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Protein

Neural proliferation differentiation and control protein 1

Gene

Npdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation.

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Neural proliferation differentiation and control protein 1
Short name:
NPDC-1
Gene namesi
Name:Npdc1
Synonyms:Npdc-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1099802 Npdc1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000002183135 – 332Neural proliferation differentiation and control protein 1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ64322
PaxDbiQ64322
PRIDEiQ64322

PTM databases

iPTMnetiQ64322
PhosphoSitePlusiQ64322

Expressioni

Tissue specificityi

Expressed in the brain and nervous system. Not detected in liver, heart, skeletal muscle, spleen, pancreas, pituitary and adrenal glands. Expression increases when cultured neural cells are growth-arrested and begin to differentiate.

Gene expression databases

BgeeiENSMUSG00000015094 Expressed in 279 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ64322 baseline and differential
GenevisibleiQ64322 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071387

Structurei

3D structure databases

ProteinModelPortaliQ64322
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi151 – 173Pro/Ser/Thr-richAdd BLAST23
Compositional biasi234 – 244Pro/Ser/Thr-richAdd BLAST11

Sequence similaritiesi

Belongs to the NPDC1/cab-1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3884 Eukaryota
ENOG4111QDP LUCA
GeneTreeiENSGT00440000038604
HOGENOMiHOG000231546
HOVERGENiHBG052657
InParanoidiQ64322
OMAiEPVHMSP
TreeFamiTF318443

Family and domain databases

InterProiView protein in InterPro
IPR009635 NPDC1
PANTHERiPTHR23352 PTHR23352, 1 hit
PfamiView protein in Pfam
PF06809 NPDC1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q64322-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPVPPPSP RHLRLLRLLL SGLILGAALN GATARRPDAT TCPGSLDCAL
60 70 80 90 100
KRRAKCPPGA HACGPCLQSF QEDQRGFCVP RKHLSSGEGL PQPRLEEEID
110 120 130 140 150
SLAQELALKE KEAGHSRLTA QPLLEAAQKL LEPAATLGFS QWGQRLEPGL
160 170 180 190 200
PSTHGTSSPI PHTSLSSRAS SGPVQMSPLE PQGRHGNGLT LVLILAFCLA
210 220 230 240 250
SSAALAVAAL CWCRLQREIR LTQKADYAAT AKGPTSPSTP RISPGDQRLA
260 270 280 290 300
HSAEMYHYQH QRQQMLCLER HKEPPKELES ASSDEENEDG DFTVYECPGL
310 320 330
APTGEMEVRN PLFDHSTLSA PVPGPHSLPP LQ
Length:332
Mass (Da):35,720
Last modified:July 27, 2011 - v2
Checksum:i22BDD66E8392B171
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJ20A2AJ20_MOUSE
Neural proliferation differentiatio...
Npdc1
231Annotation score:
A2AJ21A2AJ21_MOUSE
Neural proliferation differentiatio...
Npdc1 mCG_20288
341Annotation score:
A2AJ23A2AJ23_MOUSE
Neural proliferation differentiatio...
Npdc1
274Annotation score:
A2AJ19A2AJ19_MOUSE
Neural proliferation differentiatio...
Npdc1
141Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126A → R in CAA47648 (PubMed:7903403).Curated1
Sequence conflicti126A → R in AAA39836 (PubMed:7878019).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67209 mRNA Translation: CAA47648.1
L03814 mRNA Translation: AAA39836.1
AK146466 mRNA Translation: BAE27193.1
AL732557 Genomic DNA Translation: CAM25615.1
CH466542 Genomic DNA Translation: EDL08243.1
BC003320 mRNA Translation: AAH03320.1
CCDSiCCDS15771.1
PIRiI48691
RefSeqiNP_032747.2, NM_008721.4
UniGeneiMm.1131

Genome annotation databases

EnsembliENSMUST00000071442; ENSMUSP00000071387; ENSMUSG00000015094
GeneIDi18146
KEGGimmu:18146
UCSCiuc008irx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67209 mRNA Translation: CAA47648.1
L03814 mRNA Translation: AAA39836.1
AK146466 mRNA Translation: BAE27193.1
AL732557 Genomic DNA Translation: CAM25615.1
CH466542 Genomic DNA Translation: EDL08243.1
BC003320 mRNA Translation: AAH03320.1
CCDSiCCDS15771.1
PIRiI48691
RefSeqiNP_032747.2, NM_008721.4
UniGeneiMm.1131

3D structure databases

ProteinModelPortaliQ64322
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071387

PTM databases

iPTMnetiQ64322
PhosphoSitePlusiQ64322

Proteomic databases

MaxQBiQ64322
PaxDbiQ64322
PRIDEiQ64322

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071442; ENSMUSP00000071387; ENSMUSG00000015094
GeneIDi18146
KEGGimmu:18146
UCSCiuc008irx.2 mouse

Organism-specific databases

CTDi56654
MGIiMGI:1099802 Npdc1

Phylogenomic databases

eggNOGiKOG3884 Eukaryota
ENOG4111QDP LUCA
GeneTreeiENSGT00440000038604
HOGENOMiHOG000231546
HOVERGENiHBG052657
InParanoidiQ64322
OMAiEPVHMSP
TreeFamiTF318443

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

PROiPR:Q64322
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015094 Expressed in 279 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ64322 baseline and differential
GenevisibleiQ64322 MM

Family and domain databases

InterProiView protein in InterPro
IPR009635 NPDC1
PANTHERiPTHR23352 PTHR23352, 1 hit
PfamiView protein in Pfam
PF06809 NPDC1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPDC1_MOUSE
AccessioniPrimary (citable) accession number: Q64322
Secondary accession number(s): Q99J69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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