Leukocyte immunoglobulin-like receptor subfamily B member 4A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• fibronectin binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.20

    "Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice."
    Su M.T., Inui M., Wong Y.L., Takahashi M., Sugahara-Tobinai A., Ono K., Miyamoto S., Murakami K., Itoh-Nakadai A., Kezuka D., Itoi S., Endo S., Hirayasu K., Arase H., Takai T.
    Int. Immunol. 33:447-458(2021) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• integrin binding Source: ARUK-UCLInferred from direct assayⁱ
  • Ref.12

    "gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation."
    Castells M.C., Klickstein L.B., Hassani K., Cumplido J.A., Lacouture M.E., Austen K.F., Katz H.R.
    Nat. Immunol. 2:436-442(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• phosphatase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.9

    "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B."
    Wang L.L., Blasioli J., Plas D.R., Thomas M.L., Yokoyama W.M.
    J. Immunol. 162:1318-1323(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH PTPN6, ITIM MOTIFS, PHOSPHORYLATION.
• protein phosphatase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.8

    "gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization."
    Lu-Kuo J.M., Joyal D.M., Austen K.F., Katz H.R.
    J. Biol. Chem. 274:5791-5796(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PTPN6 AND PTPN11, PHOSPHORYLATION, MUTAGENESIS OF TYR-300 AND TYR-322.
• signaling receptor inhibitor activity Source: MGI
• transmembrane receptor protein tyrosine kinase inhibitor activity Source: MGI

GO - Biological processⁱ

• adaptive immune response Source: UniProtKB-KW
• blood coagulation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.14

    "Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils."
    Zhou J.S., Friend D.S., Feldweg A.M., Daheshia M., Li L., Austen K.F., Katz H.R.
    J. Exp. Med. 198:1243-1251(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
• CD4-positive, alpha-beta T cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.17

    "A novel regulatory role of gp49B on dendritic cells in T-cell priming."
    Kasai S., Inui M., Nakamura K., Kakizaki Y., Endo S., Nakamura A., Ito S., Takai T.
    Eur. J. Immunol. 38:2426-2437(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
• CD8-positive, alpha-beta T cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.17

    "A novel regulatory role of gp49B on dendritic cells in T-cell priming."
    Kasai S., Inui M., Nakamura K., Kakizaki Y., Endo S., Nakamura A., Ito S., Takai T.
    Eur. J. Immunol. 38:2426-2437(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
• cellular response to lipopolysaccharide Source: MGIInferred from mutant phenotypeⁱ
  • Ref.14

    "Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils."
    Zhou J.S., Friend D.S., Feldweg A.M., Daheshia M., Li L., Austen K.F., Katz H.R.
    J. Exp. Med. 198:1243-1251(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
• Fc receptor mediated inhibitory signaling pathway Source: MGI
• inflammatory response Source: MGIInferred from mutant phenotypeⁱ
  • Ref.16

    "Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation."
    Norris H.H., Peterson M.E., Stebbins C.C., McConchie B.W., Bundoc V.G., Trivedi S., Hodges M.G., Anthony R.M., Urban J.F. Jr., Long E.O., Keane-Myers A.M.
    J. Leukoc. Biol. 82:1531-1541(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
• inflammatory response to antigenic stimulus Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibition of Th2 adaptive immune responses and pulmonary inflammation by leukocyte Ig-like receptor B4 on dendritic cells."
    Breslow R.G., Rao J.J., Xing W., Hong D.I., Barrett N.A., Katz H.R.
    J Immunol 184:1003-1013(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of activated T cell proliferation Source: MGI
• negative regulation of chemokine production Source: MGI
• negative regulation of cytokine production involved in inflammatory response Source: MGI
• negative regulation of cytotoxic T cell differentiation Source: MGI
• negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
• negative regulation of immunoglobulin production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.19

    "gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells."
    Fukao S., Haniuda K., Nojima T., Takai T., Kitamura D.
    J. Immunol. 193:635-644(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
• negative regulation of interferon-gamma production Source: MGI
• negative regulation of interleukin-10 production Source: MGI
• negative regulation of interleukin-1 beta production Source: MGI
• negative regulation of interleukin-2 production Source: MGI
• negative regulation of interleukin-5 production Source: MGI
• negative regulation of interleukin-6 production Source: MGI
• negative regulation of IP-10 production Source: MGI
• negative regulation of MAPK cascade Source: MGI
• negative regulation of mast cell activation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.13

    "gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo."
    Feldweg A.M., Friend D.S., Zhou J.S., Kanaoka Y., Daheshia M., Li L., Austen K.F., Katz H.R.
    Eur. J. Immunol. 33:2262-2268(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• negative regulation of mast cell activation involved in immune response Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization."
    Lu-Kuo J.M., Joyal D.M., Austen K.F., Katz H.R.
    J. Biol. Chem. 274:5791-5796(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PTPN6 AND PTPN11, PHOSPHORYLATION, MUTAGENESIS OF TYR-300 AND TYR-322.
  • Ref.3

    "Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE."
    Katz H.R., Vivier E., Castells M.C., McCormick M.J., Chambers J.M., Austen K.F.
    Proc. Natl. Acad. Sci. U.S.A. 93:10809-10814(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, ITIM MOTIFS.
• negative regulation of monocyte activation Source: UniProtKBInferred from direct assayⁱ
  • Ref.20

    "Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice."
    Su M.T., Inui M., Wong Y.L., Takahashi M., Sugahara-Tobinai A., Ono K., Miyamoto S., Murakami K., Itoh-Nakadai A., Kezuka D., Itoi S., Endo S., Hirayasu K., Arase H., Takai T.
    Int. Immunol. 33:447-458(2021) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of natural killer cell activation Source: UniProtKBInferred from direct assayⁱ
  • Ref.5

    "Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells."
    Rojo S., Burshtyn D.N., Long E.O., Wagtmann N.
    J. Immunol. 158:9-12(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• negative regulation of osteoclast differentiation Source: MGI
• negative regulation of plasma cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.19

    "gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells."
    Fukao S., Haniuda K., Nojima T., Takai T., Kitamura D.
    J. Immunol. 193:635-644(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
• negative regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
• negative regulation of protein localization to nucleus Source: MGI
• negative regulation of protein tyrosine kinase activity Source: MGI
• negative regulation of signaling receptor activity Source: MGI
• negative regulation of T cell costimulation Source: MGI
• negative regulation of T cell cytokine production Source: MGI
• negative regulation of T cell proliferation Source: MGI
• negative regulation of T cell receptor signaling pathway Source: MGI
• neutrophil homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "gp49B1 deficiency is associated with increases in cytokine and chemokine production and severity of proliferative synovitis induced by anti-type II collagen mAb."
    Zhou J.S., Friend D.S., Lee D.M., Li L., Austen K.F., Katz H.R.
    Eur J Immunol 35:1530-1538(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of CD8-positive, alpha-beta T cell differentiation Source: MGI
• positive regulation of regulatory T cell differentiation Source: MGI
• positive regulation of T cell anergy Source: MGI
• receptor internalization Source: MGI
• response to extracellular stimulus Source: MGIInferred from mutant phenotypeⁱ
  • "Downregulation of key early events in the mobilization of antigen-bearing dendritic cells by leukocyte immunoglobulin-like Receptor B4 in a mouse model of allergic pulmonary inflammation."
    Fanning L.B., Buckley C.C., Xing W., Breslow R.G., Katz H.R.
    PLoS One 8:e57007-e57007(2013) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: MGIInferred from mutant phenotypeⁱ
  • Ref.14

    "Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils."
    Zhou J.S., Friend D.S., Feldweg A.M., Daheshia M., Li L., Austen K.F., Katz H.R.
    J. Exp. Med. 198:1243-1251(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
  • "gp49B1 deficiency is associated with increases in cytokine and chemokine production and severity of proliferative synovitis induced by anti-type II collagen mAb."
    Zhou J.S., Friend D.S., Lee D.M., Li L., Austen K.F., Katz H.R.
    Eur J Immunol 35:1530-1538(2005) [PubMed] [Europe PMC] [Abstract]
  • "Downregulation of key early events in the mobilization of antigen-bearing dendritic cells by leukocyte immunoglobulin-like Receptor B4 in a mouse model of allergic pulmonary inflammation."
    Fanning L.B., Buckley C.C., Xing W., Breslow R.G., Katz H.R.
    PLoS One 8:e57007-e57007(2013) [PubMed] [Europe PMC] [Abstract]
• response to nematode Source: MGIInferred from mutant phenotypeⁱ
  • Ref.16

    "Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation."
    Norris H.H., Peterson M.E., Stebbins C.C., McConchie B.W., Bundoc V.G., Trivedi S., Hodges M.G., Anthony R.M., Urban J.F. Jr., Long E.O., Keane-Myers A.M.
    J. Leukoc. Biol. 82:1531-1541(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
• response to other organism Source: MGIInferred from mutant phenotypeⁱ
  • "Decidual Macrophage Functional Polarization during Abnormal Pregnancy due to <i>Toxoplasma gondii</i>: Role for LILRB4."
    Li Z., Zhao M., Li T., Zheng J., Liu X., Jiang Y., Zhang H., Hu X.
    Front Immunol 8:1013-1013(2017) [PubMed] [Europe PMC] [Abstract]
• response to wounding Source: MGIInferred from mutant phenotypeⁱ
  • Ref.14

    "Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils."
    Zhou J.S., Friend D.S., Feldweg A.M., Daheshia M., Li L., Austen K.F., Katz H.R.
    J. Exp. Med. 198:1243-1251(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
• tolerance induction Source: MGI
• type 2 immune response Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibition of Th2 adaptive immune responses and pulmonary inflammation by leukocyte Ig-like receptor B4 on dendritic cells."
    Breslow R.G., Rao J.J., Xing W., Hong D.I., Barrett N.A., Katz H.R.
    J Immunol 184:1003-1013(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• fibronectin binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.20

    "Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice."
    Su M.T., Inui M., Wong Y.L., Takahashi M., Sugahara-Tobinai A., Ono K., Miyamoto S., Murakami K., Itoh-Nakadai A., Kezuka D., Itoi S., Endo S., Hirayasu K., Arase H., Takai T.
    Int. Immunol. 33:447-458(2021) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• integrin binding Source: ARUK-UCLInferred from direct assayⁱ
  • Ref.12

    "gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation."
    Castells M.C., Klickstein L.B., Hassani K., Cumplido J.A., Lacouture M.E., Austen K.F., Katz H.R.
    Nat. Immunol. 2:436-442(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• phosphatase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.9

    "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B."
    Wang L.L., Blasioli J., Plas D.R., Thomas M.L., Yokoyama W.M.
    J. Immunol. 162:1318-1323(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH PTPN6, ITIM MOTIFS, PHOSPHORYLATION.
• protein phosphatase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.8

    "gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization."
    Lu-Kuo J.M., Joyal D.M., Austen K.F., Katz H.R.
    J. Biol. Chem. 274:5791-5796(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PTPN6 AND PTPN11, PHOSPHORYLATION, MUTAGENESIS OF TYR-300 AND TYR-322.

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MIAMLTVLLY LGLILEPRTA VQAGHLPKPI IWAEPGSVIA AYTSVITWCQ 
        60         70         80         90        100
GSWEAQYYHL YKEKSVNPWD TQVPLETRNK AKFNIPSMTT SYAGIYKCYY 
       110        120        130        140        150
ESAAGFSEHS DAMELVMTGA YENPSLSVYP SSNVTSGVSI SFSCSSSIVF 
       160        170        180        190        200
GRFILIQEGK HGLSWTLDSQ HQANQPSYAT FVLDAVTPNH NGTFRCYGYF 
       210        220        230        240        250
RNEPQVWSKP SNSLDLMISE TKDQSSTPTE DGLETYQKIL IGVLVSFLLL 
       260        270        280        290        300
FFLLLFLILI GYQYGHKKKA NASVKNTQSE NNAELNSWNP QNEDPQGIVY 
       310        320        330 
AQVKPSRLQK DTACKETQDV TYAQLCIRTQ EQNNS                 

        10         20         30         40         50
MIAMLTVLLY LGLILEPRTA VQAGHLPKPI IWAEPGSVIA AYTSVITWCQ 
        60         70         80         90        100
GSWEAQYYHL YKEKSVNPWD TQVPLETRNK AKFNIPSMTT SYAGIYKCYY 
       110        120        130        140        150
ESAAGFSEHS DAMELVMTGA YENPSLSVYP SSNVTSGVSI SFSCSSSIVF 
       160        170        180        190        200
GRFILIQEGK HGLSWTLDSQ HQANQPSYAT FVLDAVTPNH NGTFRCYGYF 
       210        220        230        240        250
RNEPQVWSKP SNSLDLMISE TKDQSSTPTE DDASVKNTQS ENNAELNSWN 
       260        270        280        290 
PQNEDPQGIV YAQVKPSRLQ KDTACKETQD VTYAQLCIRT QEQNNS     

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot