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Entry version 144 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Cyclin-dependent kinase inhibitor 1A

Gene

Cdkn1a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclinImported, KinaseImported, Protein kinase inhibitorARBA annotation, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-187577, SCF(Skp2)-mediated degradation of p27/p21
R-RNO-198323, AKT phosphorylates targets in the cytosol
R-RNO-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-RNO-2559586, DNA Damage/Telomere Stress Induced Senescence
R-RNO-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-RNO-69202, Cyclin E associated events during G1/S transition
R-RNO-69231, Cyclin D associated events in G1
R-RNO-69563, p53-Dependent G1 DNA Damage Response
R-RNO-69656, Cyclin A:Cdk2-associated events at S phase entry
R-RNO-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-9616222, Transcriptional regulation of granulopoiesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cyclin-dependent kinase inhibitor 1AImported
Submitted name:
Cyclin-dependent kinase inhibitor 1A (P21, Cip1)Imported
Submitted name:
p21Imported
Submitted name:
p21 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cdkn1aImported
Synonyms:cip1Imported, WAF1Imported
ORF Names:rCG_61102Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Rat genome database

More...
RGDi
69328, Cdkn1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q64315

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000000521, Expressed in esophagus and 22 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-29867N

Protein interaction database and analysis system

More...
IntActi
Q64315, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000000628

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q64315

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni74 – 150DisorderedSequence analysisAdd BLAST77

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CDI family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4743, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159918

KEGG Orthology (KO)

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KOi
K06625

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRRLVFC

Database of Orthologous Groups

More...
OrthoDBi
1595421at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101038

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003175, CDI
IPR029841, CDKN1A

The PANTHER Classification System

More...
PANTHERi
PTHR46778, PTHR46778, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02234, CDI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q64315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDPGDVRPV PHRSKVCRRL FGPVDSEQLS RDCDALMASC LQEARERWNF
60 70 80 90 100
DFATETPLEG NYVWERVRSP GLPKIYLSPG SRRRDDLGGD KRPSTSSALL
110 120 130 140 150
QGPGPAPEDH VALSLSCTLV SHAPERPEDS PGGTGTSQGR KRRQTSLTDF
160
YHSKRRLVFC KRKP
Length:164
Mass (Da):18,319
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6057E86045B6435F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07044451 Genomic DNA No translation available.
L41275 Genomic DNA Translation: AAC42084.1
U24174 mRNA Translation: AAC52221.1
BC100620 mRNA Translation: AAI00621.1
CH473988 Genomic DNA Translation: EDL96953.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I84725

NCBI Reference Sequences

More...
RefSeqi
NP_542960.1, NM_080782.3
XP_006256190.1, XM_006256128.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000000628; ENSRNOP00000000628; ENSRNOG00000000521
ENSRNOT00000091731; ENSRNOP00000072242; ENSRNOG00000000521

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114851

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:114851

UCSC genome browser

More...
UCSCi
RGD:69328, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044451 Genomic DNA No translation available.
L41275 Genomic DNA Translation: AAC42084.1
U24174 mRNA Translation: AAC52221.1
BC100620 mRNA Translation: AAI00621.1
CH473988 Genomic DNA Translation: EDL96953.1
PIRiI84725
RefSeqiNP_542960.1, NM_080782.3
XP_006256190.1, XM_006256128.3

3D structure databases

SMRiQ64315
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-29867N
IntActiQ64315, 1 interactor
STRINGi10116.ENSRNOP00000000628

Proteomic databases

PRIDEiQ64315

Genome annotation databases

EnsembliENSRNOT00000000628; ENSRNOP00000000628; ENSRNOG00000000521
ENSRNOT00000091731; ENSRNOP00000072242; ENSRNOG00000000521
GeneIDi114851
KEGGirno:114851
UCSCiRGD:69328, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1026
RGDi69328, Cdkn1a

Phylogenomic databases

eggNOGiKOG4743, Eukaryota
GeneTreeiENSGT00940000159918
KOiK06625
OMAiKRRLVFC
OrthoDBi1595421at2759
TreeFamiTF101038

Enzyme and pathway databases

ReactomeiR-RNO-187577, SCF(Skp2)-mediated degradation of p27/p21
R-RNO-198323, AKT phosphorylates targets in the cytosol
R-RNO-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-RNO-2559586, DNA Damage/Telomere Stress Induced Senescence
R-RNO-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-RNO-69202, Cyclin E associated events during G1/S transition
R-RNO-69231, Cyclin D associated events in G1
R-RNO-69563, p53-Dependent G1 DNA Damage Response
R-RNO-69656, Cyclin A:Cdk2-associated events at S phase entry
R-RNO-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-9616222, Transcriptional regulation of granulopoiesis

Gene expression databases

BgeeiENSRNOG00000000521, Expressed in esophagus and 22 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003175, CDI
IPR029841, CDKN1A
PANTHERiPTHR46778, PTHR46778, 1 hit
PfamiView protein in Pfam
PF02234, CDI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ64315_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q64315
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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