UniProtKB - Q64305 (PTF1A_RAT)
Pancreas transcription factor 1 subunit alpha
Ptf1a
Functioni
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
3 PublicationsGO - Molecular functioni
- chromatin binding Source: RGD
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- E-box binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- amacrine cell differentiation Source: UniProtKB
- cell differentiation Source: RGD
- cell fate commitment Source: RGD
- cerebellum development Source: UniProtKB
- developmental process Source: GO_Central
- exocrine pancreas development Source: UniProtKB
- generation of neurons Source: HGNC
- hindbrain development Source: HGNC
- neuron fate commitment Source: RGD
- pancreas development Source: RGD
- positive regulation of transcription, DNA-templated Source: HGNC
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of neural retina development Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- retina layer formation Source: UniProtKB
- retina morphogenesis in camera-type eye Source: RGD
- retinoic acid receptor signaling pathway Source: HGNC
- tissue development Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Pancreas transcription factor 1 subunit alphaAlternative name(s): Pancreas-specific transcription factor 1a bHLH transcription factor p48 p48 DNA-binding subunit of transcription factor PTF1 Short name: PTF1-p48 |
Gene namesi | Name:Ptf1a Synonyms:Ptf1p48 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621709, Ptf1a |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- transcription regulator complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233145 | 1 – 326 | Pancreas transcription factor 1 subunit alphaAdd BLAST | 326 |
Proteomic databases
PaxDbi | Q64305 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSRNOG00000016902, Expressed in pancreas and 4 other tissues |
Genevisiblei | Q64305, RN |
Interactioni
Subunit structurei
Component of the pancreas transcription factor 1 complex (PTF1) which is composed of TCF3/p75, TCF12/p64 and PTF1A/p48. TCF3 is responsible for the nuclear import of the p48/p64 complex.
Interacts with TCF3 and RBPSUH/RBP-Jkappa (By similarity).
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 250633, 1 interactor |
CORUMi | Q64305 |
STRINGi | 10116.ENSRNOP00000022727 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 162 – 214 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 229 – 249 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 304 – 326 | DisorderedSequence analysisAdd BLAST | 23 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161000 |
HOGENOMi | CLU_053709_0_0_1 |
InParanoidi | Q64305 |
OMAi | CYRDGAC |
OrthoDBi | 1269550at2759 |
PhylomeDBi | Q64305 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MDAVLLEHFP GALDTFPSSY FDEEDFFTDQ SSRDPLEDGD ELLGDEQAEV
60 70 80 90 100
EFLSHQLHEY CYRDGACLLL QPAPSAAPHA LAPPPLGDPG EPEDSGSYCC
110 120 130 140 150
DAGAPLGAFP YSPGSPPSCL AYPCTAVLSP GTRLRGLNGA AAAAAAAARR
160 170 180 190 200
RRRVRSEAEL QQLRQAANVR ERRRMQSIND AFEGLRSHIP TLPYEKRLSK
210 220 230 240 250
VDTLRLAIGY INFLSELVQA DLPLRGSGTG GCGGPGGSRH LGGDSPGNQA
260 270 280 290 300
QKVIICHRGT RSPSPSDPDY GLPPLAGHSL SWADEKQLKE QNIIRTAKVW
310 320
TPEDPRKLNS KSFDNIENEP PFEFVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98170 mRNA Translation: CAA66851.1 X98446 Genomic DNA Translation: CAA67076.1 |
PIRi | S71755 |
RefSeqi | NP_446416.1, NM_053964.1 |
Genome annotation databases
Ensembli | ENSRNOT00000022727; ENSRNOP00000022727; ENSRNOG00000016902 |
GeneIDi | 117034 |
KEGGi | rno:117034 |
UCSCi | RGD:621709, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98170 mRNA Translation: CAA66851.1 X98446 Genomic DNA Translation: CAA67076.1 |
PIRi | S71755 |
RefSeqi | NP_446416.1, NM_053964.1 |
3D structure databases
AlphaFoldDBi | Q64305 |
SMRi | Q64305 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 250633, 1 interactor |
CORUMi | Q64305 |
STRINGi | 10116.ENSRNOP00000022727 |
Proteomic databases
PaxDbi | Q64305 |
Genome annotation databases
Ensembli | ENSRNOT00000022727; ENSRNOP00000022727; ENSRNOG00000016902 |
GeneIDi | 117034 |
KEGGi | rno:117034 |
UCSCi | RGD:621709, rat |
Organism-specific databases
CTDi | 256297 |
RGDi | 621709, Ptf1a |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161000 |
HOGENOMi | CLU_053709_0_0_1 |
InParanoidi | Q64305 |
OMAi | CYRDGAC |
OrthoDBi | 1269550at2759 |
PhylomeDBi | Q64305 |
TreeFami | TF315153 |
Miscellaneous databases
PROi | PR:Q64305 |
Gene expression databases
Bgeei | ENSRNOG00000016902, Expressed in pancreas and 4 other tissues |
Genevisiblei | Q64305, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PTF1A_RAT | |
Accessioni | Q64305Primary (citable) accession number: Q64305 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |