source: MGI
- synaptic vesicle membrane Source: MGI
Keywords - Cellular componenti
Cell junction, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183022 | 1 – 586 | Synapsin-2Add BLAST | 586 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | Phosphoserine; by PKA and CaMK1By similarity | 1 | |
Modified residuei | 422 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 426 | PhosphoserineCombined sources1 Publication | 1 |
Post-translational modificationi
Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles (By similarity). Phosphorylation at Ser-426 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons.By similarity1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q64332 |
PeptideAtlasi | Q64332 |
PRIDEi | Q64332 |
PTM databases
iPTMneti | Q64332 |
PhosphoSitePlusi | Q64332 |
SwissPalmi | Q64332 |
Expressioni
Tissue specificityi
Expressed exclusively in neuronal cells. Isoform IIb is enriched in sympathetic cervical ganglion.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000009394, Expressed in subiculum and 210 other tissues |
Genevisiblei | Q64332, MM |
Interactioni
Subunit structurei
Interacts with CAPON.
By similarityGO - Molecular functioni
- calcium-dependent protein binding Source: MGI
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203601, 16 interactors |
CORUMi | Q64332 |
IntActi | Q64332, 9 interactors |
MINTi | Q64332 |
STRINGi | 10090.ENSMUSP00000009538 |
Miscellaneous databases
RNActi | Q64332, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | AAdd BLAST | 29 | |
Regioni | 33 – 113 | B; linkerAdd BLAST | 81 | |
Regioni | 114 – 421 | C; actin-binding and synaptic-vesicle bindingAdd BLAST | 308 | |
Regioni | 422 – 458 | G; Pro-rich linkerAdd BLAST | 37 | |
Regioni | 459 – 537 | H; Pro/Ser-rich linkerAdd BLAST | 79 | |
Regioni | 538 – 586 | EAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 486 – 499 | Poly-SerAdd BLAST | 14 | |
Compositional biasi | 515 – 520 | Poly-Ser | 6 |
Domaini
The A region binds phospholipids with a preference for negatively charged species.By similarity
Sequence similaritiesi
Belongs to the synapsin family.Curated
Phylogenomic databases
eggNOGi | KOG3895, Eukaryota |
GeneTreei | ENSGT00940000156062 |
HOGENOMi | CLU_010582_3_0_1 |
InParanoidi | Q64332 |
OMAi | HADWAKC |
OrthoDBi | 799740at2759 |
PhylomeDBi | Q64332 |
TreeFami | TF319919 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR016185, PreATP-grasp_dom_sf IPR028712, SYN2/3 IPR001359, Synapsin IPR020898, Synapsin_ATP-bd_dom IPR019735, Synapsin_CS IPR019736, Synapsin_P_site IPR020897, Synapsin_pre-ATP-grasp_dom |
PANTHERi | PTHR10841:SF20, PTHR10841:SF20, 1 hit |
Pfami | View protein in Pfam PF02078, Synapsin, 1 hit PF02750, Synapsin_C, 1 hit PF10581, Synapsin_N, 1 hit |
PRINTSi | PR01368, SYNAPSIN |
SUPFAMi | SSF52440, SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS00415, SYNAPSIN_1, 1 hit PS00416, SYNAPSIN_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform IIa (identifier: Q64332-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPAPGP GAATASAATS
60 70 80 90 100
AASPGPERRP PPAQAPAPQP APQPAPTPSV GSSFFSSLSQ AVKQTAASAG
110 120 130 140 150
LVDAPAPSAA SRKAKVLLVV DEPHTDWAKC FRGKKILGDY DIKVEQAEFS
160 170 180 190 200
ELNLVAHADG TYAVDMQVLR NGTKVVRSFR PDFVLIRQHA FGMAENEDFR
210 220 230 240 250
HLVIGMQYAG LPSINSLESI YNFCDKPWVF AQMVAIFKTL GGEKFPLIEQ
260 270 280 290 300
TYYPNHREML TLPTFPVVVK IGHAHSGMGK VKVENHYDFQ DIASVVALTQ
310 320 330 340 350
TYATAEPFID AKYDIRVQKI GNNYKAYMRT SISGNWKTNT GSAMLEQIAM
360 370 380 390 400
SDRYKLWVDA CSEMFGGLDI CAVKAVHGKD GKDYIFEVMD CSMPLIGEHQ
410 420 430 440 450
VEDRQLITDL VISKMNQLLS RTPALSPQRP LTTQQPQSGT LKEPDSSKTP
460 470 480 490 500
PQRPPPQGGP GQPQGMQPPG KVLPPRRLPS GPSLPSSSSS SSSSSSSSSA
510 520 530 540 550
PQRPGGPTTT HGDASSSSNS LAEAQAPQAA PAQKPQPHPQ LNKSQSLTNA
560 570 580
FSFSESSFFR SSANEDEAKA ETIRSLRKSF ASLFSD
Isoform IIb (identifier: Q64332-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
459-479: GPGQPQGMQPPGKVLPPRRLP → CLQYILDCNGIAVGPKQVQAS
480-586: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015203 | 459 – 479 | GPGQP…PRRLP → CLQYILDCNGIAVGPKQVQA S in isoform IIb. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_015204 | 480 – 586 | Missing in isoform IIb. 1 PublicationAdd BLAST | 107 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF096867 mRNA Translation: AAC72966.1 L32026 Genomic DNA Translation: AAA79964.1 BC066004 mRNA Translation: AAH66004.1 BC085129 mRNA Translation: AAH85129.1 |
CCDSi | CCDS51874.1 [Q64332-1] CCDS51875.1 [Q64332-2] |
PIRi | I61260 |
RefSeqi | NP_001104485.1, NM_001111015.1 [Q64332-1] NP_038709.1, NM_013681.3 [Q64332-2] |
Genome annotation databases
Ensembli | ENSMUST00000009538; ENSMUSP00000009538; ENSMUSG00000009394 [Q64332-1] ENSMUST00000169345; ENSMUSP00000133121; ENSMUSG00000009394 [Q64332-2] ENSMUST00000203450; ENSMUSP00000144921; ENSMUSG00000009394 [Q64332-2] |
GeneIDi | 20965 |
KEGGi | mmu:20965 |
UCSCi | uc009dim.3, mouse [Q64332-2] uc009din.2, mouse [Q64332-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF096867 mRNA Translation: AAC72966.1 L32026 Genomic DNA Translation: AAA79964.1 BC066004 mRNA Translation: AAH66004.1 BC085129 mRNA Translation: AAH85129.1 |
CCDSi | CCDS51874.1 [Q64332-1] CCDS51875.1 [Q64332-2] |
PIRi | I61260 |
RefSeqi | NP_001104485.1, NM_001111015.1 [Q64332-1] NP_038709.1, NM_013681.3 [Q64332-2] |
3D structure databases
SMRi | Q64332 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203601, 16 interactors |
CORUMi | Q64332 |
IntActi | Q64332, 9 interactors |
MINTi | Q64332 |
STRINGi | 10090.ENSMUSP00000009538 |
PTM databases
iPTMneti | Q64332 |
PhosphoSitePlusi | Q64332 |
SwissPalmi | Q64332 |
Proteomic databases
PaxDbi | Q64332 |
PeptideAtlasi | Q64332 |
PRIDEi | Q64332 |
Protocols and materials databases
ABCDi | Q64332, 1 sequenced antibody |
Antibodypediai | 4054, 109 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000009538; ENSMUSP00000009538; ENSMUSG00000009394 [Q64332-1] ENSMUST00000169345; ENSMUSP00000133121; ENSMUSG00000009394 [Q64332-2] ENSMUST00000203450; ENSMUSP00000144921; ENSMUSG00000009394 [Q64332-2] |
GeneIDi | 20965 |
KEGGi | mmu:20965 |
UCSCi | uc009dim.3, mouse [Q64332-2] uc009din.2, mouse [Q64332-1] |
Organism-specific databases
CTDi | 6854 |
MGIi | MGI:103020, Syn2 |
Phylogenomic databases
eggNOGi | KOG3895, Eukaryota |
GeneTreei | ENSGT00940000156062 |
HOGENOMi | CLU_010582_3_0_1 |
InParanoidi | Q64332 |
OMAi | HADWAKC |
OrthoDBi | 799740at2759 |
PhylomeDBi | Q64332 |
TreeFami | TF319919 |
Enzyme and pathway databases
Reactomei | R-MMU-181429, Serotonin Neurotransmitter Release Cycle R-MMU-212676, Dopamine Neurotransmitter Release Cycle |
Miscellaneous databases
BioGRID-ORCSi | 20965, 0 hits in 17 CRISPR screens |
ChiTaRSi | Syn2, mouse |
PROi | PR:Q64332 |
RNActi | Q64332, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000009394, Expressed in subiculum and 210 other tissues |
Genevisiblei | Q64332, MM |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR016185, PreATP-grasp_dom_sf IPR028712, SYN2/3 IPR001359, Synapsin IPR020898, Synapsin_ATP-bd_dom IPR019735, Synapsin_CS IPR019736, Synapsin_P_site IPR020897, Synapsin_pre-ATP-grasp_dom |
PANTHERi | PTHR10841:SF20, PTHR10841:SF20, 1 hit |
Pfami | View protein in Pfam PF02078, Synapsin, 1 hit PF02750, Synapsin_C, 1 hit PF10581, Synapsin_N, 1 hit |
PRINTSi | PR01368, SYNAPSIN |
SUPFAMi | SSF52440, SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS00415, SYNAPSIN_1, 1 hit PS00416, SYNAPSIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYN2_MOUSE | |
Accessioni | Q64332Primary (citable) accession number: Q64332 Secondary accession number(s): Q6NZR0, Q9QWV7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | August 30, 2005 | |
Last modified: | February 10, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families