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Protein

Bile salt-activated lipase

Gene

Cel

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides (By similarity).By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.
A steryl ester + H2O = a sterol + a fatty acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei214Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei340Charge relay systemBy similarity1
Active sitei455Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ceramide catabolic process Source: MGI
  • cholesterol catabolic process Source: MGI
  • pancreatic juice secretion Source: MGI

Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processLipid degradation, Lipid metabolism

Protein family/group databases

ESTHERimouse-pches Cholesterol_esterase
MEROPSiS09.985

Chemistry databases

SwissLipidsiSLP:000001681

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt-activated lipase (EC:3.1.1.13, EC:3.1.1.3)
Short name:
BAL
Alternative name(s):
Bile salt-stimulated lipase
Short name:
BSSL
Carboxyl ester lipase
Cholesterol esterase
Pancreatic lysophospholipase
Sterol esterase
Gene namesi
Name:Cel
Synonyms:Lip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88374 Cel

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000000863221 – 599Bile salt-activated lipaseAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 100By similarity
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi266 ↔ 277By similarity
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ64285
PaxDbiQ64285
PRIDEiQ64285

2D gel databases

SWISS-2DPAGEiQ64285

PTM databases

PhosphoSitePlusiQ64285

Expressioni

Tissue specificityi

EXpressed by eosinophils.1 Publication

Gene expression databases

BgeeiENSMUSG00000026818 Expressed in 59 organ(s), highest expression level in stomach
CleanExiMM_CEL
ExpressionAtlasiQ64285 baseline and differential
GenevisibleiQ64285 MM

Interactioni

Subunit structurei

Interacts with CLC.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028161

Structurei

3D structure databases

ProteinModelPortaliQ64285
SMRiQ64285
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati559 – 5691Add BLAST11
Repeati570 – 5802Add BLAST11
Repeati581 – 58838

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni559 – 5884 X 11 AA tandem repeats, O-glycosylated regionAdd BLAST30

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000091866
HOVERGENiHBG008839
InParanoidiQ64285
KOiK12298
OMAiKWMGADH
OrthoDBiEOG091G04Y0
PhylomeDBiQ64285
TreeFamiTF315470

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR033560 BAL
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PANTHERiPTHR43903:SF1 PTHR43903:SF1, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64285-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRLEVLFLG LTCCLAAACA AKLGAVYTEG GFVEGVNKKL SLLGGDSVDI
60 70 80 90 100
FKGIPFATAK TLENPQRHPG WQGTLKATNF KKRCLQATIT QDNTYGQEDC
110 120 130 140 150
LYLNIWVPQG RKQVSHNLPV MVWIYGGAFL MGSGQGANFL KNYLYDGEEI
160 170 180 190 200
ATRGNVIVVT FNYRVGPLGF LSTGDANLPG NFGLRDQHMA IAWVKRNIAA
210 220 230 240 250
FGGDPDNITI FGESAGAASV SLQTLSPYNK GLIRRAISQS GMALSPWAIQ
260 270 280 290 300
KNPLFWAKTI AKKVGCPTED TGKMAACLKI TDPRALTLAY KLPVKKQEYP
310 320 330 340 350
VVHYLAFIPV IDGDFIPDDP INLYNNTADI DYIAGINNMD GHLFATIDVP
360 370 380 390 400
AVDKTKQTVT EEDFYRLVSG HTVAKGLKGA QATFDIYTES WAQDPSQENM
410 420 430 440 450
KKTVVAFETD VLFLIPTEIA LAQHKAHAKS AKTYSYLFSH PSRMPIYPKW
460 470 480 490 500
MGADHADDLQ YVFGKPFATP LGYRPQDRAV SKAMIAYWTN FARSGDPNMG
510 520 530 540 550
NSPVPTHWYP YTLENGNYLD ITKTITSASM KEHLREKFLK FWAVTFEVLP
560 570 580 590
TVTGDQDTLT PPEDDSEVAP DPPSDDSQVV PVPPTDDSVE AQMPATIGF
Length:599
Mass (Da):65,813
Last modified:November 1, 1996 - v1
Checksum:i9E4428FDFCA8602E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33169 mRNA Translation: AAA92088.1
U37386 mRNA Translation: AAC52279.1
CCDSiCCDS15841.1
PIRiA57701
RefSeqiNP_034015.1, NM_009885.2
UniGeneiMm.236017

Genome annotation databases

EnsembliENSMUST00000028161; ENSMUSP00000028161; ENSMUSG00000026818
GeneIDi12613
KEGGimmu:12613
UCSCiuc008iyr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33169 mRNA Translation: AAA92088.1
U37386 mRNA Translation: AAC52279.1
CCDSiCCDS15841.1
PIRiA57701
RefSeqiNP_034015.1, NM_009885.2
UniGeneiMm.236017

3D structure databases

ProteinModelPortaliQ64285
SMRiQ64285
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028161

Chemistry databases

SwissLipidsiSLP:000001681

Protein family/group databases

ESTHERimouse-pches Cholesterol_esterase
MEROPSiS09.985

PTM databases

PhosphoSitePlusiQ64285

2D gel databases

SWISS-2DPAGEiQ64285

Proteomic databases

MaxQBiQ64285
PaxDbiQ64285
PRIDEiQ64285

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028161; ENSMUSP00000028161; ENSMUSG00000026818
GeneIDi12613
KEGGimmu:12613
UCSCiuc008iyr.1 mouse

Organism-specific databases

CTDi1056
MGIiMGI:88374 Cel

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000091866
HOVERGENiHBG008839
InParanoidiQ64285
KOiK12298
OMAiKWMGADH
OrthoDBiEOG091G04Y0
PhylomeDBiQ64285
TreeFamiTF315470

Miscellaneous databases

ChiTaRSiCel mouse
PROiPR:Q64285
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026818 Expressed in 59 organ(s), highest expression level in stomach
CleanExiMM_CEL
ExpressionAtlasiQ64285 baseline and differential
GenevisibleiQ64285 MM

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR033560 BAL
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PANTHERiPTHR43903:SF1 PTHR43903:SF1, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEL_MOUSE
AccessioniPrimary (citable) accession number: Q64285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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