Ptf1a

Functionⁱ

Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.3 Publications

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 2788241
DNA-binding transcription factor activity
Source: RGD
Traceable author statementⁱ
- 8861960
E-box binding Source: Ensembl
protein dimerization activity Source: InterPro
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 1840677

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amacrine cell differentiation Source: UniProtKB
cerebellum development Source: UniProtKB
exocrine pancreas development
Source: UniProtKB
Inferred from direct assayⁱ
- 10768861
generation of neurons Source: UniProtKB
hindbrain development Source: UniProtKB
neuron fate commitment Source: Ensembl
positive regulation of transcription, DNA-templated Source: UniProtKB
regulation of neural retina development Source: UniProtKB
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 2788241
retina layer formation Source: UniProtKB
retinoic acid receptor signaling pathway Source: UniProtKB
tissue development Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pancreas transcription factor 1 subunit alpha Alternative name(s): Pancreas-specific transcription factor 1a bHLH transcription factor p48 p48 DNA-binding subunit of transcription factor PTF1 Short name: PTF1-p48
Gene namesⁱ	Name:Ptf1a Synonyms:Ptf1p48
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 17

Organism-specific databases

Rat genome database More...RGDⁱ	621709 Ptf1a

RGDⁱ

621709 Ptf1a

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000233145	1 – 326	Pancreas transcription factor 1 subunit alphaAdd BLAST		326

Proteomic databases

PaxDbⁱ	Q64305
PRIDEⁱ	Q64305

Expressionⁱ

Tissue specificityⁱ

Exocrine pancreas-specific. Expressed in azaserine-induced pancreatic tumors (at protein level). Expressed in AR42J cells but not in ARIP, DSL6A, or DSL6B cells. Down-regulation is associated with the change of an azaserine-induced acinar cell carcinoma to a ductal phenotype.1 Publication

Developmental stageⁱ

Expressed from day 12 of gestation in pancreatic structures.1 Publication

Gene expression databases

Genevisibleⁱ	Q64305 RN

Genevisibleⁱ

Q64305 RN

Interactionⁱ

Subunit structureⁱ

Component of the pancreas transcription factor 1 complex (PTF1) which is composed of TCF3/p75, TCF12/p64 and PTF1A/p48. TCF3 is responsible for the nuclear import of the p48/p64 complex. Interacts with TCF3 and RBPSUH/RBP-Jkappa (By similarity).By similarity

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	250633, 1 interactor
CORUMⁱ	Q64305
STRINGⁱ	10116.ENSRNOP00000022727

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q64305
SMRⁱ	Q64305
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	162 – 214	bHLHPROSITE-ProRule annotationAdd BLAST		53

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	140 – 148	Poly-Ala		9

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110958
HOGENOMⁱ	HOG000231913
HOVERGENⁱ	HBG082224
InParanoidⁱ	Q64305
KEGG Orthology (KO) More...KOⁱ	K09073
OMAⁱ	YCCEAGA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RR2
PhylomeDBⁱ	Q64305
TreeFamⁱ	TF315153

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q64305-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDAVLLEHFP GALDTFPSSY FDEEDFFTDQ SSRDPLEDGD ELLGDEQAEV 
        60         70         80         90        100
EFLSHQLHEY CYRDGACLLL QPAPSAAPHA LAPPPLGDPG EPEDSGSYCC 
       110        120        130        140        150
DAGAPLGAFP YSPGSPPSCL AYPCTAVLSP GTRLRGLNGA AAAAAAAARR 
       160        170        180        190        200
RRRVRSEAEL QQLRQAANVR ERRRMQSIND AFEGLRSHIP TLPYEKRLSK 
       210        220        230        240        250
VDTLRLAIGY INFLSELVQA DLPLRGSGTG GCGGPGGSRH LGGDSPGNQA 
       260        270        280        290        300
QKVIICHRGT RSPSPSDPDY GLPPLAGHSL SWADEKQLKE QNIIRTAKVW 
       310        320 
TPEDPRKLNS KSFDNIENEP PFEFVS

Length:326

Mass (Da):35,305

Last modified:November 1, 1996 - v1

Checksum:ⁱE06D0132390E429F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X98170 mRNA Translation: CAA66851.1 X98446 Genomic DNA Translation: CAA67076.1
PIRⁱ	S71755
NCBI Reference Sequences More...RefSeqⁱ	NP_446416.1, NM_053964.1
UniGeneⁱ	Rn.10536

Genome annotation databases

Ensemblⁱ	ENSRNOT00000022727; ENSRNOP00000022727; ENSRNOG00000016902
GeneIDⁱ	117034
KEGGⁱ	rno:117034
UCSC genome browser More...UCSCⁱ	RGD:621709 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q64305	Pancreas transcription factor 1 subunit alpha		MOUSE		324	UniRef90_Q9QX98
Pancreas transcription factor 1 subunit alpha		HUMAN		328
Pancreas associated transcription factor 1a		CALJA		332
Uncharacterized protein		Cebus capucinus imitator		332
pancreas transcription factor 1 subunit alpha		ODORO		331
+57

Protein	Similar proteins		Species	Score	Length	Source
Q64305	Pancreas transcription factor 1 subunit alpha		MOUSE		324	UniRef50_Q9QX98
Pancreas transcription factor 1 subunit alpha		HUMAN		328
Pancreas associated transcription factor 1a		CALJA		332
Uncharacterized protein		Cebus capucinus imitator		332
Uncharacterized protein		AOTNA		331
+125

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X98170 mRNA Translation: CAA66851.1 X98446 Genomic DNA Translation: CAA67076.1
PIRⁱ	S71755
RefSeqⁱ	NP_446416.1, NM_053964.1
UniGeneⁱ	Rn.10536

3D structure databases

ProteinModelPortalⁱ	Q64305
SMRⁱ	Q64305
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	250633, 1 interactor
CORUMⁱ	Q64305
STRINGⁱ	10116.ENSRNOP00000022727

Proteomic databases

PaxDbⁱ	Q64305
PRIDEⁱ	Q64305

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000022727; ENSRNOP00000022727; ENSRNOG00000016902
GeneIDⁱ	117034
KEGGⁱ	rno:117034
UCSCⁱ	RGD:621709 rat

Organism-specific databases

CTDⁱ	256297
RGDⁱ	621709 Ptf1a

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00730000110958
HOGENOMⁱ	HOG000231913
HOVERGENⁱ	HBG082224
InParanoidⁱ	Q64305
KOⁱ	K09073
OMAⁱ	YCCEAGA
OrthoDBⁱ	EOG091G0RR2
PhylomeDBⁱ	Q64305
TreeFamⁱ	TF315153

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q64305

PROⁱ

PR:Q64305

Gene expression databases

Genevisibleⁱ	Q64305 RN

Genevisibleⁱ

Q64305 RN

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTF1A_RAT
Accessionⁱ	Q64305Primary (citable) accession number: Q64305
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - Q64305 (PTF1A_RAT)

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Pancreas transcription factor 1 subunit alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ