Heart- and neural crest derivatives-expressed protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: MGI
• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2."
    Hill A.A., Riley P.R.
    Mol Cell Biol 24:9835-9847(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCLInferred from direct assayⁱ
  • "Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2."
    Hill A.A., Riley P.R.
    Mol Cell Biol 24:9835-9847(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
• enzyme binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.7

    "Nucleolar release of Hand1 acts as a molecular switch to determine cell fate."
    Martindill D.M.J., Risebro C.A., Smart N., Franco-Viseras Mdel M., Rosario C.O., Swallow C.J., Dennis J.W., Riley P.R.
    Nat. Cell Biol. 9:1131-1141(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MDFIC, PHOSPHORYLATION AT THR-107 AND SER-109, MUTAGENESIS OF THR-107 AND SER-109.
• identical protein binding Source: MGIInferred from direct assayⁱ
  • "The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer."
    Hu D., Scott I.C., Snider F., Geary-Joo C., Zhao X., Simmons D.G., Cross J.C.
    Dev Biol 382:470-481(2013) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • Ref.5

    "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function."
    Firulli B.A., Hadzic D.B., McDaid J.R., Firulli A.B.
    J. Biol. Chem. 275:33567-33573(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBUNIT.
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding."
    McFadden D.G., McAnally J., Richardson J.A., Charite J., Olson E.N.
    Development 129:3077-3088(2002) [PubMed] [Europe PMC] [Abstract]
• transcription coregulator binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2."
    Hill A.A., Riley P.R.
    Mol Cell Biol 24:9835-9847(2004) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: MGIInferred from physical interactionⁱ
  • "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2."
    Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., Richardson J.A., Yanagisawa H.
    Development 136:615-625(2009) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse."
    Oude Elferink R.P., Ottenhoff R., van Wijland M., Smit J.J., Schinkel A.H., Groen A.K.
    J. Clin. Invest. 95:31-38(1995) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• angiogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Extra-embryonic vasculature development is regulated by the transcription factor HAND1."
    Morikawa Y., Cserjesi P.
    Development 131:2195-2204(2004) [PubMed] [Europe PMC] [Abstract]
• cardiac left ventricle formation Source: MGI
• cardiac right ventricle formation Source: MGI
• cardiac septum morphogenesis Source: MGI
• cartilage morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme."
    Barbosa A.C., Funato N., Chapman S., McKee M.D., Richardson J.A., Olson E.N., Yanagisawa H.
    Dev Biol 310:154-168(2007) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: MGIInferred from genetic interactionⁱ
  • Ref.6

    "Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta."
    Yamada K., Kanda H., Tanaka S., Takamatsu N., Shiba T., Ito M.
    Differentiation 74:212-221(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SOX15, DEVELOPMENTAL STAGE.
• cell fate determination Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.7

    "Nucleolar release of Hand1 acts as a molecular switch to determine cell fate."
    Martindill D.M.J., Risebro C.A., Smart N., Franco-Viseras Mdel M., Rosario C.O., Swallow C.J., Dennis J.W., Riley P.R.
    Nat. Cell Biol. 9:1131-1141(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MDFIC, PHOSPHORYLATION AT THR-107 AND SER-109, MUTAGENESIS OF THR-107 AND SER-109.
• determination of heart left/right asymmetry Source: MGIInferred from mutant phenotypeⁱ
  • "Early exclusion of hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos."
    Riley P.R., Gertsenstein M., Dawson K., Cross J.C.
    Dev Biol 227:156-168(2000) [PubMed] [Europe PMC] [Abstract]
• developmental process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic heart tube development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis."
    Riley P., Anson-Cartwright L., Cross J.C.
    Nat. Genet. 18:271-275(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• embryonic heart tube formation Source: MGIInferred from mutant phenotypeⁱ
  • "Early exclusion of hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos."
    Riley P.R., Gertsenstein M., Dawson K., Cross J.C.
    Dev Biol 227:156-168(2000) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGIInferred from mutant phenotypeⁱ
  • "The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner."
    McFadden D.G., Barbosa A.C., Richardson J.A., Schneider M.D., Srivastava D., Olson E.N.
    Development 132:189-201(2005) [PubMed] [Europe PMC] [Abstract]
  • "Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1."
    Firulli A.B., McFadden D.G., Lin Q., Srivastava D., Olson E.N.
    Nat Genet 18:266-270(1998) [PubMed] [Europe PMC] [Abstract]
• heart looping Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis."
    Riley P., Anson-Cartwright L., Cross J.C.
    Nat. Genet. 18:271-275(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• heart morphogenesis Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2."
    Hill A.A., Riley P.R.
    Mol Cell Biol 24:9835-9847(2004) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis."
    Riley P., Anson-Cartwright L., Cross J.C.
    Nat. Genet. 18:271-275(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• mesenchyme development Source: MGIInferred from genetic interactionⁱ
  • "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme."
    Barbosa A.C., Funato N., Chapman S., McKee M.D., Richardson J.A., Olson E.N., Yanagisawa H.
    Dev Biol 310:154-168(2007) [PubMed] [Europe PMC] [Abstract]
• mesoderm formation Source: MGIInferred from mutant phenotypeⁱ
  • "Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1."
    Firulli A.B., McFadden D.G., Lin Q., Srivastava D., Olson E.N.
    Nat Genet 18:266-270(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2."
    Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., Richardson J.A., Yanagisawa H.
    Development 136:615-625(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • Ref.6

    "Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta."
    Yamada K., Kanda H., Tanaka S., Takamatsu N., Shiba T., Ito M.
    Differentiation 74:212-221(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SOX15, DEVELOPMENTAL STAGE.
• odontogenesis of dentin-containing tooth Source: MGIInferred from genetic interactionⁱ
  • "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme."
    Barbosa A.C., Funato N., Chapman S., McKee M.D., Richardson J.A., Olson E.N., Yanagisawa H.
    Dev Biol 310:154-168(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2."
    Hill A.A., Riley P.R.
    Mol Cell Biol 24:9835-9847(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• trophectodermal cell differentiation Source: Ensembl
• trophoblast giant cell differentiation Source: MGIInferred from direct assayⁱ
  • "The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer."
    Hu D., Scott I.C., Snider F., Geary-Joo C., Zhao X., Simmons D.G., Cross J.C.
    Dev Biol 382:470-481(2013) [PubMed] [Europe PMC] [Abstract]
• ventricular cardiac muscle tissue morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis."
    Riley P., Anson-Cartwright L., Cross J.C.
    Nat. Genet. 18:271-275(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: MGI
• enzyme binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.7

    "Nucleolar release of Hand1 acts as a molecular switch to determine cell fate."
    Martindill D.M.J., Risebro C.A., Smart N., Franco-Viseras Mdel M., Rosario C.O., Swallow C.J., Dennis J.W., Riley P.R.
    Nat. Cell Biol. 9:1131-1141(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MDFIC, PHOSPHORYLATION AT THR-107 AND SER-109, MUTAGENESIS OF THR-107 AND SER-109.
• identical protein binding Source: MGIInferred from direct assayⁱ
  • "The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer."
    Hu D., Scott I.C., Snider F., Geary-Joo C., Zhao X., Simmons D.G., Cross J.C.
    Dev Biol 382:470-481(2013) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • Ref.5

    "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function."
    Firulli B.A., Hadzic D.B., McDaid J.R., Firulli A.B.
    J. Biol. Chem. 275:33567-33573(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBUNIT.
• transcription coregulator binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2."
    Hill A.A., Riley P.R.
    Mol Cell Biol 24:9835-9847(2004) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: MGIInferred from physical interactionⁱ
  • "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2."
    Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., Richardson J.A., Yanagisawa H.
    Development 136:615-625(2009) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse."
    Oude Elferink R.P., Ottenhoff R., van Wijland M., Smit J.J., Schinkel A.H., Groen A.K.
    J. Clin. Invest. 95:31-38(1995) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MNLVGSYAHH HHHHHSHPPH PMLHEPFLFG PASRCHQERP YFQSWLLSPA 
        60         70         80         90        100
DAAPDFPAGG PPPTTAVAAA AYGPDARPSQ SPGRLEALGS RLPKRKGSGP 
       110        120        130        140        150
KKERRRTESI NSAFAELREC IPNVPADTKL SKIKTLRLAT SYIAYLMDVL 
       160        170        180        190        200
AKDAQAGDPE AFKAELKKTD GGRESKRKRE LPQQPESFPP ASGPGEKRIK 
       210 
GRTGWPQQVW ALELNQ                                      

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot