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Protein

Pancreas transcription factor 1 subunit alpha

Gene

Ptf1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreas transcription factor 1 subunit alpha
Alternative name(s):
Pancreas-specific transcription factor 1a
bHLH transcription factor p48
p48 DNA-binding subunit of transcription factor PTF1
Short name:
PTF1-p48
Gene namesi
Name:Ptf1a
Synonyms:Ptf1p48
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi621709 Ptf1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331451 – 326Pancreas transcription factor 1 subunit alphaAdd BLAST326

Proteomic databases

PaxDbiQ64305
PRIDEiQ64305

Expressioni

Tissue specificityi

Exocrine pancreas-specific. Expressed in azaserine-induced pancreatic tumors (at protein level). Expressed in AR42J cells but not in ARIP, DSL6A, or DSL6B cells. Down-regulation is associated with the change of an azaserine-induced acinar cell carcinoma to a ductal phenotype.1 Publication

Developmental stagei

Expressed from day 12 of gestation in pancreatic structures.1 Publication

Gene expression databases

GenevisibleiQ64305 RN

Interactioni

Subunit structurei

Component of the pancreas transcription factor 1 complex (PTF1) which is composed of TCF3/p75, TCF12/p64 and PTF1A/p48. TCF3 is responsible for the nuclear import of the p48/p64 complex. Interacts with TCF3 and RBPSUH/RBP-Jkappa (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250633, 1 interactor
CORUMiQ64305
STRINGi10116.ENSRNOP00000022727

Structurei

3D structure databases

ProteinModelPortaliQ64305
SMRiQ64305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 214bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 148Poly-Ala9

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00730000110958
HOGENOMiHOG000231913
HOVERGENiHBG082224
InParanoidiQ64305
KOiK09073
OMAiYCCEAGA
OrthoDBiEOG091G0RR2
PhylomeDBiQ64305
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q64305-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAVLLEHFP GALDTFPSSY FDEEDFFTDQ SSRDPLEDGD ELLGDEQAEV
60 70 80 90 100
EFLSHQLHEY CYRDGACLLL QPAPSAAPHA LAPPPLGDPG EPEDSGSYCC
110 120 130 140 150
DAGAPLGAFP YSPGSPPSCL AYPCTAVLSP GTRLRGLNGA AAAAAAAARR
160 170 180 190 200
RRRVRSEAEL QQLRQAANVR ERRRMQSIND AFEGLRSHIP TLPYEKRLSK
210 220 230 240 250
VDTLRLAIGY INFLSELVQA DLPLRGSGTG GCGGPGGSRH LGGDSPGNQA
260 270 280 290 300
QKVIICHRGT RSPSPSDPDY GLPPLAGHSL SWADEKQLKE QNIIRTAKVW
310 320
TPEDPRKLNS KSFDNIENEP PFEFVS
Length:326
Mass (Da):35,305
Last modified:November 1, 1996 - v1
Checksum:iE06D0132390E429F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98170 mRNA Translation: CAA66851.1
X98446 Genomic DNA Translation: CAA67076.1
PIRiS71755
RefSeqiNP_446416.1, NM_053964.1
UniGeneiRn.10536

Genome annotation databases

EnsembliENSRNOT00000022727; ENSRNOP00000022727; ENSRNOG00000016902
GeneIDi117034
KEGGirno:117034
UCSCiRGD:621709 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98170 mRNA Translation: CAA66851.1
X98446 Genomic DNA Translation: CAA67076.1
PIRiS71755
RefSeqiNP_446416.1, NM_053964.1
UniGeneiRn.10536

3D structure databases

ProteinModelPortaliQ64305
SMRiQ64305
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250633, 1 interactor
CORUMiQ64305
STRINGi10116.ENSRNOP00000022727

Proteomic databases

PaxDbiQ64305
PRIDEiQ64305

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022727; ENSRNOP00000022727; ENSRNOG00000016902
GeneIDi117034
KEGGirno:117034
UCSCiRGD:621709 rat

Organism-specific databases

CTDi256297
RGDi621709 Ptf1a

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00730000110958
HOGENOMiHOG000231913
HOVERGENiHBG082224
InParanoidiQ64305
KOiK09073
OMAiYCCEAGA
OrthoDBiEOG091G0RR2
PhylomeDBiQ64305
TreeFamiTF315153

Miscellaneous databases

PROiPR:Q64305

Gene expression databases

GenevisibleiQ64305 RN

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTF1A_RAT
AccessioniPrimary (citable) accession number: Q64305
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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