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Protein

Surfeit locus protein 4

Gene

Surf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 4
Gene namesi
Name:Surf4
Synonyms:Surf-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98445 Surf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001276651 – 269Surfeit locus protein 4Add BLAST269

Proteomic databases

EPDiQ64310
MaxQBiQ64310
PaxDbiQ64310
PRIDEiQ64310

PTM databases

iPTMnetiQ64310
PhosphoSitePlusiQ64310
SwissPalmiQ64310

Expressioni

Gene expression databases

BgeeiENSMUSG00000014867 Expressed in 296 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_SURF4
ExpressionAtlasiQ64310 baseline and differential
GenevisibleiQ64310 MM

Interactioni

Subunit structurei

Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1 (By similarity). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701).By similarity1 Publication

Protein-protein interaction databases

BioGridi203581, 2 interactors
IntActiQ64310, 1 interactor
STRINGi10090.ENSMUSP00000015011

Structurei

3D structure databases

SMRiQ64310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi266 – 269Di-lysine motifBy similarity4

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Belongs to the SURF4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3998 Eukaryota
COG2259 LUCA
GeneTreeiENSGT00530000064123
HOGENOMiHOG000206959
HOVERGENiHBG054238
InParanoidiQ64310
KOiK20369
OMAiDQLWYLQ
OrthoDBiEOG091G0H3P
PhylomeDBiQ64310
TreeFamiTF300001

Family and domain databases

InterProiView protein in InterPro
IPR002995 Surf4
PfamiView protein in Pfam
PF02077 SURF4, 1 hit
PROSITEiView protein in PROSITE
PS01339 SURF4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q64310-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE
60 70 80 90 100
QRDYIDTTWS CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI
110 120 130 140 150
IALQTIAYSI LWDLKFLMRN LALGGGLLLL LAESRSEGKS MFAGVPTMRE
160 170 180 190 200
SSPKQYMQLG GRVLLVLMFM TLLHFDASFF SIIQNIVGTA LMILVAIGFK
210 220 230 240 250
TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF QTMSVIGGLL
260
LVVALGPGGV SMDEKKKEW
Length:269
Mass (Da):30,381
Last modified:November 1, 1996 - v1
Checksum:iCC1F5219400E52F8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CH13F7CH13_MOUSE
Surfeit locus protein 4
Surf4
124Annotation score:
E0CXD9E0CXD9_MOUSE
Surfeit locus protein 4
Surf4
82Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62606
, M62601, M62602, M62603, M62605 Genomic DNA Translation: AAA40155.1
M63114 mRNA Translation: AAA40156.1
BC003280 mRNA Translation: AAH03280.1
BC027352 mRNA Translation: AAH27352.1
CCDSiCCDS15817.1
PIRiA34727
RefSeqiNP_035642.1, NM_011512.3
UniGeneiMm.300594

Genome annotation databases

EnsembliENSMUST00000015011; ENSMUSP00000015011; ENSMUSG00000014867
GeneIDi20932
KEGGimmu:20932
UCSCiuc008iwl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62606
, M62601, M62602, M62603, M62605 Genomic DNA Translation: AAA40155.1
M63114 mRNA Translation: AAA40156.1
BC003280 mRNA Translation: AAH03280.1
BC027352 mRNA Translation: AAH27352.1
CCDSiCCDS15817.1
PIRiA34727
RefSeqiNP_035642.1, NM_011512.3
UniGeneiMm.300594

3D structure databases

SMRiQ64310
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203581, 2 interactors
IntActiQ64310, 1 interactor
STRINGi10090.ENSMUSP00000015011

PTM databases

iPTMnetiQ64310
PhosphoSitePlusiQ64310
SwissPalmiQ64310

Proteomic databases

EPDiQ64310
MaxQBiQ64310
PaxDbiQ64310
PRIDEiQ64310

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015011; ENSMUSP00000015011; ENSMUSG00000014867
GeneIDi20932
KEGGimmu:20932
UCSCiuc008iwl.2 mouse

Organism-specific databases

CTDi6836
MGIiMGI:98445 Surf4

Phylogenomic databases

eggNOGiKOG3998 Eukaryota
COG2259 LUCA
GeneTreeiENSGT00530000064123
HOGENOMiHOG000206959
HOVERGENiHBG054238
InParanoidiQ64310
KOiK20369
OMAiDQLWYLQ
OrthoDBiEOG091G0H3P
PhylomeDBiQ64310
TreeFamiTF300001

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiSurf4 mouse
PROiPR:Q64310
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014867 Expressed in 296 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_SURF4
ExpressionAtlasiQ64310 baseline and differential
GenevisibleiQ64310 MM

Family and domain databases

InterProiView protein in InterPro
IPR002995 Surf4
PfamiView protein in Pfam
PF02077 SURF4, 1 hit
PROSITEiView protein in PROSITE
PS01339 SURF4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSURF4_MOUSE
AccessioniPrimary (citable) accession number: Q64310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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