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Protein

Translation initiation factor eIF-2B subunit alpha

Gene

Eif2b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

  • GDP binding Source: RGD
  • GTP binding Source: RGD
  • translation initiation factor activity Source: RGD

GO - Biological processi

  • negative regulation of guanyl-nucleotide exchange factor activity Source: RGD
  • oligodendrocyte development Source: UniProtKB
  • response to amino acid starvation Source: RGD
  • response to glucose Source: UniProtKB
  • response to heat Source: UniProtKB
  • response to peptide hormone Source: UniProtKB
  • T cell receptor signaling pathway Source: UniProtKB
  • translation Source: RGD
  • translational initiation Source: RGD

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-72731 Recycling of eIF2:GDP

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit alpha
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit alpha
Gene namesi
Name:Eif2b1
Synonyms:Eif2ba
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi620819 Eif2b1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560571 – 305Translation initiation factor eIF-2B subunit alphaAdd BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ64270
PRIDEiQ64270

PTM databases

PhosphoSitePlusiQ64270

Expressioni

Gene expression databases

BgeeiENSRNOG00000001039
ExpressionAtlasiQ64270 baseline and differential
GenevisibleiQ64270 RN

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001373

Structurei

3D structure databases

ProteinModelPortaliQ64270
SMRiQ64270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1466 Eukaryota
COG1184 LUCA
GeneTreeiENSGT00550000074853
HOGENOMiHOG000175731
HOVERGENiHBG051457
InParanoidiQ64270
KOiK03239
OrthoDBiEOG091G0CQR
PhylomeDBiQ64270
TreeFamiTF101505

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit

Sequencei

Sequence statusi: Complete.

Q64270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGELIKYF KSQMKGDPNM ASAVAAIQTL LEFLKRDKGE TIQGLRAHLT
60 70 80 90 100
KAIETLCAVD SSVAVSSGGE LFLRFISLTS LEYSDYSKCK KIMIERGELF
110 120 130 140 150
LSRISLSRTK IASLCHAFIK DGARILTHAY SRVVLRVLEE AVAAKKRFSV
160 170 180 190 200
YITESQPDLS GKKMAKALCH LNVPVTVVLD AAVGYIMEKV DLVIVGAEGV
210 220 230 240 250
VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQQDVPDKF
260 270 280 290 300
KYKADTLKSV QAGQDLKEEH PWVDYTSPSL ITLLFTDLGV LTPSAVSDEL

IKLYL
Length:305
Mass (Da):33,678
Last modified:November 1, 1997 - v1
Checksum:iE0ACC1756E118101
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05821 mRNA Translation: AAC52196.1
L41679 Genomic DNA Translation: AAA91276.1
BC081709 mRNA Translation: AAH81709.1
PIRiI59376
RefSeqiNP_742026.1, NM_172029.2
UniGeneiRn.9181

Genome annotation databases

EnsembliENSRNOT00000001373; ENSRNOP00000001373; ENSRNOG00000001039
GeneIDi64514
KEGGirno:64514
UCSCiRGD:620819 rat

Similar proteinsi

Entry informationi

Entry nameiEI2BA_RAT
AccessioniPrimary (citable) accession number: Q64270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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