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Protein

Homeobox protein DLX-1

Gene

Dlx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a transcriptional activator or repressor (PubMed:21875655). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (PubMed:21875655). Likely to play a regulatory role in the development of the ventral forebrain (PubMed:1676488). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (PubMed:1676488).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi128 – 187HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-1
Gene namesi
Name:Dlx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:94901 Dlx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490211 – 255Homeobox protein DLX-1Add BLAST255

Proteomic databases

MaxQBiQ64317
PaxDbiQ64317
PeptideAtlasiQ64317
PRIDEiQ64317

PTM databases

PhosphoSitePlusiQ64317

Expressioni

Tissue specificityi

Expressed in a restricted region of the developing brain, within the diencephalon and the adjacent telencephalic regions.1 Publication

Developmental stagei

Expressed in developing retinal progenitor cells at 12 dpc (PubMed:21875655). Has a segmental expression in the developing forebrain (PubMed:1676488).2 Publications

Gene expression databases

BgeeiENSMUSG00000041911 Expressed in 211 organ(s), highest expression level in ganglionic eminence
CleanExiMM_DLX1
ExpressionAtlasiQ64317 baseline and differential
GenevisibleiQ64317 MM

Interactioni

Subunit structurei

Interacts with SMAD4 (via homeobox DNA-binding domain) (By similarity). Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction suppresses DLX1-mediated transcriptional activity in postnatal retina and enhances retinal ganglion cell (RGC) differentiation (PubMed:21875655).By similarity1 Publication

Protein-protein interaction databases

BioGridi199234, 10 interactors
STRINGi10090.ENSMUSP00000042413

Structurei

3D structure databases

ProteinModelPortaliQ64317
SMRiQ64317
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The homeobox DNA-binding domain is necessary for its nuclear localization, transcriptional and erythroid differentiation activities.By similarity

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231941
HOVERGENiHBG005493
InParanoidiQ64317
KOiK09314
OMAiQHDSSYS
OrthoDBiEOG091G0P17
PhylomeDBiQ64317
TreeFamiTF315720

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q64317-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH
60 70 80 90 100
SQPDGAYSSA SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR
110 120 130 140 150
LEDPGADSEK STVVEGGEVR FNGKGKKIRK PRTIYSSLQL QALNRRFQQT
160 170 180 190 200
QYLALPERAE LAASLGLTQT QVKIWFQNKR SKFKKLMKQG GAALEGSALA
210 220 230 240 250
NGRALSAGSP PVPPGWNPNS SSGKGSGSSA GSYVPSYTSW YPSAHQEAMQ

QPQLM
Length:255
Mass (Da):27,309
Last modified:November 1, 1996 - v1
Checksum:i99B474F5D3FD8B6D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V009G3V009_MOUSE
Homeobox protein DLX-1
Dlx1
110Annotation score:
G3XA72G3XA72_MOUSE
Homeobox protein DLX-1
Dlx1
79Annotation score:
G3UX87G3UX87_MOUSE
Homeobox protein DLX-1
Dlx1
22Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98 – 103QSRLED → PEPPGG (PubMed:1676488).Curated6
Sequence conflicti123G → GQ (PubMed:1676488).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51001 mRNA Translation: AAB40900.1
U51000 Genomic DNA Translation: AAB40899.1
BC079609 mRNA Translation: AAH79609.1
X57552 Genomic DNA Translation: CAB37647.1
CCDSiCCDS16116.1
RefSeqiNP_034183.1, NM_010053.2
XP_006498734.1, XM_006498671.3
XP_006498735.1, XM_006498672.3
XP_006498736.1, XM_006498673.3
XP_017170794.1, XM_017315305.1
XP_017170796.1, XM_017315307.1
XP_017170800.1, XM_017315311.1
UniGeneiMm.475101

Genome annotation databases

EnsembliENSMUST00000037119; ENSMUSP00000042413; ENSMUSG00000041911
GeneIDi13390
KEGGimmu:13390
UCSCiuc008kau.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51001 mRNA Translation: AAB40900.1
U51000 Genomic DNA Translation: AAB40899.1
BC079609 mRNA Translation: AAH79609.1
X57552 Genomic DNA Translation: CAB37647.1
CCDSiCCDS16116.1
RefSeqiNP_034183.1, NM_010053.2
XP_006498734.1, XM_006498671.3
XP_006498735.1, XM_006498672.3
XP_006498736.1, XM_006498673.3
XP_017170794.1, XM_017315305.1
XP_017170796.1, XM_017315307.1
XP_017170800.1, XM_017315311.1
UniGeneiMm.475101

3D structure databases

ProteinModelPortaliQ64317
SMRiQ64317
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199234, 10 interactors
STRINGi10090.ENSMUSP00000042413

PTM databases

PhosphoSitePlusiQ64317

Proteomic databases

MaxQBiQ64317
PaxDbiQ64317
PeptideAtlasiQ64317
PRIDEiQ64317

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037119; ENSMUSP00000042413; ENSMUSG00000041911
GeneIDi13390
KEGGimmu:13390
UCSCiuc008kau.1 mouse

Organism-specific databases

CTDi1745
MGIiMGI:94901 Dlx1

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231941
HOVERGENiHBG005493
InParanoidiQ64317
KOiK09314
OMAiQHDSSYS
OrthoDBiEOG091G0P17
PhylomeDBiQ64317
TreeFamiTF315720

Miscellaneous databases

PROiPR:Q64317
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041911 Expressed in 211 organ(s), highest expression level in ganglionic eminence
CleanExiMM_DLX1
ExpressionAtlasiQ64317 baseline and differential
GenevisibleiQ64317 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLX1_MOUSE
AccessioniPrimary (citable) accession number: Q64317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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