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Protein

Hematopoietic progenitor cell antigen CD34

Gene

Cd34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • sulfate binding Source: MGI
  • transcription factor binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hematopoietic progenitor cell antigen CD34
Alternative name(s):
CD_antigen: CD34
Gene namesi
Name:Cd34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88329 Cd34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 287ExtracellularSequence analysisAdd BLAST253
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 382CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000002090135 – 382Hematopoietic progenitor cell antigen CD34Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei326PhosphotyrosineCombined sources1
Modified residuei336PhosphotyrosineCombined sources1
Modified residuei343PhosphoserineCombined sources1

Post-translational modificationi

Highly glycosylated.By similarity
Phosphorylated on serine residues by PKC.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ64314
PRIDEiQ64314

PTM databases

iPTMnetiQ64314
PhosphoSitePlusiQ64314

Expressioni

Tissue specificityi

Highly expressed in hematopoietic progenitor cell lines, brain and testis, and moderately in the thymus, spleen, and bone marrow, but not in adult liver.

Gene expression databases

BgeeiENSMUSG00000016494 Expressed in 278 organ(s), highest expression level in skin of back
CleanExiMM_CD34
ExpressionAtlasiQ64314 baseline and differential
GenevisibleiQ64314 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ64314, 1 interactor
MINTiQ64314
STRINGi10090.ENSMUSP00000016638

Structurei

3D structure databases

ProteinModelPortaliQ64314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD34 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPJJ Eukaryota
ENOG410YPR6 LUCA
GeneTreeiENSGT00390000008414
HOGENOMiHOG000052513
HOVERGENiHBG003461
InParanoidiQ64314
KOiK06474
OMAiGMPRGWT
OrthoDBiEOG091G0K1S
PhylomeDBiQ64314
TreeFamiTF335795

Family and domain databases

InterProiView protein in InterPro
IPR008083 CD34
IPR013836 CD34/Podocalyxin
PANTHERiPTHR16677 PTHR16677, 1 hit
PfamiView protein in Pfam
PF06365 CD34_antigen, 1 hit
PRINTSiPR01700 CD34ANTIGEN

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: Q64314-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQVHRDTRAG LLLPWRWVAL CLMSLLHLNN LTSATTETST QGISPSVPTN
60 70 80 90 100
ESVEENITSS IPGSTSHYLI YQDSSKTTPA ISETMVNFTV TSGIPSGSGT
110 120 130 140 150
PHTFSQPQTS PTGILPTTSD SISTSEMTWK SSLPSINVSD YSPNNSSFEM
160 170 180 190 200
TSPTEPYAYT SSSAPSAIKG EIKCSGIREV RLAQGICLEL SEASSCEEFK
210 220 230 240 250
KEKGEDLIQI LCEKEEAEAD AGASVCSLLL AQSEVRPECL LMVLANSTEL
260 270 280 290 300
PSKLQLMEKH QSDLRKLGIQ SFNKQDIGSH QSYSRKTLIA LVTSGVLLAI
310 320 330 340 350
LGTTGYFLMN RRSWSPTGER LGEDPYYTEN GGGQGYSSGP GASPETQGKA
360 370 380
NVTRGAQENG TGQATSRNGH SARQHVVADT EL
Length:382
Mass (Da):40,983
Last modified:November 1, 1996 - v1
Checksum:iEAE611ABE85C4957
GO
Isoform Short (identifier: Q64314-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-325: GEDP → ELEP
     326-382: Missing.

Show »
Length:325
Mass (Da):35,263
Checksum:i940BDA6660E65C4C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YX84A0A0A6YX84_MOUSE
Hematopoietic progenitor cell antig...
Cd34
104Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004161322 – 325GEDP → ELEP in isoform Short. Curated4
Alternative sequenceiVSP_004162326 – 382Missing in isoform Short. CuratedAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69293 mRNA Translation: AAB19246.1
S69302 Genomic DNA No translation available.
S69295 Genomic DNA No translation available.
S69299 mRNA Translation: AAB22108.1 Sequence problems.
S69301 mRNA Translation: AAB22109.1
BC006607 mRNA Translation: AAH06607.1
CCDSiCCDS15640.1 [Q64314-1]
CCDS48490.1 [Q64314-2]
PIRiI65354
RefSeqiNP_598415.1, NM_133654.3 [Q64314-1]
UniGeneiMm.29798

Genome annotation databases

EnsembliENSMUST00000016638; ENSMUSP00000016638; ENSMUSG00000016494 [Q64314-1]
ENSMUST00000110815; ENSMUSP00000106439; ENSMUSG00000016494 [Q64314-2]
GeneIDi12490
KEGGimmu:12490
UCSCiuc007eeq.2 mouse [Q64314-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69293 mRNA Translation: AAB19246.1
S69302 Genomic DNA No translation available.
S69295 Genomic DNA No translation available.
S69299 mRNA Translation: AAB22108.1 Sequence problems.
S69301 mRNA Translation: AAB22109.1
BC006607 mRNA Translation: AAH06607.1
CCDSiCCDS15640.1 [Q64314-1]
CCDS48490.1 [Q64314-2]
PIRiI65354
RefSeqiNP_598415.1, NM_133654.3 [Q64314-1]
UniGeneiMm.29798

3D structure databases

ProteinModelPortaliQ64314
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64314, 1 interactor
MINTiQ64314
STRINGi10090.ENSMUSP00000016638

PTM databases

iPTMnetiQ64314
PhosphoSitePlusiQ64314

Proteomic databases

PaxDbiQ64314
PRIDEiQ64314

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016638; ENSMUSP00000016638; ENSMUSG00000016494 [Q64314-1]
ENSMUST00000110815; ENSMUSP00000106439; ENSMUSG00000016494 [Q64314-2]
GeneIDi12490
KEGGimmu:12490
UCSCiuc007eeq.2 mouse [Q64314-1]

Organism-specific databases

CTDi947
MGIiMGI:88329 Cd34

Phylogenomic databases

eggNOGiENOG410IPJJ Eukaryota
ENOG410YPR6 LUCA
GeneTreeiENSGT00390000008414
HOGENOMiHOG000052513
HOVERGENiHBG003461
InParanoidiQ64314
KOiK06474
OMAiGMPRGWT
OrthoDBiEOG091G0K1S
PhylomeDBiQ64314
TreeFamiTF335795

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiCd34 mouse
PROiPR:Q64314
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016494 Expressed in 278 organ(s), highest expression level in skin of back
CleanExiMM_CD34
ExpressionAtlasiQ64314 baseline and differential
GenevisibleiQ64314 MM

Family and domain databases

InterProiView protein in InterPro
IPR008083 CD34
IPR013836 CD34/Podocalyxin
PANTHERiPTHR16677 PTHR16677, 1 hit
PfamiView protein in Pfam
PF06365 CD34_antigen, 1 hit
PRINTSiPR01700 CD34ANTIGEN
ProtoNetiSearch...

Entry informationi

Entry nameiCD34_MOUSE
AccessioniPrimary (citable) accession number: Q64314
Secondary accession number(s): Q62550, Q62551
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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